Locus_Name: 15S_RRNA Alias_Name: 15S_RRNA_2 Description: Ribosomal RNA of the small mitochondrial ribosomal subunit; MSU1 allele suppresses ochre stop mutations in mitochondrial protein-coding genes Gene_Product: 14s rRNA SGDID: S000007287 Locus_Name: 21S_RRNA Alias_Name: 21S_rRNA_3|21S_rRNA_4 Description: Mitochondrial 21S rRNA; intron encodes the I-SceI DNA endonuclease SGDID: S000007288 Locus_Name: 21S_RRNA_4 Description: Merged rRNA, does not encodes a discrete transcript; 21S_rRNA_4 was merged into 21S_rRNA_3 to produce a single feature named 21S_rRNA (See GenBank AJ011856) SGDID: S000007289 Locus_Name: 9S_RRNA_1 Description: Deleted rRNA, does not encode a discrete transcript; the annotations for 9S_rRNA_1 and 9S_rRNA_5 have been removed and replaced with a single gene, RPM1, which provides the correct annotation of the 9S RNA component of RNase P SGDID: S000007285 Locus_Name: 9S_RRNA_5 Description: Deleted rRNA, does not encode a discrete transcript; the annotations for 9S_rRNA_1 and 9S_rRNA_5 have been removed and replaced with a single gene, RPM1, which provides the correct annotation of the 9S RNA component of RNase P SGDID: S000007286 Locus_Name: AAC1 Description: Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator Phenotype: Null mutant is viable, shows altered colony morphology ORF_Name: YMR056C SGDID: S000004660 Locus_Name: AAC3 Alias_Name: ANC3 Description: Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Pet9p and Aac1p; has roles in maintenance of viability and in respiration Phenotype: Null mutant is viable; pet9,aac3 double null mutant is inviable under anaerobic conditions ORF_Name: YBR085W SGDID: S000000289 Locus_Name: AAD10 Description: Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role ORF_Name: YJR155W SGDID: S000003916 Locus_Name: AAD14 Description: Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role ORF_Name: YNL331C SGDID: S000005275 Locus_Name: AAD15 Description: Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role ORF_Name: YOL165C SGDID: S000005525 Locus_Name: AAD16 Description: Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role ORF_Name: YFL057C SGDID: S000001837 Locus_Name: AAD3 Description: Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role ORF_Name: YCR107W SGDID: S000000704 Locus_Name: AAD4 Description: Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase, involved in the oxidative stress response; expression induced in cells treated with the mycotoxin patulin Phenotype: Responds to oxidative stress induced by diamide and di-ethyl maleic acid ester in a YAP1 dependant manner ORF_Name: YDL243C SGDID: S000002402 Locus_Name: AAD6 Description: Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase, involved in the oxidative stress response; expression induced in cells treated with the mycotoxin patulin Phenotype: Responds to oxidative stress induced by diamide and di-ethyl maleic acid ester in YAP1 dependant manner ORF_Name: YFL056C SGDID: S000001838 Locus_Name: AAH1 Description: Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome ORF_Name: YNL141W SGDID: S000005085 Locus_Name: AAP1 Alias_Name: AAP1' Description: Arginine/alanine aminopeptidase, overproduction stimulates glycogen accumulation Phenotype: null mutant is viable, decrease in glycogen accumulation ORF_Name: YHR047C SGDID: S000001089 Locus_Name: AAR2 Description: Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron Phenotype: growth defect and defect in splicing the pre-mRNA of the MATa1 cistron ORF_Name: YBL074C SGDID: S000000170 Locus_Name: AAT1 Description: Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis Phenotype: Null mutant is viable; aat1 leu2 double mutant is inviable. ORF_Name: YKL106W SGDID: S000001589 Locus_Name: AAT2 Alias_Name: ASP5 Description: Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells ORF_Name: YLR027C SGDID: S000004017 Locus_Name: ABC1 Alias_Name: COQ8 Description: Protein required for ubiquinone (coenzyme Q) biosynthesis and for respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis ORF_Name: YGL119W SGDID: S000003087 Locus_Name: ABD1 Description: Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA ORF_Name: YBR236C SGDID: S000000440 Locus_Name: ABF1 Alias_Name: BAF1|OBF1|REB2|SBF1 Description: DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair ORF_Name: YKL112W SGDID: S000001595 Locus_Name: ABF2 Description: Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation ORF_Name: YMR072W SGDID: S000004676 Locus_Name: ABM1 Description: Protein of unknown function, required for normal microtubule organization ORF_Name: YJR108W SGDID: S000003869 Locus_Name: ABP1 Description: Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization ORF_Name: YCR088W SGDID: S000000684 Locus_Name: ABP140 Alias_Name: YOR240W Description: Nonessential protein that binds actin filaments and localizes to actin patches and cables, has similarity to S-adenosylmethionine (AdoMet)-dependent methyltransferases ORF_Name: YOR239W SGDID: S000005765 Locus_Name: ABZ1 Description: Para-aminobenzoate (PABA) synthase, has similarity to Escherichia coli PABA synthase components PabA and PabB Phenotype: Null mutant is viable and PABA auxotroph ORF_Name: YNR033W SGDID: S000005316 Locus_Name: ABZ2 Description: Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis Phenotype: Null: PABA auxotrophy. Defective in 4-amino-4-deoxychorismate lyase activity. ORF_Name: YMR289W SGDID: S000004902 Locus_Name: ACA1 Description: Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, may regulate transcription of genes involved in utilization of non-optimal carbon sources ORF_Name: YER045C SGDID: S000000847 Locus_Name: ACB1 Description: Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes Phenotype: Null mutant is viable, slightly reduced growth rate on ethanol ORF_Name: YGR037C SGDID: S000003269 Locus_Name: ACC1 Alias_Name: ABP2|FAS3|MTR7 Description: Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids Phenotype: acc1 spores fail to enter vegetative growth ORF_Name: YNR016C SGDID: S000005299 Locus_Name: ACD1 SGDID: S000029024 Locus_Name: ACE2 Description: Transcription factor that activates expression of early G1-specific genes, localizes to daughter cell nuclei after cytokinesis and delays G1 progression in daughters, localization is regulated by phosphorylation; potential Cdc28p substrate Phenotype: Null mutant is viable, exhibits decreased CUP1 mRNA expression ORF_Name: YLR131C SGDID: S000004121 Locus_Name: ACF2 Alias_Name: ENG2|PCA1 Description: Intracellular beta-1,3-endoglucanase, expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly Phenotype: Null mutant shows defect in in vitro actin assembly in the permeabilized cell assay ORF_Name: YLR144C SGDID: S000004134 Locus_Name: ACF4 Description: Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate ORF_Name: YJR083C SGDID: S000003843 Locus_Name: ACH1 Description: Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth ORF_Name: YBL015W SGDID: S000000111 Locus_Name: ACK1 Description: Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria ORF_Name: YDL203C SGDID: S000002362 Locus_Name: ACM1 Description: Pseudosubstrate inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein ORF_Name: YPL267W SGDID: S000006188 Locus_Name: ACN9 Description: Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes ORF_Name: YDR511W SGDID: S000002919 Locus_Name: ACO1 Alias_Name: GLU1 Description: Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy ORF_Name: YLR304C SGDID: S000004295 Locus_Name: ACO2 Description: Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol ORF_Name: YJL200C SGDID: S000003736 Locus_Name: ACP1 Description: Mitochondrial matrix acyl carrier protein, involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p Phenotype: The null mutant is viable but respiratory-deficient and contains only 5-10% of the wild-type amount of lipoic acid. ORF_Name: YKL192C SGDID: S000001675 Locus_Name: ACR1 Description: Involved in sensitivity to aculeacin A Phenotype: Resistant to aculeacin A, echinocandin B, and papulacandin B SGDID: S000029025 Locus_Name: ACR2 Description: Involved in sensitivity to aculeacin A Phenotype: Resistant to aculeacin A, echinocandin B, but not papulacandin B SGDID: S000029026 Locus_Name: ACR3 Description: Involved in sensitivity to aculeacin A Phenotype: Resistant to aculeacin A, echinocandin B, and papulacandin B SGDID: S000029027 Locus_Name: ACR4 Description: Involved in sensitivity to aculeacin A Phenotype: Resistant to aculeacin A, echinocandin B, and papulacandin B SGDID: S000029028 Locus_Name: ACS1 Alias_Name: FUN44 Description: Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions Phenotype: Null mutant is viable and grows on ethanol or glucose (but not acetate) as sole carbon source (but with long lag-phase); acs1 acs2 double null mutant is inviable ORF_Name: YAL054C SGDID: S000000050 Locus_Name: ACS2 Description: Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions Phenotype: Null mutant is viable, and grows on ethanol or acetate as sole carbon source, but is unable to grow on glucose as sole carbon source; acs1 acs2 double null mutant is inviable ORF_Name: YLR153C SGDID: S000004143 Locus_Name: ACT1 Alias_Name: ABY1|END7 Description: Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions Gene_Product: actin ORF_Name: YFL039C SGDID: S000001855 Locus_Name: ADA2 Alias_Name: SWI8 Description: Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes Phenotype: Null mutant is viable, grows poorly on minimal media ORF_Name: YDR448W SGDID: S000002856 Locus_Name: ADD1 SGDID: S000029029 Locus_Name: ADD37 Description: Protein of unknown function involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene ORF_Name: YMR184W SGDID: S000004796 Locus_Name: ADD66 Alias_Name: PBA2|POC2 Description: Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly ORF_Name: YKL206C SGDID: S000001689 Locus_Name: ADE1 Description: N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine Phenotype: Null mutant is viable and adenine auxotroph; ade1 mutants produce red pigment when grown in media containing low lvels of adenine. ORF_Name: YAR015W SGDID: S000000070 Locus_Name: ADE12 Alias_Name: BRA9 Description: Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence Phenotype: Adenine requiring ORF_Name: YNL220W SGDID: S000005164 Locus_Name: ADE13 Alias_Name: BRA1|BRA8 Description: Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency Phenotype: Unable to grow on complete media with glucose or fructose as a carbon source, but can grow with glycerol or ethanol ORF_Name: YLR359W SGDID: S000004351 Locus_Name: ADE15 Phenotype: Adenine requiring SGDID: S000029030 Locus_Name: ADE16 Description: Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade17p; ade16 ade17 mutants require adenine and histidine Phenotype: Null mutant is viable; ade16 ade17 double mutant requires adenine ORF_Name: YLR028C SGDID: S000004018 Locus_Name: ADE17 Description: Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade16p; ade16 ade17 mutants require adenine and histidine Phenotype: Null mutant is viable; ade16 ade17 double mutants require adenine ORF_Name: YMR120C SGDID: S000004727 Locus_Name: ADE2 Description: Phosphoribosylaminoimidazole carboxylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; red pigment accumulates in mutant cells deprived of adenine Phenotype: Null mutant is viable and requires adenine. ade2 mutants are blocked at a stage in the adenine biosynthetic pathway that causes an intermediate to accumulate in the vacuole; the intermediate gives the cell a red color. ORF_Name: YOR128C SGDID: S000005654 Locus_Name: ADE3 Description: Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine Phenotype: Null mutant is viable, adenine auxotroph, histidine auxotroph ORF_Name: YGR204W SGDID: S000003436 Locus_Name: ADE4 Description: Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway Phenotype: Adenine requiring ORF_Name: YMR300C SGDID: S000004915 Locus_Name: ADE5,7 Description: Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities Phenotype: Adenine requiring ORF_Name: YGL234W SGDID: S000003203 Locus_Name: ADE6 Description: Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway Phenotype: Adenine requiring ORF_Name: YGR061C SGDID: S000003293 Locus_Name: ADE8 Description: Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway Phenotype: Adenine requiring ORF_Name: YDR408C SGDID: S000002816 Locus_Name: ADH1 Alias_Name: ADC1 Description: Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway Phenotype: Null mutant is viable and sensitive to formaldehyde. ORF_Name: YOL086C SGDID: S000005446 Locus_Name: ADH2 Alias_Name: ADR2 Description: Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1 ORF_Name: YMR303C SGDID: S000004918 Locus_Name: ADH3 Description: Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production ORF_Name: YMR083W SGDID: S000004688 Locus_Name: ADH4 Alias_Name: NRC465|ZRG5 Description: Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency ORF_Name: YGL256W SGDID: S000003225 Locus_Name: ADH5 Description: Alcohol dehydrogenase isoenzyme V; involved in ethanol production ORF_Name: YBR145W SGDID: S000000349 Locus_Name: ADH6 Alias_Name: ADHVI Description: NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance ORF_Name: YMR318C SGDID: S000004937 Locus_Name: ADH7 Alias_Name: ADHVII Description: NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance ORF_Name: YCR105W SGDID: S000000702 Locus_Name: ADI1 Description: Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions ORF_Name: YMR009W SGDID: S000004611 Locus_Name: ADK1 Alias_Name: AKY1|AKY2 Description: Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence ORF_Name: YDR226W SGDID: S000002634 Locus_Name: ADK2 Alias_Name: AKY3|PAK3 Description: Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background ORF_Name: YER170W SGDID: S000000972 Locus_Name: ADO1 Description: Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle ORF_Name: YJR105W SGDID: S000003866 Locus_Name: ADP1 Description: Putative ATP-dependent permease of the ABC transporter family of proteins ORF_Name: YCR011C SGDID: S000000604 Locus_Name: ADR1 Description: Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization Phenotype: abolished derepression of ADH2 ORF_Name: YDR216W SGDID: S000002624 Locus_Name: ADY2 Alias_Name: ATO1 Description: Acetate transporter required for normal sporulation; phosphorylated in mitochondria Phenotype: Null mutant is viable; forms predominantly asci containing 2 spores (dyads) whensporulated; required for long-term growth on YPD at 37 degrees C; defect in ammonia production in S.cerevisiae colonies ORF_Name: YCR010C SGDID: S000000603 Locus_Name: ADY3 Description: Protein required for spore wall formation, thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p Phenotype: Null forms largely asci that contain 2 spores (dyads) when sporulated. Sporulation defect in ady3ady3 cells is due to a failure to synthesize spore wall polymers. ORF_Name: YDL239C SGDID: S000002398 Locus_Name: ADY4 Description: Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane ORF_Name: YLR227C SGDID: S000004217 Locus_Name: AEP1 Alias_Name: NCA1 Description: Protein required for expression of the mitochondrial OLI1 gene encoding subunit 9 of F1-F0 ATP synthase Phenotype: permanently respiratory defective; unable to translate OLI1 transcripts ORF_Name: YMR064W SGDID: S000004668 Locus_Name: AEP2 Alias_Name: ATP13 Description: Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader Phenotype: non-conditional respiratory mutant; unable to express the mitochondrial OLI1 gene; pet mutant ORF_Name: YMR282C SGDID: S000004895 Locus_Name: AEP3 Description: Peripheral mitochondrial inner membrane protein, located on the matrix face of the membrane; stabilizes the bicistronic AAP1-ATP6 mRNA encoding subunits 6 and 8 of the ATP synthase complex ORF_Name: YPL005W SGDID: S000005926 Locus_Name: AFG1 Description: Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain ORF_Name: YEL052W SGDID: S000000778 Locus_Name: AFG2 Alias_Name: DRG1 Description: ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; is essential for pre-60S maturation and release of several preribosome maturation factors; may be involved in degradation of aberrant mRNAs ORF_Name: YLR397C SGDID: S000004389 Locus_Name: AFG3 Alias_Name: YTA10 Description: Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes Phenotype: nuclear petite phenotype; loss of repspiratory competence ORF_Name: YER017C SGDID: S000000819 Locus_Name: AFI1 Description: Arf3p polarization-specific docking factor, required for the polarized distribution of the ADP-ribosylation factor, Arf3p; participates in polarity development and maintenance of a normal haploid budding pattern; interacts with Cnm7p ORF_Name: YOR129C SGDID: S000005655 Locus_Name: AFR1 Description: Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; interacts with Cdc12p Phenotype: defect in alpha-factor-stimulated morphogenesis ORF_Name: YDR085C SGDID: S000002492 Locus_Name: AFT1 Alias_Name: RCS1 Description: Transcription factor involved in iron utilization and homeostasis; binds the consensus site PyPuCACCCPu and activates the expression of target genes in response to changes in iron availability Phenotype: Null mutant is viable; mutant cells are larger than normal, since critical size for budding is increased; mutant shows incorrect regulation of expression of genes involved in iron uptake; spores from heterozygous diploid have reduced ability to germinate; ORF_Name: YGL071W SGDID: S000003039 Locus_Name: AFT2 Description: Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; similar to Aft1p Phenotype: Null: Deletion of AFT2 exacerates iron deficiency of AFT1 disruption. ORF_Name: YPL202C SGDID: S000006123 Locus_Name: AGA1 Description: Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds Gene_Product: a-agglutinin anchorage subunit Phenotype: mating defect in liquid medium ORF_Name: YNR044W SGDID: S000005327 Locus_Name: AGA2 Description: Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds Gene_Product: a-agglutinin adhesion subunit ORF_Name: YGL032C SGDID: S000003000 Locus_Name: AGC1 Description: Mitochondrial amino acid transporter, acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis Phenotype: Null: viable. Other phenotypes: not viable on minimal medium supplemented with acetate or oleate ORF_Name: YPR021C SGDID: S000006225 Locus_Name: AGE1 Alias_Name: SAT1 Description: ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif ORF_Name: YDR524C SGDID: S000002932 Locus_Name: AGE2 Alias_Name: SAT2 Description: ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif ORF_Name: YIL044C SGDID: S000001306 Locus_Name: AGP1 Alias_Name: YCC5 Description: Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p) Phenotype: Null mutant is viable; resistant to the amino acid analog gamma-hydroxyaspartate, decreased growth on asn, gln and some other amino acids in strains in which Gap1 and Gnp1 are also missing. ORF_Name: YCL025C SGDID: S000000530 Locus_Name: AGP2 Description: High affinity polyamine permease, preferentially uses spermidine over putrescine; expression is down-regulated by osmotic stress; plasma membrane carnitine transporter, also functions as a low-affinity amino acid permease Phenotype: Null mutant is viable; loss of growth on some amino acids as nitrogen source (leu, thr) in a strain which has no Gap1p or Agp1p function ORF_Name: YBR132C SGDID: S000000336 Locus_Name: AGP3 Description: Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition Phenotype: Null mutant is viable; loss of growth on some amino acids as nitrogen source (leu, thr) in a strain which has no Gap1p or Agp1p function ORF_Name: YFL055W SGDID: S000001839 Locus_Name: AGS1 Phenotype: aminoglycoside antibiotic sensitive SGDID: S000029031 Locus_Name: AGX1 Description: Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases Gene_Product: alanine:glyoxylate aminotransferase ORF_Name: YFL030W SGDID: S000001864 Locus_Name: AHA1 Description: Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock ORF_Name: YDR214W SGDID: S000002622 Locus_Name: AHC1 Description: Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex ORF_Name: YOR023C SGDID: S000005549 Locus_Name: AHC2 Description: Protein of unknown function, putative transcriptional regulator; proposed to be a Ada Histone acetyltransferase complex component; GFP tagged protein is localized to the cytoplasm and nucleus ORF_Name: YCR082W SGDID: S000000678 Locus_Name: AHP1 Description: Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p Gene_Product: cTPxIII Phenotype: hypersensitive to tert-butyl hydroperoxide ORF_Name: YLR109W SGDID: S000004099 Locus_Name: AHT1 Description: Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; multicopy suppressor of glucose transport defects, likely due to the presence of an HXT4 regulatory element in the region ORF_Name: YHR093W SGDID: S000001135 Locus_Name: AI1 Description: Reverse transcriptase required for splicing of the COX1 pre-mRNA, encoded by a mobile group II intron within the mitochondrial COX1 gene Phenotype: unable to excise adjacent aI2 intron; reduced intron mobility ORF_Name: Q0050 SGDID: S000007261 Locus_Name: AI2 Description: Reverse transcriptase required for splicing of the COX1 pre-mRNA, encoded by a mobile group II intron within the mitochondrial COX1 gene Phenotype: defective in aI1 and aI2 intron mobility ORF_Name: Q0055 SGDID: S000007262 Locus_Name: AI3 Description: Endonuclease I-SceIII, encoded by a mobile group I intron within the mitochondrial COX1 gene Gene_Product: I-SceIII Phenotype: Mutations that block aI3 splicing cause defects in respiration and accumulate I-SceIII endonuclease. ORF_Name: Q0060 SGDID: S000007263 Locus_Name: AI4 Description: Endonuclease I-SceII, encoded by a mobile group I intron within the mitochondrial COX1 gene; intron is normally spliced by the BI4p maturase but AI4p can mutate to acquire the same maturase activity Gene_Product: I-SceII Phenotype: Mutations that block aI4 splicing cause defects in respiration; other mutations affect intron mobility or maturase functions. ORF_Name: Q0065 SGDID: S000007264 Locus_Name: AI5_ALPHA Description: Endonuclease I-SceIV, involved in intron mobility; encoded by a mobile group I intron within the mitochondrial COX1 gene ORF_Name: Q0070 SGDID: S000007265 Locus_Name: AI5_BETA Description: Protein of unknown function, encoded within an intron of the mitochondrial COX1 gene; translational initiation codon is predicted to be ATA rather than ATG ORF_Name: Q0075 SGDID: S000007266 Locus_Name: AIF1 Alias_Name: CPD1 Description: Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase ORF_Name: YNR074C SGDID: S000005357 Locus_Name: AIM1 Description: Protein involved in mitochondrial function or organization; null mutant displays elevated frequency of mitochondrial genome loss ORF_Name: YAL046C SGDID: S000000044 Locus_Name: AIM10 Description: Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss ORF_Name: YER087W SGDID: S000000889 Locus_Name: AIM11 Alias_Name: GEP8 Description: Protein of unknown function; null mutant is viable but shows increased loss of mitochondrial genome and synthetic interaction with prohibitin (phb1); contains an intron ORF_Name: YER093C-A SGDID: S000002960 Locus_Name: AIM13 Description: Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria; null mutant displays reduced respiratory growth and reduced frequency of mitochondrial genome loss ORF_Name: YFR011C SGDID: S000001907 Locus_Name: AIM14 Description: Putative protein of with similarity to iron/copper reductases (FRE1-8), possibly involved in iron homeostasis; may interact with ribosomes; null mutant displays elevated frequency of mitochondrial genome loss ORF_Name: YGL160W SGDID: S000003128 Locus_Name: AIM17 Alias_Name: FMP12 Description: Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss ORF_Name: YHL021C SGDID: S000001013 Locus_Name: AIM18 Alias_Name: FMP22 Description: Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss ORF_Name: YHR198C SGDID: S000001241 Locus_Name: AIM19 Alias_Name: LRC2 Description: Putative protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth ORF_Name: YIL087C SGDID: S000001349 Locus_Name: AIM2 Description: Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced frequency of mitochondrial genome loss; potential Hsp82p interactor ORF_Name: YAL049C SGDID: S000000047 Locus_Name: AIM20 Description: Putative protein of unknown function; overexpression causes a cell cycle delay or arrest; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; null mutant displays elevated frequency of mitochondrial genome loss ORF_Name: YIL158W SGDID: S000001420 Locus_Name: AIM21 Description: Protein of unknown function involved in mitochondrial migration along actin filament; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton ORF_Name: YIR003W SGDID: S000001442 Locus_Name: AIM22 Alias_Name: LIP3|RRG3 Description: Putative lipoate-protein ligase, required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss ORF_Name: YJL046W SGDID: S000003582 Locus_Name: AIM23 Description: Putative protein of unknown function; the authentic non-tagged protein is detected in highly purified mitochondria; null mutant is viable, displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss ORF_Name: YJL131C SGDID: S000003667 Locus_Name: AIM24 Alias_Name: FMP26 Description: Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss ORF_Name: YJR080C SGDID: S000003841 Locus_Name: AIM25 Description: Putative protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to murine NOR1; null mutant is viable and displays elevated frequency of mitochondrial genome loss ORF_Name: YJR100C SGDID: S000003861 Locus_Name: AIM26 Description: Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT ORF_Name: YKL037W SGDID: S000001520 Locus_Name: AIM27 Alias_Name: EMC3|LRC3 Description: Member of a transmembrane complex required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response ORF_Name: YKL207W SGDID: S000001690 Locus_Name: AIM29 Description: Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YKR074W is not an essential gene; null mutant displays elevated frequency of mitochondrial genome loss ORF_Name: YKR074W SGDID: S000001782 Locus_Name: AIM3 Description: Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss ORF_Name: YBR108W SGDID: S000000312 Locus_Name: AIM31 Description: Putative protein of unknown function; GFP-fusion protein localizes to mitochondria; may interact with respiratory chain complexes III or IV; null mutant is viable and displays reduced frequency of mitochondrial genome loss ORF_Name: YML030W SGDID: S000004492 Locus_Name: AIM32 Description: Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss ORF_Name: YML050W SGDID: S000004514 Locus_Name: AIM33 Description: Putative protein of unknown function, highly conserved across species and orthologous to human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss ORF_Name: YML087C SGDID: S000004552 Locus_Name: AIM34 Description: Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss ORF_Name: YMR003W SGDID: S000004605 Locus_Name: AIM36 Alias_Name: FMP39 Description: Protein of unknown function; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies ORF_Name: YMR157C SGDID: S000004766 Locus_Name: AIM37 Description: Putative protein of unknown function; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays reduced respiratory growth and reduced frequency of mitochondrial genome los ORF_Name: YNL100W SGDID: S000005044 Locus_Name: AIM38 Description: Putative protein of unknown function; non-tagged protein is detected in purified mitochondria; may interact with respiratory chain complex IV; null mutant is viable and displays reduced frequency of mitochondrial genome loss ORF_Name: YNR018W SGDID: S000005301 Locus_Name: AIM39 Description: Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss ORF_Name: YOL053W SGDID: S000005414 Locus_Name: AIM4 Alias_Name: SOY1 Description: Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress ORF_Name: YBR194W SGDID: S000000398 Locus_Name: AIM41 Description: Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss ORF_Name: YOR215C SGDID: S000005741 Locus_Name: AIM43 Alias_Name: FMP14 Description: Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss ORF_Name: YPL099C SGDID: S000006020 Locus_Name: AIM44 Description: Protein of unknown function; GFP-fusion protein localizes to the bud neck; transcription is regulated by Swi5p; null mutant displays elevated frequency of mitochondrial genome loss ORF_Name: YPL158C SGDID: S000006079 Locus_Name: AIM45 Description: Protein with similarity to mammalian electron transfer flavoprotein complex subunit ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss ORF_Name: YPR004C SGDID: S000006208 Locus_Name: AIM46 Alias_Name: FMP34 Description: Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss ORF_Name: YHR199C SGDID: S000001242 Locus_Name: AIM5 Alias_Name: FMP51 Description: Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss ORF_Name: YBR262C SGDID: S000000466 Locus_Name: AIM6 Alias_Name: LRC1 Description: Putative protein of unknown function, required for respiratory growth; YDL237W is not an essential gene ORF_Name: YDL237W SGDID: S000002396 Locus_Name: AIM7 Description: Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is viable and displays elevated frequency of mitochondrial genome loss ORF_Name: YDR063W SGDID: S000002470 Locus_Name: AIM9 Alias_Name: FMP29 Description: Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss ORF_Name: YER080W SGDID: S000000882 Locus_Name: AIP1 Description: Actin cortical patch component, interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats ORF_Name: YMR092C SGDID: S000004698 Locus_Name: AIR1 Description: Zinc knuckle protein, involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; functionally redundant with Air2p ORF_Name: YIL079C SGDID: S000001341 Locus_Name: AIR2 Description: Zinc knuckle protein, involved in nuclear RNA processing and degredation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; functionally redundant with Air1p ORF_Name: YDL175C SGDID: S000002334 Locus_Name: AKL1 Description: Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization ORF_Name: YBR059C SGDID: S000000263 Locus_Name: AKR1 Description: Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats Phenotype: Null mutant is viable, exhibits slow growth, abnormal morphology, and partial activation of pheromone response; defective for endocytosis of Ste2p and Ste3p ORF_Name: YDR264C SGDID: S000002672 Locus_Name: AKR2 Description: Ankyrin repeat-containing protein similar to Akr1p; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p ORF_Name: YOR034C SGDID: S000005560 Locus_Name: ALA1 Alias_Name: CDC64 Description: Cytoplasmic and mitochondrial alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog Phenotype: null mutant is inviable; allele cdc64-1: arrest of proliferation at the regulatory step Start, inhibition of zygote formation and successful conjugation ORF_Name: YOR335C SGDID: S000005862 Locus_Name: ALB1 Description: Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p ORF_Name: YJL122W SGDID: S000003658 Locus_Name: ALD2 Description: Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p ORF_Name: YMR170C SGDID: S000004780 Locus_Name: ALD3 Description: Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose ORF_Name: YMR169C SGDID: S000004779 Locus_Name: ALD4 Alias_Name: ALD7|ALDH2 Description: Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed ORF_Name: YOR374W SGDID: S000005901 Locus_Name: ALD5 Description: Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed ORF_Name: YER073W SGDID: S000000875 Locus_Name: ALD6 Alias_Name: ALD1 Description: Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress Phenotype: Null mutant is viable, grows at approximately one-third the rate of wild-type, unable to grow on ethanol as a carbon source ORF_Name: YPL061W SGDID: S000005982 Locus_Name: ALE1 Alias_Name: LCA1|LPT1|SLC4 Description: Broad-specificity lysophospholipid acyltransferase, part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids ORF_Name: YOR175C SGDID: S000005701 Locus_Name: ALF1 Description: Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance Phenotype: Null mutant is viable, benomyl super-sensitive, alf1 tub1 mutants are inviable ORF_Name: YNL148C SGDID: S000005092 Locus_Name: ALG1 Description: Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog ORF_Name: YBR110W SGDID: S000000314 Locus_Name: ALG11 Description: Alpha-1,2-mannosyltransferase, catalyzes sequential addition of the two terminal alpha 1,2-mannose residues to the Man5GlcNAc2-PP-dolichol intermediate during asparagine-linked glycosylation in the ER Phenotype: Null mutant displays poor growth and temperature-sensitive lethality ORF_Name: YNL048W SGDID: S000004993 Locus_Name: ALG12 Alias_Name: ECM39 Description: Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation ORF_Name: YNR030W SGDID: S000005313 Locus_Name: ALG13 Description: Catalytic component of UDP-GlcNAc transferase, required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER membrane via interaction with Alg14p; similar to bacterial and human glycosyltransferases ORF_Name: YGL047W SGDID: S000003015 Locus_Name: ALG14 Description: Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases ORF_Name: YBR070C SGDID: S000000274 Locus_Name: ALG2 Description: Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol Phenotype: Null mutant is inviable, mutants accumulate Man1-2GlcNAc2 and arrest at G1 ORF_Name: YGL065C SGDID: S000003033 Locus_Name: ALG3 Alias_Name: RHK1 Description: Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins Phenotype: Null mutant is viable, resistant to Hansenula killer toxin ORF_Name: YBL082C SGDID: S000000178 Locus_Name: ALG5 Description: UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum Phenotype: underglycosylation of carboxypeptidase Y ORF_Name: YPL227C SGDID: S000006148 Locus_Name: ALG6 Description: Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease Phenotype: Null mutant is viable and defective in protein glycosylation. ORF_Name: YOR002W SGDID: S000005528 Locus_Name: ALG7 Alias_Name: TUR1 Description: UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin Phenotype: Asparagine-linked glycosylation deficient; Null mutant is inviable ORF_Name: YBR243C SGDID: S000000447 Locus_Name: ALG8 Alias_Name: YOR29-18 Description: Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p ORF_Name: YOR067C SGDID: S000005593 Locus_Name: ALG9 Description: Mannosyltransferase, involved in N-linked glycosylation; catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation ORF_Name: YNL219C SGDID: S000005163 Locus_Name: ALK1 Description: Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; similar to Alk2p and to mammalian haspins ORF_Name: YGL021W SGDID: S000002989 Locus_Name: ALK2 Description: Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; similar to Alk1p and to mammalian haspins ORF_Name: YBL009W SGDID: S000000105 Locus_Name: ALO1 Description: D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress Phenotype: Null mutant is viable, shows increased sensitivity towards oxidative stress ORF_Name: YML086C SGDID: S000004551 Locus_Name: ALP1 Alias_Name: APL1 Description: Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression ORF_Name: YNL270C SGDID: S000005214 Locus_Name: ALR1 Alias_Name: SWC3 Description: Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions Phenotype: Null mutant is inviable; overexpression increases resistance to aluminum and gallium toxicity ORF_Name: YOL130W SGDID: S000005490 Locus_Name: ALR2 Description: Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition Phenotype: Null mutant is viable, overexpression increases resistance to aluminum and gallium toxicity ORF_Name: YFL050C SGDID: S000001844 Locus_Name: ALT1 Description: Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthetic and catabolic processes; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies ORF_Name: YLR089C SGDID: S000004079 Locus_Name: ALT2 Description: Putative alanine transaminase (glutamic pyruvic transaminase) ORF_Name: YDR111C SGDID: S000002518 Locus_Name: ALY1 Alias_Name: ART6 Description: Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm ORF_Name: YKR021W SGDID: S000001729 Locus_Name: ALY2 Alias_Name: ART3 Description: Protein proposed to regulate the endocytosis of plasma membrane proteins; interacts with the cyclin Pcl7p and ubiquitin ligase Rsp5p; phosphorylated by the cyclin-CDK complex, Pcl7p-Pho85p; mRNA is cell cycle regulated, peaking in M phase ORF_Name: YJL084C SGDID: S000003620 Locus_Name: AMA1 Alias_Name: SPO70 Description: Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis Phenotype: Null mutant is viable; homozygous null mutant does not sporulate but does not exhibit any vegetative phenotype. ORF_Name: YGR225W SGDID: S000003457 Locus_Name: AMC1 Alias_Name: CHL6 Description: controls segregation of artificial minichromosomes during mitosis Phenotype: affects mitotic transmission of natural chromosomes SGDID: S000029032 Locus_Name: AMD1 Alias_Name: AMD3 Description: AMP deaminase, tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; may be involved in regulation of intracellular adenine nucleotide pools ORF_Name: YML035C SGDID: S000004498 Locus_Name: AMD2 Description: Putative amidase ORF_Name: YDR242W SGDID: S000002650 Locus_Name: AME1 Alias_Name: ARP100 Description: Essential kinetochore protein associated with microtubules and spindle pole bodies; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance Phenotype: Null: Null mutant is inviable; localizes to microtubules and SPB region, ame1-1 arrests in G2/M, mutant rescues benomyl sensitivity of TUB4/ tub4 heterozygote, ame1-4 mutant allele and heterozygous mutant confer benomyl resistance, interacts with APC lid protein by two-hybrid ORF_Name: YBR211C SGDID: S000000415 Locus_Name: AML1 Description: Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae ORF_Name: YGR001C SGDID: S000003233 Locus_Name: AMN1 Alias_Name: CST13|ICS4 Description: Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN) ORF_Name: YBR158W SGDID: S000000362 Locus_Name: AMS1 Description: Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway ORF_Name: YGL156W SGDID: S000003124 Locus_Name: ANB1 Alias_Name: HYP1|TIF51B|eIF-5A Description: Translation elongation factor eIF-5A, previously thought to function in translation initiation; similar to and functionally redundant with Hyp2p; undergoes an essential hypusination modification; expressed under anaerobic conditions Phenotype: null mutant is viable; a double mutant containing disruptions of both ANB1 and and the highly homologous HYP2 is inviable ORF_Name: YJR047C SGDID: S000003808 Locus_Name: ANC4 Description: actin non-complementing mutant SGDID: S000029033 Locus_Name: ANI1 Phenotype: Anisomycin resistance SGDID: S000029034 Locus_Name: ANP1 Alias_Name: GEM3|MNN8 Description: Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol Phenotype: Null mutant has altered mannoprotein glycosylation and a defect in N-linked outerchain glycan mannosylation; other mutant phenotypes include aminonitrophenyl propanediol resistance, vanadate resistance, hygromycin B sensitive and a clumpy growth morphology. ORF_Name: YEL036C SGDID: S000000762 Locus_Name: ANR2 Description: Putative protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm ORF_Name: YKL047W SGDID: S000001530 Locus_Name: ANS1 Description: Putative protein of unknown function; transcription dependent upon Azf1p ORF_Name: YHR126C SGDID: S000001168 Locus_Name: ANT1 Description: Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation Phenotype: Null: growth defect on medium-chain length fatty acids. ORF_Name: YPR128C SGDID: S000006332 Locus_Name: AOS1 Alias_Name: RHC31 Description: Nuclear protein that acts as a heterodimer with Uba2p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability ORF_Name: YPR180W SGDID: S000006384 Locus_Name: APA1 Alias_Name: DTP1 Description: Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase I (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa2p ORF_Name: YCL050C SGDID: S000000555 Locus_Name: APA2 Description: Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase II (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa1p ORF_Name: YDR530C SGDID: S000002938 Locus_Name: APC1 Description: Largest subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition ORF_Name: YNL172W SGDID: S000005116 Locus_Name: APC11 Description: Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition Phenotype: Null mutant is inviable at 25 C ORF_Name: YDL008W SGDID: S000002166 Locus_Name: APC2 Alias_Name: RSI1|TID2 Description: Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; similar to cullin Cdc53p Phenotype: Null mutant is inviable at 25 deg. C; ts mutants arrest in metaphase due to defect in the degradation of Pds1; extracts from G1-arrested apc2 mutants are defective in the ubiquitination of mitotic cyclins ORF_Name: YLR127C SGDID: S000004117 Locus_Name: APC4 Description: Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition Phenotype: Null mutant is inviable at 25 C ORF_Name: YDR118W SGDID: S000002525 Locus_Name: APC5 Alias_Name: RMC1 Description: Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition Phenotype: Null mutant is inviable at 25 C ORF_Name: YOR249C SGDID: S000005775 Locus_Name: APC9 Description: Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition Phenotype: Null mutant is viable at 37 C but show delay in entry into anaphase at 37 C ORF_Name: YLR102C SGDID: S000004092 Locus_Name: APD1 Description: Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus ORF_Name: YBR151W SGDID: S000000355 Locus_Name: APE2 Alias_Name: LAP1|YKL158W Description: Aminopeptidase yscII; may have a role in obtaining leucine from dipeptide substrates; sequence coordinates have changed since RT-PCR analysis showed that the adjacent ORF YKL158W comprises the 5' exon of APE2/YKL157W ORF_Name: YKL157W SGDID: S000001640 Locus_Name: APE3 Alias_Name: APY1 Description: Vacuolar aminopeptidase Y, processed to mature form by Prb1p Phenotype: Null mutant is viable but exhibited reduced vacuolar aminopeptidase activities and could not hydrolyze Lys-Ala-MCA to Lys and Ala-MCA. ORF_Name: YBR286W SGDID: S000000490 Locus_Name: API2 Description: Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology ORF_Name: YDR525W SGDID: S000002933 Locus_Name: APJ1 Description: Putative chaperone of the HSP40 (DNAJ) family; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies ORF_Name: YNL077W SGDID: S000005021 Locus_Name: APL1 Alias_Name: YAP80 Description: Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex ORF_Name: YJR005W SGDID: S000003765 Locus_Name: APL2 Description: Beta-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting ORF_Name: YKL135C SGDID: S000001618 Locus_Name: APL3 Description: Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport ORF_Name: YBL037W SGDID: S000000133 Locus_Name: APL4 Description: Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport ORF_Name: YPR029C SGDID: S000006233 Locus_Name: APL5 Alias_Name: YKS4 Description: Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function Phenotype: Null mutant is viable, rescues yck1,yck2 double mutant ORF_Name: YPL195W SGDID: S000006116 Locus_Name: APL6 Alias_Name: YKS5 Description: Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools Phenotype: Null mutant is viable, null rescues yck1 yck2 double mutant ORF_Name: YGR261C SGDID: S000003493 Locus_Name: APM1 Alias_Name: YAP54 Description: Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting Phenotype: Null mutant is viable, enhances the slow growth and late Golgi sorting defects of a chc1-ts mutant ORF_Name: YPL259C SGDID: S000006180 Locus_Name: APM2 Description: Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport ORF_Name: YHL019C SGDID: S000001011 Locus_Name: APM3 Alias_Name: YKS6 Description: Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway Phenotype: Null mutant is viable, even combined with apm1 and apm2 ORF_Name: YBR288C SGDID: S000000492 Locus_Name: APM4 Alias_Name: AMP1 Description: Mu2-like subunit of the clathrin associated protein complex (AP-2); involved in vesicle transport ORF_Name: YOL062C SGDID: S000005423 Locus_Name: APN1 Description: Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine Phenotype: hypersensitive to both oxidative and alkylating agents that damage DNA; higher rate of spontaneous mutation ORF_Name: YKL114C SGDID: S000001597 Locus_Name: APN2 Alias_Name: ETH1 Description: Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII ORF_Name: YBL019W SGDID: S000000115 Locus_Name: APP1 Description: Protein of unknown function, interacts with Rvs161p and Rvs167p; computational analysis of protein-protein interactions in large-scale studies suggests a possible role in actin filament organization Phenotype: Null: Viable. Other phenotypes: Unknown ORF_Name: YNL094W SGDID: S000005038 Locus_Name: APQ12 Description: Protein required for nuclear envelope morphology, nuclear pore complex localization, mRNA export from the nucleus; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism ORF_Name: YIL040W SGDID: S000001302 Locus_Name: APQ13 Description: Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene NET1; null mutant is sensitive to sorbate ORF_Name: YJL075C SGDID: S000003611 Locus_Name: APR2 SGDID: S000029037 Locus_Name: APR3 SGDID: S000029038 Locus_Name: APR4 SGDID: S000029039 Locus_Name: APR5 SGDID: S000029040 Locus_Name: APS1 Alias_Name: YAP19 Description: Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex Phenotype: Null mutant is viable; aps1 mutants demonstrate synthetic effects with chc1 alleles ORF_Name: YLR170C SGDID: S000004160 Locus_Name: APS2 Alias_Name: YAP17 Description: Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex Phenotype: null mutant is viable; slight effect on chc1-ts cell growth ORF_Name: YJR058C SGDID: S000003819 Locus_Name: APS3 Alias_Name: YKS7 Description: Small subunit of the clathrin-associated adaptor complex AP-3, which is involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function Phenotype: Null mutant is viable, rescues yck1,yck2 double mutant ORF_Name: YJL024C SGDID: S000003561 Locus_Name: APT1 Description: Adenine phosphoribosyltransferase, catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis ORF_Name: YML022W SGDID: S000004484 Locus_Name: APT2 Description: Apparent pseudogene, not transcribed or translated under normal conditions; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity ORF_Name: YDR441C SGDID: S000002849 Locus_Name: AQR1 Description: Plasma membrane multidrug transporter of the major facilitator superfamily, confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids Phenotype: Null mutant is viable, but exhibits increased susceptibility to low-chain organic acids (C2-C6), azoles, antimalarial quinoline-ring containing drugs, malachite green and crystal violet ORF_Name: YNL065W SGDID: S000005009 Locus_Name: AQY1 Description: Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance Phenotype: Null mutant is viable and exhibits improved viability when grown under hypo-osmolar or hyper-osmolar stress. ORF_Name: YPR192W SGDID: S000006396 Locus_Name: AQY2 Description: Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains ORF_Name: YLL052C SGDID: S000003975 Locus_Name: ARA1 Description: NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product Phenotype: Null mutant is viable but cannot produce D-arabinono-1,4-lactone, a precursor of D-erythroascorbic acid ORF_Name: YBR149W SGDID: S000000353 Locus_Name: ARA2 Description: NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase ORF_Name: YMR041C SGDID: S000004644 Locus_Name: ARB1 Description: ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p ORF_Name: YER036C SGDID: S000000838 Locus_Name: ARC1 Description: Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids Phenotype: Null mutant is viable, leads to slow growth and reduced MetRS activity; arc1- mutants are synthetic lethals and are complemented by the genes for methionyl-tRNA and glutamyl-tRNA synthetase. ORF_Name: YGL105W SGDID: S000003073 Locus_Name: ARC15 Description: Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches Phenotype: Null mutant exhibits severe growth defects. Cells with mutations in Arp2 and Arc15 are defective in mitochondrial movement. ORF_Name: YIL062C SGDID: S000001324 Locus_Name: ARC18 Description: Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches ORF_Name: YLR370C SGDID: S000004362 Locus_Name: ARC19 Description: Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches Phenotype: Null mutant is viable, but exhibits severe growth defects ORF_Name: YKL013C SGDID: S000001496 Locus_Name: ARC35 Alias_Name: END9 Description: Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin Phenotype: Null mutant exhibits severe growth defects; synthetic lethal with vma2. ORF_Name: YNR035C SGDID: S000005318 Locus_Name: ARC40 Description: Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches ORF_Name: YBR234C SGDID: S000000438 Locus_Name: ARD1 Alias_Name: NAA10 Description: Subunit of N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); acetylates many proteins and thus affects telomeric silencing, cell cycle, heat-shock resistance, mating, and sporulation; human Ard1p levels are elevated in cancer cells ORF_Name: YHR013C SGDID: S000001055 Locus_Name: ARE1 Alias_Name: SAT2 Description: Acyl-CoA:sterol acyltransferase, isozyme of Are2p; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen Phenotype: Null mutant is viable, slightly reduces in vivo and in vitro ergosterol esterification. Deletion of both ARE1 and ARE2 completely eliminates of in vivo and in vitro ergosterol esterification ORF_Name: YCR048W SGDID: S000000644 Locus_Name: ARE2 Alias_Name: SAT1 Description: Acyl-CoA:sterol acyltransferase, isozyme of Are1p; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen Phenotype: Null mutant is viable; greatly reduces in vivo and in vitro ergosterol esterification (to 15 - 35 % of wild-type). Deletion of both ARE1 and ARE2 completely eliminates in vivo and in vitro ergosterol esterification ORF_Name: YNR019W SGDID: S000005302 Locus_Name: ARF1 Description: ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; functionally interchangeable with Arf2p Phenotype: Null mutant is viable and shows slow growth, cold sensitivity and sensitivity to normally sublethal concentrations of fluoride ion in the medium. ORF_Name: YDL192W SGDID: S000002351 Locus_Name: ARF2 Description: ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; functionally interchangeable with Arf1p ORF_Name: YDL137W SGDID: S000002296 Locus_Name: ARF3 Alias_Name: ARL2 Description: Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity ORF_Name: YOR094W SGDID: S000005620 Locus_Name: ARG1 Alias_Name: ARG10 Description: Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate Phenotype: Arginine requiring ORF_Name: YOL058W SGDID: S000005419 Locus_Name: ARG2 Alias_Name: HRB574 Description: Acetylglutamate synthase (glutamate N-acetyltransferase), mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p ORF_Name: YJL071W SGDID: S000003607 Locus_Name: ARG3 Alias_Name: argF Description: Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine Phenotype: Arginine requiring ORF_Name: YJL088W SGDID: S000003624 Locus_Name: ARG4 Description: Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway Phenotype: Arginine requiring ORF_Name: YHR018C SGDID: S000001060 Locus_Name: ARG5,6 Description: Protein that is processed in the mitochondrion to yield acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase, which catalyze the 2nd and 3rd steps in arginine biosynthesis; enzymes form a complex with Arg2p Phenotype: Arginine requiring ORF_Name: YER069W SGDID: S000000871 Locus_Name: ARG7 Alias_Name: ECM40 Description: Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine ORF_Name: YMR062C SGDID: S000004666 Locus_Name: ARG8 Description: Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine Phenotype: Arginine requiring ORF_Name: YOL140W SGDID: S000005500 Locus_Name: ARG80 Alias_Name: ARGR1|ARGRI Description: Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p Phenotype: Arginine requiring ORF_Name: YMR042W SGDID: S000004645 Locus_Name: ARG81 Alias_Name: ARGR2|ARGRII Description: Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p ORF_Name: YML099C SGDID: S000004565 Locus_Name: ARG82 Alias_Name: ARGR3|ARGRIII|IPK2 Description: Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes Phenotype: Null mutant is viable but requires arginine at 23C; growth defect at 30C; inviable at 37C; null is defective in sporulation, mating, amino acid metabolism (fails to grow on medium in which arginine or ornithine is the sole nitrogen source); null mutants accumulate IP3, I(4,5)P2 and have drastically reduced levels of IP4, IP5 and IP6. ORF_Name: YDR173C SGDID: S000002580 Locus_Name: ARG84 Phenotype: Arginine requiring SGDID: S000029041 Locus_Name: ARH1 Description: Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability ORF_Name: YDR376W SGDID: S000002784 Locus_Name: ARI1 Description: NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily ORF_Name: YGL157W SGDID: S000003125 Locus_Name: ARK1 Description: Serine/threonine protein kinase involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis Phenotype: Null mutant is viable and shows slight delocalisation of actin cytoskeleton ORF_Name: YNL020C SGDID: S000004965 Locus_Name: ARL1 Alias_Name: DLP2 Description: Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor ORF_Name: YBR164C SGDID: S000000368 Locus_Name: ARL3 Description: GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor Phenotype: Null mutant is viable, displays cold-sensitive growth ORF_Name: YPL051W SGDID: S000005972 Locus_Name: ARN1 Description: Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores ORF_Name: YHL040C SGDID: S000001032 Locus_Name: ARN2 Alias_Name: TAF1 Description: Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C ORF_Name: YHL047C SGDID: S000001039 Locus_Name: ARO1 Description: Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids Phenotype: aromatic amino acid requiring; lack of premeiotic DNA synthesis; blocked sporulation in homozygous mutant ORF_Name: YDR127W SGDID: S000002534 Locus_Name: ARO10 Description: Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway ORF_Name: YDR380W SGDID: S000002788 Locus_Name: ARO2 Description: Bifunctional chorismate synthase and flavin reductase, catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids Phenotype: aromatic amino acid requiring; lack of premeiotic DNA synthesis; blocked sporulation in homozygous mutant ORF_Name: YGL148W SGDID: S000003116 Locus_Name: ARO3 Description: 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan ORF_Name: YDR035W SGDID: S000002442 Locus_Name: ARO4 Description: 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan ORF_Name: YBR249C SGDID: S000000453 Locus_Name: ARO7 Alias_Name: HGS1|OSM2|TYR7 Description: Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis Phenotype: Aromatic amino acid requiring; Low osmotic pressure sensitive ORF_Name: YPR060C SGDID: S000006264 Locus_Name: ARO8 Description: Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis ORF_Name: YGL202W SGDID: S000003170 Locus_Name: ARO80 Description: Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids ORF_Name: YDR421W SGDID: S000002829 Locus_Name: ARO9 Description: Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism ORF_Name: YHR137W SGDID: S000001179 Locus_Name: ARP1 Alias_Name: ACT5 Description: Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin Phenotype: Null mutant is viable, but both null mutations and overexpression lead to defects in spindle orientation and nuclear migration (during mitosis in arp1 mutants the nucleus fails to move into the neck). ORF_Name: YHR129C SGDID: S000001171 Locus_Name: ARP10 Description: Component of the dynactin complex, localized to the pointed end of the Arp1p filament; may regulate membrane association of the complex ORF_Name: YDR106W SGDID: S000002513 Locus_Name: ARP2 Alias_Name: ACT2 Description: Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity Phenotype: cells with mutations in Arp2 and Arc15 are defective in mitochondrial movement. ORF_Name: YDL029W SGDID: S000002187 Locus_Name: ARP3 Alias_Name: ACT4 Description: Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity Phenotype: Mutations in Arp3 lead to defects in actin-patch motility and a rearrangement of the cortical actin cytoskeleton. ORF_Name: YJR065C SGDID: S000003826 Locus_Name: ARP4 Alias_Name: ACT3 Description: Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes ORF_Name: YJL081C SGDID: S000003617 Locus_Name: ARP5 Description: Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes ORF_Name: YNL059C SGDID: S000005004 Locus_Name: ARP6 Description: Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A ORF_Name: YLR085C SGDID: S000004075 Locus_Name: ARP7 Alias_Name: RSC11|SWP61 Description: Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation Phenotype: Null mutant is viable, exhibits typical swi/snf phenotypes, including growth defects on media containing galactose, glycerol, or sucrose as sole carbon sources. ARP7 is required for expression of an HO-lacZ fusion gene and for full transcriptional enhancement by the GAL4 activator ORF_Name: YPR034W SGDID: S000006238 Locus_Name: ARP8 Description: Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes ORF_Name: YOR141C SGDID: S000005667 Locus_Name: ARP9 Alias_Name: RSC12|SWP59 Description: Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation Phenotype: Null mutant is viable, exhibits typical swi/snf phenotypes, including growth defects on media containing galactose, glycerol, or sucrose as sole carbon sources. ARP9 is required for expression of an HO-lacZ fusion gene and for full transcriptional enhancement by the GAL4 activator ORF_Name: YMR033W SGDID: S000004636 Locus_Name: ARR1 Alias_Name: ACR1|YAP8 Description: Transcriptional activator of the basic leucine zipper (bZIP) family, required for transcription of genes involved in resistance to arsenic compounds Phenotype: Null mutant is viable, confers arsenite and arsenate hypersensitivity ORF_Name: YPR199C SGDID: S000006403 Locus_Name: ARR2 Alias_Name: ACR2 Description: Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p Phenotype: Null mutant is viable but sensitive to arsenate (but not arsenite). ORF_Name: YPR200C SGDID: S000006404 Locus_Name: ARR3 Alias_Name: ACR3 Description: Arsenite transporter of the plasma membrane, required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite Phenotype: Overexpression confers arsenite but not arsenate resistance ORF_Name: YPR201W SGDID: S000006405 Locus_Name: ARS1 Description: Early-firing autonomously replicating sequence; highly efficient chromosomal replicator active in nearly every cell cycle SGDID: S000029652 Locus_Name: ARS101 Alias_Name: ARSI-160 Description: ARS containing multiple redundant binding sites for the origin recognition complex SGDID: S000077372 Locus_Name: ARS110 Alias_Name: ARSI-176 Description: Autonomously Replicating Sequence, originally referred to as ADE1 ARS SGDID: S000114488 Locus_Name: ARS1208 Alias_Name: ARSXII-151|CEN12 ARS Description: Autonomously Replicating Sequence SGDID: S000114848 Locus_Name: ARS1516 Alias_Name: ADE2 ARS|ARSXV-567 Description: Autonomously Replicating Sequence SGDID: S000114843 Locus_Name: ARS2 Description: Autonomously Replicating Sequence SGDID: S000029042 Locus_Name: ARS209 Description: Autonomously Replicating Sequence, originally referred to as H4 ARS SGDID: S000114517 Locus_Name: ARS300 Description: Autonomously Replicating Sequence SGDID: S000028476 Locus_Name: ARS301 Alias_Name: HML-E ARS Description: Inactive replication origin associated with the silent mating type locus HML, where it functions as a transcriptional silencer SGDID: S000028477 Locus_Name: ARS302 Alias_Name: HML-I ARS Description: Inactive replication origin associated with the silent mating type locus HML, where it functions as a transcriptional silencer SGDID: S000028478 Locus_Name: ARS303 Description: Autonomously Replicating Sequence on Chromosome III, inactive as replication origin at native locus near HML SGDID: S000028479 Locus_Name: ARS304 Description: Autonomously Replicating Sequence on Chromosome III SGDID: S000028481 Locus_Name: ARS305 Description: Efficient, early-firing chromosomal replication origin on Chromosome III SGDID: S000028482 Locus_Name: ARS306 Description: Early-firing autonomously replicating sequence on Chromosome III SGDID: S000028483 Locus_Name: ARS307 Description: Autonomously Replicating Sequence on Chromosome III SGDID: S000028484 Locus_Name: ARS308 Description: Autonomously Replicating Sequence on Chromosome III SGDID: S000028485 Locus_Name: ARS309 Description: Autonomously Replicating Sequence on Chromosome III SGDID: S000028486 Locus_Name: ARS310 Description: Compound autonomously replicating sequence on Chromosome III SGDID: S000028487 Locus_Name: ARS313 Alias_Name: ARSIII-194 Description: Autonomously Replicating Sequence on Chromosome III SGDID: S000028488 Locus_Name: ARS314 Alias_Name: ARSIII-198 Description: Autonomously Replicating Sequence on Chromosome III, active in <10% of cell cycles SGDID: S000028489 Locus_Name: ARS315 Alias_Name: ARSIII-225 Description: Highly-active autonomously replicating sequence, initiates replication in ~90% of cell cycles SGDID: S000028490 Locus_Name: ARS316 Alias_Name: ARSIII-273 Description: Inefficient autonomously replicating sequence, active in ~25% of cell cycles SGDID: S000028491 Locus_Name: ARS317 Alias_Name: HMR-E ARS Description: Autonomously replicating sequence active in only a small fraction of cell cycles; fires extremely inefficiently and late during S phase compared to other origins in the genome SGDID: S000028492 Locus_Name: ARS318 Alias_Name: HMR-I ARS Description: Autonomously replicating sequence active in only a small fraction of cell cycles; becomes active if the nearby ARS317/HMR-E silencer is deleted SGDID: S000028493 Locus_Name: ARS319 Description: Highly-active subtelomeric autonomously replicating sequence, initiates replication in ~90% of cell cycles SGDID: S000028494 Locus_Name: ARS320 Description: Autonomously Replicating Sequence on Chromosome III, inactive as replication origin at native locus near HML SGDID: S000028480 Locus_Name: ARS404 Alias_Name: HO ARS Description: Autonomously Replicating Sequence SGDID: S000114787 Locus_Name: ARS422 Alias_Name: ARO1 ARS|ARSIV-703 Description: Autonomously Replicating Sequence SGDID: S000114834 Locus_Name: ARS600 Alias_Name: ARS120 Description: Subtelomeric Autonomously Replicating Sequence; originally published as ARS120 SGDID: S000029653 Locus_Name: ARS601 Description: Autonomously replicating sequence on Chromosome VI, overlaps ARS602, ARS601/ARS602 together appear to be activated during the second half of S phase in ~32% of cell cycles SGDID: S000007633 Locus_Name: ARS602 Description: Autonomously replicating sequence on Chromosome VI, overlaps ARS601, ARS601/ARS602 together appear to be activated during the second half of S phase in ~32% of cell cycles SGDID: S000007634 Locus_Name: ARS603 Description: Highly-efficient autonomously replicating sequence on Chromosome VI, activated during the second half of S phase in ~67% of cell cycles SGDID: S000007635 Locus_Name: ARS603.5 Description: Autonomously replicating sequence on Chromosome VI, activated early in S phase in ~50% of cell cycles SGDID: S000007645 Locus_Name: ARS604 Description: Extremely inefficient autonomously replicating sequence on Chromosome VI SGDID: S000007636 Locus_Name: ARS605 Description: Autonomously replicating sequence on Chromosome VI, activated early in S phase in ~27% of cell cycles; inactive during premeiotic S phase SGDID: S000007637 Locus_Name: ARS606 Description: Highly-efficient autonomously replicating sequence on Chromosome VI, activated early in S phase in ~74% of cell cycles; replication capacity dependent upon Sum1p SGDID: S000007638 Locus_Name: ARS607 Description: Highly-efficient autonomously replicating sequence on Chromosome VI, activated very early in S phase in >85% of cell cycles SGDID: S000007639 Locus_Name: ARS608 Description: Extremely inefficient autonomously replicating sequence on Chromosome VI, activated early in S phase in <10% of cell cycles SGDID: S000007640 Locus_Name: ARS609 Description: Autonomously replicating sequence on Chromosome VI, activated very late in S phase in ~37% of cell cycles SGDID: S000007641 Locus_Name: ARS610 Alias_Name: ARSVI-270 Description: Autonomously Replicating Sequence SGDID: S000121260 Locus_Name: ARS706 Alias_Name: ARO8 ARS Description: Autonomously Replicating Sequence SGDID: S000114845 Locus_Name: ARS805 Alias_Name: ARSVIII-64|SPO11 ARS Description: Autonomously Replicating Sequence SGDID: S000114849 Locus_Name: ARS901 Alias_Name: ARS249|ARSIX-215 Description: Autonomously Replicating Sequence SGDID: S000007644 Locus_Name: ART10 Description: Protein of unknown function that contains 2 PY motifs and is ubiquinated by Rsp5p; green fluorescent protein (GFP)-fusion protein localizes it to the cytoplasm; non-essential gene ORF_Name: YLR392C SGDID: S000004384 Locus_Name: ART5 Description: Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane ORF_Name: YGR068C SGDID: S000003300 Locus_Name: ARV1 Description: Protein functioning in transport of glycosylphosphatidylinositol intermediates into the ER lumen; required for normal intracellular sterol distribution and for sphingolipid metabolism; similar to Nup120p and C. elegans R05H5.5 protein Phenotype: Subcellular membrane accumulation of free sterol; Mutations in yeast ARV1 are complemented by expression of human ARV1|Subcellular membrane accumulation of free sterol; arv1 mutations are complemented by human ARV1 and are synthetically lethal with are1 and are2 null mutations; null mutant is temperature sensitive, anaerobically inviable, polyene antibiotic sensitive, and inviable in the absence of sterol esterification|temperature sensitive, anaerobically inviable, polyene antibiotic sensitive, inviable in the absence of sterol esterification ORF_Name: YLR242C SGDID: S000004232 Locus_Name: ARX1 Description: Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex ORF_Name: YDR101C SGDID: S000002508 Locus_Name: ASA1 Description: Putative protein of unknown function; subunit of the ASTRA complex (Rvb1p, Rvb2p, Tra1p, Tti1p, Tti2, Asa1p and Tra1p) which is part of the chromatin remodeling machinery ORF_Name: YPR085C SGDID: S000006289 Locus_Name: ASC1 Alias_Name: CPC2 Description: G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; represses Gcn4p in the absence of amino acid starvation Phenotype: Null mutant is viable. Null mutation suppresses the absence of growth of a cyp1- strain in anaerobiosis and also causes delayed growth in aerobic or heme sufficient conditions; trp auxotrophs of the asc1 null allele are cold sensitive for growth; other mutants have increased cell size ORF_Name: YMR116C SGDID: S000004722 Locus_Name: ASC2 Description: CYP1 absence of growth supressor SGDID: S000029043 Locus_Name: ASE1 Alias_Name: YOR29-09 Description: Mitotic spindle midzone localized microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate Phenotype: Null mutant is viable but temperature sensitive. ORF_Name: YOR058C SGDID: S000005584 Locus_Name: ASF1 Alias_Name: CIA1 Description: Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition ORF_Name: YJL115W SGDID: S000003651 Locus_Name: ASF2 Description: Anti-silencing protein that causes derepression of silent loci when overexpressed ORF_Name: YDL197C SGDID: S000002356 Locus_Name: ASG1 Description: Zinc cluster protein proposed to function as a transcriptional regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance Phenotype: Null: viable. Other phenotypes: suppressor of gcn5 catalytically inactive mutants ORF_Name: YIL130W SGDID: S000001392 Locus_Name: ASG7 Description: Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell; specific to a-cells and induced by alpha-factor ORF_Name: YJL170C SGDID: S000003706 Locus_Name: ASH1 Description: Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate Phenotype: Mutant ash1 daughters can transcribe HO and switch mating type ORF_Name: YKL185W SGDID: S000001668 Locus_Name: ASI1 Description: Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals ORF_Name: YMR119W SGDID: S000004725 Locus_Name: ASI2 Description: Integral inner nuclear membrane protein that acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals ORF_Name: YNL159C SGDID: S000005103 Locus_Name: ASI3 Description: Putative integral membrane E3 ubiquitin ligase; acts with Asi1p and Asi2p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals ORF_Name: YNL008C SGDID: S000004953 Locus_Name: ASK1 Description: Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases ORF_Name: YKL052C SGDID: S000001535 Locus_Name: ASK10 Alias_Name: RGC2 Description: Component of the RNA polymerase II holoenzyme, phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p, which relieves repression of stress-response genes ORF_Name: YGR097W SGDID: S000003329 Locus_Name: ASL1 SGDID: S000029044 Locus_Name: ASM4 Alias_Name: NUP59 Description: Nuclear pore complex subunit, part of a subcomplex also containing Nup53p, Nup170p, and Pse1p Phenotype: Null mutant is viable in some strain backgrounds (including CEN.PK2); however, in the FY1679 genetic background, it is inviable. ORF_Name: YDL088C SGDID: S000002246 Locus_Name: ASN1 Description: Asparagine synthetase, isozyme of Asn2p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway Phenotype: Null mutant is viable; L-asparagine auxotrophy occurs upon mutation of both ASN1 and ASN2 ORF_Name: YPR145W SGDID: S000006349 Locus_Name: ASN2 Description: Asparagine synthetase, isozyme of Asn1p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway Phenotype: Null mutant is viable; L-asparagine auxotrophy occurs upon mutation of both ASN1 and ASN2 ORF_Name: YGR124W SGDID: S000003356 Locus_Name: ASP1 Description: Cytosolic L-asparaginase, involved in asparagine catabolism Phenotype: Aspartic acid requiring ORF_Name: YDR321W SGDID: S000002729 Locus_Name: ASP3-1 Alias_Name: ASP3 Description: Cell-wall L-asparaginase II, involved in asparagine catabolism; expression is induced during nitrogen starvation; four copies of ASP3 are present in the genome reference strain S288C ORF_Name: YLR155C SGDID: S000004145 Locus_Name: ASP3-2 Alias_Name: ASP3 Description: Cell-wall L-asparaginase II, involved in asparagine catabolism; expression is induced during nitrogen starvation; four copies of ASP3 are present in the genome reference strain S288C ORF_Name: YLR157C SGDID: S000004147 Locus_Name: ASP3-3 Alias_Name: ASP3 Description: Cell-wall L-asparaginase II, involved in asparagine catabolism; expression is induced during nitrogen starvation; four copies of ASP3 are present in the genome reference strain S288C ORF_Name: YLR158C SGDID: S000004148 Locus_Name: ASP3-4 Alias_Name: ASP3 Description: Cell-wall L-asparaginase II, involved in asparagine catabolism; expression is induced during nitrogen starvation; four copies of ASP3 are present in the genome reference strain S288C ORF_Name: YLR160C SGDID: S000004150 Locus_Name: ASR1 Description: Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein ORF_Name: YPR093C SGDID: S000006297 Locus_Name: AST1 Description: Peripheral membrane protein that interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane, possibly by influencing its incorporation into lipid rafts Phenotype: multicopy AST1 suppresses pma1 alleles defective for targeting ORF_Name: YBL069W SGDID: S000000165 Locus_Name: AST2 Description: Protein that may have a role in targeting of plasma membrane [H+]ATPase (Pma1p) to the plasma membrane, as suggested by analysis of genetic interactions Phenotype: in high copy number, suppresses a pma1 ts mutant that is mis-routed to the vacuole at the restrictive temperature ORF_Name: YER101C SGDID: S000000903 Locus_Name: ASU9 Description: anti-suppressor that reduces the efficiency of sup45 and sup35 Phenotype: asu9 allele causes sensitivity to paromomycin SGDID: S000029045 Locus_Name: ATA1 Description: Sporulation-specific gene characterized by ATA sequences SGDID: S000029046 Locus_Name: ATC1 Alias_Name: LIC4 Description: Nuclear protein, possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern ORF_Name: YDR184C SGDID: S000002592 Locus_Name: ATE1 Description: Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway Gene_Product: arginyl-tRNA-protein transferase Phenotype: Null mutant is viable, but unable to degrade substrates of the N-end rule pathway that start with residues recognized by the Arg-transferase ORF_Name: YGL017W SGDID: S000002985 Locus_Name: ATF1 Description: Alcohol acetyltransferase with potential roles in lipid and sterol metabolism; responsible for the major part of volatile acetate ester production during fermentation ORF_Name: YOR377W SGDID: S000005904 Locus_Name: ATF2 Description: Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important in brewing ORF_Name: YGR177C SGDID: S000003409 Locus_Name: ATG1 Alias_Name: APG1|AUT3|CVT10 Description: Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p Phenotype: Defective in autophagy; loses viability more rapidly than wild type during nitrogen starvation; defective in vacuolar protein degradation during nitrogen starvation; defective in sporulation ORF_Name: YGL180W SGDID: S000003148 Locus_Name: ATG10 Alias_Name: APG10 Description: Conserved E2-like conjugating enzyme that mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy Phenotype: Defective autophagy, apg10-1 allele shows reduced viablility under starvation conditions ORF_Name: YLL042C SGDID: S000003965 Locus_Name: ATG11 Alias_Name: CVT9 Description: Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the (PAS) Phenotype: cvt9 is defective in vacuolar delivery of aminopeptidase I and peroxisome degradation but is not needed for macroautophagy. The null mutant is viable and is relatively starvation-insensitive.|cvt9 is defective in maturation of the vacuolar protein, aminopeptidase I and exhibits minor defects in autophagy ORF_Name: YPR049C SGDID: S000006253 Locus_Name: ATG12 Alias_Name: APG12 Description: Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation Phenotype: Null mutant is viable, defective in autophagy ORF_Name: YBR217W SGDID: S000000421 Locus_Name: ATG13 Alias_Name: APG13 Description: Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling Phenotype: Defective in autophagy ORF_Name: YPR185W SGDID: S000006389 Locus_Name: ATG14 Alias_Name: APG14|CVT12 Description: Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I (with Vps34/15/30p); Atg14p targets complex I to the phagophore assembly site (PAS); required for localizing additional ATG proteins to the PAS; homolog of human Barkor Phenotype: Null mutant is viable but defective in autophagy. ORF_Name: YBR128C SGDID: S000000332 Locus_Name: ATG15 Alias_Name: AUT5|CVT17 Description: Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway Phenotype: cvt17 is defective in lysis of autophagic vesicles after delivery to the vacuole. Null mutant is starvation-sensitive, accumulates subvacuolar vesicles, defective in maturation of aminopeptidase I and in autophagy. ORF_Name: YCR068W SGDID: S000000664 Locus_Name: ATG16 Alias_Name: APG15|APG16|CVT11|SAP18 Description: Conserved protein that interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which localize to the pre-autophagosomal structure and are required for autophagy Phenotype: Null mutant is viable, defective in autophagy ORF_Name: YMR159C SGDID: S000004769 Locus_Name: ATG17 Alias_Name: APG17 Description: Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity Phenotype: Null mutant is viable and has defect in autophagy|required for activation of Apg1 protein kinase ORF_Name: YLR423C SGDID: S000004415 Locus_Name: ATG18 Alias_Name: AUT10|CVT18|NMR1|SVP1 Description: Phosphoinositide binding protein required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein Phenotype: (NMR1)Null mutant is viable; arrests with 2C DNA content after shift to sporulation medium. ORF_Name: YFR021W SGDID: S000001917 Locus_Name: ATG19 Alias_Name: CVT19 Description: Receptor protein specific for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Lap4p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles Phenotype: Null: viable, unable to target vacuolar aminopeptidase I and to vacuoles, both under growing and nitrogen starvation conditions. ORF_Name: YOL082W SGDID: S000005442 Locus_Name: ATG2 Alias_Name: APG2|AUT8|SPO72 Description: Peripheral membrane protein required for vesicle formation during autophagy, pexophagy, and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria Phenotype: The null mutant is viable but blocked in autophagy, pexophagy and import of Ape1 by the cytoplasm to vacuole targeting pathway. Diploids homozygous for the null mutation lack premeitoic DNA synthesis and do not sporulate. ORF_Name: YNL242W SGDID: S000005186 Locus_Name: ATG20 Alias_Name: CVT20|SNX42 Description: Sorting nexin family member required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate Phenotype: Null: The cvt20 mutant accumulates precursor Ape1 but is normal for autophagy.. Other phenotypes: A mutation of a conserved tyrosine to alanine in the PX domain abolishes binding to PtdIns(3)P. ORF_Name: YDL113C SGDID: S000002271 Locus_Name: ATG21 Alias_Name: HSV1|MAI1 Description: Phosphoinositide binding protein required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein Phenotype: mai1 null is viable; mai1 aut10 ygr223c triple deletion strain does not grow on a specific acetate medium at 15C ORF_Name: YPL100W SGDID: S000006021 Locus_Name: ATG22 Alias_Name: AUT4 Description: Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation Phenotype: Null mutant is viable, but exhibits defects in lysis of autophagic vesicles after delivery to the vacuole; vesicles accumulate in the vacuole in the absence of PMSF; maturation of the vacuolar protein, aminopeptidase I is unaffected in aut4 ORF_Name: YCL038C SGDID: S000000543 Locus_Name: ATG23 Alias_Name: CVT23 Description: Peripheral membrane protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway and efficient macroautophagy; cycles between the phagophore assembly site (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p ORF_Name: YLR431C SGDID: S000004423 Locus_Name: ATG26 Alias_Name: UGT51 Description: UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy Phenotype: Null mutant is viable and unable to synthesize sterol glucoside ORF_Name: YLR189C SGDID: S000004179 Locus_Name: ATG27 Alias_Name: ETF1 Description: Type I membrane protein involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; may be involved in membrane delivery to the phagophore assembly site ORF_Name: YJL178C SGDID: S000003714 Locus_Name: ATG29 Description: Autophagy-specific protein that is required for recruitment of other ATG proteins to the pre-autophagosomal structure (PAS); interacts with Atg17p and localizas to the PAS in a manner interdependent with Atg17p and Cis1p; not conserved ORF_Name: YPL166W SGDID: S000006087 Locus_Name: ATG3 Alias_Name: APG3|AUT1 Description: E2-like enzyme involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt Phenotype: Null mutant is viable, defective in starvation-induced bulk flow transport of cytoplasmic proteins to the vacuole, exhibits decreased survival rates during starvation, defective in protein degradation in the vacuoles induced by nitrogen starvation, homozygous diploids fail to sporulate ORF_Name: YNR007C SGDID: S000005290 Locus_Name: ATG32 Alias_Name: ECM37 Description: Mitochondrial-anchored transmembrane receptor that interacts with the autophagy adaptor protein, Atg11p, and is essential for mitophagy, the selective vacuolar degradation of mitochondria in response to starvation ORF_Name: YIL146C SGDID: S000001408 Locus_Name: ATG33 Description: Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at the post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes ORF_Name: YLR356W SGDID: S000004348 Locus_Name: ATG4 Alias_Name: APG4|AUT2 Description: Conserved cysteine protease required for autophagy; cleaves Atg8p to a form required for autophagosome and Cvt vesicle generation Phenotype: Null mutant is viable but lacks autophagocytosis: i.e. starvation-induced protein transport to the vacuole; homozygous aut2-mutant diploids cannot sporulate ORF_Name: YNL223W SGDID: S000005167 Locus_Name: ATG5 Alias_Name: APG5 Description: Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a complex with Atg16p that is essential for autophagosome formation Phenotype: reduced viability upon nutrient starvation; defective in autophagy ORF_Name: YPL149W SGDID: S000006070 Locus_Name: ATG7 Alias_Name: APG11|APG7|CVT2 Description: Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation Phenotype: Null mutant is viable, defective in autophagy ORF_Name: YHR171W SGDID: S000001214 Locus_Name: ATG8 Alias_Name: APG8|AUT7|CVT5 Description: Component of autophagosomes and Cvt vesicles; undergoes conjugation to phosphatidylethanolamine (PE); Atg8p-PE is anchored to membranes, is involved in phagophore expansion, and may mediate membrane fusion during autophagosome formation Phenotype: Null mutant is viable but lacks autophagocytosis and is unable to sporulate. AUT7 is a suppressor of mutant phenotypes of aut2-1 cells. Uptake of precursor Aminopeptidase I into the vacuole depends on Aut2p and Aut7p. ORF_Name: YBL078C SGDID: S000000174 Locus_Name: ATG9 Alias_Name: APG9|AUT9|CVT7 Description: Transmembrane protein involved in forming Cvt and autophagic vesicles; cycles between the phagophore assembly site (PAS) and other cytosolic punctate structures, not found in autophagosomes; may be involved in membrane delivery to the PAS Phenotype: Null mutant is viable but blocked in autophagy and aminopeptidase I import into vacuole. Temperature-sensitive mutant accumulates membrane-associated, protease-sensitive API. ORF_Name: YDL149W SGDID: S000002308 Locus_Name: ATH1 Description: Acid trehalase required for utilization of extracellular trehalose Phenotype: Null mutant is viable; shows lack of vacuolar acid trehalase activity ORF_Name: YPR026W SGDID: S000006230 Locus_Name: ATI5 Description: acaciae toxin insensitive Phenotype: Recessives are insensitive to the toxin produced by Pichia acaciae SGDID: S000029047 Locus_Name: ATM1 Description: Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol Phenotype: slow growth on rich medium, inviable on minimal medium; unstable mitochondrial genome; have 'white' mitochondria that completely lack cytochromes ORF_Name: YMR301C SGDID: S000004916 Locus_Name: ATO2 Alias_Name: FUN34 Description: Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p Phenotype: Null mutant is viable. Other phenotype: defect in ammonia production in S.cerevisiae colonies ORF_Name: YNR002C SGDID: S000005285 Locus_Name: ATO3 Description: Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters Phenotype: Null: viable. Other phenotypes: defect in ammonia production in S.cerevisiae colonies ORF_Name: YDR384C SGDID: S000002792 Locus_Name: ATP1 Description: Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated Phenotype: null mutant is viable; grows slowly on fermentable carbon sources; exhibits delayed kinetics of protein import for several mitochondrial precursors ORF_Name: YBL099W SGDID: S000000195 Locus_Name: ATP10 Description: Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6 Phenotype: loss of rutamycin sensitivity in mitochondrial ATPase but no effect on respiratory enzymes ORF_Name: YLR393W SGDID: S000004385 Locus_Name: ATP11 Description: Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase Phenotype: greatly reduced ATPase activity; alpha and beta subunits of F1-ATPase accumulate in mitochondria as inactive aggregates ORF_Name: YNL315C SGDID: S000005259 Locus_Name: ATP12 Description: Conserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency Phenotype: greatly reduced ATPase activity; alpha and beta subunits of F1-ATPase accumulate in mitochondria as inactive aggregates ORF_Name: YJL180C SGDID: S000003716 Locus_Name: ATP14 Description: Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis Phenotype: unable to grow on glycerol medium; no detectable oligomycin-sensitive ATPase activity ORF_Name: YLR295C SGDID: S000004286 Locus_Name: ATP15 Alias_Name: ATPEPSILON Description: Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated Phenotype: unable to grow on glycerol medium; no detectable oligomycin-sensitive ATPase activity; oligomycin-sensitive uncoupling of the mitochondrial respiration rate ORF_Name: YPL271W SGDID: S000006192 Locus_Name: ATP16 Description: Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated Phenotype: cells are entirely cytoplasmic petite ORF_Name: YDL004W SGDID: S000002162 Locus_Name: ATP17 Description: Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis Phenotype: No growth on glycerol ORF_Name: YDR377W SGDID: S000002785 Locus_Name: ATP18 Description: Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms Phenotype: Null mutant is viable, deficient in oligomycin-sensitive ATPase activity, and is unable to grow on nonfermentable carbon sources. ORF_Name: YML081C-A SGDID: S000007247 Locus_Name: ATP19 Description: Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase ORF_Name: YOL077W-A SGDID: S000007339 Locus_Name: ATP2 Description: Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated Phenotype: Mutant displays a growth defect on glycerol ORF_Name: YJR121W SGDID: S000003882 Locus_Name: ATP20 Description: Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex Phenotype: Null mutant is viable but exhibits a reduced growth rate on respiratory substrates ORF_Name: YPR020W SGDID: S000006224 Locus_Name: ATP22 Alias_Name: TCM10 Description: Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis ORF_Name: YDR350C SGDID: S000002758 Locus_Name: ATP23 Description: Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex ORF_Name: YNR020C SGDID: S000005303 Locus_Name: ATP25 Alias_Name: LRC4 Description: Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene ORF_Name: YMR098C SGDID: S000004704 Locus_Name: ATP3 Description: Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis ORF_Name: YBR039W SGDID: S000000243 Locus_Name: ATP4 Alias_Name: LPF7 Description: Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated Phenotype: Null mutant is viable but is oxidative phosphorylation deficient, is unable to grow on glycerol, shows an F1 loosely bound to mitochondrial membrane, lacks subunit 6 in F0, has a five times lower cytochrome oxidase activity, produces a high percentage of sponteneous rho- mutants, and is oligomycin-insensitive ORF_Name: YPL078C SGDID: S000005999 Locus_Name: ATP5 Alias_Name: OSC1 Description: Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated Gene_Product: oligomycin sensitivity-conferring protein Phenotype: null mutant is viable, but unable to grow on glycerol; exhibits high level of genetic instability ORF_Name: YDR298C SGDID: S000002706 Locus_Name: ATP6 Alias_Name: OLI2|OLI4|PHO1 Description: Mitochondrially encoded subunit a of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis Phenotype: oligomycin resistance ORF_Name: Q0085 SGDID: S000007268 Locus_Name: ATP7 Description: Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis Phenotype: glycerol minus phenotype; mitochondria have no detectable oligomycin-sensitive ATPase activity; F1 loosely bound to the membranous portion ORF_Name: YKL016C SGDID: S000001499 Locus_Name: ATP8 Alias_Name: AAP1 Description: Subunit 8 of the F0 sector of mitochondrial inner membrane F1-F0 ATP synthase, encoded on the mitochondrial genome Phenotype: Loss of respiratory function ORF_Name: Q0080 SGDID: S000007267 Locus_Name: ATR1 Alias_Name: SNQ1 Description: Multidrug efflux pump of the major facilitator superfamily, required for resistance to aminotriazole and 4-nitroquinoline-N-oxide Phenotype: Null mutant is viable, but is sensitive to very low (5 mM) levels of aminotriazole and to 4-nitroquinoline-N-oxide (4-NQO); multiple copies of ATR1 confer hyper-resistance to 4-NQO; multiple copies of ATR1 in gcn4 background confer resistance to high (80mM) levels of aminotriazole ORF_Name: YML116W SGDID: S000004584 Locus_Name: ATS1 Alias_Name: FUN28|KTI13 Description: Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle Phenotype: slow growth ORF_Name: YAL020C SGDID: S000000018 Locus_Name: ATX1 Description: Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake Phenotype: hypersensitive toward paraquat (a generator of superoxide anion) ORF_Name: YNL259C SGDID: S000005203 Locus_Name: ATX2 Alias_Name: YOR29-30 Description: Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation Phenotype: Null mutant is viable but has reduced levels of intracellular manganese. ORF_Name: YOR079C SGDID: S000005605 Locus_Name: AUA1 Alias_Name: YFL011W-A Description: Protein required for the negative regulation by ammonia of Gap1p, which is a general amino acid permease ORF_Name: YFL010W-A SGDID: S000001955 Locus_Name: AUR1 Description: Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance Phenotype: Null mutant is inviable; mutant exhibits dominant resistance to aureobasidin A. Wild type (sensitive) is recessive. ORF_Name: YKL004W SGDID: S000001487 Locus_Name: AUS1 Description: Transporter of the ATP-binding cassette family, involved in uptake of sterols and anaerobic growth Phenotype: Null mutant is viable but exhibits reduced cholesterol accumulation. ORF_Name: YOR011W SGDID: S000005537 Locus_Name: AUT6 Description: Defective in autophagocytosis Phenotype: AUT6 was isolated genetically as a mutant defective in autophagy. SGDID: S000029048 Locus_Name: AVL9 Description: Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms Phenotype: Transposon insertion allele is synthetically lethal with pho85-delta ORF_Name: YLR114C SGDID: S000004104 Locus_Name: AVO1 Description: Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth ORF_Name: YOL078W SGDID: S000005438 Locus_Name: AVO2 Description: Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth ORF_Name: YMR068W SGDID: S000004672 Locus_Name: AVT1 Description: Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters ORF_Name: YJR001W SGDID: S000003761 Locus_Name: AVT2 Description: Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters ORF_Name: YEL064C SGDID: S000000790 Locus_Name: AVT3 Description: Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters ORF_Name: YKL146W SGDID: S000001629 Locus_Name: AVT4 Description: Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters ORF_Name: YNL101W SGDID: S000005045 Locus_Name: AVT5 Description: Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters ORF_Name: YBL089W SGDID: S000000185 Locus_Name: AVT6 Description: Vacuolar amino acid transporter, exports aspartate and glutamate from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters ORF_Name: YER119C SGDID: S000000921 Locus_Name: AVT7 Description: Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters ORF_Name: YIL088C SGDID: S000001350 Locus_Name: AWA1 Description: Putative GPI-anchored protein, localized to the cell wall; involved in foam formation in sake mash by conferring hydrophobicity to the cell surface SGDID: S000029703 Locus_Name: AXE1 Description: Is very likely an allele of PDR1 Phenotype: Axenomycin resistance SGDID: S000029050 Locus_Name: AXL1 Alias_Name: FUS5|STE22 Description: Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells Phenotype: Null mutant is viable; exhibits reduced a-factor expresion; haploid mutants show bipolar budding pattern (diploid pattern) rather than the normal axial (spiral) budding pattern ORF_Name: YPR122W SGDID: S000006326 Locus_Name: AXL2 Alias_Name: BUD10|SRO4 Description: Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate ORF_Name: YIL140W SGDID: S000001402 Locus_Name: AYR1 Description: NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones Gene_Product: 1-acyl dihydroxyacetone phosphate reductase Phenotype: Null mutant is viable. ybr159w/ayr1 double mutant is inviable. ORF_Name: YIL124W SGDID: S000001386 Locus_Name: AYT1 Description: Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis ORF_Name: YLL063C SGDID: S000003986 Locus_Name: AZF1 Description: Zinc-finger transcription factor, involved in induction of CLN3 transcription in response to glucose; genetic and physical interactions indicate a possible role in mitochondrial transcription or genome maintenance ORF_Name: YOR113W SGDID: S000005639 Locus_Name: AZR1 Description: Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole ORF_Name: YGR224W SGDID: S000003456 Locus_Name: BAG7 Description: Rho GTPase activating protein (RhoGAP), stimulates the intrinsic GTPase activity of Rho1p, which plays a role in actin cytoskeleton organization and control of cell wall synthesis; structurally and functionally related to Sac7p Phenotype: Null mutant is viable; overexpression suppresses sac7 null mutation ORF_Name: YOR134W SGDID: S000005660 Locus_Name: BAP2 Description: High-affinity leucine permease, functions as a branched-chain amino acid permease involved in the uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains Phenotype: reduced uptake of leucine, isoleucine, and valine ORF_Name: YBR068C SGDID: S000000272 Locus_Name: BAP3 Alias_Name: PAP1 Description: Amino acid permease involved in the uptake of cysteine, leucine, isoleucine and valine ORF_Name: YDR046C SGDID: S000002453 Locus_Name: BAR1 Alias_Name: SST1 Description: Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest Phenotype: MATa bar1 cells are supersensitive to the G1 arrest induced by alpha factor ORF_Name: YIL015W SGDID: S000001277 Locus_Name: BAS1 Description: Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes ORF_Name: YKR099W SGDID: S000001807 Locus_Name: BAT1 Alias_Name: ECA39|TWT1 Description: Mitochondrial branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during logarithmic phase and repressed during stationary phase Phenotype: Null mutant is viable; ILV auxotrophy in bat1 bat2 double mutant ORF_Name: YHR208W SGDID: S000001251 Locus_Name: BAT2 Alias_Name: ECA40|TWT2 Description: Cytosolic branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase ORF_Name: YJR148W SGDID: S000003909 Locus_Name: BBC1 Alias_Name: MTI1|YJL021C Description: Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches ORF_Name: YJL020C SGDID: S000003557 Locus_Name: BBP1 Description: Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p Phenotype: Null mutant is inviable; cells depleted of Bbp1p are defective in nuclear segregation, bud formation, cytokinesis and nuclear spindle formation; overexpression gives ascus that contains asci instead of spores ORF_Name: YPL255W SGDID: S000006176 Locus_Name: BCD1 Description: Essential protein required for the accumulation of box C/D snoRNA ORF_Name: YHR040W SGDID: S000001082 Locus_Name: BCH1 Description: Member of the ChAPs family (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; may interact with ribosomes ORF_Name: YMR237W SGDID: S000004850 Locus_Name: BCH2 Alias_Name: FMP50 Description: Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane ORF_Name: YKR027W SGDID: S000001735 Locus_Name: BCK1 Alias_Name: LAS3|SAP3|SLK1|SSP31 Description: Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p Phenotype: Null mutants are temperature-sensitive and exhibit cell lysis, which can be rescued by 1M sorbitol; null mutants grow very poorly even at the permissive temperature. Some dominant alleles suppress a pkc1 null mutant. ORF_Name: YJL095W SGDID: S000003631 Locus_Name: BCK2 Alias_Name: CTR7 Description: Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations ORF_Name: YER167W SGDID: S000000969 Locus_Name: BCP1 Description: Essential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport ORF_Name: YDR361C SGDID: S000002769 Locus_Name: BCS1 Description: Protein of the mitochondrial inner membrane that functions as an ATP-dependent chaperone, required for the incorporation of the Rip1p and Qcr10p subunits into the cytochrome bc(1) complex; member of the CDC48/PAS1/SEC18 ATPase family Phenotype: Gross reduction in the Rieske iron-sulfur subunit ORF_Name: YDR375C SGDID: S000002783 Locus_Name: BCY1 Alias_Name: SRA1 Description: Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA), a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation Phenotype: Null mutant is viable; sra1 mutants are associated with reduction of glycogen accumulation, temperature sensitivity, reduced growth rate on maltose and sucrose, inability to grow on galactose and nonfermentable carbon sources and nitrogen starvation intolerance. Cells lacking Sra1p are constitutive for cAPK activity resulting in meiotic arrest prior to premeiotic DNA synthesis ORF_Name: YIL033C SGDID: S000001295 Locus_Name: BDF1 Description: Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p Phenotype: Null mutant is viable; defect in sporulation and spore formation, reduced rate of vegetative growth, sensitivity to a DNA-damaging agent, defective in snRNA production ORF_Name: YLR399C SGDID: S000004391 Locus_Name: BDF2 Description: Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p Phenotype: Null mutant is viable in FY1679, RAY3A-D, and CEN.PK2 backgrounds, and synthetic lethal with bdf1 ORF_Name: YDL070W SGDID: S000002228 Locus_Name: BDH1 Alias_Name: BDH Description: NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source Gene_Product: (2R,3R)-2,3-butanediol dehydrogenase ORF_Name: YAL060W SGDID: S000000056 Locus_Name: BDH2 Description: Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3 ORF_Name: YAL061W SGDID: S000000057 Locus_Name: BDP1 Alias_Name: TFC5 Description: Essential subunit of RNA polymerase III transcription factor (TFIIIB), which is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs Gene_Product: B"|TFIIIB90 Phenotype: Null mutant is inviable; tfc5 mutant suppresses mutations in the class III transcription system ORF_Name: YNL039W SGDID: S000004984 Locus_Name: BDS1 Description: Bacterially-derived sulfatase required for use of alkyl- and aryl-sulfates as sulfur sources ORF_Name: YOL164W SGDID: S000005524 Locus_Name: BEL3 Phenotype: bel3 bel7 mutations cause enhanced transcription of a gene fusion, consisting of the open reading frame of PHO5 connected to the HIS5 promoter (HIS5p) integrated at the ura3 or leu2 locus in a gcn4 null background SGDID: S000029051 Locus_Name: BEL4 Phenotype: bel4 mutations cause enhanced transcription of a gene fusion, consisting of the open reading frame of PHO5 connected to the HIS5 promoter (HIS5p) integrated at the ura3 or leu2 locus in a gcn4 null background SGDID: S000029052 Locus_Name: BEL5 Phenotype: bel5 bel6 mutations cause enhanced transcription of a gene fusion, consisting of the open reading frame of PHO5 connected to the HIS5 promoter (HIS5p) integrated at the ura3 or leu2 locus in a gcn4 null background SGDID: S000029053 Locus_Name: BEL6 Phenotype: bel6 bel5 mutations cause enhanced transcription of a gene fusion, consisting of the open reading frame of PHO5 connected to the HIS5 promoter (HIS5p) integrated at the ura3 or leu2 locus in a gcn4 null background SGDID: S000029054 Locus_Name: BEL7 Phenotype: bel7 bel3 mutations cause enhanced transcription of a gene fusion, consisting of the open reading frame of PHO5 connected to the HIS5 promoter (HIS5p) integrated at the ura3 or leu2 locus in a gcn4 null background SGDID: S000029055 Locus_Name: BEM1 Alias_Name: SRO1 Description: Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p Phenotype: Null mutant is viable; exhibits a defect in polarization in vegetative cells, exhibits decreased expression of FUS1 ORF_Name: YBR200W SGDID: S000000404 Locus_Name: BEM2 Alias_Name: IPL2|SUP9|TSL1 Description: Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence Phenotype: randomized bud-site selection at 26 degrees C and defective bud emergence and growth at 37 degrees C ORF_Name: YER155C SGDID: S000000957 Locus_Name: BEM3 Description: Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly ORF_Name: YPL115C SGDID: S000006036 Locus_Name: BEM4 Alias_Name: ROM7 Description: Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length ORF_Name: YPL161C SGDID: S000006082 Locus_Name: BER1 Description: Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene ORF_Name: YLR412W SGDID: S000004404 Locus_Name: BET1 Alias_Name: SLY12 Description: Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins ORF_Name: YIL004C SGDID: S000001266 Locus_Name: BET2 Description: Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p ORF_Name: YPR176C SGDID: S000006380 Locus_Name: BET3 Description: Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles; component of the TRAPP (transport protein particle) complex ORF_Name: YKR068C SGDID: S000001776 Locus_Name: BET4 Description: Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p ORF_Name: YJL031C SGDID: S000003568 Locus_Name: BET5 Description: Component of the TRAPP (transport protein particle) complex, which plays an essential role in the vesicular transport from endoplasmic reticulum to Golgi ORF_Name: YML077W SGDID: S000004542 Locus_Name: BFA1 Alias_Name: IBD1 Description: Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis Phenotype: Null mutant is viable; mutants are sensitive to microtubule inhibitors, exhibit defects in mitotic checkpoints, and exhibit moderate defects in mating efficiency ORF_Name: YJR053W SGDID: S000003814 Locus_Name: BFR1 Description: Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity ORF_Name: YOR198C SGDID: S000005724 Locus_Name: BFR2 Description: Essential protein that is a component of 90S preribosomes; may be involved in rRNA processing; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock Phenotype: Null mutant is inviable; BFR2 overexpression can suppress the growth defect of mutants blocked at the step of budding or docking of small vessicles en route to the Golgi ORF_Name: YDR299W SGDID: S000002707 Locus_Name: BGL2 Description: Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance ORF_Name: YGR282C SGDID: S000003514 Locus_Name: BI2 Description: Mitochondrial mRNA maturase with a role in splicing, encoded by both exon and intron sequences of partially processed COB mRNA ORF_Name: Q0110 SGDID: S000007271 Locus_Name: BI3 Description: Mitochondrial mRNA maturase, forms a complex with Mrs1p to mediate splicing of the bI3 intron of the COB gene; encoded by both exon and intron sequences of partially processed COB mRNA ORF_Name: Q0115 SGDID: S000007272 Locus_Name: BI4 Description: Mitochondrial mRNA maturase, forms a complex with Nam2p to mediate splicing of the bI4 intron of the COB gene; encoded by both exon and intron sequences of partially processed COB mRNA ORF_Name: Q0120 SGDID: S000007273 Locus_Name: BIG1 Description: Integral membrane protein of the endoplasmic reticulum, required for normal content of cell wall beta-1,6-glucan Phenotype: Null mutant is viable but shows very slow growth on glucose, cells are big and accumulate increased ploidy; overexpression suppresses rot1 rot2 synthetic lethality ORF_Name: YHR101C SGDID: S000001143 Locus_Name: BIK1 Alias_Name: ARM5|PAC14 Description: Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170 Phenotype: Null mutant is viable, bik1 mutants exhibit bilateral defects in karyogamy ORF_Name: YCL029C SGDID: S000000534 Locus_Name: BIM1 Alias_Name: EB1|YEB1 Description: Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally Phenotype: Null mutant is viable, causes cold sensitivity, benomyl supersensitivity, aberrant microtubule morphology. During mitosis in bim1 mutants, the nucleus fails to move to the mother-bud neck. ORF_Name: YER016W SGDID: S000000818 Locus_Name: BIO1 Description: Putative pimeloyl-CoA synthetase in S. cerevisiae strains YJM627 and A364a, involved in the biotin biosynthesis pathway SGDID: S000125018 Locus_Name: BIO2 Description: Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant ORF_Name: YGR286C SGDID: S000003518 Locus_Name: BIO3 Description: 7,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis ORF_Name: YNR058W SGDID: S000005341 Locus_Name: BIO4 Description: Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels ORF_Name: YNR057C SGDID: S000005340 Locus_Name: BIO5 Description: Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis ORF_Name: YNR056C SGDID: S000005339 Locus_Name: BIO6 Description: Putative 7-keto-8-aminopelargonic acid (KAPA) synthetase in sake strains and S. cerevisiae strains YJM627 and A364a, involved in the biotin biosynthesis pathway; homologs present in S. bayanus, S. paradoxus, S. mikatae and S. kudriavzevii SGDID: S000029723 Locus_Name: BIO7 Description: Putative pimeloyl-CoA synthetase in S. cerevisiae strains YJM627 and A364a, involved in the biotin biosynthesis pathway SGDID: S000125022 Locus_Name: BIO8 Description: Putative 7-keto-8-aminopelargonic acid (KAPA) synthetase in S. cerevisiae strains YJM627 and A364a, involved in the biotin biosynthesis pathway SGDID: S000125021 Locus_Name: BIR1 Description: Subunit of chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates chromosome segregation; required for chromosome bi-orientation and for spindle assembly checkpoint activation upon reduced sister kinetochore tension ORF_Name: YJR089W SGDID: S000003849 Locus_Name: BIT2 Description: Subunit of TORC2, a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; similar to Bit61p ORF_Name: YBR270C SGDID: S000000474 Locus_Name: BIT61 Description: Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p-Slm1p-Slm2 p), a membrane-associated complex that regulates cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity ORF_Name: YJL058C SGDID: S000003594 Locus_Name: BLM1 Description: Required for resistance to bleomycin, ionizing radiation and oxidative damage by hydrogen peroxide; mutants display slow growth and abnormal morphology; homozygous mutant has reduced spore viability; bleomycin resistance suppressed by MSH4 SGDID: S000119219 Locus_Name: BLM10 Alias_Name: YFL006W Description: Proteasome activator subunit; found in association with core particles, with and without the 19S regulatory particle; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200 ORF_Name: YFL007W SGDID: S000001887 Locus_Name: BLM5 Description: Required for resistance to bleomycin, ionizing radiation and oxidative damage by hydrogen peroxide, required for sporulation Phenotype: blm5 mutants arrest in meiosis at the mononucleate stage SGDID: S000029056 Locus_Name: BLS2 Phenotype: Blasticidin-S resistance SGDID: S000029057 Locus_Name: BMH1 Alias_Name: APR6 Description: 14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling Phenotype: Null mutant is viable; bmh1 bmh2 double mutant is inviable; (in strain Sigma-1278b, required for pseudohyphal development but not for viability) ORF_Name: YER177W SGDID: S000000979 Locus_Name: BMH2 Alias_Name: SCD3 Description: 14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling Phenotype: Null mutant is viable; bmh1 bmh2 double mutant is inviable; (in strain Sigma-1278b, required for pseudohyphal development but not for viability) ORF_Name: YDR099W SGDID: S000002506 Locus_Name: BMK6 SGDID: S000029058 Locus_Name: BMK7 SGDID: S000029059 Locus_Name: BMK8 SGDID: S000029060 Locus_Name: BMS1 Description: GTPase required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, which stimulates its GTPase and U3 snoRNA binding activities; has similarity to Tsr1p Phenotype: Null mutant is inviable; a temperature-sensitive allele exhibits a synthetic growth defect with bmh1-delta; the temperature-sensitive allele also exhibits diploid specific bud site randomization at the semi-permissive temperature ORF_Name: YPL217C SGDID: S000006138 Locus_Name: BNA1 Alias_Name: HAD1 Description: 3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p Phenotype: Null mutant is viable, nicotinic acid auxotroph. Deletion results in significant rDNA silencing defect only on medium deficient in nicotinic acid, an NAD(+) precursor. ORF_Name: YJR025C SGDID: S000003786 Locus_Name: BNA2 Description: Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expresssion is upregulated upon telomere uncapping; regulated by Hst1p and Aft2p Phenotype: Null: Nicotinic acid auxotroph. Other phenotypes: Deletion of the gene is co-lethal with the deletion of NPT1 ORF_Name: YJR078W SGDID: S000003839 Locus_Name: BNA3 Description: Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate Phenotype: Null: none detected ORF_Name: YJL060W SGDID: S000003596 Locus_Name: BNA4 Description: Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease Phenotype: Null: Nicotinic acid auxotroph. Other phenotypes: Deletion of the gene is co-lethal with the deletion of NPT1 ORF_Name: YBL098W SGDID: S000000194 Locus_Name: BNA5 Description: Kynureninase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p Phenotype: Null: Nicotinic acid auxotroph. Other phenotypes: Deletion of the gene is co-lethal with the deletion of NPT1 ORF_Name: YLR231C SGDID: S000004221 Locus_Name: BNA6 Alias_Name: QPT1 Description: Quinolinate phosphoribosyl transferase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p Phenotype: Null: Nicotinic acid auxotroph. Other phenotypes: Deletion of the gene is co-lethal with the deletion of NPT1 ORF_Name: YFR047C SGDID: S000001943 Locus_Name: BNA7 Description: Formylkynurenine formamidase, involved in the de novo biosynthesis of NAD from tryptophan via kynurenine ORF_Name: YDR428C SGDID: S000002836 Locus_Name: BNI1 Alias_Name: PPF3|SHE5 Description: Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1 Phenotype: Null mutant is viable, bni1 bnr1 double deletion mutants are temperature sensitive and are deficient in bud emergence, exhibit a random distribution of cortical actin patches and often become multinucleate at the restrictive temperature; rho1 bni1 double mutants exhibit synthetic lethality ORF_Name: YNL271C SGDID: S000005215 Locus_Name: BNI4 Description: Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p Phenotype: Null mutant is viable, shows delocalized chitin, elongated buds, enlarged bud necks ORF_Name: YNL233W SGDID: S000005177 Locus_Name: BNI5 Description: Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner Phenotype: Null: Null mutant is viable, interacts genetically with CDC3, CDC10, CDC11, and CDC12 (septin) genes ORF_Name: YNL166C SGDID: S000005110 Locus_Name: BNR1 Description: Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1 Phenotype: Null mutant is viable; bni1 bnr1 double mutant exhibits severe temperature sensitive growth ORF_Name: YIL159W SGDID: S000001421 Locus_Name: BNS1 Description: Protein with some similarity to Spo12p; overexpression bypasses need for Spo12p, but not required for meiosis Phenotype: Null mutant is viable and exhibits no obvious meiotic defects. When overexpressed, BNS1 can partially suppress the meiotic defect of spo12/spo12 deletion mutants. ORF_Name: YGR230W SGDID: S000003462 Locus_Name: BOI1 Alias_Name: BOB1|GIN7 Description: Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain ORF_Name: YBL085W SGDID: S000000181 Locus_Name: BOI2 Alias_Name: BEB1 Description: Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain Phenotype: Null boi1 boi2 mutants become large round cells or lysed with buds, display defects in bud formation and in the maintenance of cell polarity ORF_Name: YER114C SGDID: S000000916 Locus_Name: BOP2 Description: Protein of unknown function Phenotype: Null: Multicopy suppressor of a pam1 slv3 double deletion mutant ORF_Name: YLR267W SGDID: S000004257 Locus_Name: BOP3 Description: Protein of unknown function, potential Cdc28p substrate; overproduction confers resistance to methylmercury Phenotype: Null: Multicopy suppressor of a pam1 slv3 double deletion mutant ORF_Name: YNL042W SGDID: S000004987 Locus_Name: BOR1 Description: Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1 ORF_Name: YNL275W SGDID: S000005219 Locus_Name: BOS1 Alias_Name: SEC32 Description: v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi ORF_Name: YLR078C SGDID: S000004068 Locus_Name: BPH1 Description: PProtein homologous to human Chediak-Higashi syndrome and murine Beige proteins, which are implicated in disease syndromes due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting Phenotype: Null mutant is viable, sensitive to low pH ORF_Name: YCR032W SGDID: S000000628 Locus_Name: BPL1 Alias_Name: ACC2 Description: Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation ORF_Name: YDL141W SGDID: S000002300 Locus_Name: BPT1 Description: ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p Phenotype: Null mutant is viable but lacks approximately 40% of the trasport activity of unconjugated bilirubin into the vacuolar system of yeast ORF_Name: YLL015W SGDID: S000003938 Locus_Name: BRE1 Description: E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control Phenotype: null mutant is sensitive to brefeldin A ORF_Name: YDL074C SGDID: S000002232 Locus_Name: BRE2 Alias_Name: CPS60 Description: Subunit of COMPASS (Set1C) complex, which methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L Phenotype: Null: null mutant is sensitive to brefeldin A ORF_Name: YLR015W SGDID: S000004005 Locus_Name: BRE4 Description: Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport ORF_Name: YDL231C SGDID: S000002390 Locus_Name: BRE5 Description: Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A ORF_Name: YNR051C SGDID: S000005334 Locus_Name: BRF1 Alias_Name: PCF4|TDS4 Description: TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB Gene_Product: TFIIIB70 ORF_Name: YGR246C SGDID: S000003478 Locus_Name: BRL1 Description: Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export ORF_Name: YHR036W SGDID: S000001078 Locus_Name: BRN1 Description: Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus; may influence multiple aspects of chromosome transmission ORF_Name: YBL097W SGDID: S000000193 Locus_Name: BRO1 Alias_Name: ASI6|LPF2|NPI3|VPS31 Description: Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes ORF_Name: YPL084W SGDID: S000006005 Locus_Name: BRP1 Description: Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1 ORF_Name: YGL007W SGDID: S000002975 Locus_Name: BRR1 Description: snRNP protein component of spliceosomal snRNPs, required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed ORF_Name: YPR057W SGDID: S000006261 Locus_Name: BRR2 Alias_Name: PRP44|RSS1|SLT22|SNU246 Description: RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD Phenotype: Null mutant is inviable; stabilized splicing intermediates which contain a mutant hammerhead cis-targeted ribozyme, decreased steady-state levels of endogneous mRNAs, increased ratio of pre-mRNA to mRNA of specific message(s); synthetic lethal with U2 mutants ORF_Name: YER172C SGDID: S000000974 Locus_Name: BRR4 Phenotype: brr4 mutations inhibit splicing before the first step of the reaction SGDID: S000029061 Locus_Name: BRR6 Description: Essential nuclear envelope integral membrane protein required for nuclear envelope morphology, nuclear pore complex localization, nuclear export; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism ORF_Name: YGL247W SGDID: S000003216 Locus_Name: BRX1 Description: Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif ORF_Name: YOL077C SGDID: S000005437 Locus_Name: BSC1 Description: Protein of unconfirmed function, similar to cell surface flocculin Muc1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression ORF_Name: YDL037C SGDID: S000002195 Locus_Name: BSC2 Description: Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression ORF_Name: YDR275W SGDID: S000002683 Locus_Name: BSC3 Description: Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 100% of YLR465C overlaps the uncharacterized ORF YLR464W and 86% of YLR465C overlaps the verified gene YRF1-4 ORF_Name: YLR465C SGDID: S000004457 Locus_Name: BSC4 Description: Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p ORF_Name: YNL269W SGDID: S000005213 Locus_Name: BSC5 Description: Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression ORF_Name: YNR069C SGDID: S000005352 Locus_Name: BSC6 Description: Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression ORF_Name: YOL137W SGDID: S000005497 Locus_Name: BSD2 Description: Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification ORF_Name: YBR290W SGDID: S000000494 Locus_Name: BSP1 Description: Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton ORF_Name: YPR171W SGDID: S000006375 Locus_Name: BST1 Alias_Name: PER17 Description: GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules ORF_Name: YFL025C SGDID: S000001869 Locus_Name: BST3 Description: Negatively regulated COPII vesicle formation Phenotype: Suppress mutations in SEC13; mutation slows secretion of some secretory proteins and causes resident ER proteins Kar2p and Pdi1p to leak more rapidly from the ER SGDID: S000029062 Locus_Name: BTN2 Description: v-SNARE binding protein that facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase ORF_Name: YGR142W SGDID: S000003374 Locus_Name: BTS1 Description: Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic ORF_Name: YPL069C SGDID: S000005990 Locus_Name: BTT1 Description: Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3 ORF_Name: YDR252W SGDID: S000002660 Locus_Name: BUB1 Description: Protein kinase that forms a complex with Mad1p and Bub3p that is crucial in the checkpoint mechanism required to prevent cell cycle progression into anaphase in the presence of spindle damage, associates with centromere DNA via Skp1p Phenotype: Mutants are unable to recover from transient loss of spindle function. Overexpression of BUB1 rescues the cold sensitivity of tub1-729. ORF_Name: YGR188C SGDID: S000003420 Locus_Name: BUB2 Alias_Name: PAC7 Description: Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage Phenotype: Reduces the cell cycle delay which accompanies activation of a conditionally dicentric chromosome ORF_Name: YMR055C SGDID: S000004659 Locus_Name: BUB3 Description: Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p ORF_Name: YOR026W SGDID: S000005552 Locus_Name: BUD11 Description: bud site selection Phenotype: Recessive mutants have a bud site selection phenotype in a and alpha cells and are sensitive to hydroxyurea. SGDID: S000029063 Locus_Name: BUD12 Description: bud site selection Phenotype: Semi-dominant mutants have a bud site selection phenotype in a and alpha cells. SGDID: S000029064 Locus_Name: BUD13 Alias_Name: CWC26 Description: Subunit of the RES complex, which is required for nuclear pre-mRNA retention and splicing; involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern Phenotype: Null mutant is viable; diploid null mutants exhibit unipolar budding and elongate phenotype. ORF_Name: YGL174W SGDID: S000003142 Locus_Name: BUD14 Description: Protein involved in bud-site selection, Bud14p-Glc7p complex is a cortical regulator of dynein; inhibitor of the actin assembly factor Bnr1p (formin); diploid mutants display a random budding pattern instead of the wild-type bipolar pattern ORF_Name: YAR014C SGDID: S000000069 Locus_Name: BUD16 Description: Putative pyridoxal kinase, a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; similarity to yeast BUD17 and human pyridoxal kinase (PDXK) ORF_Name: YEL029C SGDID: S000000755 Locus_Name: BUD17 Description: Putative pyridoxal kinase, a key enzyme in vitamin B6 metabolism; involved in bud-site selection; diploid mutants display a random rather than a bipolar budding pattern; similarity to yeast BUD16 and human pyridoxal kinase (PDXK) ORF_Name: YNR027W SGDID: S000005310 Locus_Name: BUD19 Description: Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay ORF_Name: YJL188C SGDID: S000003724 Locus_Name: BUD2 Alias_Name: CLA2|ERC25 Description: GTPase activating factor for Rsr1p/Bud1p required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types Phenotype: Null mutant is viable, with random bud site selection in all cell types ORF_Name: YKL092C SGDID: S000001575 Locus_Name: BUD20 Description: Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern ORF_Name: YLR074C SGDID: S000004064 Locus_Name: BUD21 Alias_Name: UTP16|YOR29-29 Description: Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern Phenotype: Null mutant is viable; random budding in diploid null mutants; null has both reduced growth and reduced protein synthesis rates ORF_Name: YOR078W SGDID: S000005604 Locus_Name: BUD22 Description: Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern ORF_Name: YMR014W SGDID: S000004616 Locus_Name: BUD23 Description: Methyltransferase, methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; diploid mutant displays random budding pattern ORF_Name: YCR047C SGDID: S000000643 Locus_Name: BUD25 Description: Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern ORF_Name: YER014C-A SGDID: S000007590 Locus_Name: BUD26 Description: Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay ORF_Name: YDR241W SGDID: S000002649 Locus_Name: BUD27 Alias_Name: URI1 Description: Protein involved in bud-site selection, nutrient signaling, and gene expression controlled by TOR kinase; diploid mutants show a random budding pattern rather than the wild-type bipolar pattern; plays a role in regulating Ty1 transposition ORF_Name: YFL023W SGDID: S000001871 Locus_Name: BUD28 Description: Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay Phenotype: Diploid null mutants exhibit random budding ORF_Name: YLR062C SGDID: S000004052 Locus_Name: BUD3 Alias_Name: YCL012W Description: Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding Phenotype: Null mutant is viable; bipolar budding pattern in all cell types ORF_Name: YCL014W SGDID: S000000520 Locus_Name: BUD30 Description: Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay ORF_Name: YDL151C SGDID: S000002310 Locus_Name: BUD31 Alias_Name: CWC14 Description: Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern Phenotype: Diploid mutants exhibit random budding ORF_Name: YCR063W SGDID: S000000659 Locus_Name: BUD32 Alias_Name: LDB14 Description: Protein kinase proposed to be involved in bud-site selection, telomere uncapping and elongation, and transcription; component of the EKC/KEOPS protein complex with Kae1p, Cgi121p, Pcc1p, and Gon7p Phenotype: Diploid mutants exhibit random budding ORF_Name: YGR262C SGDID: S000003494 Locus_Name: BUD4 Description: Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding; potential Cdc28p substrate Phenotype: Null mutant is viable, haploids have dipolar budding, normally they have axial budding, no effects on diploids ORF_Name: YJR092W SGDID: S000003852 Locus_Name: BUD5 Description: GTP/GDP exchange factor for Rsr1p (Bud1p) required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types Phenotype: bud5 mutants select bud sites randomly ORF_Name: YCR038C SGDID: S000000634 Locus_Name: BUD6 Alias_Name: AIP3 Description: Actin- and formin-interacting protein, involved in actin cable nucleation and polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate Phenotype: Null mutant is viable; mutants exhibit severe disruption of the actin cytoskeleton; deletion strains have a depolarized cytoskeleton, mitotic delay, and probable cytokinesis defects ORF_Name: YLR319C SGDID: S000004311 Locus_Name: BUD7 Description: Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane Phenotype: Diploid-specific heterogenous bud site selection ORF_Name: YOR299W SGDID: S000005825 Locus_Name: BUD8 Description: Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole Phenotype: A bud8 bud9 double mutant buds almost exclusively from the proximal pole ORF_Name: YLR353W SGDID: S000004345 Locus_Name: BUD9 Description: Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole Phenotype: In null mutants bipolar-budding cells bud preferentially at distal pole ORF_Name: YGR041W SGDID: S000003273 Locus_Name: BUG1 Description: Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes ORF_Name: YDL099W SGDID: S000002257 Locus_Name: BUL1 Alias_Name: DAG1|RDS1|SMM2 Description: Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex, functional homolog of Bul2p, disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases ORF_Name: YMR275C SGDID: S000004888 Locus_Name: BUL2 Description: Component of the Rsp5p E3-ubiquitin ligase complex, involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions, functional homolog of BUL1 ORF_Name: YML111W SGDID: S000004579 Locus_Name: BUR2 Alias_Name: CST4 Description: Cyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II Phenotype: Uncharacterized mutant allele causes increased transcription of SUC2 in the absence of its UAS; Overexpression induces chromosome loss ORF_Name: YLR226W SGDID: S000004216 Locus_Name: BUR6 Alias_Name: NCB1 Description: Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha Phenotype: Null mutant is viable, but grows very poorly ORF_Name: YER159C SGDID: S000000961 Locus_Name: BYE1 Description: Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit Phenotype: Null: viable, 6-AU resistant ORF_Name: YKL005C SGDID: S000001488 Locus_Name: BZZ1 Alias_Name: LSB7 Description: SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins ORF_Name: YHR114W SGDID: S000001156 Locus_Name: CAB1 Description: Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA) ORF_Name: YDR531W SGDID: S000002939 Locus_Name: CAB2 Description: Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity) ORF_Name: YIL083C SGDID: S000001345 Locus_Name: CAB3 Description: Subunit of a phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaBC ORF_Name: YKL088W SGDID: S000001571 Locus_Name: CAB4 Description: Probable pantetheine-phosphate adenylyltransferase (PPAT), which catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; null mutant lethality is complemented by E. coli coaD (encoding PPAT); widely conserved ORF_Name: YGR277C SGDID: S000003509 Locus_Name: CAB5 Description: Probable dephospho-CoA kinase (DPCK) that catalyzes the last step in coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaE (encoding DPCK); detected in purified mitochondria in high-throughput studies ORF_Name: YDR196C SGDID: S000002604 Locus_Name: CAC2 Description: Component of the chromatin assembly complex (with Rlf2p and Msi1p) that assembles newly synthesized histones onto recently replicated DNA, required for building functional kinetochores, conserved from yeast to humans ORF_Name: YML102W SGDID: S000004570 Locus_Name: CAD1 Alias_Name: YAP2 Description: AP-1-like basic leucine zipper (bZIP) transcriptional activator involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA ORF_Name: YDR423C SGDID: S000002831 Locus_Name: CAF120 Description: Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation ORF_Name: YNL278W SGDID: S000005222 Locus_Name: CAF130 Description: Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation ORF_Name: YGR134W SGDID: S000003366 Locus_Name: CAF16 Description: Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator ORF_Name: YFL028C SGDID: S000001866 Locus_Name: CAF20 Alias_Name: CAF2|CAP20 Description: Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E Gene_Product: p20 ORF_Name: YOR276W SGDID: S000005802 Locus_Name: CAF4 Description: WD40 repeat-containing protein associated with the CCR4-NOT complex, interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission ORF_Name: YKR036C SGDID: S000001744 Locus_Name: CAF40 Description: Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p ORF_Name: YNL288W SGDID: S000005232 Locus_Name: CAG1 Description: alpha-specific gene involved in the regulation of sex agglutinin synthesis Phenotype: Constitutively agglutinable at 36 degrees C SGDID: S000029065 Locus_Name: CAJ1 Description: Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly ORF_Name: YER048C SGDID: S000000850 Locus_Name: CAK1 Alias_Name: CIV1 Description: Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases Phenotype: Null mutant is inviable; temperature-sensitive mutant confers a G2 delay accompanied by low Cdc28p protein kinase activity ORF_Name: YFL029C SGDID: S000001865 Locus_Name: CAM1 Alias_Name: TEF3 Description: Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma Gene_Product: CPBP ORF_Name: YPL048W SGDID: S000005969 Locus_Name: CAN1 Description: Plasma membrane arginine permease, requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance Phenotype: Canavanine resistance ORF_Name: YEL063C SGDID: S000000789 Locus_Name: CAP1 Description: Alpha subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches Phenotype: Null mutant is viable; severe deficit of actin cables and increased number of actin spots in the mother; round, relatively large cells ORF_Name: YKL007W SGDID: S000001490 Locus_Name: CAP2 Description: Beta subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches Phenotype: Null mutant is viable, exhibits abnormal actin distribution (including loss of actin cables); round, large cells with heterogeneous size distribution; slower growing; chitin found over entire mother cell surface rather than restricted to the mother-bud junction ORF_Name: YIL034C SGDID: S000001296 Locus_Name: CAR1 Alias_Name: LPH15|cargA Description: Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance Phenotype: Null mutant is viable but defective in arginine catabolism ORF_Name: YPL111W SGDID: S000006032 Locus_Name: CAR2 Alias_Name: cargB Description: L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive Phenotype: Catabolism of arginine defective ORF_Name: YLR438W SGDID: S000004430 Locus_Name: CAT2 Alias_Name: YCAT Description: Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes Phenotype: Null mutant is viable; cat2 cit2 double mutants cannot grow on oleate. ORF_Name: YML042W SGDID: S000004506 Locus_Name: CAT5 Alias_Name: COQ7 Description: Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation Phenotype: Null mutant is viable, results in complete loss of glucose derepression affecting gluconeogenic key enzymes. Respiration, but not mitochondrial cytochrome c oxidase activity, are also affected; fails to synthesize ubiquinone ORF_Name: YOR125C SGDID: S000005651 Locus_Name: CAT8 Alias_Name: DIL1|MSP8 Description: Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements Phenotype: Null mutant is viable but unable to grow on non-fermentable carbon sources due to failure to derepress all major gluconeogenic enzymes; overexpression of Cat8p suppress inability of snf1 and snf4 mutants to grow on ethanol ORF_Name: YMR280C SGDID: S000004893 Locus_Name: CAX4 Alias_Name: CWH8 Description: Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation Phenotype: Null mutant is viable with severely affected growth rate, hypo-N-glycosylation of secretory proteins, and severely reduced levels of dolichol-linked oligosaccharides in the endoplasmic reticulum. Exhibits defective actin organization and calcofluor white hypersensitivity. Synthetically lethal with a temperature sensitve allele of CMD1 ORF_Name: YGR036C SGDID: S000003268 Locus_Name: CBC2 Alias_Name: CBP20|MUD13|SAE1 Description: Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif Phenotype: mutants exhibit promiscuous 3'-end formation; sae-1 mutation causes temporary cell cycle arrest in meiotic prophase ORF_Name: YPL178W SGDID: S000006099 Locus_Name: CBF1 Alias_Name: CEP1|CPF1 Description: Helix-loop-helix protein that binds the motif CACRTG, which is present at several sites including MET gene promoters and centromere DNA element I (CDEI); required for nucleosome positioning at this motif; targets Isw1p to DNA Phenotype: Null mutant is viable, but grows slowly and causes partial loss of centromere function (increased chromosome loss), benomyl and thiabendazole sensitivity, methionine auxotrophy, and changes in chromatin structure at CENs and some promoters. Null mutation causes precocious sister segregation at MI, and reduced spore viability. ORF_Name: YJR060W SGDID: S000003821 Locus_Name: CBF2 Alias_Name: CBF3A|CEP2|CSL5|CTF14|NDC10 Description: Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo ORF_Name: YGR140W SGDID: S000003372 Locus_Name: CBF5 Description: Pseudouridine synthase catalytic subunit of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), acts on both large and small rRNAs and on snRNA U2; mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita ORF_Name: YLR175W SGDID: S000004165 Locus_Name: CBK1 Description: Serine/threonine protein kinase that regulates cell morphogenesis pathways; involved in cell wall biosynthesis, apical growth, proper mating projection morphology, bipolar bud site selection in diploid cells, and cell separation Phenotype: Null mutation is viable; shows alpha factor resistance; in liquid culture large aggregates of cells are formed ORF_Name: YNL161W SGDID: S000005105 Locus_Name: CBP1 Description: Mitochondrial protein that interacts with the 5'-untranslated region of the COB mRNA and has a role in its stability and translation; found in a complex at the inner membrane along with Pet309p Phenotype: Null mutant is viable, unable to respire due to degradation of mitochondrially encoded cytochrome b (cob) RNA ORF_Name: YJL209W SGDID: S000003745 Locus_Name: CBP2 Description: Mitochondrial protein required for splicing of the group I intron aI5 of the COB pre-mRNA, binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene ORF_Name: YHL038C SGDID: S000001030 Locus_Name: CBP3 Description: Mitochondrial protein required for assembly of ubiquinol cytochrome-c reductase complex (cytochrome bc1 complex); interacts with Cbp4p and function is partially redundant with that of Cbp4p Phenotype: reduced levels of a subset of subunit polypeptides of the coenzyme QH2-cytochrome c reductase complex ORF_Name: YPL215W SGDID: S000006136 Locus_Name: CBP4 Description: Mitochondrial protein required for assembly of ubiquinol cytochrome-c reductase complex (cytochrome bc1 complex); interacts with Cbp3p and function is partially redundant with that of Cbp3p Phenotype: Inability to respire, pleiotropic reduction in steady state levels of four subunits of ubiquinol-cytochrome c reductase ORF_Name: YGR174C SGDID: S000003406 Locus_Name: CBP6 Description: Mitochondrial translational activator of the COB mRNA; phosphorylated Phenotype: Null mutant is viable, repiratory deficiency with concomitant loss of cytochrome b ORF_Name: YBR120C SGDID: S000000324 Locus_Name: CBR1 Alias_Name: CBR5 Description: Microsomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia ORF_Name: YIL043C SGDID: S000001305 Locus_Name: CBS1 Description: Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader ORF_Name: YDL069C SGDID: S000002227 Locus_Name: CBS2 Alias_Name: CBP7 Description: Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader Phenotype: Null mutant is viable, exhibits a mitochondrial apocytochrome b mRNA translational defect ORF_Name: YDR197W SGDID: S000002605 Locus_Name: CBT1 Alias_Name: SOC1 Description: Protein involved in 5' end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p ORF_Name: YKL208W SGDID: S000001691 Locus_Name: CCA1 Alias_Name: TNT1 Description: ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites ORF_Name: YER168C SGDID: S000000970 Locus_Name: CCB1 Description: cross-complementation of budding defect SGDID: S000029066 Locus_Name: CCC1 Description: Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation Phenotype: Wild-type complements csg1 (calcium sensitive-group) mutants when overexpressed. Deletion of CCC1 results in decreased vacuolar iron content and decreased iron stores, which affect cytosolic iron levels and cell growth. ORF_Name: YLR220W SGDID: S000004210 Locus_Name: CCC2 Description: Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases Phenotype: Null mutant is viable, exhibits defects in respiration and iron uptake ORF_Name: YDR270W SGDID: S000002678 Locus_Name: CCE1 Alias_Name: MGT1 Description: Mitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA Phenotype: Null mutant is viable, exhibits a higher than normal frequency of appearance of petite cells ORF_Name: YKL011C SGDID: S000001494 Locus_Name: CCH1 Description: Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together Phenotype: Null mutant is viable; exhibits reduced growth rate, viability and calcium uptake; exhibits a defect in pheromone-induced Ca2+ uptake; suppressor of cdc1 temperature-sensitive mutant ORF_Name: YGR217W SGDID: S000003449 Locus_Name: CCL1 Description: Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters ORF_Name: YPR025C SGDID: S000006229 Locus_Name: CCM1 Alias_Name: RRG2 Description: Protein required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport ORF_Name: YGR150C SGDID: S000003382 Locus_Name: CCP1 Description: Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress ORF_Name: YKR066C SGDID: S000001774 Locus_Name: CCR4 Alias_Name: FUN27|NUT21 Description: Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening Phenotype: reduced levels of ADH2 expression under both glucose and ethanol growth conditions; temperature sensitive growth on nonfermentative medium ORF_Name: YAL021C SGDID: S000000019 Locus_Name: CCS1 Alias_Name: CCS|LYS7 Description: Copper chaperone for superoxide dismutase Sod1p, involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation Phenotype: Null mutant is viable, methionine and lysine auxotroph, pH and temperature sensitive; sensitive to superoxide generating drugs and light irradiation, exhibits diminution of calcineurin activity ORF_Name: YMR038C SGDID: S000004641 Locus_Name: CCT2 Alias_Name: BIN3|TCP2 Description: Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo ORF_Name: YIL142W SGDID: S000001404 Locus_Name: CCT3 Alias_Name: BIN2|TCP3 Description: Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Phenotype: Defects in microtubule and actin assembly in vivo, aberrant chromosome segregation, supersensitivity to benomyl ORF_Name: YJL014W SGDID: S000003551 Locus_Name: CCT4 Alias_Name: ANC2|TCP4 Description: Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo ORF_Name: YDL143W SGDID: S000002302 Locus_Name: CCT5 Alias_Name: TCP5 Description: Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo ORF_Name: YJR064W SGDID: S000003825 Locus_Name: CCT6 Alias_Name: HTR3|TCP20|TCP6 Description: Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif ORF_Name: YDR188W SGDID: S000002596 Locus_Name: CCT7 Alias_Name: TCP7 Description: Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo ORF_Name: YJL111W SGDID: S000003647 Locus_Name: CCT8 Description: Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo ORF_Name: YJL008C SGDID: S000003545 Locus_Name: CCW1 SGDID: S000029067 Locus_Name: CCW10 SGDID: S000029068 Locus_Name: CCW12 Description: Cell wall mannoprotein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor Phenotype: Null mutant is viable and shows decrease in mating efficiency and defect in agglutination ORF_Name: YLR110C SGDID: S000004100 Locus_Name: CCW14 Alias_Name: SSR1|YLR391W|YLR391W-A Description: Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall Phenotype: Null mutant is viable but causes increased sensitivities to calcofluor white, Congo red, and zymolyase digestion. Overexpression also causes calcofluor white and Congo red sensitivity. (see Moukadiri et al (1997) J. Bacteriol. 179:2154-62). ORF_Name: YLR390W-A SGDID: S000006429 Locus_Name: CCW2 SGDID: S000029069 Locus_Name: CCW3 SGDID: S000029070 Locus_Name: CCW4 SGDID: S000029071 Locus_Name: CCW9 SGDID: S000029073 Locus_Name: CCZ1 Alias_Name: CVT16 Description: Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway Phenotype: Null mutant is viable, but is sensitive to caffeine, calcium and zinc; no sporulation in homozygous null diploids ORF_Name: YBR131W SGDID: S000000335 Locus_Name: CDA1 Description: Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall Phenotype: Null mutant is viable, mutants spores disrupted for both cda1 and cda2 fail to emit natural fluorescence and are sensitive to hydrolyrtic enzymes, ether, and heat shock ORF_Name: YLR307W SGDID: S000004298 Locus_Name: CDA2 Description: Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall Phenotype: Null mutant is viable, mutant spores disrupted for both cda1 and cda2 fail to emit natural fluorescence and are sensitive to hydrolyrtic enzymes, ether, and heat shock ORF_Name: YLR308W SGDID: S000004299 Locus_Name: CDC1 Alias_Name: DSC1|DSR1|ESP2 Description: Putative lipid phosphatase of the endoplasmic reticulum; shows Mn2+ dependence and may affect Ca2+ signaling; mutants display actin and general growth defects and pleiotropic defects in cell cycle progression and organelle distribution ORF_Name: YDR182W SGDID: S000002590 Locus_Name: CDC10 Description: Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM Phenotype: abnormal cell-wall deposition and bud growth, inability to complete cytokinesis, failure to form the ring of 10nm filaments in the neck region of budding cells ORF_Name: YCR002C SGDID: S000000595 Locus_Name: CDC11 Alias_Name: PSL9 Description: Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM Phenotype: abnormal cell-wall deposition and bud growth, inability to complete cytokinesis, failure to form the ring of 10nm filaments in the neck region of budding cells ORF_Name: YJR076C SGDID: S000003837 Locus_Name: CDC12 Alias_Name: CLA10|PSL7 Description: Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM Phenotype: abnormal cell-wall deposition and bud growth, inability to complete cytokinesis, failure to form the ring of 10nm filaments in the neck region of budding cells ORF_Name: YHR107C SGDID: S000001149 Locus_Name: CDC123 Description: Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein ORF_Name: YLR215C SGDID: S000004205 Locus_Name: CDC13 Alias_Name: EST4 Description: Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping ORF_Name: YDL220C SGDID: S000002379 Locus_Name: CDC14 Alias_Name: OAF3 Description: Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit Phenotype: Null mutant is inviable; ts mutant arrests at late anaphase with phenotypes similar to cdc5 mutants ORF_Name: YFR028C SGDID: S000001924 Locus_Name: CDC15 Alias_Name: LYT1 Description: Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II Phenotype: Null mutant inviable, arrests in G2; buds at distal instead of axial position, undergoes autolysis when buds reach the size of mother cells; the mitotic, but not meiotic, phenotype is suppressible by overexpressing SPO12. ORF_Name: YAR019C SGDID: S000000072 Locus_Name: CDC16 Description: Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation Phenotype: Null mutant is inviable; sensitive to caffeine; cdc16 mutants are unable to progress through the G(sub)2/M transition, cell division cycle blocked at 36 degrees C ORF_Name: YKL022C SGDID: S000001505 Locus_Name: CDC19 Alias_Name: PYK1 Description: Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration Phenotype: Null mutant is inviable. cdc19 mutants are pyruvate kinase deficient and show cell division cycle blocked at 36 degrees C ORF_Name: YAL038W SGDID: S000000036 Locus_Name: CDC20 Alias_Name: PAC5 Description: Cell-cycle regulated activator of anaphase-promoting complex/cyclosome (APC/C), which is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; potential Cdc28p substrate Phenotype: Null mutant is inviable; conditional alleles show cell cycle arrest in G2 ORF_Name: YGL116W SGDID: S000003084 Locus_Name: CDC21 Alias_Name: CRT9|TMP1|YOR29-25 Description: Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S Phenotype: defective in continued replication during S phase of the cell cycle; temperature-sensitive thymidylate auxotroph ORF_Name: YOR074C SGDID: S000005600 Locus_Name: CDC22 Alias_Name: DNA1 SGDID: S000029074 Locus_Name: CDC23 Description: Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition Phenotype: unable to complete G(sub)2/M transition ORF_Name: YHR166C SGDID: S000001209 Locus_Name: CDC24 Alias_Name: CLS4 Description: Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing Phenotype: temperature sensitive mutation affecting bud formation and localized cell surface growth at a restrictive temperature ORF_Name: YAL041W SGDID: S000000039 Locus_Name: CDC25 Alias_Name: CDC25'|CTN1 Description: Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1 Phenotype: Null mutant is inviable; arrests at G(sub)1; low levels cAMP and decreased levels of Mg2+-dependent cyclase activity ORF_Name: YLR310C SGDID: S000004301 Locus_Name: CDC26 Alias_Name: HIT3|SCD26 Description: Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition Phenotype: thermosensitive cell growth (lethal at high temperature) ORF_Name: YFR036W SGDID: S000001932 Locus_Name: CDC27 Alias_Name: APC3|SNB1 Description: Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition Phenotype: Null mutant is inviable. Some conditional alleles overreplicate their DNA. ORF_Name: YBL084C SGDID: S000000180 Locus_Name: CDC28 Alias_Name: CDK1|HSL5|SRM5 Description: Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates Phenotype: arrests at G1/S transition
arrests at G2/M transition ORF_Name: YBR160W SGDID: S000000364 Locus_Name: CDC29 Description: Cell division cycle blocked at 36 degree C SGDID: S000029075 Locus_Name: CDC3 Description: Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM Phenotype: Null mutant is inviable; other mutants show abnormal cell-wall deposition and bud growth, inability to complete cytokinesis, and failure to form the ring of 10nm filaments in the neck region of budding cells. ORF_Name: YLR314C SGDID: S000004306 Locus_Name: CDC31 Alias_Name: DSK1 Description: Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation Phenotype: Null mutant is inviable. cdc31 mutants form reductional dyads with unduplicated spindle pole bodies ORF_Name: YOR257W SGDID: S000005783 Locus_Name: CDC33 Alias_Name: TIF45 Description: Cytoplasmic mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p) Gene_Product: eIF4E Phenotype: Null mutant is inviable. cdc33 mutants arrest at G(sub)1. cdc33 has normal cAMP pools and is not suppressed by cAPK mutants, suggesting sporulation is independent of the cAMP pathway ORF_Name: YOL139C SGDID: S000005499 Locus_Name: CDC34 Alias_Name: DNA6|UBC3 Description: Ubiquitin-conjugating enzyme (E2) and catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation Phenotype: overexpression confers resistance to xenobiotics (methylmercury, mercuric chloride, and p-chloromercuribenzoate). ORF_Name: YDR054C SGDID: S000002461 Locus_Name: CDC36 Alias_Name: DNA19|NOT2 Description: Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor Phenotype: Null mutant is viable, cdc36 mutant arrests in G(sub)1; forms shmoo morphology at restrictive temperature, arrests at pachytene at the mononucleate stage with duplicated spindle pole bodies and no spindles ORF_Name: YDL165W SGDID: S000002324 Locus_Name: CDC37 Alias_Name: SMO1 Description: Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding Phenotype: Null mutant is inviable; temperature-sensitive mutants arrest in G1 and form shmoo morphology at the restrictive temperature ORF_Name: YDR168W SGDID: S000002575 Locus_Name: CDC39 Alias_Name: NOT1|ROS1|SMD6 Description: Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor Phenotype: Null mutant is inviable; arrests in G(sub)1 at pachytene at the mononucleate stage with duplicated, unseparated spindle pole bodies and no spindles; temperature sensitive mutation which causes increased basal transcription of many genes ORF_Name: YCR093W SGDID: S000000689 Locus_Name: CDC4 Description: F-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p Phenotype: Null mutant is inviable. cdc4 mutants arrest in meiosis at the mononucleate stage with duplicated spindle pole bodies. ORF_Name: YFL009W SGDID: S000001885 Locus_Name: CDC40 Alias_Name: PRP17|SLT15|SLU4 Description: Pre-mRNA splicing factor, important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression; required for DNA synthesis during mitosis and meiosis; has WD repeats Phenotype: Null mutant is viable, temperature sensitive at 36 degrees celsius, arrests at the mononucleate stage; synthetically lethal with U2 snRNA LSR1; blocks pre-mRNA splicing in vivo and in vitro ORF_Name: YDR364C SGDID: S000002772 Locus_Name: CDC42 Description: Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins Phenotype: Null mutant is inviable; temperature sensitive mutations unable to form buds and display delocalized cell-surface deposition at the restrictive temperature ORF_Name: YLR229C SGDID: S000004219 Locus_Name: CDC43 Alias_Name: CAL1 Description: Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis Phenotype: temperature sensitive mutants unable to form buds and display delocalized cell-surface deposition ORF_Name: YGL155W SGDID: S000003123 Locus_Name: CDC45 Alias_Name: SLD4 Description: DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes Phenotype: required for minichromosome maintenance and chromosomal DNA replication ORF_Name: YLR103C SGDID: S000004093 Locus_Name: CDC48 Description: ATPase in ER, nuclear membrane and cytosol with homology to mammalian p97; in a complex with Npl4p and Ufd1p participates in retrotranslocation of ubiquitinated proteins from the ER into the cytosol for degradation by the proteasome ORF_Name: YDL126C SGDID: S000002284 Locus_Name: CDC5 Alias_Name: MSD2|PKX2 Description: Polo-like kinase with similarity to Xenopus Plx1 and S. pombe Plo1p; found at bud neck, nucleus and SPBs; has multiple functions in mitosis and cytokinesis through phosphorylation of substrates; may be a Cdc28p substrate ORF_Name: YMR001C SGDID: S000004603 Locus_Name: CDC50 Description: Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Ynr048wp and Lem3p Phenotype: Null mutant is cold-sensitive and sensitive to MMS and HU ORF_Name: YCR094W SGDID: S000000690 Locus_Name: CDC53 Description: Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation Phenotype: Cells arrest in G1 with active Cln kinases but no Clb-associated Cdc28p kinase activity ORF_Name: YDL132W SGDID: S000002290 Locus_Name: CDC55 Description: Non-essential regulatory subunit B of protein phosphatase 2A (PP2A), which has multiple roles in mitosis and protein biosynthesis; involved in regulation of mitotic exit; found in the nucleus of most cells, also at bud neck and bud tip Phenotype: abnormally elongated buds, delay or partial block of septation and/or cell separation; deletion mutant is cold-sensitive ORF_Name: YGL190C SGDID: S000003158 Locus_Name: CDC6 Description: Essential ATP-binding protein required for DNA replication, component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p Phenotype: arrest at initiation of S phase ORF_Name: YJL194W SGDID: S000003730 Locus_Name: CDC60 Description: Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA Gene_Product: LeuRS|leucyl-tRNA synthetase Phenotype: arrest at START point of cell cycle upon shift to restrictive temperature ORF_Name: YPL160W SGDID: S000006081 Locus_Name: CDC61 SGDID: S000029076 Locus_Name: CDC62 Description: Cell division cycle blocked at 36 degree C SGDID: S000029077 Locus_Name: CDC65 Alias_Name: DNA33|SUP60|SUP70 Description: tRNA-Gln; glutamine tRNA with anticodon CUG Phenotype: A temperature-sensitive allele inhibits zygote formation and conjugation. SGDID: S000006690 Locus_Name: CDC67 Description: Regulator of the cell cycle at Start Phenotype: Arrest of proliferation at the regulatory step Start, inhibition of zygote formation and successful conjugation SGDID: S000029078 Locus_Name: CDC7 Alias_Name: LSD6|SAS1 Description: DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in mitosis through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression Phenotype: Null mutant is inviable. cdc7 mutant arrests at G(sub)1/S phase with duplicated spindle pole bodies and no spindles; the spindle pole bodies eventually enlarge, invaginate from the nuclear envelope into the center of the nucleus, sometimes fragmenting into three or four smaller spindle pole bodies. In heterozygotes, cdc7 spores fail to germinate. ORF_Name: YDL017W SGDID: S000002175 Locus_Name: CDC73 Description: Component of the Paf1p complex that binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance Phenotype: Mutations affect cell growth and the abundance of transcripts from a subset of genes ORF_Name: YLR418C SGDID: S000004410 Locus_Name: CDC77 Alias_Name: NDC2 Description: Cell division cycle blocked at 36 degree C SGDID: S000029079 Locus_Name: CDC8 Description: Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p Phenotype: Null mutant is inviable. cdc8 mutants are defective in continued replication during S phase of the cell cycle. cdc8 arrests at the mononucleate stage with duplicated spindle pole bodies and no spindles. ORF_Name: YJR057W SGDID: S000003818 Locus_Name: CDC9 Alias_Name: MMS8 Description: DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination Phenotype: cell division cycle blocked at 36 degrees, increased sensitivity to ultraviolet radiation and bleomycin; temperature sensitive ORF_Name: YDL164C SGDID: S000002323 Locus_Name: CDD1 Description: Cytidine deaminase; catalyzes the modification of cytidine to uridine in vitro but native RNA substrates have not been identified, localizes to both the nucleus and cytoplasm ORF_Name: YLR245C SGDID: S000004235 Locus_Name: CDH1 Alias_Name: HCT1 Description: Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p Phenotype: Null mutant is viable but defective in Clb2p and Ase1p degradation; deletion of cdh1 causes pheromone resistance and is synthetically lethal with sic1 deletion; overexpression causes ectopic degradation of Clb2p and Ase1p ORF_Name: YGL003C SGDID: S000002971 Locus_Name: CDL1 Phenotype: some alleles cause lethality in combination with chc1 null mutants SGDID: S000029080 Locus_Name: CDS1 Alias_Name: CDG1 Description: Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids ORF_Name: YBR029C SGDID: S000000233 Locus_Name: CEF1 Alias_Name: NTC85 Description: Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p Phenotype: Null mutant is inviable, arrests in G2/M, exhibits abnormal nuclear morphologies. Essential for mRNA splicing. ORF_Name: YMR213W SGDID: S000004826 Locus_Name: CEG1 Description: Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphophatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide ORF_Name: YGL130W SGDID: S000003098 Locus_Name: CEM1 Description: Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration Phenotype: Null mutant is viable; exhibits respiratory-deficient growth ORF_Name: YER061C SGDID: S000000863 Locus_Name: CEM11 SGDID: S000029081 Locus_Name: CEN1 Description: Chromosome I centromere SGDID: S000006463 Locus_Name: CEN10 Description: Chromosome X centromere SGDID: S000006471 Locus_Name: CEN11 Description: Chromosome XI centromere SGDID: S000006472 Locus_Name: CEN12 Description: Chromosome XII centromere SGDID: S000006473 Locus_Name: CEN13 Description: Chromosome XIII centromere SGDID: S000006474 Locus_Name: CEN14 Description: Chromosome XIV centromere SGDID: S000006475 Locus_Name: CEN15 Description: Chromosome XV centromere SGDID: S000006476 Locus_Name: CEN16 Description: Chromosome XVI centromere SGDID: S000006477 Locus_Name: CEN2 Description: Chromosome II centromere SGDID: S000006464 Locus_Name: CEN3 Description: Chromosome III centromere SGDID: S000006465 Locus_Name: CEN4 Description: Chromosome IV centromere SGDID: S000006466 Locus_Name: CEN5 Description: Chromosome V centromere SGDID: S000006467 Locus_Name: CEN6 Description: Chromosome VI centromere SGDID: S000001896 Locus_Name: CEN7 Description: Chromosome VII centromere SGDID: S000006468 Locus_Name: CEN8 Description: Chromosome VIII centromere SGDID: S000006469 Locus_Name: CEN9 Description: Chromosome IX centromere SGDID: S000006470 Locus_Name: CEP3 Alias_Name: CBF3|CBF3B|CSL1 Description: Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain Phenotype: Null mutant is inviable; mutations within the zinc finger domain result in cells that exhibit a G2-M cell cycle delay and increased chromosome loss in each mitotic cell division; at nonpermissive temperature the cep3 cells arrest with an undivided nucleus and a short mitotic spindle; at permissive temperature cep3 cells are unable to support segregation of minichromosomes with mutations in the central part of element III of yeast centromere DNA ORF_Name: YMR168C SGDID: S000004778 Locus_Name: CET1 Alias_Name: CES5 Description: Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide ORF_Name: YPL228W SGDID: S000006149 Locus_Name: CEX1 Description: Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p ORF_Name: YOR112W SGDID: S000005638 Locus_Name: CFD1 Alias_Name: DRE3 Description: Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol ORF_Name: YIL003W SGDID: S000001265 Locus_Name: CFT1 Alias_Name: YHH1 Description: RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF ORF_Name: YDR301W SGDID: S000002709 Locus_Name: CFT13 SGDID: S000029082 Locus_Name: CFT2 Alias_Name: YDH1 Description: Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein. ORF_Name: YLR115W SGDID: S000004105 Locus_Name: CGI121 Description: Protein involved in telomere uncapping and elongation as component of the KEOPS protein complex with Bud32p, Kae1p, Pcc1p, and Gon7p; also shown to be a component of the EKC protein complex; homolog of human CGI-121 ORF_Name: YML036W SGDID: S000004500 Locus_Name: CGR1 Description: Protein involved in nucleolar integrity and processing of the pre-rRNA for the 60S ribosome subunit; transcript is induced in response to cytotoxic stress but not genotoxic stress Phenotype: Null mutant is inviable; CGR1 expression is down-regulated in the postdiauxic growth phase ORF_Name: YGL029W SGDID: S000002997 Locus_Name: CHA1 Description: Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine Phenotype: Null mutant is viable and cannot grow on media with L-serine or L-threonine as sole nitrogen source ORF_Name: YCL064C SGDID: S000000569 Locus_Name: CHA4 Alias_Name: SIL2|SIL3 Description: DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain Phenotype: Unable to grow with serine or threonine as the sole nitrogen source, suppresses ilv1 mutant by causing inducer-independent, constitutive expression of CHA1 ORF_Name: YLR098C SGDID: S000004088 Locus_Name: CHC1 Alias_Name: SWA5 Description: Clathrin heavy chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; two heavy chains form the clathrin triskelion structural component; the light chain (CLC1) is thought to regulate function Phenotype: Null mutant is viable, but is slow-growing and shows defects in mating, sporulation and vesicle ultrastructure (however it shows little or no defect in secretion); null mutants easily become inviable due to second site mutations in a number of unlinked genes such as SCD1 and CDL1. Null mutants also exhibit an endocytosis defect, late Golgi protein mislocalization. chc1-5 exhibits delayed vacuolar protein transport. ORF_Name: YGL206C SGDID: S000003174 Locus_Name: CHD1 Description: Nucleosome remodeling factor that functions in regulation of transcription elongation; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes Phenotype: Null mutant is viable, resistant to 6-azauracil ORF_Name: YER164W SGDID: S000000966 Locus_Name: CHK1 Description: Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase Phenotype: Mutants are defective in the DNA damage checkpoint operating at metaphase ORF_Name: YBR274W SGDID: S000000478 Locus_Name: CHL1 Alias_Name: CTF1|LPA9|MCM12 Description: Conserved nuclear protein required to establish sister-chromatid pairing during S-phase, probable DNA helicase with similarity to human BACH1, which associates with tumor suppressor BRCA1; associates with acetyltransferase Ctf7p Phenotype: Null mutant is viable, ts mutants mis-segregate chromosomes at permissive temperature leading to increased rate of mitotic chromosome loss, at non-permissive temperature ts mutants transiently arrest as large-budded cells with G(sub)2 DNA content and short spindle ORF_Name: YPL008W SGDID: S000005929 Locus_Name: CHL2 Description: Involved in controlling mitotic transmission of yeast chromosomes Phenotype: increase in the rate of mitotic chromosome loss SGDID: S000029083 Locus_Name: CHL4 Alias_Name: CTF17|MCM17 Description: Outer kinetochore protein required for chromosome stability, interacts with kinetochore proteins Ctf19p, Ctf3p, and Iml3p; exhibits a two-hybrid interaction with Mif2p; association with CEN DNA requires Ctf19p Phenotype: Null mutant is viable. Some authors report a temperature-senstive deletion allele, while others fine no temperature sensitivity in another deletion allele. Fidelity of chromosome transmission and minichromosome nondisjunction in mitosis is decreased at all temperatures. ORF_Name: YDR254W SGDID: S000002662 Locus_Name: CHL5 Description: Involved in controlling mitotic transmission of yeast chromosomes Phenotype: increase in the rate of mitotic chromosome loss SGDID: S000029084 Locus_Name: CHL8 Alias_Name: AMC3|CTF12 Description: Identified as a chromosome transmission fidelity mutant that has a high rate of chromosome loss Phenotype: Increase in the rate of mitotic chromosome loss and temperature sensitivity SGDID: S000029085 Locus_Name: CHL9 Alias_Name: AMC4 Description: Involved in controlling the segregation of natural chromosomes in yeast Phenotype: Impaired segregation of artificial minichromosomes, affects on the mitotic transmission of natural chromosomes SGDID: S000029086 Locus_Name: CHO1 Alias_Name: PSS1 Description: Phosphatidylserine synthase, functions in phospholipid biosynthesis; catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine, transcriptionally repressed by myo-inositol and choline Phenotype: The null mutant is viable but grows slowly on minimal medium. The growth rate of the null mutant on minimal medium can be increased by supplementing the medium with choline or other phospholipid precursors. ORF_Name: YER026C SGDID: S000000828 Locus_Name: CHO2 Alias_Name: PEM1 Description: Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis Phenotype: Null mutant is viable and accumulates phosphatidylethanolamine and has reduced levels of phosphatidylcholine ORF_Name: YGR157W SGDID: S000003389 Locus_Name: CHS1 Alias_Name: USA4 Description: Chitin synthase I, requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for repairing the chitin septum during cytokinesis; transcription activated by mating factor ORF_Name: YNL192W SGDID: S000005136 Locus_Name: CHS2 Description: Chitin synthase II; catalyzes transfer of N-acetylglucosamine (GlcNAc) to chitin upon activation of zymogenic form; required for chitin synthesis in the primary septum during cytokinesis; localization regulated by Cdk1p during mitosis ORF_Name: YBR038W SGDID: S000000242 Locus_Name: CHS3 Alias_Name: CAL1|CSD2|DIT101|KTI2 Description: Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan ORF_Name: YBR023C SGDID: S000000227 Locus_Name: CHS5 Alias_Name: CAL3 Description: Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane ORF_Name: YLR330W SGDID: S000004322 Locus_Name: CHS6 Alias_Name: CSD3 Description: Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane ORF_Name: YJL099W SGDID: S000003635 Locus_Name: CHS7 Description: Protein of unknown function, involved in chitin biosynthesis by regulating Chs3p export from the ER ORF_Name: YHR142W SGDID: S000001184 Locus_Name: CHZ1 Description: Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif ORF_Name: YER030W SGDID: S000000832 Locus_Name: CIA1 Description: WD40 repeat protein involved in assembly of cytosolic and nuclear iron-sulfur proteins; similar to the human Ciao1 protein; YDR267C is an essential gene ORF_Name: YDR267C SGDID: S000002675 Locus_Name: CIC1 Alias_Name: NSA3 Description: Essential protein that interacts with proteasome components and has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles Phenotype: Null: lethal. Other phenotypes: cic1-2 ts mutant stabilizes F-box proteins. ORF_Name: YHR052W SGDID: S000001094 Locus_Name: CIK1 Description: Kinesin-associated protein required for both karyogamy and mitotic spindle organization, interacts stably and specifically with Kar3p and may function to target this kinesin to a specific cellular role; has similarity to Vik1p Phenotype: Null mutant is viable but is defective in both karyogamy and chromosome maintenance and does not show proper localization of Kar3p to microtubule-associated structures ORF_Name: YMR198W SGDID: S000004811 Locus_Name: CIN1 Description: Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl Phenotype: Null mutant is viable, exhibits cold sensitivity for viability; defect in nuclear migration and nuclear fusion, supersensitivity to benomyl and nocodozole ORF_Name: YOR349W SGDID: S000005876 Locus_Name: CIN2 Description: GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2 Phenotype: Null mutant is viable but shows supersensitivity to benomyl and nocodazole, cold sensitivity, defects in karyogamy, and increased rates of chromosome loss; shows genetic interaction with tubulin mutations ORF_Name: YPL241C SGDID: S000006162 Locus_Name: CIN4 Alias_Name: GTP1|UGX1 Description: GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog Phenotype: Null mutant is viable; supersensitivity to benomyl and nocodozole ORF_Name: YMR138W SGDID: S000004746 Locus_Name: CIN5 Alias_Name: HAL6|YAP4 Description: Basic leucine zipper (bZIP) transcription factor of the yAP-1 family, mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions Phenotype: Null mutant is viable and suppresses the cold sensitivity of yap1 mutants ORF_Name: YOR028C SGDID: S000005554 Locus_Name: CIN8 Alias_Name: KSL2|SDS15 Description: Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation Phenotype: Null mutant is viable; cin8 dyn1 and cin8 kip1 double deletion mutants are inviable ORF_Name: YEL061C SGDID: S000000787 Locus_Name: CIR1 Description: Protein that interacts with frataxin (Yfh1p); putative homolog of mammalian electron transfer flavoprotein complex subunit ETF-beta; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies ORF_Name: YGR207C SGDID: S000003439 Locus_Name: CIR2 Description: Mitochondrial protein with similarity to flavoprotein-type oxidoreductases; found in a large supramolecular complex with other mitochondrial dehydrogenases ORF_Name: YOR356W SGDID: S000005883 Locus_Name: CIS1 Alias_Name: ATG31 Description: Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion ORF_Name: YDR022C SGDID: S000002429 Locus_Name: CIS3 Alias_Name: CCW11|CCW5|PIR4 Description: Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family Phenotype: Null mutant is viable; CIS3 is a high copy suppressor of cik1 deletion mutants ORF_Name: YJL158C SGDID: S000003694 Locus_Name: CIT1 Alias_Name: CS1|LYS6 Description: Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein Phenotype: Null mutant is viable; disruption of both CIT1 and CIT2 result in glutamate auxotrophy and poor growth on rich medium containing lactate ORF_Name: YNR001C SGDID: S000005284 Locus_Name: CIT2 Description: Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors ORF_Name: YCR005C SGDID: S000000598 Locus_Name: CIT3 Description: Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate Phenotype: Null mutant shows severely reduced growth on the respiratory substrate glycerol in a delta cit1 background ORF_Name: YPR001W SGDID: S000006205 Locus_Name: CKA1 Description: Alpha catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA2, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases Phenotype: Null mutant is viable; however, strains lacking both cka1 and cka2 (the alpha and alpha' subunits of protein kinase CK2, respectively) are inviable. ORF_Name: YIL035C SGDID: S000001297 Locus_Name: CKA2 Alias_Name: YOR29-12 Description: Alpha' catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases Phenotype: Null mutant is viable, cka1 cka2 double deletion mutants are inviable; Cells in which protein kinase CK2 activity is depleted increase substantially in size prior to growth arrest, and a significant fraction of the arrested cells exhibit a pseudomycelial morphology. Disruption of the activity also results in flocculation. Yeast strains lacking both endogenous catalytic subunit genes can be rescued by expression of the alpha and beta subunits of Drosophila protein kinase CK2 or by expression of the Drosophila alpha subunit alone ORF_Name: YOR061W SGDID: S000005587 Locus_Name: CKB1 Description: Beta regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB2, the many substrates include transcription factors and all RNA polymerases Phenotype: Null mutant is viable, exhibits salt sensitivity specific to NaCl and LiCl ORF_Name: YGL019W SGDID: S000002987 Locus_Name: CKB2 Description: Beta' regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB1, the many substrates include transcription factors and all RNA polymerases ORF_Name: YOR039W SGDID: S000005565 Locus_Name: CKI1 Description: Choline kinase, catalyzing the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway ORF_Name: YLR133W SGDID: S000004123 Locus_Name: CKS1 Description: Cyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters Phenotype: Null mutant is viable in W303 and BF246-15DU backgrounds|Null mutant is inviable and arrests in G1. ORF_Name: YBR135W SGDID: S000000339 Locus_Name: CLA4 Alias_Name: ERC10 Description: Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, which also includes Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, and cytokinesis; phosphorylates septins Cdc3p and Cdc10p Phenotype: Null mutant is viable, possesses a cytokinesis defect; cla4 cln1 cln2 strains are inviable; cla4 ste20 double deletion mutants cannot maintain septin rings at the bud neck and and cannot undergo cytokinesis ORF_Name: YNL298W SGDID: S000005242 Locus_Name: CLB1 Alias_Name: SCB1 Description: B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome ORF_Name: YGR108W SGDID: S000003340 Locus_Name: CLB2 Description: B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome ORF_Name: YPR119W SGDID: S000006323 Locus_Name: CLB3 Description: B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation ORF_Name: YDL155W SGDID: S000002314 Locus_Name: CLB4 Description: B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation ORF_Name: YLR210W SGDID: S000004200 Locus_Name: CLB5 Description: B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase Phenotype: Null mutant is viable, but has an extended S phase ORF_Name: YPR120C SGDID: S000006324 Locus_Name: CLB6 Description: B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 ORF_Name: YGR109C SGDID: S000003341 Locus_Name: CLC1 Alias_Name: SCD4 Description: Clathrin light chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component Phenotype: Null mutant is viable but slow-growing and shows defects in receptor-mediated endocytosis, maturation of alpha factor and levels of clathrin heavy chain (Chc1p); high copy suppresses the inviable double mutant chc1-delete, scd1-i-allele; elevated CHC1 expression suppresses some clc1-delete phenotypes ORF_Name: YGR167W SGDID: S000003399 Locus_Name: CLD1 Description: Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58 ORF_Name: YGR110W SGDID: S000003342 Locus_Name: CLF1 Alias_Name: NTC77|SYF3 Description: Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins Phenotype: Null mutant is inviable; clf1 alleles show synthetic lethality with cdc40/prp17 and are defective in 5' splice site cleavage ORF_Name: YLR117C SGDID: S000004107 Locus_Name: CLG1 Description: Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2 ORF_Name: YGL215W SGDID: S000003183 Locus_Name: CLN1 Description: G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) Phenotype: Null mutant is viable, exhibits G1 arrest ORF_Name: YMR199W SGDID: S000004812 Locus_Name: CLN2 Description: G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) Phenotype: Null mutant is viable, exhibits G1 arrest; dominant mutation advances the G(sub)1- to S- phase transition and impairs ability of cells to arrest in G(sub)1 phase in response to external signals ORF_Name: YPL256C SGDID: S000006177 Locus_Name: CLN3 Alias_Name: DAF1|FUN10|WHI1 Description: G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis Phenotype: Null mutant is viable; dominant mutation causes alpha-factor resistance and small cell size; chromosomal deletion increases cell volume ORF_Name: YAL040C SGDID: S000000038 Locus_Name: CLP1 Description: Subunit of cleavage factor I (CFI), involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation ORF_Name: YOR250C SGDID: S000005776 Locus_Name: CLS1 Phenotype: Calcium-sensitive SGDID: S000029088 Locus_Name: CLU1 Alias_Name: TIF31 Description: eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant Phenotype: Null mutant is viable, growth is normal, mitochondrial network is collapsed to one side of the cell ORF_Name: YMR012W SGDID: S000004614 Locus_Name: CLY2 Phenotype: Cell lysis at 36 degree C SGDID: S000029089 Locus_Name: CLY3 Phenotype: Cell lysis at 36 degree C SGDID: S000029090 Locus_Name: CLY7 Phenotype: Null phenotype unknown; cly7 mutants lyse at high temperature SGDID: S000029091 Locus_Name: CLY8 Phenotype: Cell lysis at 36 degree C SGDID: S000029092 Locus_Name: CLY9 SGDID: S000029093 Locus_Name: CMC1 Description: Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif ORF_Name: YKL137W SGDID: S000001620 Locus_Name: CMC2 Description: Protein of the mitochondrial intermembrane space with a role in respiratory chain complex assembly or maintenance; contains twin Cx9C motifs that can form coiled coil-helix-coiled-coil helix fold ORF_Name: YBL059C-A SGDID: S000007488 Locus_Name: CMC4 Description: Protein that is necessary for respiratory growth and that localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; contains twin cysteine-x(9)-cysteine motifs ORF_Name: YMR194C-B SGDID: S000028514 Locus_Name: CMD1 Alias_Name: CaM Description: Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin ORF_Name: YBR109C SGDID: S000000313 Locus_Name: CMK1 Description: Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk2p and mammalian Cam Kinase II ORF_Name: YFR014C SGDID: S000001910 Locus_Name: CMK2 Description: Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk1p and mammalian Cam Kinase II Phenotype: Null mutant is viable, exhibits slow rate of spore germination ORF_Name: YOL016C SGDID: S000005376 Locus_Name: CMP2 Alias_Name: CNA2 Description: Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1 ORF_Name: YML057W SGDID: S000004521 Locus_Name: CMR1 Description: Putative protein of unknown function; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus ORF_Name: YDL156W SGDID: S000002315 Locus_Name: CMR2 Description: Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents ORF_Name: YOR093C SGDID: S000005619 Locus_Name: CMR3 Description: Putative zinc finger protein; YPR013C is not an essential gene ORF_Name: YPR013C SGDID: S000006217 Locus_Name: CMS1 Description: Subunit of U3-containing 90S preribosome processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; overexpression rescues supressor mutant of mcm10; null mutant is viable ORF_Name: YLR003C SGDID: S000003993 Locus_Name: CNA1 Alias_Name: CMP1 Description: Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1 ORF_Name: YLR433C SGDID: S000004425 Locus_Name: CNB1 Alias_Name: CRV1|YCN2 Description: Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1 Phenotype: Null mutant is viable, Li+ and Na+ sensitive, cnb1 fks1 and cnb1 vma3 double mutants are inviable ORF_Name: YKL190W SGDID: S000001673 Locus_Name: CNE1 Alias_Name: FUN48 Description: Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast Phenotype: Null mutant is viable, increase of cell-surface expression of ste2-3p, increase in secretion of heterologously expressed mammalian alpha 1-antitrypsin. ~30% decrease in beta-1,6-glucan upon disruption of CNE1. ORF_Name: YAL058W SGDID: S000000054 Locus_Name: CNM67 Description: Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration Phenotype: Null mutant is viable but shows slow growth and a nuclear migration defect ORF_Name: YNL225C SGDID: S000005169 Locus_Name: CNN1 Description: Kinetochore protein of unknown function; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by both Clb5-Cdk1 and, to a lesser extent, Clb2-Cdk1. ORF_Name: YFR046C SGDID: S000001942 Locus_Name: CNS1 Description: TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion Phenotype: Null mutant is inviable; overexpression of CNS1 restores normal growth and Hsp90 activity in a cpr7 mutant strain. ORF_Name: YBR155W SGDID: S000000359 Locus_Name: COA1 Alias_Name: FMP35 Description: Mitochondrial inner membrane protein required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assembly ORF_Name: YIL157C SGDID: S000001419 Locus_Name: COA2 Description: Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p ORF_Name: YPL189C-A SGDID: S000028527 Locus_Name: COA4 Alias_Name: CMC3 Description: Protein that localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; mutants exhibit glycogen storage defects and growth defects on a non-fermentable carbon source; contains twin cysteine-x9-cysteine motifs ORF_Name: YLR218C SGDID: S000004208 Locus_Name: COB Alias_Name: COB1|CYTB Description: Cytochrome b, mitochondrially encoded subunit of the ubiquinol-cytochrome c reductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p ORF_Name: Q0105 SGDID: S000007270 Locus_Name: COF1 Description: Cofilin, promotes actin filament depolarization in a pH-dependent manner; binds both actin monomers and filaments and severs filaments; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes Gene_Product: cofilin ORF_Name: YLL050C SGDID: S000003973 Locus_Name: COG1 Alias_Name: COD3|LDB11|SEC36 Description: Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments ORF_Name: YGL223C SGDID: S000003191 Locus_Name: COG2 Alias_Name: SEC35 Description: Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Phenotype: Null mutant shows severe growth defect at 30 degrees and is inviable at 21 degrees; sec35-1 allele is temperature-sensitive for growth ORF_Name: YGR120C SGDID: S000003352 Locus_Name: COG3 Alias_Name: GRD20|SEC34 Description: Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Phenotype: Strains carrying the null allele are extremely slow growing; they display a severe growth defect at 25 or 30 degrees, and fail to grow at 14 or 37 degrees. In addition to defects in protein localization and sorting, sec34 mutants exhibit defects in polarization of filamentous actin. ORF_Name: YER157W SGDID: S000000959 Locus_Name: COG4 Alias_Name: COD1|SEC38|SGF1 Description: Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments ORF_Name: YPR105C SGDID: S000006309 Locus_Name: COG5 Alias_Name: API4|COD4 Description: Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments ORF_Name: YNL051W SGDID: S000004996 Locus_Name: COG6 Alias_Name: COD2|SEC37 Description: Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments ORF_Name: YNL041C SGDID: S000004986 Locus_Name: COG7 Alias_Name: COD5 Description: Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments ORF_Name: YGL005C SGDID: S000002973 Locus_Name: COG8 Alias_Name: DOR1 Description: Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments ORF_Name: YML071C SGDID: S000004536 Locus_Name: COM2 Description: Protein of unknown function ORF_Name: YER130C SGDID: S000000932 Locus_Name: COP1 Alias_Name: RET1|SEC33|SOO1 Description: Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway Phenotype: Null mutant is inviable; other cop1 alleles show secretion and protein sorting defects ORF_Name: YDL145C SGDID: S000002304 Locus_Name: COQ1 Description: Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis ORF_Name: YBR003W SGDID: S000000207 Locus_Name: COQ10 Description: Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q6 to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes ORF_Name: YOL008W SGDID: S000005368 Locus_Name: COQ2 Description: Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis Phenotype: Null mutant is viable but is respiratory defective and lacks PHB:polyprenyltransferase activity ORF_Name: YNR041C SGDID: S000005324 Locus_Name: COQ3 Description: O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein Phenotype: Null mutant is viable, fails to grow on H2O2; fails to grow on glycerol ORF_Name: YOL096C SGDID: S000005456 Locus_Name: COQ4 Description: Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex Phenotype: Unable to produce ubiquinone, hypersensitivity to polyunsaturated fatty acid treatment ORF_Name: YDR204W SGDID: S000002612 Locus_Name: COQ5 Alias_Name: DBI56 Description: 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes Gene_Product: 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase Phenotype: Null mutant is viable, respiratory deficient, petite. ORF_Name: YML110C SGDID: S000004578 Locus_Name: COQ6 Description: Putative flavin-dependent monooxygenase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes Phenotype: Unable to produce ubiquinone, hypersensitivity to polyunsaturated fatty acid treatment ORF_Name: YGR255C SGDID: S000003487 Locus_Name: COQ9 Alias_Name: FMP53 Description: Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes ORF_Name: YLR201C SGDID: S000004191 Locus_Name: COR1 Alias_Name: QCR1 Description: Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain Phenotype: deficiency in cytochrome b; slow growth on glycerol ORF_Name: YBL045C SGDID: S000000141 Locus_Name: COS1 Description: Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins ORF_Name: YNL336W SGDID: S000005280 Locus_Name: COS10 Description: Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins ORF_Name: YNR075W SGDID: S000005358 Locus_Name: COS111 Description: Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies ORF_Name: YBR203W SGDID: S000000407 Locus_Name: COS12 Description: Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins ORF_Name: YGL263W SGDID: S000003232 Locus_Name: COS2 Description: Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins ORF_Name: YBR302C SGDID: S000000506 Locus_Name: COS3 Description: Protein involved in salt resistance; interacts with sodium:hydrogen antiporter Nha1p; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins ORF_Name: YML132W SGDID: S000004601 Locus_Name: COS4 Description: Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins ORF_Name: YFL062W SGDID: S000001832 Locus_Name: COS5 Description: Protein of unknown function, member the DUP380 subfamily of conserved, often subtelomerically-encoded proteins ORF_Name: YJR161C SGDID: S000003922 Locus_Name: COS6 Description: Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins ORF_Name: YGR295C SGDID: S000003527 Locus_Name: COS7 Description: Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies ORF_Name: YDL248W SGDID: S000002407 Locus_Name: COS8 Description: Nuclear membrane protein, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; regulation suggests a potential role in the unfolded protein response ORF_Name: YHL048W SGDID: S000001040 Locus_Name: COS9 Description: Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins ORF_Name: YKL219W SGDID: S000001702 Locus_Name: COT1 Description: Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium Phenotype: Null mutant is viable, yet increased sensitivity to cobalt ORF_Name: YOR316C SGDID: S000005843 Locus_Name: COX1 Alias_Name: OXI3 Description: Subunit I of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits ORF_Name: Q0045 SGDID: S000007260 Locus_Name: COX10 Description: Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders Phenotype: mutant lacks cytochrome oxidase activity and cytochromes a and a3 and is respiratory-defective ORF_Name: YPL172C SGDID: S000006093 Locus_Name: COX11 Alias_Name: LPI13|PSO7 Description: Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p Phenotype: deficient in cytochrome oxidase; sensitive to photoactivated 3-carbethoxypsoralen, UV light, radiomimetic mutagens, and oxidative stress ORF_Name: YPL132W SGDID: S000006053 Locus_Name: COX12 Description: Subunit VIb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated Phenotype: Null mutant is viable, grows poorly at room temperature, fails to grow on glycerol/ethanol media at 37 degrees ORF_Name: YLR038C SGDID: S000004028 Locus_Name: COX13 Description: Subunit VIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP Phenotype: Null mutant is viable, shows slightly reduced growth rate on nonfermentable carbon sources ORF_Name: YGL191W SGDID: S000003159 Locus_Name: COX14 Description: Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes Phenotype: Nuclear respiration deficient, lack cytochromes a and a3 and detectable cytochrome oxidase activity ORF_Name: YML129C SGDID: S000004598 Locus_Name: COX15 Description: Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase Phenotype: fail to synthesize cytochrome oxidase ORF_Name: YER141W SGDID: S000000943 Locus_Name: COX16 Description: Mitochondrial inner membrane protein, required for assembly of cytochrome c oxidase Phenotype: Null: viable, respiration deficient ORF_Name: YJL003W SGDID: S000003540 Locus_Name: COX17 Description: Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs Phenotype: Null mutant is viable, respiratory defective, rescued by addition of copper to growth media and/or high copy expression of SCO1 and SCO2 genes ORF_Name: YLL009C SGDID: S000003932 Locus_Name: COX18 Alias_Name: OXA2 Description: Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC Phenotype: Null mutant is viable, respiratory deficient due to inactivity of cytochrome oxidase ORF_Name: YGR062C SGDID: S000003294 Locus_Name: COX19 Description: Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs ORF_Name: YLL018C-A SGDID: S000007245 Locus_Name: COX2 Alias_Name: OXI1|OXII Description: Subunit II of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits ORF_Name: Q0250 SGDID: S000007281 Locus_Name: COX20 Description: Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase Phenotype: Null mutant is respiratory-deficient and has no cytochrome oxidase activity or accumulation of precursor of CoxII ORF_Name: YDR231C SGDID: S000002639 Locus_Name: COX23 Description: Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs ORF_Name: YHR116W SGDID: S000001158 Locus_Name: COX3 Alias_Name: OXI2 Description: Subunit III of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits ORF_Name: Q0275 SGDID: S000007283 Locus_Name: COX4 Description: Subunit IV of cytochrome c oxidase, the terminal member of the mitochondrial inner membrane electron transport chain; precursor N-terminal 25 residues are cleaved during mitochondrial import; phosphorylated; spermidine enhances translation ORF_Name: YGL187C SGDID: S000003155 Locus_Name: COX5A Description: Subunit Va of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth Phenotype: Null mutant is viable, respires at 10-15% of the wild-type rate due to the presence of COX5B; cox5a cox5b double deletion mutants are completely non-respiratory ORF_Name: YNL052W SGDID: S000004997 Locus_Name: COX5B Description: Subunit Vb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth ORF_Name: YIL111W SGDID: S000001373 Locus_Name: COX6 Description: Subunit VI of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels Phenotype: Null mutant is viable, sensitive to H2O2 ORF_Name: YHR051W SGDID: S000001093 Locus_Name: COX7 Description: Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain Phenotype: Null mutant is viable, lacks cytochrome c oxidase activity and haem a/a3 spectra; respiratory deficient ORF_Name: YMR256C SGDID: S000004869 Locus_Name: COX8 Description: Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain Phenotype: Null mutant is viable, deficient in cellular respiration and cytochrome C oxidase activity ORF_Name: YLR395C SGDID: S000004387 Locus_Name: COX9 Description: Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain Phenotype: Lacks functional cytochrome c oxidase holoenzyme ORF_Name: YDL067C SGDID: S000002225 Locus_Name: COY1 Description: Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function ORF_Name: YKL179C SGDID: S000001662 Locus_Name: CPA1 Description: Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader ORF_Name: YOR303W SGDID: S000005829 Locus_Name: CPA2 Description: Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor ORF_Name: YJR109C SGDID: S000003870 Locus_Name: CPD1 Description: Cyclic nucleotide phosphodiesterase, hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression Phenotype: null: viable, no detected growth defects, defective in hydrolysis of ADP-ribose 1'',2''-cyclic phosphate (Appr>p) ORF_Name: YGR247W SGDID: S000003479 Locus_Name: CPR1 Alias_Name: CPH1|CYP1 Description: Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A ORF_Name: YDR155C SGDID: S000002562 Locus_Name: CPR2 Alias_Name: CYP2 Description: Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway Phenotype: Null mutant is viable; sensitive to heat ORF_Name: YHR057C SGDID: S000001099 Locus_Name: CPR3 Alias_Name: CYP3 Description: Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria Phenotype: Null mutant is viable, unable to grow on L-lactate at 37 degrees C ORF_Name: YML078W SGDID: S000004543 Locus_Name: CPR4 Alias_Name: CYP4|SCC3|YCR070W Description: Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway Phenotype: suppressor of cdc65 ORF_Name: YCR069W SGDID: S000000665 Locus_Name: CPR5 Alias_Name: CYP5 Description: Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER ORF_Name: YDR304C SGDID: S000002712 Locus_Name: CPR6 Alias_Name: CYP40 Description: Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity Phenotype: Null mutant is viable, has normal growth rate ORF_Name: YLR216C SGDID: S000004206 Locus_Name: CPR7 Description: Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity ORF_Name: YJR032W SGDID: S000003793 Locus_Name: CPR8 Description: Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway ORF_Name: YNR028W SGDID: S000005311 Locus_Name: CPS1 Description: Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions Phenotype: Null mutant is viable; leucine auxotroph ORF_Name: YJL172W SGDID: S000003708 Locus_Name: CPT1 Description: Cholinephosphotransferase, required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription Phenotype: Null mutant is viable, cpt1 ept1 double deletion mutants are viable ORF_Name: YNL130C SGDID: S000005074 Locus_Name: CRC1 Description: Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation ORF_Name: YOR100C SGDID: S000005626 Locus_Name: CRD1 Alias_Name: CLS1 Description: Cardiolipin synthase; produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function; also required for normal vacuolar ion homeostasis Phenotype: Null mutant is viable, exhibits growth defects in galactose and glycerol/ethanol media ORF_Name: YDL142C SGDID: S000002301 Locus_Name: CRF1 Description: Transcriptional corepressor involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain ORF_Name: YDR223W SGDID: S000002631 Locus_Name: CRG1 Description: Putative S-adenosylmethionine-dependent methyltransferase; mediates cantharidin resistance ORF_Name: YHR209W SGDID: S000001252 Locus_Name: CRH1 Description: Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress Phenotype: Null mutant is viable and hypersensitive to Congo Red and Calcofluor White ORF_Name: YGR189C SGDID: S000003421 Locus_Name: CRL1 Phenotype: Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole. SGDID: S000029095 Locus_Name: CRL10 Description: may be involved in the fidelity of protein translation Phenotype: Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole. SGDID: S000029096 Locus_Name: CRL11 Phenotype: Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole. SGDID: S000029097 Locus_Name: CRL12 Description: may be involved in the fidelity of protein translation Phenotype: arrest late in the cell cycle after several divisions at the nonpermissive temperature SGDID: S000029098 Locus_Name: CRL15 Phenotype: Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole. SGDID: S000029099 Locus_Name: CRL16 Phenotype: Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole. SGDID: S000029100 Locus_Name: CRL17 Phenotype: Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole. SGDID: S000029101 Locus_Name: CRL18 Phenotype: Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole. SGDID: S000029102 Locus_Name: CRL2 Phenotype: Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole. SGDID: S000029103 Locus_Name: CRL22 Phenotype: Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole. SGDID: S000029104 Locus_Name: CRL4 Phenotype: Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole. SGDID: S000029105 Locus_Name: CRL7 Phenotype: Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole. SGDID: S000029106 Locus_Name: CRL9 Phenotype: Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole. SGDID: S000029107 Locus_Name: CRM1 Alias_Name: KAP124|XPO1 Description: Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin Phenotype: Null mutant is inviable; a temperature sensitive crm1 allele shows defects in nuclear protein export ORF_Name: YGR218W SGDID: S000003450 Locus_Name: CRN1 Description: Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly Phenotype: Overexpression of CRN1 causes growth arrest and redistribution of Arp2p and Crn1p into aberrant actin loops. ORF_Name: YLR429W SGDID: S000004421 Locus_Name: CRP1 Description: Protein that binds to cruciform DNA structures Phenotype: Null: Null mutant is viable and shows no growth defects ORF_Name: YHR146W SGDID: S000001189 Locus_Name: CRR1 Description: Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation ORF_Name: YLR213C SGDID: S000004203 Locus_Name: CRS5 Description: Copper-binding metallothionein, required for wild-type copper resistance Phenotype: Null mutant is viable, exhibits increased sensitivity to copper toxicity ORF_Name: YOR031W SGDID: S000005557 Locus_Name: CRT10 Alias_Name: HUS1 Description: Protein involved in transcriptional regulation of RNR2 and RNR3; expression of the gene is induced by DNA damage and null mutations confer increased resistance to hydroxyurea; N-terminal region has a leucine repeat and a WD40 repeat ORF_Name: YOL063C SGDID: S000005424 Locus_Name: CRT2 Phenotype: crt2 mutants show a defect in basal level expression of RNR1-lacZ reporter constructs SGDID: S000029108 Locus_Name: CRZ1 Alias_Name: HAL8|TCN1 Description: Transcription factor that activates transcription of genes involved in stress response; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation ORF_Name: YNL027W SGDID: S000004972 Locus_Name: CSE1 Alias_Name: KAP109 Description: Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation ORF_Name: YGL238W SGDID: S000003207 Locus_Name: CSE2 Alias_Name: MED9 Description: Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; component of the Med9/10 module; required for regulation of RNA polymerase II activity Phenotype: Null mutant is viable, accumulates large-budded cells, results in significant increase in chromosome missegregation, slower growth, and defective meiosis ORF_Name: YNR010W SGDID: S000005293 Locus_Name: CSE4 Alias_Name: CSL2 Description: Centromere protein that resembles histone H3, required for proper kinetochore function; homolog of human CENP-A Phenotype: Null mutant is inviable; cse4-1 mutant causes increased non-disjunction of chromosome with mutated CEN and t.s. arrest at G2/M boundary with 2N DNA content ORF_Name: YKL049C SGDID: S000001532 Locus_Name: CSF1 Description: Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies ORF_Name: YLR087C SGDID: S000004077 Locus_Name: CSG2 Alias_Name: CLS2 Description: Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations Phenotype: Null mutant is viable but Ca2+-sensitive; a presumed point mutant is sensitive to Ca2+ levels greater than 10 mM (but remains insensitive to 50 mM Sr2+) ORF_Name: YBR036C SGDID: S000000240 Locus_Name: CSH1 Description: Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p Phenotype: Null mutant is viable, does not exhibit calcium sensitivity or alter the calcium sensitive phenotype of a sur1 null strain ORF_Name: YBR161W SGDID: S000000365 Locus_Name: CSI1 Description: Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling ORF_Name: YMR025W SGDID: S000004627 Locus_Name: CSI2 Description: Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene Phenotype: Null mutant is viable but shows delocalized chitin deposition ORF_Name: YOL007C SGDID: S000005367 Locus_Name: CSL4 Alias_Name: SKI4 Description: Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1) Phenotype: Null mutant is inviable, csl4-1 exhibits double mutant inviability in combination with cbf1(cep1) deletion mutants ORF_Name: YNL232W SGDID: S000005176 Locus_Name: CSM1 Description: Nucleolar protein that forms a complex with Lrs4p and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation ORF_Name: YCR086W SGDID: S000000682 Locus_Name: CSM2 Description: Protein involved in a Rad51p-, Rad54p-dependent pathway for homologous recombination repair, required for accurate chromosome segregation during meiosis Phenotype: Null: missegregates chromosomes in meiosis ORF_Name: YIL132C SGDID: S000001394 Locus_Name: CSM3 Description: Protein required for accurate chromosome segregation during meiosis Phenotype: Null: missegregates chromosomes in meiosis ORF_Name: YMR048W SGDID: S000004651 Locus_Name: CSM4 Description: Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements Phenotype: Null: missegregates chromosomes in meiosis ORF_Name: YPL200W SGDID: S000006121 Locus_Name: CSN12 Description: Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in mRNA splicing and adaptation to pheromone signaling ORF_Name: YJR084W SGDID: S000003844 Locus_Name: CSN9 Description: Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling ORF_Name: YDR179C SGDID: S000002586 Locus_Name: CSR1 Alias_Name: SFH2 Description: Phosphatidylinositol transfer protein with a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance ORF_Name: YLR380W SGDID: S000004372 Locus_Name: CSR2 Alias_Name: ART8|MRG19 Description: Nuclear protein proposed to regulate utilization of nonfermentable carbon sources and endocytosis of plasma membrane proteins; overproduction suppresses chs5 spa2 lethality at high temp; ubiquitinated by Rsp5p, deubiquitinated by Ubp2p ORF_Name: YPR030W SGDID: S000006234 Locus_Name: CST14 Description: Chromosome STability Phenotype: Overexpression of CSTs induces chromosome loss SGDID: S000029121 Locus_Name: CST18 Description: Chromosome STability Phenotype: Overexpression of CSTs induces chromosome loss SGDID: S000029122 Locus_Name: CST21 Description: Chromosome STability Phenotype: Overexpression of CSTs induces chromosome loss SGDID: S000029123 Locus_Name: CST26 Alias_Name: PSI1 Description: Protein required for incorporation of stearic acid into phosphatidylinositol; affects chromosome stability when overexpressed ORF_Name: YBR042C SGDID: S000000246 Locus_Name: CST3 Description: Chromosome STability Phenotype: Overexpression of CSTs induces chromosome loss SGDID: S000029124 Locus_Name: CST6 Alias_Name: ACA2|SHF1 Description: Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, activates transcription of genes involved in utilization of non-optimal carbon sources; involved in telomere maintenance Phenotype: Overexpression of CSTs induces chromosome loss ORF_Name: YIL036W SGDID: S000001298 Locus_Name: CST9 Alias_Name: ZIP3 Description: SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; potential Cdc28p substrate Phenotype: Null mutant is viable, but exhibits delayed sporulation and reduced viability; overexpression of CSTs induces chromosome loss ORF_Name: YLR394W SGDID: S000004386 Locus_Name: CTA1 Description: Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation Phenotype: Null mutant is viable and heat sensitive ORF_Name: YDR256C SGDID: S000002664 Locus_Name: CTF13 Alias_Name: CBF3C Description: Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis ORF_Name: YMR094W SGDID: S000004700 Locus_Name: CTF18 Alias_Name: CHL12 Description: Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint Phenotype: Null mutant is viable, exhibits increased level of spontaneous mitotic recombination, slow growth, and cold sensitivity ORF_Name: YMR078C SGDID: S000004683 Locus_Name: CTF19 Alias_Name: MCM18 Description: Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly ORF_Name: YPL018W SGDID: S000005939 Locus_Name: CTF3 Alias_Name: CHL3 Description: Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules ORF_Name: YLR381W SGDID: S000004373 Locus_Name: CTF4 Alias_Name: CHL15|POB1 Description: Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion Phenotype: Null mutant is viable but shows increase in the rate of mitotic chromosome loss, increased mitotic recombination, shift toward cells with G2 DNA content, and large budded cells with the nucleus in the bud neck; shows synthetic interactions with rad52, pol1, rad9, and esr1 ORF_Name: YPR135W SGDID: S000006339 Locus_Name: CTF8 Description: Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion ORF_Name: YHR191C SGDID: S000001234 Locus_Name: CTH1 Description: Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis Phenotype: Null mutant is viable, displays a threefold increase in CTH2 mRNA accumulation. CTH1 overexpression causes delayed entry of cell cultures into exponential growth, and a decrease in final cell density. Removal of the zinc finger domain of Cth1p by truncation or deletion completely reverses the overexpression slow growth phenotype ORF_Name: YDR151C SGDID: S000002558 Locus_Name: CTI6 Alias_Name: RXT1 Description: Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain ORF_Name: YPL181W SGDID: S000006102 Locus_Name: CTK1 Description: Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity Phenotype: Null mutations in each of the CTK1, CTK2, and CTK3 genes cause slow growth, cold-sensitivity, flocculence, and enlarged cell size. ORF_Name: YKL139W SGDID: S000001622 Locus_Name: CTK2 Description: Beta subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity Phenotype: Null mutations in each of the CTK1, CTK2, and CTK3 genes cause slow growth, cold-sensitivity, flocculence, and enlarged cell size. ORF_Name: YJL006C SGDID: S000003543 Locus_Name: CTK3 Description: Gamma subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity Phenotype: Null mutations in each of the CTK1, CTK2, and CTK3 genes cause slow growth, cold-sensitivity, flocculence, and enlarged cell size. ORF_Name: YML112W SGDID: S000004580 Locus_Name: CTL1 Alias_Name: CTH1 Description: RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm Phenotype: Null mutant is viable at 15/30/37C, on media lacking inositol, and on media containing 15nM caffeine. CTL1 shows no genetic interaction with ceg1-250, cet1-4, nor CTD truncation mutants and does not suppress (in high copy) any of these mutants. ORF_Name: YMR180C SGDID: S000004792 Locus_Name: CTM1 Description: Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth Phenotype: lack of trimethylation of cytochrome C Lys72 ORF_Name: YHR109W SGDID: S000001151 Locus_Name: CTP1 Description: Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family ORF_Name: YBR291C SGDID: S000000495 Locus_Name: CTR1 Description: High-affinity copper transporter of the plasma membrane, mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels Phenotype: Null mutant is viable, deficient in ferrous iron uptake ORF_Name: YPR124W SGDID: S000006328 Locus_Name: CTR2 Description: Putative low-affinity copper transporter of the vacuolar membrane; mutation confers resistance to toxic copper concentrations, while overexpression confers resistance to copper starvation Phenotype: ctr2 mutants display a high level of resistance to toxic copper concentrations. CTR2 overexpression provides increased resistance to copper starvation and is also associated with an increased sensitivity to copper toxicity. ORF_Name: YHR175W SGDID: S000001218 Locus_Name: CTR3 Description: High-affinity copper transporter of the plasma membrane, acts as a trimer; gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae Phenotype: Null mutant is viable, grows slower than w.t. under conditons of copper limitation on non-fermentable carbon source; strains with a deletion of both CTR1 and CTR3 are unable to grow on nonfermentable carbon sources ORF_Name: YLR411W SGDID: S000004403 Locus_Name: CTR86 Description: Essential protein of unknown function; upstream region contains a Gcn4p responsive site suggesting a possible role in amino acid biosynthesis ORF_Name: YCR054C SGDID: S000000650 Locus_Name: CTR9 Alias_Name: CDP1 Description: Component of the Paf1p complex that binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; contains TPR repeats Phenotype: Null mutant is viable, loses chromosomes and shows temperature sensitivity ORF_Name: YOL145C SGDID: S000005505 Locus_Name: CTS1 Description: Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p ORF_Name: YLR286C SGDID: S000004276 Locus_Name: CTS2 Description: Protein similar to Ashbya gossypii sporulation-specific chitinase Phenotype: Null mutant fails to form mature asci, synthesis of spore wall surface layers is affected. ORF_Name: YDR371W SGDID: S000002779 Locus_Name: CTT1 Alias_Name: SPS101 Description: Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide Phenotype: Null mutant is viable and heat sensitive ORF_Name: YGR088W SGDID: S000003320 Locus_Name: CUE1 Alias_Name: KIS4 Description: Endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination Phenotype: Null mutant is viable and shows stabilization of ER degradation substrates ORF_Name: YMR264W SGDID: S000004877 Locus_Name: CUE2 Description: Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination ORF_Name: YKL090W SGDID: S000001573 Locus_Name: CUE3 Description: Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination ORF_Name: YGL110C SGDID: S000003078 Locus_Name: CUE4 Description: Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination ORF_Name: YML101C SGDID: S000004568 Locus_Name: CUE5 Description: Protein containing a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern ORF_Name: YOR042W SGDID: S000005568 Locus_Name: CUL3 Alias_Name: CULB Description: Ubiquitin-protein ligase, member of the cullin family with similarity to Cdc53p and human CUL3; required for ubiquitin-dependent degredation of the RNA Polymerase II subunit RPO21 Gene_Product: CULLIN B ORF_Name: YGR003W SGDID: S000003235 Locus_Name: CUP1-1 Alias_Name: CUP1 Description: Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C Phenotype: Copper resistance ORF_Name: YHR053C SGDID: S000001095 Locus_Name: CUP1-2 Alias_Name: CUP1 Description: Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C Phenotype: Copper resistance ORF_Name: YHR055C SGDID: S000001097 Locus_Name: CUP14 Description: copper homeostasis Phenotype: Copper resistance SGDID: S000029125 Locus_Name: CUP2 Alias_Name: ACE1 Description: Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations Phenotype: Null mutant is sensitive to Cu2+ ORF_Name: YGL166W SGDID: S000003134 Locus_Name: CUP3 Phenotype: Copper resistance SGDID: S000029126 Locus_Name: CUP5 Alias_Name: CLS7|GEF2|VMA3 Description: Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis Phenotype: Null mutant is viable, petite, copper sensitive ORF_Name: YEL027W SGDID: S000000753 Locus_Name: CUP9 Description: Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription Phenotype: Null mutant is viable, associated with loss of copper resistance ORF_Name: YPL177C SGDID: S000006098 Locus_Name: CUR1 Description: Protein of unknown function involved in destabilization of [URE3] prions; similar in sequence to Btn2p ORF_Name: YPR158W SGDID: S000006362 Locus_Name: CUS1 Description: Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p Phenotype: suppresses cold sensitivity of a U2 G53A cs mutant ORF_Name: YMR240C SGDID: S000004853 Locus_Name: CUS2 Description: Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs) Phenotype: Null mutant is viable, enhances U2 mutations; mutations in this gene suppress the cold sensitive phenotype of U2 RNA mutation G53A ORF_Name: YNL286W SGDID: S000005230 Locus_Name: CVT14 Phenotype: cvt14 is defective in maturation of the vacuolar protein, aminopeptidase I SGDID: S000029127 Locus_Name: CVT15 Phenotype: cvt15 is defective in maturation of the vacuolar protein, aminopeptidase I SGDID: S000029128 Locus_Name: CVT16 Phenotype: cvt16 is defective in maturation of the vacuolar protein, aminopeptidase I SGDID: S000029129 Locus_Name: CVT3 Phenotype: cvt3 is defective in maturation of the vacuolar protein, aminopeptidase I and exhibits minor defects in autophagy SGDID: S000029130 Locus_Name: CVT6 Phenotype: cvt6 is defective in maturation of the vacuolar protein, aminopeptidase I and exhibits minor defects in autophagy SGDID: S000029131 Locus_Name: CWC15 Description: Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p ORF_Name: YDR163W SGDID: S000002570 Locus_Name: CWC2 Alias_Name: NTC40 Description: Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2 Phenotype: Null: required for pre-mRNA splicing ORF_Name: YDL209C SGDID: S000002368 Locus_Name: CWC21 Description: Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; may bind RNA; has similarity to S. pombe Cwf21p ORF_Name: YDR482C SGDID: S000002890 Locus_Name: CWC22 Description: Essential protein, component of a complex containing Cef1p, has similarity to S. pombe Cwf22p; putative spliceosomal component, based on computational analysis of large-scale protein-protein interaction data ORF_Name: YGR278W SGDID: S000003510 Locus_Name: CWC23 Description: Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p ORF_Name: YGL128C SGDID: S000003096 Locus_Name: CWC24 Description: Essential protein, component of a complex containing Cef1p; has similarity to S. pombe Cwf24p ORF_Name: YLR323C SGDID: S000004315 Locus_Name: CWC25 Description: Heat-stable protein required for the first step of pre-mRNA splicing; component of a complex containing Cef1p; has similarity to S. pombe Cwf25p ORF_Name: YNL245C SGDID: S000005189 Locus_Name: CWC27 Description: Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p ORF_Name: YPL064C SGDID: S000005985 Locus_Name: CWH41 Alias_Name: DER7|GLS1 Description: Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress Phenotype: Null mutant is viable, associated with K1 killer toxin-resistant phenotype and a 50% reduction in the cell wall beta 1,6-glucan level ORF_Name: YGL027C SGDID: S000002995 Locus_Name: CWH43 Description: Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion ORF_Name: YCR017C SGDID: S000000610 Locus_Name: CWP1 Alias_Name: YJU1 Description: Cell wall mannoprotein that localizes specifically to birth scars of daughter cells, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance Phenotype: Null mutant is viable, has increased sensitivities to calcoflour white and congo red ORF_Name: YKL096W SGDID: S000001579 Locus_Name: CWP2 Alias_Name: LPR1|YKL097W-A Description: Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored Phenotype: Null mutant is viable, displays increased sensitivity to Congo red, calcofluor white, and Zymolyase ORF_Name: YKL096W-A SGDID: S000001956 Locus_Name: CYB2 Description: Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions Phenotype: Null mutant is viable but is deficient in cytochrome b2 and L-lactate dehydrogenase activity and is unable to use L-lactate as a sole carbon source ORF_Name: YML054C SGDID: S000004518 Locus_Name: CYB5 Description: Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation Phenotype: Null mutant is viable, cyb5 mutations suppress ketoconazole hypersensitivity of a P450 reductase deficient strain ORF_Name: YNL111C SGDID: S000005055 Locus_Name: CYC1 Description: Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration Gene_Product: iso-1-cytochrome c Phenotype: Cytochrome c deficiency ORF_Name: YJR048W SGDID: S000003809 Locus_Name: CYC2 Description: Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p) Phenotype: Null mutant is viable. Deletion of CYC2 leads to accumulation of apocytochrome c in the cytoplasm; strains with deletions of CYC2 still import low levels of cytochrome c into mitochondria ORF_Name: YOR037W SGDID: S000005563 Locus_Name: CYC3 Description: Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS) Phenotype: Cytochrome c deficiency ORF_Name: YAL039C SGDID: S000000037 Locus_Name: CYC7 Description: Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration Gene_Product: iso-2-cytochrome c ORF_Name: YEL039C SGDID: S000000765 Locus_Name: CYC8 Alias_Name: CRT8|SSN6 Description: General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters; can form the prion [OCT+] Phenotype: Null mutant is viable; high level constitutivity for invertase, clumpiness, temperature-sensitive growth, alpha-specific mating defects and failure of homozygous diploids to sporulate ORF_Name: YBR112C SGDID: S000000316 Locus_Name: CYH1 Phenotype: Cycloheximide resistance SGDID: S000029132 Locus_Name: CYH10 Phenotype: Cycloheximide resistance SGDID: S000029133 Locus_Name: CYH101 SGDID: S000029134 Locus_Name: CYH35 SGDID: S000029135 Locus_Name: CYH4 Phenotype: Cycloheximide resistance SGDID: S000029136 Locus_Name: CYH5 Phenotype: Cycloheximide resistance SGDID: S000029137 Locus_Name: CYH82 SGDID: S000029138 Locus_Name: CYH98 SGDID: S000029139 Locus_Name: CYK3 Description: SH3-domain protein located in the mother-bud neck and the cytokinetic actin ring; mutant phenotype and genetic interactions suggest a role in cytokinesis Phenotype: Null mutant is viable, exhibits slow growth, mild cytokinesis defects, and aberrant mother-bud neck morphology. cyk3/hof1 and cyk3/myo1 double mutants are inviable ORF_Name: YDL117W SGDID: S000002275 Locus_Name: CYM1 Alias_Name: MOP112 Description: Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology ORF_Name: YDR430C SGDID: S000002838 Locus_Name: CYR1 Alias_Name: CDC35|FIL1|HSR1|SRA4|TSM0185 Description: Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation Phenotype: Null mutant is inviable. cyr1 transiently arrests in G1 and sporulates precociously. N-terminal domain is dispensable for mitotic G1 arrest after nitrogen starvation, but required for sporulation. When altered, cAMP levels remain high and cells continue to bud with abnormal spindles ORF_Name: YJL005W SGDID: S000003542 Locus_Name: CYS1 Phenotype: Mutant is a cysteine auxotroph and lacks serine acetyltransferase activity SGDID: S000029140 Locus_Name: CYS2 Phenotype: cys2 and cys4 mutations are linked together and co-operatively confer cysteine dependence SGDID: S000029141 Locus_Name: CYS3 Alias_Name: CYI1|FUN35|STR1 Description: Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine Phenotype: Null mutant is viable, cysteine auxotroph ORF_Name: YAL012W SGDID: S000000010 Locus_Name: CYS4 Alias_Name: NHS5|STR4|VMA41 Description: Cystathionine beta-synthase, catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; mutations in human ortholog cause homocystinuria Phenotype: Null exhibits vacuolar acidification defects; cys2 and cys4 mutations are linked together and cooperatively confer cysteine dependence. ORF_Name: YGR155W SGDID: S000003387 Locus_Name: CYT1 Alias_Name: CTC1|YOR29-16 Description: Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex ORF_Name: YOR065W SGDID: S000005591 Locus_Name: CYT2 Description: Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1 Gene_Product: CC1HL|cytochrome c1 heme lyase ORF_Name: YKL087C SGDID: S000001570 Locus_Name: DAD1 Description: Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis Phenotype: Null mutant is inviable; temperature-sensitive mutant arrests with large buds and a short mitotic spindle ORF_Name: YDR016C SGDID: S000002423 Locus_Name: DAD2 Alias_Name: HSK1 Description: Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis ORF_Name: YKR083C SGDID: S000001791 Locus_Name: DAD3 Description: Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis ORF_Name: YBR233W-A SGDID: S000007595 Locus_Name: DAD4 Alias_Name: HSK2 Description: Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis ORF_Name: YDR320C-A SGDID: S000007604 Locus_Name: DAK1 Description: Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation Phenotype: Null mutant is viable and shows no growth defect in normal medium; mutant lacking both dak1 and dak2 is sensitive to dihydroxyacetone during saline growth ORF_Name: YML070W SGDID: S000004535 Locus_Name: DAK2 Description: Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation Phenotype: Null mutant is viable and show no growth defect in normal medium; mutant lacking both dak1 and dak2 is sensitive to dihydroxyacetone during saline growth ORF_Name: YFL053W SGDID: S000001841 Locus_Name: DAL1 Description: Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression Phenotype: Allantoin degradation deficient ORF_Name: YIR027C SGDID: S000001466 Locus_Name: DAL2 Alias_Name: ALC1 Description: Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation Phenotype: Allantoin degradation deficient ORF_Name: YIR029W SGDID: S000001468 Locus_Name: DAL3 Description: Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression ORF_Name: YIR032C SGDID: S000001471 Locus_Name: DAL4 Description: Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation Phenotype: Null mutant is viable, lacks allantoin transport capability ORF_Name: YIR028W SGDID: S000001467 Locus_Name: DAL5 Alias_Name: UREP1 Description: Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression Phenotype: Null mutant is viable, unable to transport allontoate or ureidosuccinate ORF_Name: YJR152W SGDID: S000003913 Locus_Name: DAL7 Alias_Name: MLS2|MSL2 Description: Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation ORF_Name: YIR031C SGDID: S000001470 Locus_Name: DAL80 Alias_Name: UGA43 Description: Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Deh1p Phenotype: Null mutant is viable, deficient in allantoin degradation ORF_Name: YKR034W SGDID: S000001742 Locus_Name: DAL81 Alias_Name: UGA35 Description: Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism Phenotype: Null mutant is viable, unable to degrade allantoin ORF_Name: YIR023W SGDID: S000001462 Locus_Name: DAL82 Description: Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain Phenotype: loss of induction for allantoin degradation pathways ORF_Name: YNL314W SGDID: S000005258 Locus_Name: DAM1 Description: Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments ORF_Name: YGR113W SGDID: S000003345 Locus_Name: DAN1 Alias_Name: CCW13 Description: Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth ORF_Name: YJR150C SGDID: S000003911 Locus_Name: DAN4 Description: Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth ORF_Name: YJR151C SGDID: S000003912 Locus_Name: DAP1 Description: Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis Phenotype: Null mutant exhibits sensitivity to MMS, elongated telomeres, elevated petite formation, partial arrest in sterol synthesis ORF_Name: YPL170W SGDID: S000006091 Locus_Name: DAP2 Alias_Name: DPP2 Description: Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p Phenotype: Null mutant is viable and lacks dipeptidyl aminopeptidase yscV activity ORF_Name: YHR028C SGDID: S000001070 Locus_Name: DAS1 Description: Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C ORF_Name: YJL149W SGDID: S000003685 Locus_Name: DAS2 Alias_Name: RRT3 Description: Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases ORF_Name: YDR020C SGDID: S000002427 Locus_Name: DAT1 Description: DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability Phenotype: Null mutant is viable, but phenotypically distinguishable ORF_Name: YML113W SGDID: S000004581 Locus_Name: DBF1 Description: Protein required for DNA replication; expression is constant across the cell cycle Phenotype: Dumbell formation SGDID: S000029142 Locus_Name: DBF2 Description: Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis Phenotype: Null mutant is viable, dbf1 dbf20 null mutants are inviable; mutants show dumb-bell phenotype ORF_Name: YGR092W SGDID: S000003324 Locus_Name: DBF20 Description: Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis Phenotype: Dumbell formation ORF_Name: YPR111W SGDID: S000006315 Locus_Name: DBF4 Alias_Name: DNA52|LSD7 Description: Regulatory subunit of Cdc7p-Dbf4p kinase complex, required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated Phenotype: Null mutant is inviable; conditional alleles cause cell cycle arrest at the G1/S transition; dumbbell shape ORF_Name: YDR052C SGDID: S000002459 Locus_Name: DBL1 Phenotype: Alcian blue dye binding deficient SGDID: S000029143 Locus_Name: DBP1 Alias_Name: LPH8 Description: Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs ORF_Name: YPL119C SGDID: S000006040 Locus_Name: DBP10 Description: Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis ORF_Name: YDL031W SGDID: S000002189 Locus_Name: DBP2 Description: Essential ATP-dependent RNA helicase of the DEAD-box protein family, involved in nonsense-mediated mRNA decay and rRNA processing ORF_Name: YNL112W SGDID: S000005056 Locus_Name: DBP3 Description: Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis ORF_Name: YGL078C SGDID: S000003046 Locus_Name: DBP5 Alias_Name: RAT8 Description: Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family involved in mRNA export from the nucleus; involved in translation termination Phenotype: dbp5(ts) strains exhibit rapid, synchronous accumulation of poly(A)+ RNA in nuclei when shifted to the non-permissive temperature ORF_Name: YOR046C SGDID: S000005572 Locus_Name: DBP6 Description: Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family Phenotype: Null mutant is inviable; Dbp6p depletion leads to decreased production of the 27S and 7S precursors, resulting in a depletion of the mature 25S and 5.8S rRNAs ORF_Name: YNR038W SGDID: S000005321 Locus_Name: DBP7 Description: Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis; essential for growth under anaerobic conditions ORF_Name: YKR024C SGDID: S000001732 Locus_Name: DBP8 Description: ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esp2p ORF_Name: YHR169W SGDID: S000001212 Locus_Name: DBP9 Description: ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 60S ribosomal subunit ORF_Name: YLR276C SGDID: S000004266 Locus_Name: DBR1 Alias_Name: PRP26 Description: RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition Phenotype: Null mutant is viable; reduces Ty1 transposition frequency; defective in the process of intron turnover ORF_Name: YKL149C SGDID: S000001632 Locus_Name: DCC1 Description: Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance Phenotype: benomyl sensitive and defective in sister chromatid cohesion ORF_Name: YCL016C SGDID: S000000521 Locus_Name: DCD1 Description: Deoxycytidine monophosphate (dCMP) deaminase required for dCTP and dTTP synthesis; expression is NOT cell cycle regulated Phenotype: Null mutant is viable, resistant to 5-fluoro-2'-deoxycytidylate ORF_Name: YHR144C SGDID: S000001187 Locus_Name: DCG1 Description: Protein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain ORF_Name: YIR030C SGDID: S000001469 Locus_Name: DCI1 Alias_Name: ECI2 Description: Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed ORF_Name: YOR180C SGDID: S000005706 Locus_Name: DCN1 Description: Scaffold-type E3 ligase required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation ORF_Name: YLR128W SGDID: S000004118 Locus_Name: DCP1 Description: Subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p Phenotype: Null mutant is inviable in the FY1679 background, but viable, though grows slowly, in the CEN.PK141 background. ORF_Name: YOL149W SGDID: S000005509 Locus_Name: DCP2 Alias_Name: PSU1 Description: Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; member of the Nudix hydrolase family ORF_Name: YNL118C SGDID: S000005062 Locus_Name: DCR2 Description: Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START ORF_Name: YLR361C SGDID: S000004353 Locus_Name: DCS1 Alias_Name: DcpS Description: Non-essential hydrolase involved in mRNA decapping, may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; interacts with neutral trehalase Nth1p ORF_Name: YLR270W SGDID: S000004260 Locus_Name: DCS2 Description: Non-essential, stress induced regulatory protein containing a HIT (histidine triad) motif; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway, similar to Dcs1p. ORF_Name: YOR173W SGDID: S000005699 Locus_Name: DCW1 Description: Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p ORF_Name: YKL046C SGDID: S000001529 Locus_Name: DDC1 Description: DNA damage checkpoint protein, part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate Phenotype: Null mutant is viable, sensitive to DNA damage and defective in delaying G1-S and G2-M transistion and in decreasing rate of DNA synthesis when DNA is damaged during G1, G2 or S phase, respectively ORF_Name: YPL194W SGDID: S000006115 Locus_Name: DDI1 Alias_Name: VSM1 Description: DNA damage-inducible v-SNARE binding protein, contains a ubiquitin-associated (UBA) domain, may act as a negative regulator of constitutive exocytosis, may play a role in S-phase checkpoint control ORF_Name: YER143W SGDID: S000000945 Locus_Name: DDI2 Description: Protein of unknown function; expression is induced over 100-fold by DNA damage; induction decreased in rad6 and rad18 mutants ORF_Name: YFL061W SGDID: S000001833 Locus_Name: DDI3 Description: Protein of unknown function; expression is induced over 100-fold by DNA damage; induction decreased in rad6 and rad18 mutants ORF_Name: YNL335W SGDID: S000005279 Locus_Name: DDP1 Description: Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; has high specificity for diadenosine hexa- and pentaphosphates; member of the MutT family of nucleotide hydrolases ORF_Name: YOR163W SGDID: S000005689 Locus_Name: DDR2 Alias_Name: DDRA2|YOL053C-A Description: Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses Phenotype: Null mutant is viable, shows no defect in heat shock recovery or thermotolerance and appear normal for DNA damage sensitivity and mutagenesis ORF_Name: YOL052C-A SGDID: S000005413 Locus_Name: DDR48 Alias_Name: FSP Description: DNA damage-responsive protein, expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS Phenotype: Null mutant is viable, displays reduced spontaneous mutation rate ORF_Name: YMR173W SGDID: S000004784 Locus_Name: DDS2 Description: Depressed DNA synthesis Phenotype: Null phenotype unknown; temperature sensitive mutant ceases DNA synthesis at restrictive temperature SGDID: S000029144 Locus_Name: DED1 Alias_Name: SPP81 Description: ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility ORF_Name: YOR204W SGDID: S000005730 Locus_Name: DED81 Description: Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA Gene_Product: asparaginyl-tRNA synthetase ORF_Name: YHR019C SGDID: S000001061 Locus_Name: DEF1 Alias_Name: VID31 Description: RNAPII degradation factor, forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; mutant is deficient in Zip1p loading onto chromosomes during meiosis Phenotype: Null: slow growth. Other phenotypes: unable to degrade RNAPII in response to UV-damage. def1delta and def1delta rad26delta cells are not UV-sensitive, but def1delta rad16delta and def1delta rad14delta cells are much more sensitive than the rad16delta and rad14delta single mutants. def1delta and to a much larger degree def1delta dst1delta are sensitive to the elongation inhibitor 6-azauracil. ORF_Name: YKL054C SGDID: S000001537 Locus_Name: DEG1 Alias_Name: HRM3|PUS3 Description: tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability Phenotype: Null mutant is viable, but demonstrates depressed growth rate ORF_Name: YFL001W SGDID: S000001895 Locus_Name: DEM1 Alias_Name: EXO5 Description: Mitochondrial 5'-3' exonuclease and sliding exonuclease, required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2 ORF_Name: YBR163W SGDID: S000000367 Locus_Name: DEP1 Alias_Name: FUN54 Description: Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation ORF_Name: YAL013W SGDID: S000000011 Locus_Name: DER1 Description: Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p Phenotype: Null mutant is viable, but blocks ER-degradation of target proteins ORF_Name: YBR201W SGDID: S000000405 Locus_Name: DET1 Description: Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel ORF_Name: YDR051C SGDID: S000002458 Locus_Name: DFG10 Description: Protein of unknown function, involved in filamentous growth Phenotype: Null mutant is viable and defective in filamentous growth ORF_Name: YIL049W SGDID: S000001311 Locus_Name: DFG16 Alias_Name: ECM41|ZRG12 Description: Probable multiple transmembrane protein, involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; required for accumulation of processed Rim101p Phenotype: Null mutant is viable, a Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white. ORF_Name: YOR030W SGDID: S000005556 Locus_Name: DFG5 Description: Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p Phenotype: Null mutant is viable and defective in filamentous growth ORF_Name: YMR238W SGDID: S000004851 Locus_Name: DFM1 Description: ER localized derlin-like family member involved in ER stress and homeostasis; not involved in ERAD or substrate retrotranslocation; interacts with CDC48; contains four transmembrane domains and two SHP boxes ORF_Name: YDR411C SGDID: S000002819 Locus_Name: DFR1 Description: Dihydrofolate reductase, part of the dTTP biosynthetic pathway, involved in folate metabolism, possibly required for mitochondrial function ORF_Name: YOR236W SGDID: S000005762 Locus_Name: DGA1 Description: Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles ORF_Name: YOR245C SGDID: S000005771 Locus_Name: DGK1 Alias_Name: HSD1 Description: Diacylglycerol kinase, localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain ORF_Name: YOR311C SGDID: S000005838 Locus_Name: DGR1 Description: Protein of unknown function; dgr1 null mutant is resistant to 2-deoxy-D-glucose ORF_Name: YNL130C-A SGDID: S000028579 Locus_Name: DGR2 Description: Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds ORF_Name: YKL121W SGDID: S000001604 Locus_Name: DHH1 Description: Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping, coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation Phenotype: Null mutant is viable, but grows poorly ORF_Name: YDL160C SGDID: S000002319 Locus_Name: DHR2 Description: Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis Phenotype: Null: essential ORF_Name: YKL078W SGDID: S000001561 Locus_Name: DIA1 Description: Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Phenotype: Null mutant is viable and causes invasive growth in haploids and pseudohyphal growth in diploids ORF_Name: YMR316W SGDID: S000004935 Locus_Name: DIA2 Alias_Name: YOR29-31 Description: Origin-binding F-box protein that forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication, involved in invasive and pseudohyphal growth Phenotype: Enhanced invasive growth in haploids; haploid budding pattern becomes polar. ORF_Name: YOR080W SGDID: S000005606 Locus_Name: DIA3 Description: Protein of unknown function, involved in invasive and pseudohyphal growth Phenotype: Null mutant is viable and causes invasive growth in haploids and pseudohyphal growth in diploids ORF_Name: YDL024C SGDID: S000002182 Locus_Name: DIA4 Description: Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth Phenotype: Null mutant is viable and causes agar invasion in haploids, pseudohyphal growth in diploids; unable to grow on glycerol ORF_Name: YHR011W SGDID: S000001053 Locus_Name: DIB1 Alias_Name: SNU16 Description: 17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein ORF_Name: YPR082C SGDID: S000006286 Locus_Name: DIC1 Description: Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix ORF_Name: YLR348C SGDID: S000004340 Locus_Name: DID2 Alias_Name: CHM1|FTI1|VPL30|VPS46 Description: Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors Phenotype: Overexpression causes growth inhibition and G2 arrest in rad52 and cdc9 mutants; null mutants are canavanine-hypersensitive, temperature sensitive, and suppress defects associated with loss of DOA4 ORF_Name: YKR035W-A SGDID: S000006435 Locus_Name: DID4 Alias_Name: CHM2|GRD7|REN1|VPL2|VPS14|VPS2|VPT14 Description: Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis ORF_Name: YKL002W SGDID: S000001485 Locus_Name: DIE2 Alias_Name: ALG10 Description: Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase of the ER, functions in the pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1 ORF_Name: YGR227W SGDID: S000003459 Locus_Name: DIE3 Description: De-repression of ITR1 Expression SGDID: S000029145 Locus_Name: DIF1 Description: Protein that regulates the nuclear localization of ribonucleotide reductase Rnr2p and Rnr4p subunits; phosphorylated by Dun1p in response to DNA damage and degraded; N-terminal half has similarity to S. pombe Spd1 protein ORF_Name: YLR437C SGDID: S000004429 Locus_Name: DIG1 Alias_Name: RST1 Description: Regulatory protein of unknown function, constitutively-expressed, involved in the regulation of mating-specific genes and the invasive growth pathway, required for MAP-kinase imposed repression, inhibits pheromone-responsive transcription Phenotype: Null mutant is viable, shows abnormal bud morphology; dig1 dig2 double mutants show constitutive mating defect and invasive growth; overexpression causes pheromone resistance ORF_Name: YPL049C SGDID: S000005970 Locus_Name: DIG2 Alias_Name: RST2 Description: Regulatory protein of unknown function, pheromone-inducible, involved in the regulation of mating-specific genes and the invasive growth pathway, required for MAP-kinase imposed repression, inhibits pheromone-responsive transcription Phenotype: Null mutant is viable; dig1 dig2 double mutants show constitutive mating pheromone specific gene expression and invasive growth ORF_Name: YDR480W SGDID: S000002888 Locus_Name: DIM1 Alias_Name: CDH1 Description: Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing ORF_Name: YPL266W SGDID: S000006187 Locus_Name: DIN7 Alias_Name: DIN3 Description: Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination ORF_Name: YDR263C SGDID: S000002671 Locus_Name: DIP2 Alias_Name: UTP12 Description: Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex ORF_Name: YLR129W SGDID: S000004119 Locus_Name: DIP5 Description: Dicarboxylic amino acid permease, mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly Phenotype: Null mutant is viable, exhibits loss of L-aspartate and L-glutamate uptake ORF_Name: YPL265W SGDID: S000006186 Locus_Name: DIS1 Description: Required for mitotic segregation, meiosis I segregation, and spore viability Phenotype: mutants cause mitotic and meiotic nondisjunction SGDID: S000029146 Locus_Name: DIS3 Alias_Name: RRP44 Description: Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3 ORF_Name: YOL021C SGDID: S000005381 Locus_Name: DIT1 Description: Sporulation-specific enzyme required for spore wall maturation, involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure Phenotype: lack outermost layer of spore wall ORF_Name: YDR403W SGDID: S000002811 Locus_Name: DIT2 Alias_Name: CYP56 Description: N-formyltyrosine oxidase, sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s Phenotype: lack outermost layer of spore wall ORF_Name: YDR402C SGDID: S000002810 Locus_Name: DJP1 Alias_Name: ICS1|PAS22 Description: Cytosolic J-domain-containing protein, required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ Phenotype: Null mutant is viable but shows partial mislocalisation of peroxisomal matrix proteins to the cytosol ORF_Name: YIR004W SGDID: S000001443 Locus_Name: DLD1 Description: D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane Phenotype: Null mutant is viable and cannot grow on media containing lactate as the sole carbon source ORF_Name: YDL174C SGDID: S000002333 Locus_Name: DLD2 Alias_Name: AIP2 Description: D-lactate dehydrogenase, located in the mitochondrial matrix ORF_Name: YDL178W SGDID: S000002337 Locus_Name: DLD3 Description: D-lactate dehydrogenase, part of the retrograde regulon which consists of genes whose expression is stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source, located in the cytoplasm ORF_Name: YEL071W SGDID: S000000797 Locus_Name: DLP1 Description: Delayed loss of proliferation activity SGDID: S000029147 Locus_Name: DLS1 Description: Subunit of ISW2/yCHRAC chromatin accessibility complex along with Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing ORF_Name: YJL065C SGDID: S000003601 Locus_Name: DLT1 Description: Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA) Phenotype: Null: Poor growth at 15 degrees; phenotype is less apparent in prototrophic strains. Other phenotypes: Sensitive to heat shock and hydrogen peroxide ORF_Name: YMR126C SGDID: S000004733 Locus_Name: DMA1 Alias_Name: CHF1 Description: Protein involved in ubiquitin ligation; plays a role in regulating spindle position and orientation; functionally redundant with Dma2p; orthologous to human RNF8 protein, also has sequence similarity to human Chfr. ORF_Name: YHR115C SGDID: S000001157 Locus_Name: DMA2 Alias_Name: CHF2 Description: Protein involved in ubiquitination; plays a role in regulating spindle position and orientation; functionally redundant with Dma1p; orthologous to human RNF8 protein, also has sequence similarity to human Chfr ORF_Name: YNL116W SGDID: S000005060 Locus_Name: DMC1 Alias_Name: ISC2 Description: Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein ORF_Name: YER179W SGDID: S000000981 Locus_Name: DML1 Description: Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family Phenotype: Null: inviable. Other phenotypes: Meiotic progeny DML1 cells of the DML1/dml1Delta heterozygote are completely devoid of mtDNA ([rho0]). In addition, meiotic transmission of centromeric plasmids also appears to be impaired. ORF_Name: YMR211W SGDID: S000004824 Locus_Name: DNA1 Alias_Name: MAK1-3 Phenotype: Deficient in the initiation step of DNA synthesis SGDID: S000029148 Locus_Name: DNA2 Alias_Name: WEB2 Description: Tripartite DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization ORF_Name: YHR164C SGDID: S000001207 Locus_Name: DNF1 Description: Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase Phenotype: viable. drs2 dnf1 mutant grows slowly, massively accumulates intracellular membranes, and exhibits a substantial defect in the transport of alkaline phosphatase to the vacuole. ORF_Name: YER166W SGDID: S000000968 Locus_Name: DNF2 Description: Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase ORF_Name: YDR093W SGDID: S000002500 Locus_Name: DNF3 Description: Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; localizes to the trans-Golgi network; likely involved in protein transport; type 4 P-type ATPase ORF_Name: YMR162C SGDID: S000004772 Locus_Name: DNL4 Alias_Name: LIG4 Description: DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth Phenotype: Null mutant is viable, deficient in non-homologous double-strand end joining ORF_Name: YOR005C SGDID: S000005531 Locus_Name: DNM1 Description: Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance Phenotype: Null mutant is viable, shows mating defects consistent with a delay in receptor-mediated endocytosis ORF_Name: YLL001W SGDID: S000003924 Locus_Name: DOA1 Alias_Name: UFD3|ZZZ4 Description: WD repeat protein required for ubiquitin-mediated protein degradation, forms complex with Cdc48p, plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase Phenotype: Null mutant is viable and defective in degradation of ubiquitinated proteins; homozygous null diploid shows sporulation defect ORF_Name: YKL213C SGDID: S000001696 Locus_Name: DOA4 Alias_Name: DOS1|MUT4|NPI2|SSV7|UBP4 Description: Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole Phenotype: Null mutant is viable, but exhibits uncoordinated DNA replication|A nonsense mutation in the doa4-10 mutant eliminates the catalytic residues of the deubiquitinating enzyme while keeping the rhodanase domain intact. At 36 degrees C, this doa4-10 mutant exhibits increased sensitivity to camptothecin (CPT), osmotic stress, and hydroxyurea, and a reversible petite phenotype. ORF_Name: YDR069C SGDID: S000002476 Locus_Name: DOC1 Alias_Name: APC10 Description: Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis ORF_Name: YGL240W SGDID: S000003209 Locus_Name: DOG1 Description: 2-deoxyglucose-6-phosphate phosphatase, similar to Dog2p, member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified Gene_Product: 2-deoxyglucose-6-phosphate phosphatase ORF_Name: YHR044C SGDID: S000001086 Locus_Name: DOG2 Description: 2-deoxyglucose-6-phosphate phosphatase, member of a family of low molecular weight phosphatases, similar to Dog1p, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed Gene_Product: 2-deoxyglucose-6-phosphate phosphatase ORF_Name: YHR043C SGDID: S000001085 Locus_Name: DOM34 Description: Endoribonuclease; functions in no-go mRNA decay, protein translation to promote G1 progression and differentiation, required for meiotic cell division; similar to the eukaryotic Pelota ORF_Name: YNL001W SGDID: S000004946 Locus_Name: DON1 Description: Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II ORF_Name: YDR273W SGDID: S000002681 Locus_Name: DOP1 Description: Protein of unknown function, essential for viability, involved in establishing cellular polarity and morphogenesis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Phenotype: essential gene ORF_Name: YDR141C SGDID: S000002548 Locus_Name: DOS2 Description: Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm ORF_Name: YDR068W SGDID: S000002475 Locus_Name: DOT1 Alias_Name: PCH1 Description: Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response Gene_Product: KMT4 Phenotype: Null mutant is viable, bypasses meiotic arrest of zip1 mutant, and shows decreased silencing at telomeres, HML, and HMR. Overexpression causes loss of silencing at telomeres, HML, HMR, and slightly at rDNA ORF_Name: YDR440W SGDID: S000002848 Locus_Name: DOT5 Description: Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth ORF_Name: YIL010W SGDID: S000001272 Locus_Name: DOT6 Alias_Name: PBF2 Description: Protein involved in rRNA and ribosome biogenesis; binds polymerase A and C motif; subunit of the RPD3L histone deacetylase complex; similar to Tod6p; has chromatin specific SANT domain; involved in telomeric gene silencing and filamentation ORF_Name: YER088C SGDID: S000000890 Locus_Name: DPB11 Description: Replication initiation protein that loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; ortholog of human TopBP1 Phenotype: Null mutant is inviable; conditional allele demonstrates defective S-phase progression ORF_Name: YJL090C SGDID: S000003626 Locus_Name: DPB2 Description: Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for normal yeast chromosomal replication; expression peaks at the G1/S phase boundary; potential Cdc28p substrate Phenotype: Null mutant is inviable; conditional mutant shows defects in DNA replication ORF_Name: YPR175W SGDID: S000006379 Locus_Name: DPB3 Description: Third-largest subunit of DNA polymerase II (DNA polymerase epsilon), required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; mRNA abundance peaks at the G1/S boundary of the cell cycle Phenotype: Null mutant is viable, shows increased spontaneous mutation rate ORF_Name: YBR278W SGDID: S000000482 Locus_Name: DPB4 Description: Shared subunit of DNA polymerase (II) epsilon and of ISW2/yCHRAC chromatin accessibility complex; involved in both chromosomal DNA replication and in inheritance of telomeric silencing ORF_Name: YDR121W SGDID: S000002528 Locus_Name: DPD1 SGDID: S000029150 Locus_Name: DPH1 Alias_Name: KIF48 Description: Protein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11p ORF_Name: YIL103W SGDID: S000001365 Locus_Name: DPH2 Description: Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p ORF_Name: YKL191W SGDID: S000001674 Locus_Name: DPH5 Description: Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm ORF_Name: YLR172C SGDID: S000004162 Locus_Name: DPL1 Alias_Name: BST1 Description: Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate ORF_Name: YDR294C SGDID: S000002702 Locus_Name: DPM1 Alias_Name: SED3 Description: Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation ORF_Name: YPR183W SGDID: S000006387 Locus_Name: DPP1 Alias_Name: ZRG1 Description: Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism ORF_Name: YDR284C SGDID: S000002692 Locus_Name: DPS1 Description: Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation Gene_Product: AspRS|aspartyl-tRNA synthetase ORF_Name: YLL018C SGDID: S000003941 Locus_Name: DRE2 Description: Protein that may prevent apoptosis by forming a complex with Tah18p in the absence of stress; required for iron-sulfur cluster assembly and sister chromatid cohesion; homolog of human anti-apoptotic protein Ciapin1 ORF_Name: YKR071C SGDID: S000001779 Locus_Name: DRN1 Description: Putative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus ORF_Name: YGR093W SGDID: S000003325 Locus_Name: DRS1 Description: Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles ORF_Name: YLL008W SGDID: S000003931 Locus_Name: DRS2 Alias_Name: FUN38|SWA3 Description: Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease Phenotype: Null mutant is viable, cold sensitive with perturbed late Golgi function; drs2 arf1 double mutants are inviable. drs2 dnf1 mutants grow slowly, accumulate intracellular membranes, exhibit substantial defect in transport of alkaline phosphatase to vacuole. ORF_Name: YAL026C SGDID: S000000024 Locus_Name: DRS3 Phenotype: defective in assembly of ribosomes SGDID: S000029151 Locus_Name: DSD1 Description: D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate ORF_Name: YGL196W SGDID: S000003164 Locus_Name: DSE1 Description: Daughter cell-specific protein, may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall ORF_Name: YER124C SGDID: S000000926 Locus_Name: DSE2 Description: Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP ORF_Name: YHR143W SGDID: S000001186 Locus_Name: DSE3 Description: Daughter cell-specific protein, may help establish daughter fate ORF_Name: YOR264W SGDID: S000005790 Locus_Name: DSE4 Alias_Name: ENG1 Description: Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother ORF_Name: YNR067C SGDID: S000005350 Locus_Name: DSF1 Description: Deletion suppressor of mpt5 mutation ORF_Name: YEL070W SGDID: S000000796 Locus_Name: DSF2 Description: Deletion suppressor of mpt5 mutation ORF_Name: YBR007C SGDID: S000000211 Locus_Name: DSK2 Description: Nuclear-enriched ubiquitin-like polyubiquitin-binding protein, required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle, involved in proteolysis, interacts with the proteasome ORF_Name: YMR276W SGDID: S000004889 Locus_Name: DSL1 Alias_Name: RNS1 Description: Peripheral membrane protein needed for Golgi-to-ER retrograde traffic; forms a complex with Sec39p and Tip20p that interacts with ER SNAREs Sec20p and Use1p; component of the ER target site that interacts with coatomer; interacts with Cin5p ORF_Name: YNL258C SGDID: S000005202 Locus_Name: DSM1 Phenotype: Premeiotic DNA synthesis deficient. Semi-dominant ts allele partially suppresses spo8-1 ts. Restores premeioticDNA synthesis, intragenic recombination, but not reciprocal recombination or ascus formation to spo8-1 at a restrictive temperature. DSM1 alone is dispensable for sporulation. SGDID: S000029152 Locus_Name: DSN1 Description: Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation ORF_Name: YIR010W SGDID: S000001449 Locus_Name: DSS1 Alias_Name: MSU1 Description: 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs ORF_Name: YMR287C SGDID: S000004900 Locus_Name: DSS4 Description: Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol ORF_Name: YPR017C SGDID: S000006221 Locus_Name: DST1 Alias_Name: PPR2 Description: General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites Gene_Product: P37|S-II|SII|TFIIS Phenotype: Null mutant is viable; reduced induction of DNA strand transfer; sensitivity to 6-azauracil ORF_Name: YGL043W SGDID: S000003011 Locus_Name: DTD1 Description: D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes Gene_Product: D-tyrosyl-tRNA(Tyr) deacylase ORF_Name: YDL219W SGDID: S000002378 Locus_Name: DTR1 Description: Putative dityrosine transporter, required for spore wall synthesis; expressed during sporulation; member of the major facilitator superfamily (DHA1 family) of multidrug resistance transporters Phenotype: Null: Null mutant is viable; bisformyl dityrosine accumulates in cytoplasm of spores; spore wall dityrosine is significantly reduced ORF_Name: YBR180W SGDID: S000000384 Locus_Name: DUF1 Description: Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid ORF_Name: YOL087C SGDID: S000005447 Locus_Name: DUG1 Description: Cys-Gly metallo-di-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p) ORF_Name: YFR044C SGDID: S000001940 Locus_Name: DUG2 Description: Probable di- and tri-peptidase; forms a complex with Dug1p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p) ORF_Name: YBR281C SGDID: S000000485 Locus_Name: DUG3 Description: Probable glutamine amidotransferase, forms a complex with Dug1p and Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p) ORF_Name: YNL191W SGDID: S000005135 Locus_Name: DUN1 Description: Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair Phenotype: Null mutant is viable, defective in DNA damage repair and DNA damage-resposive induction of RNR genes, and sensitive to DNA damaging agents. dun1pan2 and dun1pan3 double mutants are hypersensitive to replicational stress. ORF_Name: YDL101C SGDID: S000002259 Locus_Name: DUO1 Description: Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis Phenotype: Null mutant is inviable; overexpression arrests cells at large budded stage ORF_Name: YGL061C SGDID: S000003029 Locus_Name: DUR1,2 Alias_Name: DUR80 Description: Urea amidolyase, contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation Phenotype: Null mutant is viable; urea degradation deficient ORF_Name: YBR208C SGDID: S000000412 Locus_Name: DUR3 Description: Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway Phenotype: Null mutant is viable; urea degradation deficient ORF_Name: YHL016C SGDID: S000001008 Locus_Name: DUR4 Phenotype: Urea degradation deficient SGDID: S000029153 Locus_Name: DUS1 Description: Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17 ORF_Name: YML080W SGDID: S000004545 Locus_Name: DUS3 Description: Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region ORF_Name: YLR401C SGDID: S000004393 Locus_Name: DUS4 Description: Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p ORF_Name: YLR405W SGDID: S000004397 Locus_Name: DUT1 Description: dUTPase, catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability ORF_Name: YBR252W SGDID: S000000456 Locus_Name: DYN1 Alias_Name: DHC1|PAC6 Description: Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p Phenotype: Null mutant is viable, demonstrates misalignment of the spindle relative to the bud neck during cell division and abnormal distribution of the dividing nuclei between the mother cell and the bud ORF_Name: YKR054C SGDID: S000001762 Locus_Name: DYN2 Alias_Name: SLC1 Description: Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex ORF_Name: YDR424C SGDID: S000002832 Locus_Name: DYN3 Description: Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration ORF_Name: YMR299C SGDID: S000004914 Locus_Name: DYS1 Description: Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric ORF_Name: YHR068W SGDID: S000001110 Locus_Name: EAF1 Alias_Name: VID21 Description: Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1 ORF_Name: YDR359C SGDID: S000002767 Locus_Name: EAF3 Description: Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition ORF_Name: YPR023C SGDID: S000006227 Locus_Name: EAF5 Description: Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex ORF_Name: YEL018W SGDID: S000000744 Locus_Name: EAF6 Description: Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3 ORF_Name: YJR082C SGDID: S000003842 Locus_Name: EAF7 Description: Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A ORF_Name: YNL136W SGDID: S000005080 Locus_Name: EAM1 Description: endogenous ethanolamine biosynthesis Phenotype: Null phenotype unknown; a recessive allele suppresses ethanolamine requirement in cho1 mutants SGDID: S000029154 Locus_Name: EAM2 Description: endogenous ethanolamine biosynthesis Phenotype: Null phenotype unknown; a recessive allele suppresses ethanolamine requirement in cho1 mutants SGDID: S000029155 Locus_Name: EAM6 SGDID: S000029156 Locus_Name: EAP1 Description: eIF4E-associated protein, competes with eIF4G for binding to eIF4E; inhibits cap-dependent translation; functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade Phenotype: Mutant is temperature sensitive and partially resistant to rapamycin ORF_Name: YKL204W SGDID: S000001687 Locus_Name: EAR1 Description: Specificity factor required for Rsp5p-dependent ubiquitination and sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p ORF_Name: YMR171C SGDID: S000004781 Locus_Name: EBP2 Description: Essential protein required for the maturation of 25S rRNA and 60S ribosomal subunit assembly, localizes to the nucleolus; constituent of 66S pre-ribosomal particles ORF_Name: YKL172W SGDID: S000001655 Locus_Name: EBS1 Description: Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors ORF_Name: YDR206W SGDID: S000002614 Locus_Name: ECI1 Description: Peroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced Phenotype: Null mutant is viable but fails to metabolize unsaturated fatty acids ORF_Name: YLR284C SGDID: S000004274 Locus_Name: ECL1 Description: Protein of unknown function, affects chronological lifespan; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation ORF_Name: YGR146C SGDID: S000003378 Locus_Name: ECM1 Description: Protein of unknown function, localized in the nucleoplasm and the nucleolus, genetically interacts with MTR2 in 60S ribosomal protein subunit export ORF_Name: YAL059W SGDID: S000000055 Locus_Name: ECM10 Alias_Name: SSC3 Description: Heat shock protein of the Hsp70 family, localized in mitochondrial nucleoids, plays a role in protein translocation, interacts with Mge1p in an ATP-dependent manner; overexpression induces extensive mitochondrial DNA aggregations Phenotype: A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white. ORF_Name: YEL030W SGDID: S000000756 Locus_Name: ECM11 Description: Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure Phenotype: A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white. ORF_Name: YDR446W SGDID: S000002854 Locus_Name: ECM12 Description: Non-essential protein of unknown function Phenotype: A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white. ORF_Name: YHR021W-A SGDID: S000003531 Locus_Name: ECM13 Description: Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation Phenotype: A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white. ORF_Name: YBL043W SGDID: S000000139 Locus_Name: ECM14 Description: Putative metalloprotease with similarity to the zinc carboxypeptidase family, required for normal cell wall assembly Phenotype: A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white. ORF_Name: YHR132C SGDID: S000001174 Locus_Name: ECM15 Description: Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis Phenotype: A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white. ORF_Name: YBL001C SGDID: S000000097 Locus_Name: ECM16 Alias_Name: DHR1 Description: Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesis Phenotype: A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white. ORF_Name: YMR128W SGDID: S000004735 Locus_Name: ECM18 Description: Protein of unknown function, similar to Rlp24p Phenotype: A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white. ORF_Name: YDR125C SGDID: S000002532 Locus_Name: ECM19 Description: Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Phenotype: A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white. ORF_Name: YLR390W SGDID: S000004382 Locus_Name: ECM2 Alias_Name: SLT11 Description: Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p Phenotype: Synthetic lethal with U2 snRNA (LSR1); temperature-sensitive; blocks pre-mRNA splicing in vivo and in vitro; a Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white. ORF_Name: YBR065C SGDID: S000000269 Locus_Name: ECM21 Alias_Name: ART2 Description: Protein involved in regulating the endocytosis of plasma membrane proteins; identified as a substrate for ubiquitination by Rsp5p and deubiquitination by Ubp2p; promoter contains several Gcn4p binding elements Phenotype: A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white. ORF_Name: YBL101C SGDID: S000000197 Locus_Name: ECM22 Description: Sterol regulatory element binding protein, regulates transcription of sterol biosynthetic genes; contains Zn[2]-Cys[6] binuclear cluster; homologous to Upc2p; relocates from intracellular membranes to perinuclear foci on sterol depletion ORF_Name: YLR228C SGDID: S000004218 Locus_Name: ECM23 Alias_Name: SRD2 Description: Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p ORF_Name: YPL021W SGDID: S000005942 Locus_Name: ECM25 Description: Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p ORF_Name: YJL201W SGDID: S000003737 Locus_Name: ECM27 Description: Non-essential protein of unknown function Phenotype: A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white. ORF_Name: YJR106W SGDID: S000003867 Locus_Name: ECM29 Description: Major component of the proteasome; tethers the proteasome core particle to the regulatory particle, and enhances the stability of the proteasome ORF_Name: YHL030W SGDID: S000001022 Locus_Name: ECM3 Alias_Name: YOR3165W Description: Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation Phenotype: A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white. ORF_Name: YOR092W SGDID: S000005618 Locus_Name: ECM30 Description: Non-essential protein of unknown function ORF_Name: YLR436C SGDID: S000004428 Locus_Name: ECM31 Description: Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate ORF_Name: YBR176W SGDID: S000000380 Locus_Name: ECM32 Alias_Name: HEL1|MTT1 Description: DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes ORF_Name: YER176W SGDID: S000000978 Locus_Name: ECM33 Description: GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p ORF_Name: YBR078W SGDID: S000000282 Locus_Name: ECM34 Description: Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins ORF_Name: YHL043W SGDID: S000001035 Locus_Name: ECM38 Alias_Name: CIS2 Description: Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation ORF_Name: YLR299W SGDID: S000004290 Locus_Name: ECM4 Alias_Name: GTO2 Description: Omega class glutathione transferase; not essential; similar to Ygr154cp; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Phenotype: A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white. ORF_Name: YKR076W SGDID: S000001784 Locus_Name: ECM5 Description: Non-essential protein of unknown function, contains ATP/GTP-binding site motif A; null mutant exhibits cellular volume up to four times greater than wild-type, also large drooping buds with elongated necks ORF_Name: YMR176W SGDID: S000004788 Locus_Name: ECM7 Alias_Name: ZRG15 Description: Non-essential putative integral membrane protein; mutant has cell wall defects; transcription is induced under conditions of zinc deficiency ORF_Name: YLR443W SGDID: S000004435 Locus_Name: ECM8 Description: Non-essential protein of unknown function ORF_Name: YBR076W SGDID: S000000280 Locus_Name: ECM9 Alias_Name: YKR004C-A Description: Non-essential protein of unknown function ORF_Name: YKR004C SGDID: S000001712 Locus_Name: ECO1 Alias_Name: CTF7 Description: Acetytransferase required for sister chromatid cohesion; modifies Smc3p at DNA replication forks during S-phase; modifies Mcd1p in response to double-strand DNA breaks during G2/M; acetylation of cohesin subunits antagonizes Rad61p ORF_Name: YFR027W SGDID: S000001923 Locus_Name: EDC1 Description: RNA-binding protein, activates mRNA decapping directly by binding to the mRNA substrate and enhancing the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress ORF_Name: YGL222C SGDID: S000003190 Locus_Name: EDC2 Description: RNA-binding protein, activates mRNA decapping directly by binding to the mRNA substrate and enhancing the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress ORF_Name: YER035W SGDID: S000000837 Locus_Name: EDC3 Alias_Name: DCP3|LSM16 Description: Non-essential conserved protein of unknown function, plays a role in mRNA decapping by specifically affecting the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies ORF_Name: YEL015W SGDID: S000000741 Locus_Name: EDE1 Alias_Name: BUD15 Description: Key endocytic protein involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins ORF_Name: YBL047C SGDID: S000000143 Locus_Name: EDS1 Description: Putative zinc cluster protein; YBR033W is not an essential gene Phenotype: Null: calcofluor resistant.. Other phenotypes: Deletion suppresses lysis defect of a swi4 deletion. ORF_Name: YBR033W SGDID: S000000237 Locus_Name: EEB1 Description: Acyl-coenzymeA:ethanol O-acyltransferase responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification ORF_Name: YPL095C SGDID: S000006016 Locus_Name: EFB1 Alias_Name: TEF5 Description: Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site ORF_Name: YAL003W SGDID: S000000003 Locus_Name: EFG1 Alias_Name: YGR272C Description: Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus ORF_Name: YGR271C-A SGDID: S000007608 Locus_Name: EFR3 Description: Non-essential protein of unknown function; exhibits synthetic lethal genetic interactions with PHO85; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies and is phosphorylated ORF_Name: YMR212C SGDID: S000004825 Locus_Name: EFT1 Description: Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin ORF_Name: YOR133W SGDID: S000005659 Locus_Name: EFT2 Description: Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin ORF_Name: YDR385W SGDID: S000002793 Locus_Name: EGD1 Description: Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b ORF_Name: YPL037C SGDID: S000005958 Locus_Name: EGD2 Description: Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes ORF_Name: YHR193C SGDID: S000001236 Locus_Name: EGT2 Description: Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner ORF_Name: YNL327W SGDID: S000005271 Locus_Name: EHD3 Alias_Name: MRP5 Description: 3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis ORF_Name: YDR036C SGDID: S000002443 Locus_Name: EHT1 Description: Acyl-coenzymeA:ethanol O-acyltransferase that plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane Phenotype: Null mutant is viable, temperature sensitive, and contains higher amounts of phosphatidylinositol, phosphatidic acid, and ergosteryl esters ORF_Name: YBR177C SGDID: S000000381 Locus_Name: EIP1 SGDID: S000029157 Locus_Name: EKI1 Description: Ethanolamine kinase, primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway ORF_Name: YDR147W SGDID: S000002554 Locus_Name: ELA1 Description: Elongin A, F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degredation of the RNA Polymerase II subunit RPO21; subunit of the Elongin-Cullin-Socs (ECS) ligase complex ORF_Name: YNL230C SGDID: S000005174 Locus_Name: ELC1 Description: Elongin C, involved in transcription elongation as a heterodimer with Ela1p; required for ubiquitin-dependent degradation of Rpo21p; plays a role in global genomic nucleotide excision repair; expression highly upregulated during sporulation Phenotype: The deletion mutant is not sensitive to UV damage, however the elc1 rad23 double mutant is more UV sensitive than the rad23 mutant alone. ORF_Name: YPL046C SGDID: S000005967 Locus_Name: ELF1 Description: Transcription elongation factor that contains a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression ORF_Name: YKL160W SGDID: S000001643 Locus_Name: ELG1 Alias_Name: RTT110 Description: Protein required for S phase progression and telomere homeostasis, forms an alternative replication factor C complex important for DNA replication and genome integrity; involved in homologous recombination-mediated DNA repair ORF_Name: YOR144C SGDID: S000005670 Locus_Name: ELM1 Alias_Name: LDB9 Description: Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases; forms part of the bud neck ring ORF_Name: YKL048C SGDID: S000001531 Locus_Name: ELO1 Description: Elongase I, medium-chain acyl elongase, catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids Phenotype: Null mutant is viable, but shows no growth on media supplemented with less than 16-C saturated fatty acid in a fatty acid synthase minus background ORF_Name: YJL196C SGDID: S000003732 Locus_Name: ELP2 Alias_Name: KTI3|TOT2 Description: Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin ORF_Name: YGR200C SGDID: S000003432 Locus_Name: ELP3 Alias_Name: HPA1|KTI8|TOT3 Description: Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin Gene_Product: KAT9 ORF_Name: YPL086C SGDID: S000006007 Locus_Name: ELP4 Alias_Name: HAP1|KTI9|TOT7 Description: Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity ORF_Name: YPL101W SGDID: S000006022 Locus_Name: ELP6 Alias_Name: HAP3|KTI4|TOT6 Description: Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity ORF_Name: YMR312W SGDID: S000004929 Locus_Name: EMC1 Description: Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p ORF_Name: YCL045C SGDID: S000000550 Locus_Name: EMC2 Description: Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response ORF_Name: YJR088C SGDID: S000003848 Locus_Name: EMC4 Description: Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; human ortholog TMEM85 may function in apoptosis ORF_Name: YGL231C SGDID: S000003200 Locus_Name: EMC6 Description: Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response ORF_Name: YLL014W SGDID: S000003937 Locus_Name: EMG1 Alias_Name: NEP1 Description: Member of the alpha/beta knot fold methyltransferase superfamily; required for maturation of 18S rRNA and for 40S ribosome production; interacts with RNA and with S-adenosylmethionine; associates with spindle/microtubules; forms homodimers ORF_Name: YLR186W SGDID: S000004176 Locus_Name: EMI1 Description: Non-essential protein required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs ORF_Name: YDR512C SGDID: S000002920 Locus_Name: EMI2 Description: Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression is regulated by glucose-repression transcription factors Mig1/2p ORF_Name: YDR516C SGDID: S000002924 Locus_Name: EMI5 Alias_Name: SDH5 Description: Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma) ORF_Name: YOL071W SGDID: S000005432 Locus_Name: EMP24 Alias_Name: BST2 Description: Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport ORF_Name: YGL200C SGDID: S000003168 Locus_Name: EMP46 Description: Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport ORF_Name: YLR080W SGDID: S000004070 Locus_Name: EMP47 Description: Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport ORF_Name: YFL048C SGDID: S000001846 Locus_Name: EMP70 Alias_Name: TMN1|p24a Description: Protein with a role in cellular adhesion and filamentous growth; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments; 24kDa cleavage product found in endosome-enriched membrane fractions ORF_Name: YLR083C SGDID: S000004073 Locus_Name: EMT1 Description: tRNA-Met; tRNA that accepts methionine, functions in translational elongation but not translational initiation Phenotype: Anticodon mutation (CAT->CAG) confers defects in pre-mRNA processing. SGDID: S000006659 Locus_Name: EMT2 Description: tRNA-Met; tRNA that accepts methionine, functions in translational elongation but not translational initiation SGDID: S000006666 Locus_Name: EMT3 Description: tRNA-Met; tRNA that accepts methionine, functions in translational elongation but not translational initiation SGDID: S000006662 Locus_Name: EMT4 Description: tRNA-Met; tRNA that accepts methionine, functions in translational elongation but not translational initiation SGDID: S000006664 Locus_Name: EMT5 Description: tRNA-Met; tRNA that accepts methionine, functions in translational elongation but not translational initiation SGDID: S000006661 Locus_Name: ENA1 Alias_Name: HOR6|PMR2 Description: P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance Phenotype: Null mutant is sensitive to Na+ ORF_Name: YDR040C SGDID: S000002447 Locus_Name: ENA2 Description: P-type ATPase sodium pump, involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux Phenotype: Null mutant is viable and sensitive to Na+, Li+, and alkaline pH ORF_Name: YDR039C SGDID: S000002446 Locus_Name: ENA5 Description: Protein with similarity to P-type ATPase sodium pumps, member of the Na+ efflux ATPase family ORF_Name: YDR038C SGDID: S000002445 Locus_Name: ENA6 Description: Plasma membrane sodium-pumping ATPase; the ENA6 gene is found in the PMR2 locus in the CEN.PK113-7D strain of S. cerevisiae, where other common lab strains have a varying number of the ENA genes (ENA1-ENA5) at the same locus SGDID: S000130715 Locus_Name: ENB1 Alias_Name: ARN4 Description: Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment ORF_Name: YOL158C SGDID: S000005518 Locus_Name: END10 Phenotype: end10 mutants are synthetically lethal with vat2/vma2 mutants SGDID: S000029158 Locus_Name: END3 Description: EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p Phenotype: Null mutant is viable and defective in endocytosis ORF_Name: YNL084C SGDID: S000005028 Locus_Name: ENO1 Alias_Name: HSP48 Description: Enolase I, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose Gene_Product: enolase ORF_Name: YGR254W SGDID: S000003486 Locus_Name: ENO2 Description: Enolase II, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is induced in response to glucose Gene_Product: enolase ORF_Name: YHR174W SGDID: S000001217 Locus_Name: ENP1 Alias_Name: MEG1 Description: Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus ORF_Name: YBR247C SGDID: S000000451 Locus_Name: ENP2 Description: Essential nucleolar protein of unknown function; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p ORF_Name: YGR145W SGDID: S000003377 Locus_Name: ENS2 Alias_Name: Endo.SceI|RF3 Description: Mitochondrially-encoded 50 kD subunit of Endo.SceI, a dimeric multi-site-specific endonuclease that introduces double-stranded breaks at a number of well-defined sites on the mitochondrial DNA, inducing homologous recombination SGDID: S000029698 Locus_Name: ENT1 Description: Epsin-like protein involved in endocytosis and actin patch assembly and functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus Phenotype: Null mutant is viable, synthetically lethal with ent2 (YLR206w). ent1/2 double mutants have endocytosis and actin cytoskeleton defects. ORF_Name: YDL161W SGDID: S000002320 Locus_Name: ENT2 Description: Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus Phenotype: Null mutant is viable; synthetically lethal with ent1 (YDL161w). ent2/1 double mutants have endocytosis and actin cytoskeleton defects. ORF_Name: YLR206W SGDID: S000004196 Locus_Name: ENT3 Description: Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p ORF_Name: YJR125C SGDID: S000003886 Locus_Name: ENT4 Description: Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome ORF_Name: YLL038C SGDID: S000003961 Locus_Name: ENT5 Description: Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin ORF_Name: YDR153C SGDID: S000002560 Locus_Name: ENV7 ORF_Name: YPL236C SGDID: S000006157 Locus_Name: EOS1 Description: Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene ORF_Name: YNL080C SGDID: S000005024 Locus_Name: EPL1 Description: Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb ORF_Name: YFL024C SGDID: S000001870 Locus_Name: EPS1 Description: ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family ORF_Name: YIL005W SGDID: S000001267 Locus_Name: EPT1 Description: sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability ORF_Name: YHR123W SGDID: S000001165 Locus_Name: ERB1 Description: Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1 ORF_Name: YMR049C SGDID: S000004652 Locus_Name: ERD1 Alias_Name: LDB2 Description: Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p) Phenotype: disruption of the retention system for ER proteins; defects in the Golgi-dependent modification of glycoproteins|exhibits defects in N-glycosylation of proteins ORF_Name: YDR414C SGDID: S000002822 Locus_Name: ERD2 Description: HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins ORF_Name: YBL040C SGDID: S000000136 Locus_Name: ERF2 Description: Subunit of a palmitoyltransferase, composed of Erf2p and Shr5p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole Phenotype: Null mutant is viable, but has a synthetic growth defect in the absence of RAS2; Deletion of ERF2 results in the reduction of steady-state levels of Ras2p palmitoylation. ORF_Name: YLR246W SGDID: S000004236 Locus_Name: ERG1 Description: Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine Phenotype: Null mutant is inviable when cells are grown under aerobic conditions; erg1 null mutants are viable under anaerobic conditions during which ergosterol is taken up by the cells ORF_Name: YGR175C SGDID: S000003407 Locus_Name: ERG10 Alias_Name: LPB3|TSM0115 Description: Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis Phenotype: Nul mutant is inviable; other mutants are ergosterol biosynthesis defective or nystatin resistant ORF_Name: YPL028W SGDID: S000005949 Locus_Name: ERG11 Alias_Name: CYP51 Description: Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family Phenotype: Null mutant is inviable, erg11 null inviability is suppressed by deletion of ERG3; erg11 mutants are ergosterol biosynthesis defective; many are also nystatin resistant ORF_Name: YHR007C SGDID: S000001049 Locus_Name: ERG12 Alias_Name: RAR1 Description: Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate Phenotype: Null mutant is inviable and unable to grow vegetatively or germinate spores; mutants exhibit increased mitotic stability of plasmids with weak ARS elements. ORF_Name: YMR208W SGDID: S000004821 Locus_Name: ERG13 Alias_Name: HMGS Description: 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis ORF_Name: YML126C SGDID: S000004595 Locus_Name: ERG2 Alias_Name: END11 Description: C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis Phenotype: synthetic lethal with vma2. ORF_Name: YMR202W SGDID: S000004815 Locus_Name: ERG20 Alias_Name: BOT3|FDS1|FPP1 Description: Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis ORF_Name: YJL167W SGDID: S000003703 Locus_Name: ERG201 SGDID: S000029159 Locus_Name: ERG24 Description: C-14 sterol reductase, acts in ergosterol biosynthesis; mutants accumulate the abnormal sterol ignosterol (ergosta-8,14 dienol), and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions Phenotype: Null mutant appears to be inviable in some genetic backgrounds and conditionally lethal in others; erg24 mutations are suppessed by fen1 and fen2 mutations ORF_Name: YNL280C SGDID: S000005224 Locus_Name: ERG25 Description: C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol ORF_Name: YGR060W SGDID: S000003292 Locus_Name: ERG26 Description: C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis ORF_Name: YGL001C SGDID: S000002969 Locus_Name: ERG27 Description: 3-keto sterol reductase, catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs ORF_Name: YLR100W SGDID: S000004090 Locus_Name: ERG28 Alias_Name: BUD18 Description: Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p Phenotype: Null mutant is viable; random budding in diploid null mutants; null cells have an unusual sterol content. ORF_Name: YER044C SGDID: S000000846 Locus_Name: ERG29 Description: Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes ORF_Name: YMR134W SGDID: S000004741 Locus_Name: ERG3 Alias_Name: PSO6|SYR1 Description: C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources Phenotype: Null mutant is inviable; suppresses syringomycin resistant mutant; sensitive to photoactivated 3-carbethoxypsoralen, UV light, radiomimetic mutagens, and oxidative stress ORF_Name: YLR056W SGDID: S000004046 Locus_Name: ERG4 Description: C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol ORF_Name: YGL012W SGDID: S000002980 Locus_Name: ERG5 Alias_Name: CYP61 Description: C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs ORF_Name: YMR015C SGDID: S000004617 Locus_Name: ERG6 Alias_Name: ISE1|LIS1|SED6|VID1 Description: Delta(24)-sterol C-methyltransferase, converts zymosterol to fecosterol in the ergosterol biosynthetic pathway by methylating position C-24; localized to both lipid particles and mitochondrial outer membrane Phenotype: The null mutant is viable, cannot methylate ergosterol precursors at C-24, and lacks ergosterol. The null mutant shows defective conjugation, diminished capacity for transformation, and defective tryptophan uptake. The null mutant is hypersensitive to cycloheximide, Li+, and Na+, sensitive to anthracyclines, dactinomycin, and bretfeldin A, and resistant to nystatin. ORF_Name: YML008C SGDID: S000004467 Locus_Name: ERG7 Description: Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis ORF_Name: YHR072W SGDID: S000001114 Locus_Name: ERG8 Description: Phosphomevalonate kinase, an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate ORF_Name: YMR220W SGDID: S000004833 Locus_Name: ERG9 Description: Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway ORF_Name: YHR190W SGDID: S000001233 Locus_Name: ERI1 Alias_Name: RIN1 Description: Endoplasmic reticulum membrane protein that binds to and inhibits GTP-bound Ras2p at the ER; component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein ORF_Name: YPL096C-A SGDID: S000028423 Locus_Name: ERJ5 Description: Type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response ORF_Name: YFR041C SGDID: S000001937 Locus_Name: ERM6 Description: Vacuolar protein of unknown function; potential Cdc28p substrate ORF_Name: YJR054W SGDID: S000003815 Locus_Name: ERO1 Description: Thiol oxidase required for oxidative protein folding in the endoplasmic reticulum Phenotype: Null mutant is inviable; in ero1-1(ts) mutants newly synthesized carboxypeptidase Y is retained in the ER and lacks disulfide bonds; ero1 mutants are hypersensitive to to the reductant DTT, whereas overexpression of ERO1 confers resistance to DTT, the oxidant diamide can restore growth and secretion in ero1 mutants ORF_Name: YML130C SGDID: S000004599 Locus_Name: ERP1 Description: Protein that forms a heterotrimeric complex with Erp2p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles Phenotype: null mutant is viable; delayed transport of Gas1p and invertase ORF_Name: YAR002C-A SGDID: S000002129 Locus_Name: ERP2 Description: Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles Phenotype: null mutant is viable; delayed transport of Gas1p ORF_Name: YAL007C SGDID: S000000005 Locus_Name: ERP3 Description: Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport ORF_Name: YDL018C SGDID: S000002176 Locus_Name: ERP4 Description: Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport ORF_Name: YOR016C SGDID: S000005542 Locus_Name: ERP5 Description: Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport ORF_Name: YHR110W SGDID: S000001152 Locus_Name: ERP6 Description: Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies ORF_Name: YGL002W SGDID: S000002970 Locus_Name: ERR1 Description: Protein of unknown function, has similarity to enolases ORF_Name: YOR393W SGDID: S000005920 Locus_Name: ERR2 Description: Protein of unknown function, has similarity to enolases ORF_Name: YPL281C SGDID: S000006202 Locus_Name: ERR3 Description: Protein of unknown function, has similarity to enolases ORF_Name: YMR323W SGDID: S000004942 Locus_Name: ERS1 Description: Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains ORF_Name: YCR075C SGDID: S000000671 Locus_Name: ERT1 Description: Transcriptional regulator of nonfermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition ORF_Name: YBR239C SGDID: S000000443 Locus_Name: ERV1 Description: Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as part of a disulfide relay system that promotes IMS retention of imported proteins; ortholog of human hepatopoietin (ALR) Phenotype: Null mutant is inviable; mutants demonstrate defects in mitochondrial biogenesis ORF_Name: YGR029W SGDID: S000003261 Locus_Name: ERV14 Description: Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon Phenotype: Null mutant is viable but exhibits defects in sporulation (diploids) and bud site selection (haploids). Null mutants also retain the bud site selection marker, Axl2p, in the ER and exhibit slow recovery from selective to rich media. ORF_Name: YGL054C SGDID: S000003022 Locus_Name: ERV15 Description: Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p ORF_Name: YBR210W SGDID: S000000414 Locus_Name: ERV2 Description: Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER Phenotype: Deletion of ERV2 or depletion of Erv2p by regulated gene expression is not associated with any detectable growth defects. ORF_Name: YPR037C SGDID: S000006241 Locus_Name: ERV25 Description: Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport Phenotype: Null mutant is viable, displays a selective defect in transport of secretory proteins from the ER to Golgi complex. ORF_Name: YML012W SGDID: S000004473 Locus_Name: ERV29 Description: Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo ORF_Name: YGR284C SGDID: S000003516 Locus_Name: ERV41 Description: Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein ORF_Name: YML067C SGDID: S000004532 Locus_Name: ERV46 Alias_Name: FUN9 Description: Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport ORF_Name: YAL042W SGDID: S000000040 Locus_Name: ESA1 Alias_Name: TAS1 Description: Catalytic subunit of the histone acetyltransferase complex (NuA4) that acetylates four conserved internal lysines of histone H4 N-terminal tail; required for cell cycle progression and transcriptional silencing at the rDNA locus Gene_Product: KAT5 ORF_Name: YOR244W SGDID: S000005770 Locus_Name: ESBP6 Alias_Name: MCH3 Description: Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane ORF_Name: YNL125C SGDID: S000005069 Locus_Name: ESC1 Description: Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p ORF_Name: YMR219W SGDID: S000004832 Locus_Name: ESC2 Description: Protein involved in silencing; may recruit or stabilize Sir proteins; role in Rad51-dependent homologous recombination repair and intra S-phase DNA damage checkpoint; member of the RENi (Rad60-Esc2-Nip45) family of SUMO-like domain proteins ORF_Name: YDR363W SGDID: S000002771 Locus_Name: ESC3 Description: escape of sugars control SGDID: S000029160 Locus_Name: ESC8 Description: Protein involved in telomeric and mating-type locus silencing, interacts with Sir2p and also interacts with the Gal11p, which is a component of the RNA pol II mediator complex Phenotype: Null: Viable, HMR silencing defect ORF_Name: YOL017W SGDID: S000005377 Locus_Name: ESF1 Description: Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels ORF_Name: YDR365C SGDID: S000002773 Locus_Name: ESF2 Alias_Name: ABT1 Description: Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome ORF_Name: YNR054C SGDID: S000005337 Locus_Name: ESL1 Description: Putative protein of unknown function, predicted to contain a PINc domain ORF_Name: YIL151C SGDID: S000001413 Locus_Name: ESL2 Description: Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; predicted to contain a PINc domain ORF_Name: YKR096W SGDID: S000001804 Locus_Name: ESP1 Description: Separase, a caspase-like cysteine protease that promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p Phenotype: Null mutant is inviable, produces extra spindle pole bodies, shows disrupted cell cycle control ORF_Name: YGR098C SGDID: S000003330 Locus_Name: ESS1 Alias_Name: PIN1|PTF1 Description: Peptidylprolyl-cis/trans-isomerase (PPIase) specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNA polymerase II large subunit (Rpo21p) C-terminal domain Phenotype: Null mutant is inviable; arrest phenotype of mitotic arrest and nuclear fragmentation ORF_Name: YJR017C SGDID: S000003778 Locus_Name: EST1 Description: TLC1 RNA-associated factor involved in telomere length regulation as the recruitment subunit of the telomerase holoenzyme, has a possible role in activating Est2p-TLC1-RNA bound to the telomere ORF_Name: YLR233C SGDID: S000004223 Locus_Name: EST2 Alias_Name: TERT Description: Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia Phenotype: Null mutant is viable, exhibits progressively shorter telomeres, cellular senescence and a telomerase-minus defect; est2 rad52 mutants are inviable ORF_Name: YLR318W SGDID: S000004310 Locus_Name: EST3 Description: Component of the telomerase holoenzyme, involved in telomere replication Phenotype: Null mutant shows progressively shorter telomeres and cellular senescence; telomerase activity is still present in est3-* extracts ORF_Name: YIL009C-A SGDID: S000006432 Locus_Name: ETC1 Description: Locus of unknown function that is associated with the TFIIIC component Tfc4p, located between the two divergently transcribed genes ADE8 and SIZ1 SGDID: S000077072 Locus_Name: ETC2 Description: Locus of unknown function that is associated with the TFIIIC component Tfc4p, located upstream of ARG8 SGDID: S000077073 Locus_Name: ETC3 Description: Locus of unknown function that is associated with the TFIIIC component Tfc4p, located upstream of BCK1 SGDID: S000077074 Locus_Name: ETC4 Description: Locus of unknown function that is associated with the TFIIIC component Tfc4p, located upstream of RAD2 SGDID: S000077075 Locus_Name: ETC5 Description: Locus of unknown function that is associated with the TFIIIC component Tfc4p, located upstream of RAD14 SGDID: S000077076 Locus_Name: ETC6 Description: Locus of unknown function that is associated with the TFIIIC component Tfc4p, located between the two divergently transcribed genes TFC6 and ESC2 SGDID: S000077077 Locus_Name: ETC7 Description: Locus of unknown function that is associated with the TFIIIC component Tfc4p, located between the two divergently transcribed genes WTM2 and YOR228C SGDID: S000077078 Locus_Name: ETC8 Description: Locus of unknown function that is associated with the TFIIIC component Tfc4p, located between the two divergently transcribed genes RPB5 and CNS1 SGDID: S000077079 Locus_Name: ETH3 Description: affects methionine biosynthesis Phenotype: Ethionine resistant SGDID: S000029161 Locus_Name: ETP1 Alias_Name: BRP2 Description: Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences ORF_Name: YHL010C SGDID: S000001002 Locus_Name: ETR1 Alias_Name: MRF1|MRF1' Description: 2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis Gene_Product: 2-enoyl thioester reductase, E.C. 1.3.1.- ORF_Name: YBR026C SGDID: S000000230 Locus_Name: ETS1-1 Alias_Name: 5' ETS Description: Non-coding region located immediately upstream of RDN18, that is transcribed as part of the 35S rRNA precursor transcript; contains an essential U3 snoRNA binding site required for maturation of 18S rRNA SGDID: S000029717 Locus_Name: ETS1-2 Alias_Name: 5' ETS Description: Non-coding region located immediately upstream of RDN18, transcribed as part of the 35S rRNA precursor transcript; contains an essential U3 snoRNA binding site required for maturation of 18S rRNA SGDID: S000029707 Locus_Name: ETS2-1 Alias_Name: 3' ETS Description: Non-coding region located adjacent to and downstream of RDN25, transcribed as part of the 35S rRNA precursor transcript; contains the primary rRNA transcription termination site at +93 and a secondary termination site between +211 and +250 SGDID: S000029718 Locus_Name: ETS2-2 Alias_Name: 3' ETS Description: Non-coding region located adjacent to RDN25, transcribed as part of the 35S rRNA precursor transcript; contains the primary rRNA transcription termination site at +93 and a secondary termination site between +211 and +250 SGDID: S000029713 Locus_Name: EUG1 Description: Protein disulfide isomerase of the endoplasmic reticulum lumen, function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER ORF_Name: YDR518W SGDID: S000002926 Locus_Name: EXA2 Description: extragenic suppressor of hsp70 subfamily A Phenotype: affect regulation of the stress response SGDID: S000029162 Locus_Name: EXG1 Alias_Name: BGL1 Description: Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes Phenotype: Null mutant is viable, displays modest increase in killer toxin sensitivity and beta 1,6-glucan levels ORF_Name: YLR300W SGDID: S000004291 Locus_Name: EXG2 Description: Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor ORF_Name: YDR261C SGDID: S000002669 Locus_Name: EXO1 Alias_Name: DHS1 Description: 5'-3' exonuclease and flap-endonuclease involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains Phenotype: Mutants demonstrate sensitivity to cycloheximide, bleomycin, actinomycin D, 5-fluorouracil, and several other antibiotics, as well as irregular shapes and sensitivity to zymolase digestion ORF_Name: YOR033C SGDID: S000005559 Locus_Name: EXO70 Description: Subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which directs secretory vesicles to active sites of exocytosis; acts with Sec3p in membrane targeting of the exocyst via PI(4,5)P2 binding ORF_Name: YJL085W SGDID: S000003621 Locus_Name: EXO84 Alias_Name: USA3 Description: Essential protein with dual roles in spliceosome assembly and exocytosis; the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p) mediates polarized targeting of secretory vesicles to active sites of exocytosis Phenotype: Null mutant is inviable, defective in secretion ORF_Name: YBR102C SGDID: S000000306 Locus_Name: FAA1 Description: Long chain fatty acyl-CoA synthetase with a preference for C12:0-C16:0 fatty acids; involved in the activation of imported fatty acids; localized to both lipid particles and mitochondrial outer membrane; essential for stationary phase Phenotype: Null mutant is viable as long as fatty acid synthase (fas) complex is active ORF_Name: YOR317W SGDID: S000005844 Locus_Name: FAA2 Alias_Name: FAM1 Description: Long chain fatty acyl-CoA synthetase; accepts a wider range of acyl chain lengths than Faa1p, preferring C9:0-C13:0; involved in the activation of endogenous pools of fatty acids Phenotype: Not essential for vegetative growth when fatty acid synthase (fas) is active ORF_Name: YER015W SGDID: S000000817 Locus_Name: FAA3 Description: Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery Phenotype: Not essential for vegetative growth when fatty acid synthase (fas) is active ORF_Name: YIL009W SGDID: S000001271 Locus_Name: FAA4 Description: Long chain fatty acyl-CoA synthetase, regulates protein modification during growth in the presence of ethanol, functions to incorporate palmitic acid into phospholipids and neutral lipids Phenotype: Not essential for vegetative growth when fatty acid synthase (fas) is active ORF_Name: YMR246W SGDID: S000004860 Locus_Name: FAB1 Alias_Name: SVL7 Description: 1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis Phenotype: Null mutant is temperature-sensitive. Mutation causes pleiotropic effects on nuclear migration and orientation, and separation of mitotic chromosomes (forms aploid and binucleate cells); has defects in vacuolar function and morphology. ORF_Name: YFR019W SGDID: S000001915 Locus_Name: FAD1 Description: Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin ORF_Name: YDL045C SGDID: S000002203 Locus_Name: FAF1 Description: Protein required for pre-rRNA processing and 40S ribosomal subunit assembly ORF_Name: YIL019W SGDID: S000001281 Locus_Name: FAL1 Description: Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases Phenotype: Null mutant is inviable; when Fal1p is depleted, either in a temperature-sensitive fal1-1 mutant or in glucose medium when Fal1p is under a gal promoter, there is a decrease in 40S ribosomal subunits, and those strains are sensitive to paromomycin and neomycin ORF_Name: YDR021W SGDID: S000002428 Locus_Name: FAP1 Description: Protein that binds to Fpr1p, conferring rapamycin resistance by competing with rapamycin for Fpr1p binding; accumulates in the nucleus upon treatment of cells with rapamycin; has similarity to D. melanogaster shuttle craft and human NFX1 Phenotype: Null mutant is viable and shows no phenotype; overexpression confers rapamycin resistance ORF_Name: YNL023C SGDID: S000004968 Locus_Name: FAP7 Description: Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D ORF_Name: YDL166C SGDID: S000002325 Locus_Name: FAR1 Description: Cyclin-dependent kinase inhibitor that mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate ORF_Name: YJL157C SGDID: S000003693 Locus_Name: FAR10 Description: Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate Phenotype: Null: Defective for pheromone-induced G1 arrest ORF_Name: YLR238W SGDID: S000004228 Locus_Name: FAR11 Description: Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far10p; has similarity to the N- and C-termini of N. crassa HAM-2 Phenotype: Null: Defective for pheromone-induced G1 arrest ORF_Name: YNL127W SGDID: S000005071 Locus_Name: FAR3 Description: Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum Phenotype: Null mutant does not arrest in G1 in response to pheromone but does have an intact signal transduction pathway leading to FAR1 transcriptional induction ORF_Name: YMR052W SGDID: S000004656 Locus_Name: FAR7 Description: Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p Phenotype: Null: Defective for pheromone-induced G1 arrest ORF_Name: YFR008W SGDID: S000001904 Locus_Name: FAR8 Description: Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p Phenotype: Null: Defective for pheromone-induced G1 arrest ORF_Name: YMR029C SGDID: S000004631 Locus_Name: FAS1 Description: Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities ORF_Name: YKL182W SGDID: S000001665 Locus_Name: FAS2 Description: Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains beta-ketoacyl reductase and beta-ketoacyl synthase activities; phosphorylated Phenotype: Fatty acid synthetase deficient ORF_Name: YPL231W SGDID: S000006152 Locus_Name: FAT1 Description: Fatty acid transporter and very long-chain fatty acyl-CoA synthetase, may form a complex with Faa1p or Faa4p that imports and activates exogenous fatty acids Phenotype: Null mutant is viable, but is Ole- in presence of cerulenin (i.e., unable to grow on YPD supplemented with oleic acid and cerulenin) ORF_Name: YBR041W SGDID: S000000245 Locus_Name: FAU1 Description: 5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis Phenotype: Null mutant is viable, but is unable to utilize folinic acid in place of folic acid. ORF_Name: YER183C SGDID: S000000985 Locus_Name: FBA1 Alias_Name: LOT1 Description: Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress Phenotype: Null mutant is viable, lacks aldolase enzymatic activity and fails to grow in media containing as a carbon source metabolites of only one side of the aldolase reaction ORF_Name: YKL060C SGDID: S000001543 Locus_Name: FBP1 Alias_Name: ACN8 Description: Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; interacts with Vid30p Phenotype: unable to grow with ethanol ORF_Name: YLR377C SGDID: S000004369 Locus_Name: FBP26 Description: Fructose-2,6-bisphosphatase, required for glucose metabolism Phenotype: Null mutant lacks fructose-2,6-biphosphatase activity but can grow on glucose, fructose, galactose, pyruvate, glycerol and lactate ORF_Name: YJL155C SGDID: S000003691 Locus_Name: FCF1 Alias_Name: UTP24 Description: Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p ORF_Name: YDR339C SGDID: S000002747 Locus_Name: FCF2 Description: Essential nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon ORF_Name: YLR051C SGDID: S000004041 Locus_Name: FCJ1 Alias_Name: AIM28|FMP13 Description: Mitochondrial inner membrane protein involved in formation and molecular structure of crista junctions; impairs oligomerization of F1F0-ATP synthase; null shows altered mitochondrial morphology and abnormal mitochondrial genome maintenance ORF_Name: YKR016W SGDID: S000001724 Locus_Name: FCP1 Description: Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p) ORF_Name: YMR277W SGDID: S000004890 Locus_Name: FCY1 Alias_Name: yCD Description: Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU) ORF_Name: YPR062W SGDID: S000006266 Locus_Name: FCY2 Alias_Name: BRA7 Description: Purine-cytosine permease, mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation ORF_Name: YER056C SGDID: S000000858 Locus_Name: FCY21 Description: Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function ORF_Name: YER060W SGDID: S000000862 Locus_Name: FCY22 Description: Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function ORF_Name: YER060W-A SGDID: S000002958 Locus_Name: FDH1 Description: NAD(+)-dependent formate dehydrogenase, may protect cells from exogenous formate ORF_Name: YOR388C SGDID: S000005915 Locus_Name: FDH2 Description: NAD(+)-dependent formate dehydrogenase, may protect cells from exogenous formate; YPL275W and YPL276W comprise a continuous open reading frame in some S. cerevisiae strains but not in the genomic reference strain S288C SGDID: S000006196 Locus_Name: FEN1 Alias_Name: ELO2|GNS1|VBM2 Description: Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway Phenotype: Null mutant is viable; slow growth; fenpropimorph resistant; resistant to a pneumocandin B0 analog (L-733,560); mating and sporulation defects; synthetic lethality with ELO3 ORF_Name: YCR034W SGDID: S000000630 Locus_Name: FEN2 Description: Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph ORF_Name: YCR028C SGDID: S000000623 Locus_Name: FES1 Description: Hsp70 (Ssa1p) nucleotide exchange factor, cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum Phenotype: Null mutant is thermosensitive. Other phenotypes: cycloheximide sensitive. ORF_Name: YBR101C SGDID: S000000305 Locus_Name: FET1 SGDID: S000029163 Locus_Name: FET3 Description: Ferro-O2-oxidoreductase required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases Phenotype: The null mutant is viable but defective for high affinity Fe(II) uptake. The null mutant is inviable when environmental iron is limiting. ORF_Name: YMR058W SGDID: S000004662 Locus_Name: FET4 Description: Low-affinity Fe(II) transporter of the plasma membrane Phenotype: Mutant lacks low affinity Fe(II) transport but has more active high affinity Fe(II) transport activity ORF_Name: YMR319C SGDID: S000004938 Locus_Name: FET5 Description: Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport Phenotype: overexpression of FET5 suppresses a fet3 null mutant. ORF_Name: YFL041W SGDID: S000001853 Locus_Name: FHL1 Alias_Name: SPP42 Description: Transcriptional activator with similarity to DNA-binding domain of Drosophila forkhead but unable to bind DNA in vitro; required for rRNA processing; isolated as a suppressor of splicing factor prp4 Phenotype: Null mutant shows reduced growth rate and lower rRNA content ORF_Name: YPR104C SGDID: S000006308 Locus_Name: FIG1 Description: Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating Phenotype: Null mutant is viable, deficient in mating ORF_Name: YBR040W SGDID: S000000244 Locus_Name: FIG2 Description: Cell wall adhesin, expressed specifically during mating; may be involved in maintenance of cell wall integrity during mating Phenotype: Null mutant is viable, deficient in mating under non-optimal conditions ORF_Name: YCR089W SGDID: S000000685 Locus_Name: FIG4 Description: Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain Phenotype: Null mutant is viable, mating defective ORF_Name: YNL325C SGDID: S000005269 Locus_Name: FIM1 SGDID: S000029164 Locus_Name: FIN1 Description: Spindle pole body-related intermediate filament protein, forms cell cycle-specific filaments between spindle pole bodies in mother and daughter cells, able to self-assemble, expression induced during S/G2, localization cell-cycle dependent ORF_Name: YDR130C SGDID: S000002537 Locus_Name: FIP1 Description: Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity Phenotype: Null mutant is inviable. At restrictive temperature, a temperature-sensitive mutant shows shortening of poly(A) tails ORF_Name: YJR093C SGDID: S000003853 Locus_Name: FIR1 Alias_Name: PIP1 Description: Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate Phenotype: Null mutant is viable, shows slow growth in all media ORF_Name: YER032W SGDID: S000000834 Locus_Name: FIS1 Alias_Name: MDV2 Description: Protein involved in mitochondrial membrane fission and peroxisome abundance; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation Phenotype: Null mutant is viable, mitochondrial fission blocked, mitochondrial membranes form nets ORF_Name: YIL065C SGDID: S000001327 Locus_Name: FIT1 Description: Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall Phenotype: Impaired siderophore-iron uptake, activation of the major iron-dependent transcription factor AFT1. ORF_Name: YDR534C SGDID: S000002942 Locus_Name: FIT2 Description: Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall ORF_Name: YOR382W SGDID: S000005909 Locus_Name: FIT3 Description: Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall ORF_Name: YOR383C SGDID: S000005910 Locus_Name: FKH1 Description: Forkhead family transcription factor with a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; regulates donor preference during switching ORF_Name: YIL131C SGDID: S000001393 Locus_Name: FKH2 Description: Forkhead family transcription factor with a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase ORF_Name: YNL068C SGDID: S000005012 Locus_Name: FKR1 Description: FK506 resistant Phenotype: resistant to FK506 SGDID: S000029165 Locus_Name: FKR2 Description: FK506 resistant Phenotype: resistant to FK506 SGDID: S000029166 Locus_Name: FKR3 Description: FK506 resistant Phenotype: resistant to FK506 SGDID: S000029167 Locus_Name: FKS1 Alias_Name: CND1|CWH53|ETG1|GSC1|PBR1 Description: Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling Phenotype: Null mutant is viable, demonstrates slow growth, hypersensitivity to FK506 and cyclosporin A, sensitivity to echinocandin and a reduction in 1,3-beta-D-glucan synthase activity in vitro; sensitivity to papulacandin B ORF_Name: YLR342W SGDID: S000004334 Locus_Name: FKS3 Description: Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies ORF_Name: YMR306W SGDID: S000004923 Locus_Name: FLC1 Alias_Name: BOP1|HUF1 Description: Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance ORF_Name: YPL221W SGDID: S000006142 Locus_Name: FLC2 Alias_Name: HUF2 Description: Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance ORF_Name: YAL053W SGDID: S000000049 Locus_Name: FLC3 Alias_Name: HUF3 Description: Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER ORF_Name: YGL139W SGDID: S000003107 Locus_Name: FLD1 Alias_Name: SEI1 Description: Seipin protein involved in lipid droplet morphology, number, and size; proposed to be involved in lipid metabolism; related to the human BSCL2 which is associated with lipodystrophy Gene_Product: seipin ORF_Name: YLR404W SGDID: S000004396 Locus_Name: FLO1 Alias_Name: FLO2|FLO4 Description: Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p Phenotype: Flocculation ORF_Name: YAR050W SGDID: S000000084 Locus_Name: FLO10 Description: Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation ORF_Name: YKR102W SGDID: S000001810 Locus_Name: FLO5 Description: Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p Phenotype: Mutations in FLO5 appear to have no effect on filamentous growth. ORF_Name: YHR211W SGDID: S000001254 Locus_Name: FLO8 Alias_Name: PHD5|YER108C Description: Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene Phenotype: Null mutant is viable; wild-type gene is required for flocculation and for pseudo-hyphal growth ORF_Name: YER109C SGDID: S000000911 Locus_Name: FLO9 Description: Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation ORF_Name: YAL063C SGDID: S000000059 Locus_Name: FLP1 Description: Site-specific recombinase encoded on the 2-micron plasmid, required for 2-micron plasmid propagation as part of a plasmid amplification system that compensates for any copy number decreases caused by missegregation events ORF_Name: R0010W SGDID: S000029654 Locus_Name: FLR1 Description: Plasma membrane multidrug transporter of the major facilitator superfamily, involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin Phenotype: Null mutant is viable; overexpression confers resistance to fluconazole, cycloheximide, 4-nitroquinoline N-oxide ORF_Name: YBR008C SGDID: S000000212 Locus_Name: FLS1 Phenotype: fails to grow in the presence of 30 mg of fluphenazine per ml SGDID: S000029168 Locus_Name: FLX1 Description: Protein required for transport of flavin adenine dinucleotide (FAD), a synthesis product of riboflavin, across the mitochondrial membrane ORF_Name: YIL134W SGDID: S000001396 Locus_Name: FMC1 Description: Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p Phenotype: Null mutant is viable and shows growth deficiency on non-fermentable carbon sources at 37 degrees C ORF_Name: YIL098C SGDID: S000001360 Locus_Name: FMN1 Description: Riboflavin kinase, phosphorylates riboflavin to form riboflavin monophosphate (FMN), which is a necessary cofactor for many enzymes; localizes to microsomes and to the mitochondrial inner membrane ORF_Name: YDR236C SGDID: S000002644 Locus_Name: FMO1 Description: Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins ORF_Name: YHR176W SGDID: S000001219 Locus_Name: FMP10 Description: Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies ORF_Name: YER182W SGDID: S000000984 Locus_Name: FMP16 Description: Putative protein of unknown function; proposed to be involved in responding to conditions of stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies ORF_Name: YDR070C SGDID: S000002477 Locus_Name: FMP21 Description: Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies ORF_Name: YBR269C SGDID: S000000473 Locus_Name: FMP23 Description: Putative protein of unknown function; proposed to be involved in iron or copper homeostatis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies ORF_Name: YBR047W SGDID: S000000251 Locus_Name: FMP25 Description: Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies ORF_Name: YLR077W SGDID: S000004067 Locus_Name: FMP27 Description: Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies ORF_Name: YLR454W SGDID: S000004446 Locus_Name: FMP30 Description: Protein of unknown function proposed to be involved in N-acylethanolamine metabolism; related to human NAPE-selective phospholipase D enzyme; native protein is detected in highly purified mitochondria in high-throughput studies ORF_Name: YPL103C SGDID: S000006024 Locus_Name: FMP32 Description: Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies ORF_Name: YFL046W SGDID: S000001848 Locus_Name: FMP33 Description: Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies ORF_Name: YJL161W SGDID: S000003697 Locus_Name: FMP37 Description: Putative protein of unknown function; highly conserved across species and orthologous to human gene BRP44L; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies ORF_Name: YGL080W SGDID: S000003048 Locus_Name: FMP40 Description: Putative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies ORF_Name: YPL222W SGDID: S000006143 Locus_Name: FMP41 Description: Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies ORF_Name: YNL168C SGDID: S000005112 Locus_Name: FMP42 Description: Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy ORF_Name: YMR221C SGDID: S000004834 Locus_Name: FMP43 Description: Putative protein of unknown function; expression regulated by osmotic and alkaline stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies ORF_Name: YGR243W SGDID: S000003475 Locus_Name: FMP45 Description: Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C ORF_Name: YDL222C SGDID: S000002381 Locus_Name: FMP46 Description: Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies ORF_Name: YKR049C SGDID: S000001757 Locus_Name: FMP48 Description: Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation ORF_Name: YGR052W SGDID: S000003284 Locus_Name: FMP49 Description: Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria ORF_Name: YER038W-A SGDID: S000028746 Locus_Name: FMP52 Description: Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation ORF_Name: YER004W SGDID: S000000806 Locus_Name: FMS1 Description: Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis ORF_Name: YMR020W SGDID: S000004622 Locus_Name: FMT1 Description: Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate Gene_Product: methionyl-tRNA transformylase Phenotype: Null mutant is viable and lacks mitochondrial formyl-Met-tRNA ORF_Name: YBL013W SGDID: S000000109 Locus_Name: FOB1 Alias_Name: HRM1 Description: Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases Phenotype: Loss of replication fork blocking and recombinational hotspot activities. ORF_Name: YDR110W SGDID: S000002517 Locus_Name: FOL1 Description: Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities Phenotype: essential, induces pseudohyphal growth ORF_Name: YNL256W SGDID: S000005200 Locus_Name: FOL2 Description: GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway Phenotype: Folinic acid requiring ORF_Name: YGR267C SGDID: S000003499 Locus_Name: FOL3 Description: Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis Phenotype: Null mutant is viable; requires folinic acid for growth ORF_Name: YMR113W SGDID: S000004719 Locus_Name: FOX2 Alias_Name: POX2 Description: Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities Phenotype: mutant lacks 2-enoyl-CoA hydratase and D-3-hydroxyacyl-CoA dehydrogenase activities ORF_Name: YKR009C SGDID: S000001717 Locus_Name: FPK1 Description: Ser/Thr protein kinase that regulates the putative phospholipid translocases Lem3p-Dnf1p/Dnf2p; phosphorylates and inhibits upstream inhibitory kinase, Ypk1p; localizes to the cytoplasm, early endosome/TGN compartments, and plasma membrane ORF_Name: YNR047W SGDID: S000005330 Locus_Name: FPR1 Alias_Name: FKB1|RBP1 Description: Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function ORF_Name: YNL135C SGDID: S000005079 Locus_Name: FPR2 Alias_Name: FKB2 Description: Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking ORF_Name: YDR519W SGDID: S000002927 Locus_Name: FPR3 Alias_Name: NPI46 Description: Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p Phenotype: Null mutant is viable; overexpression gives no phenotype except is growth inhibitory in fpr1 mutant; both null mutant and over-expressor show wild-type sensitivity to FK506 and rapamycin; npi46 fpr1 fpr2 triple mutant is viable ORF_Name: YML074C SGDID: S000004539 Locus_Name: FPR4 Description: Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones ORF_Name: YLR449W SGDID: S000004441 Locus_Name: FPS1 Description: Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress ORF_Name: YLL043W SGDID: S000003966 Locus_Name: FRA1 Alias_Name: RUP2 Description: Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation ORF_Name: YLL029W SGDID: S000003952 Locus_Name: FRA2 Alias_Name: AIM15 Description: Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel ORF_Name: YGL220W SGDID: S000003188 Locus_Name: FRE1 Description: Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels Phenotype: Null mutant is viable, fre1-1 mutants are deficient in the uptake of ferric iron and are extremely sensitive to iron deprivation ORF_Name: YLR214W SGDID: S000004204 Locus_Name: FRE2 Description: Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels ORF_Name: YKL220C SGDID: S000001703 Locus_Name: FRE3 Description: Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels ORF_Name: YOR381W SGDID: S000005908 Locus_Name: FRE4 Description: Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels ORF_Name: YNR060W SGDID: S000005343 Locus_Name: FRE5 Description: Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies ORF_Name: YOR384W SGDID: S000005911 Locus_Name: FRE6 Description: Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels ORF_Name: YLL051C SGDID: S000003974 Locus_Name: FRE7 Description: Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels ORF_Name: YOL152W SGDID: S000005512 Locus_Name: FRE8 Description: Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p ORF_Name: YLR047C SGDID: S000004037 Locus_Name: FRM2 Alias_Name: YCLX08C Description: Protein of unknown function, involved in the integration of lipid signaling pathways with cellular homeostasis; expression induced in cells treated with the mycotoxin patulin; has similarity to bacterial nitroreductases Phenotype: Null mutant is viable and sensitive to arachidonic acid ORF_Name: YCL026C-A SGDID: S000000589 Locus_Name: FRO1 Phenotype: Frothing SGDID: S000029169 Locus_Name: FRO2 Phenotype: Frothing SGDID: S000029170 Locus_Name: FRQ1 Description: N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily ORF_Name: YDR373W SGDID: S000002781 Locus_Name: FRS1 Description: Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control Gene_Product: cytoplasmic phenylalanyl-tRNA synthetase beta subunit ORF_Name: YLR060W SGDID: S000004050 Locus_Name: FRS2 Description: Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar Gene_Product: cytoplasmic phenylalanyl-tRNA synthetase alpha subunit ORF_Name: YFL022C SGDID: S000001872 Locus_Name: FRT1 Alias_Name: HPH1 Description: Tail-anchored, endoplasmic reticulum membrane protein that is a substrate of the phosphatase calcineurin, interacts with homolog Frt2p, promotes cell growth in conditions of high Na+, alkaline pH, and cell wall stress ORF_Name: YOR324C SGDID: S000005851 Locus_Name: FRT2 Alias_Name: HPH2 Description: Tail-anchored endoplasmic reticulum membrane protein, interacts with homolog Frt1p but is not a substrate of calcineurin (unlike Frt1p), promotes growth in conditions of high Na+, alkaline pH, or cell wall stress; potential Cdc28p substrate ORF_Name: YAL028W SGDID: S000000026 Locus_Name: FSF1 Description: Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis ORF_Name: YOR271C SGDID: S000005797 Locus_Name: FSH1 Description: Putative serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to S. cerevisiae Fsh2p and Fsh3p and the human candidate tumor suppressor OVCA2 ORF_Name: YHR049W SGDID: S000001091 Locus_Name: FSH2 Description: Putative serine hydrolase that localizes to the cytoplasm; sequence is similar to S. cerevisiae Fsh1p and Fsh3p and the human candidate tumor suppressor OVCA2 ORF_Name: YMR222C SGDID: S000004835 Locus_Name: FSH3 Description: Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; sequence is similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2 ORF_Name: YOR280C SGDID: S000005806 Locus_Name: FSP2 Description: Protein of unknown function, expression is induced during nitrogen limitation ORF_Name: YJL221C SGDID: S000003757 Locus_Name: FSR1 Phenotype: growth arrested at 35 degrees after nuclear division SGDID: S000029171 Locus_Name: FSR2 Phenotype: Fluphenazine-resistant; arrests in G2 at 35 degrees in Ca2+-poor medium SGDID: S000029172 Locus_Name: FTH1 Description: Putative high affinity iron transporter involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis ORF_Name: YBR207W SGDID: S000000411 Locus_Name: FTR1 Description: High affinity iron permease involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron Phenotype: Lacks high affinity iron uptake ORF_Name: YER145C SGDID: S000000947 Locus_Name: FUI1 Description: High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport ORF_Name: YBL042C SGDID: S000000138 Locus_Name: FUM1 Description: Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria ORF_Name: YPL262W SGDID: S000006183 Locus_Name: FUN12 Alias_Name: yIF2 Description: GTPase, required for general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; homolog of bacterial IF2 Gene_Product: eIF5B ORF_Name: YAL035W SGDID: S000000033 Locus_Name: FUN14 Description: Mitochondrial protein of unknown function ORF_Name: YAL008W SGDID: S000000006 Locus_Name: FUN19 Description: Non-essential protein of unknown function; expression induced in response to heat stress ORF_Name: YAL034C SGDID: S000002134 Locus_Name: FUN26 Description: Nucleoside transporter with broad nucleoside selectivity; localized to intracellular membranes ORF_Name: YAL022C SGDID: S000000020 Locus_Name: FUN30 Description: Protein whose overexpression affects chromosome stability, potential Cdc28p substrate; homolog of Snf2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies ORF_Name: YAL019W SGDID: S000000017 Locus_Name: FUR1 Description: Uracil phosphoribosyltransferase, synthesizes UMP from uracil; involved in the pyrimidine salvage pathway ORF_Name: YHR128W SGDID: S000001170 Locus_Name: FUR4 Description: Uracil permease, localized to the plasma membrane; expression is tightly regulated by uracil levels and environmental cues ORF_Name: YBR021W SGDID: S000000225 Locus_Name: FUS1 Description: Membrane protein localized to the shmoo tip, required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrate Phenotype: Null mutant is viable; in fus1 x fus1 matings there is an interruption of the mating process just before cytoplasmic fusion ORF_Name: YCL027W SGDID: S000000532 Locus_Name: FUS2 Description: Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before nuclear fusion during mating Phenotype: Null mutant is viable, fus2 mutants have strong defects in karyogamy and fail to orient microtubules between parental nuclei in zygotes ORF_Name: YMR232W SGDID: S000004845 Locus_Name: FUS3 Alias_Name: DAC2 Description: Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its degradation Phenotype: sterile; divide continuously in the presence of pheromones; form prezygotes with wild-type cells of opposite mating type but cannot undergo cell fusion ORF_Name: YBL016W SGDID: S000000112 Locus_Name: FYV1 Description: Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin Phenotype: Null phenotype is K1 killer toxin hypersensitive ORF_Name: YDR024W SGDID: S000002431 Locus_Name: FYV10 Alias_Name: GID9 Description: Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in proteasome-dependent catabolite inactivation of FBPase; contains CTLH domain; plays role in anti-apoptosis Phenotype: Null mutant is viable but exhibits K1 killer toxin hypersensitivity. ORF_Name: YIL097W SGDID: S000001359 Locus_Name: FYV12 Description: Protein of unknown function, required for survival upon exposure to K1 killer toxin Phenotype: Null mutant is viable but exhibits K1 killer toxin hypersensitivity. ORF_Name: YOR183W SGDID: S000005709 Locus_Name: FYV4 Description: Protein of unknown function, required for survival upon exposure to K1 killer toxin Phenotype: Null phenotype is K1 killer toxin hypersensitive ORF_Name: YHR059W SGDID: S000001101 Locus_Name: FYV5 Description: Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in ion homeostasis Phenotype: Null mutant is viable but exhibits K1 killer toxin hypersensitivity. ORF_Name: YCL058C SGDID: S000000563 Locus_Name: FYV6 Description: Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining Phenotype: Null mutant is K1 killer toxin hypersensitive ORF_Name: YNL133C SGDID: S000005077 Locus_Name: FYV7 Description: Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin ORF_Name: YLR068W SGDID: S000004058 Locus_Name: FYV8 Description: Protein of unknown function, required for survival upon exposure to K1 killer toxin Phenotype: Null phenotype is K1 killer toxin hypersensitive ORF_Name: YGR196C SGDID: S000003428 Locus_Name: FZF1 Alias_Name: NRC299|RSU1|SUL1 Description: Transcription factor involved in sulfite metabolism, sole identified regulatory target is SSU1, overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers ORF_Name: YGL254W SGDID: S000003223 Locus_Name: FZO1 Description: Mitofusin, mitochondrial integral membrane protein involved in mitochondrial fusion and mitochondrial genome maintenance; contains N-terminal GTPase domain; targeted for destruction by cytosolic components of the ubiquitin-proteasome system Phenotype: Null mutant is viable, exhibits a petite phenotype and fragmented mitochondrial morphology ORF_Name: YBR179C SGDID: S000000383 Locus_Name: GAA1 Alias_Name: END2 Description: Subunit of the GPI (glycosylphosphatidylinositol):protein transamidase complex, removes the GPI-anchoring signal and attaches GPI to proteins in the ER ORF_Name: YLR088W SGDID: S000004078 Locus_Name: GAB1 Alias_Name: CDC91 Description: GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI ORF_Name: YLR459W SGDID: S000004451 Locus_Name: GAC1 Description: Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock ORF_Name: YOR178C SGDID: S000005704 Locus_Name: GAD1 Description: Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress ORF_Name: YMR250W SGDID: S000004862 Locus_Name: GAL1 Description: Galactokinase, phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p Phenotype: Null mutant is viable and cannot utilize galactose. ORF_Name: YBR020W SGDID: S000000224 Locus_Name: GAL10 Description: UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers Phenotype: Null mutant is viable and cannot utilize galactose. ORF_Name: YBR019C SGDID: S000000223 Locus_Name: GAL11 Alias_Name: ABE1|MED15|RAR3|SDS4|SPT13 Description: Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors Phenotype: Null mutant is viable, exhibits reduced expression of Gal4 regulated genes ORF_Name: YOL051W SGDID: S000005411 Locus_Name: GAL2 Description: Galactose permease, required for utilization of galactose; also able to transport glucose Phenotype: Galactose non-utilizer ORF_Name: YLR081W SGDID: S000004071 Locus_Name: GAL3 Description: Transcriptional regulator involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity Phenotype: Galactose non-utilizer ORF_Name: YDR009W SGDID: S000002416 Locus_Name: GAL4 Alias_Name: GAL81 Description: DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p Phenotype: Null mutant is viable, cannot utilize galactose as sole carbon source ORF_Name: YPL248C SGDID: S000006169 Locus_Name: GAL7 Description: Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism Phenotype: Null mutant is viable and cannot utilize galactose. ORF_Name: YBR018C SGDID: S000000222 Locus_Name: GAL80 Description: Transcriptional regulator involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding Phenotype: Null mutant is viable but has constitutive expression of the GAL genes. ORF_Name: YML051W SGDID: S000004515 Locus_Name: GAL83 Alias_Name: SPM1 Description: One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain ORF_Name: YER027C SGDID: S000000829 Locus_Name: GAP1 Description: General amino acid permease; localization to the plasma membrane is regulated by nitrogen source Phenotype: abolished activity of the general amino acid transport system ORF_Name: YKR039W SGDID: S000001747 Locus_Name: GAR1 Description: Protein component of the H/ACA snoRNP pseudouridylase complex, involved in the modification and cleavage of the 18S pre-rRNA ORF_Name: YHR089C SGDID: S000001131 Locus_Name: GAS1 Alias_Name: CWH52|GGP1 Description: Beta-1,3-glucanosyltransferase, required for cell wall assembly and also has a role in transcriptional silencing; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor; also found at the nuclear periphery ORF_Name: YMR307W SGDID: S000004924 Locus_Name: GAS2 Description: 1,3-beta-glucanosyltransferase, involved with Gas4p in spore wall assembly; has similarity to Gas1p ORF_Name: YLR343W SGDID: S000004335 Locus_Name: GAS3 Description: Putative 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall ORF_Name: YMR215W SGDID: S000004828 Locus_Name: GAS4 Description: 1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall ORF_Name: YOL132W SGDID: S000005492 Locus_Name: GAS5 Description: 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall ORF_Name: YOL030W SGDID: S000005390 Locus_Name: GAT1 Alias_Name: MEP80|NIL1 Description: Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p ORF_Name: YFL021W SGDID: S000001873 Locus_Name: GAT2 Description: Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine ORF_Name: YMR136W SGDID: S000004744 Locus_Name: GAT3 Description: Protein containing GATA family zinc finger motifs ORF_Name: YLR013W SGDID: S000004003 Locus_Name: GAT4 Description: Protein containing GATA family zinc finger motifs Phenotype: being investigated ORF_Name: YIR013C SGDID: S000001452 Locus_Name: GBP2 Alias_Name: RLF6 Description: Poly(A+) RNA-binding protein, involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Hrb1p and Npl3p; also binds single-stranded telomeric repeat sequence in vitro Phenotype: Mutation alters the distribution of Rap1p, a telomere-associated protein, but has no effect on telomere length or telomere position ORF_Name: YCL011C SGDID: S000000517 Locus_Name: GCD1 Alias_Name: TRA3 Description: Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression Phenotype: affect growth rate under nonstarvation conditions ORF_Name: YOR260W SGDID: S000005786 Locus_Name: GCD10 Alias_Name: TRM6 Description: Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression Gene_Product: 1-methyladenosine tRNA methyltransferase subunit Phenotype: Null mutant is inviable. There are mutants available that show constitutive HIS4 transcription and slow growth ORF_Name: YNL062C SGDID: S000005006 Locus_Name: GCD11 Alias_Name: SUI4 Description: Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met Phenotype: Null mutant is inviable, gcd11 mutants have slower growth rate under nonstarvation conditions ORF_Name: YER025W SGDID: S000000827 Locus_Name: GCD13 Description: Negative regulator of GCN4 expression Phenotype: Slow growth; constitutive expression of GCN4 SGDID: S000029173 Locus_Name: GCD14 Alias_Name: TRM61 Description: Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression Gene_Product: 1-methyladenosine tRNA methyltransferase subunit Phenotype: 3-Aminotriazole resistance; unconditional slow growth ORF_Name: YJL125C SGDID: S000003661 Locus_Name: GCD2 Alias_Name: GCD12 Description: Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression Phenotype: Null mutant is inviable; resistance to 5-methyltryptophan, 5-fluorotryptophan and canavanine; override requirement for GCN2 and GCN3 gene products for derepression of GCN4 constitutive derepression and slow growth; temperature sensitive for growth ORF_Name: YGR083C SGDID: S000003315 Locus_Name: GCD3 Description: Negative regulator gene in general amino acid biosynthetic pathway, possibly upstream of GCN4 Phenotype: Resistant to 5-methyltrytophan, 5-fluorotryptophan and canavanine; slow growth; elevated mRNA levels of genes in amino acid biosynthesis SGDID: S000029174 Locus_Name: GCD4 Description: Negative regulatory gene in general amino acid biosynthetic pathway; upstream of GCN4 Phenotype: Resistant to 5-methyltrytophan, 5-fluorotryptophan and canavanine; slow growth; elevated mRNA levels of genes in amino acid biosynthesis SGDID: S000029175 Locus_Name: GCD6 Description: Catalytic epsilon subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression Phenotype: Null mutant is inviable; non-null mutations increase GCN4 translation ORF_Name: YDR211W SGDID: S000002619 Locus_Name: GCD7 Description: Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression Phenotype: Null mutant is inviable; non-null mutants exhibit an increase in GCN4 translation ORF_Name: YLR291C SGDID: S000004282 Locus_Name: GCDX SGDID: S000029176 Locus_Name: GCE1 Description: cAMP-binding protein; localized to plasma membrane via glycosyl-phosphatidylinositol (GPI)-anchor SGDID: S000123791 Locus_Name: GCN1 Description: Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn20p; proposed to stimulate Gcn2p activation by an uncharged tRNA Phenotype: Null mutant is viable and sensitive to 3-aminotriazole ORF_Name: YGL195W SGDID: S000003163 Locus_Name: GCN2 Alias_Name: AAS1 Description: Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control Phenotype: Null mutant is viable, unable to grow on medium containing 3-aminotriazole (3-AT), a competitive inhibitor of histidine biosynthesis, because it cannot derepress GCN4 and its target genes in the histidine biosynthetic pathway ORF_Name: YDR283C SGDID: S000002691 Locus_Name: GCN20 Description: Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA Phenotype: Null mutant is viable and shows impaired derepression of GCN4 translation and reduced levels of eIF-2 alpha phosphorylation ORF_Name: YFR009W SGDID: S000001905 Locus_Name: GCN3 Alias_Name: AAS2 Description: Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression Phenotype: null mutants fail to derepress amino acid-regulated genes under conditions of amino acid starvation ORF_Name: YKR026C SGDID: S000001734 Locus_Name: GCN4 Alias_Name: AAS3|ARG9 Description: Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels Phenotype: The null mutant is viable but requires arginine on minimal medium and issensitive to 3-amino-1,2,4-triazole. General control of amino acid synthesis non-derepressible in the null mutant. ORF_Name: YEL009C SGDID: S000000735 Locus_Name: GCN5 Alias_Name: ADA4|SWI9 Description: Histone acetyltransferase, acetylates N-terminal lysines on histones H2B and H3; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; founding member of the Gcn5p-related N-acetyltransferase superfamily Gene_Product: KAT2 Phenotype: Null mutant is viable, sensitive to intra-S-phase DNA damage, and grows poorly on minimal media. ORF_Name: YGR252W SGDID: S000003484 Locus_Name: GCN6 Description: Positive regulator of GCN4 transcription Phenotype: Sensitivity to amino acid analogs; decreased mRNA levels of genes under general control of amino acid biosynthesis SGDID: S000029177 Locus_Name: GCN7 Description: Positive regulator of GCN4 transcription Phenotype: Sensitivity to amino acid analogs; decreased mRNA levels of genes under general control of amino acid biosynthesis SGDID: S000029178 Locus_Name: GCN8 Phenotype: Sensitivity to amino acid analogs; decreased mRNA levels of genes under general control of amino acid biosynthesis SGDID: S000029179 Locus_Name: GCN9 Phenotype: Sensitivity to amino acid analogs; decreased mRNA levels of genes under general control of amino acid biosynthesis SGDID: S000029180 Locus_Name: GCR1 Alias_Name: LPF10 Description: Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p Phenotype: Null mutant has a severe growth defect when grown in the presence of glucose, but grows quite well on medium with non-fermentable carbon sources; on permissive medium, the null mutant principally affects the expression of glycolytic enzyme genes and transcripts encoded by Ty elements. Mutant exhibits reduction in the intracellular concentration of enolase and glyceraldehyde-3-phosphate dehydrogenase polypeptides ORF_Name: YPL075W SGDID: S000005996 Locus_Name: GCR2 Description: Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p Phenotype: Null mutant is viable and has partial growth defect on glucose-containing media ORF_Name: YNL199C SGDID: S000005143 Locus_Name: GCS1 Description: ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p ORF_Name: YDL226C SGDID: S000002385 Locus_Name: GCV1 Alias_Name: GSD1 Description: T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm Phenotype: Null mutant is viable but cannot use glycine as sole nitrogen source ORF_Name: YDR019C SGDID: S000002426 Locus_Name: GCV2 Alias_Name: GSD2 Description: P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm Phenotype: Inability to convert glycine to serine (ser1 background); Inability to utilize glycine as a nitogen source. ORF_Name: YMR189W SGDID: S000004801 Locus_Name: GCV3 Description: H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF Phenotype: Null mutant is viable but does not grow if glycine is the sole nitrogen source ORF_Name: YAL044C SGDID: S000000042 Locus_Name: GCY1 Alias_Name: GCY Description: Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) family ORF_Name: YOR120W SGDID: S000005646 Locus_Name: GDA1 Description: Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate ORF_Name: YEL042W SGDID: S000000768 Locus_Name: GDB1 Description: Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria Phenotype: Null mutant is viable but unable to degrade glycogen. ORF_Name: YPR184W SGDID: S000006388 Locus_Name: GDE1 Description: Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes ORF_Name: YPL110C SGDID: S000006031 Locus_Name: GDH1 Alias_Name: DHE4|GDH-A|GDHA|URE1 Description: NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources ORF_Name: YOR375C SGDID: S000005902 Locus_Name: GDH2 Alias_Name: GDH-B|GDHB Description: NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels Phenotype: Null mutant is viable, grows very poorly on glutamate as a nitrogen source ORF_Name: YDL215C SGDID: S000002374 Locus_Name: GDH3 Alias_Name: FUN51 Description: NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources ORF_Name: YAL062W SGDID: S000000058 Locus_Name: GDI1 Alias_Name: SEC19 Description: GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins ORF_Name: YER136W SGDID: S000000938 Locus_Name: GDR1 Phenotype: Mutation alters nutritional control of germination SGDID: S000029181 Locus_Name: GDR2 Phenotype: Mutation alters nutritional control of germination SGDID: S000029182 Locus_Name: GDS1 Description: Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Phenotype: Null mutant is viable, shows partial impairment of growth on medium containing glycerol as the carbon source. Overexpxression suppresses NAM9-1 glycerol deficient phenotype ORF_Name: YOR355W SGDID: S000005882 Locus_Name: GDT1 Description: Putative protein of unknown function; expression is reduced in a gcr1 null mutant; GFP-fusion protein localizes to the vacuole; expression pattern and physical interactions suggest a possible role in ribosome biogenesis ORF_Name: YBR187W SGDID: S000000391 Locus_Name: GEA1 Description: Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs), involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; similar to but not functionally redundant with Gea2p ORF_Name: YJR031C SGDID: S000003792 Locus_Name: GEA2 Description: Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs), involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; similar to but not functionally redundant with Gea1p Phenotype: Null mutant is viable, synthetically lethal with gea1 null mutant ORF_Name: YEL022W SGDID: S000000748 Locus_Name: GEF1 Alias_Name: CLC Description: Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels ORF_Name: YJR040W SGDID: S000003801 Locus_Name: GEM1 Alias_Name: GON1 Description: Evolutionarily-conserved tail-anchored outer mitochondrial membrane GTPase which regulates mitochondrial morphology; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; not required for pheromone-induced cell death Phenotype: Null mutant is viable but exhibits slightly reduced secretion of over-produced PrA. Null mutants also grow slowly in the presence of high concentrations of calcium. Overexpression enhances secretion of overexpressed PrA. ORF_Name: YAL048C SGDID: S000000046 Locus_Name: GEP3 Alias_Name: AIM40|FMP38|LRC5 Description: Protein of unknown function; null mutant is defective in respiration and interacts synthetically with prohibitin (phb1); the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies ORF_Name: YOR205C SGDID: S000005731 Locus_Name: GEP4 Description: Protein of unknown function required for respiratory growth; detected in highly purified mitochondria in high-throughput studies; null mutation confers sensitivity to tunicamycin and DTT and decreased levels of phosphatidylethanol ORF_Name: YHR100C SGDID: S000001142 Locus_Name: GEP5 Alias_Name: RRG5 Description: Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine ORF_Name: YLR091W SGDID: S000004081 Locus_Name: GEP7 Description: Protein of unknown function; null mutant exhibits a respiratory growth defect and synthetic interactions with prohibitin (phb1) and gem1; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies ORF_Name: YGL057C SGDID: S000003025 Locus_Name: GET1 Alias_Name: MDM39 Description: Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance Phenotype: Null: Required for spore wall formation, but not IME1 induction or nuclear division ORF_Name: YGL020C SGDID: S000002988 Locus_Name: GET2 Alias_Name: HUR2|RMD7 Description: Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division Phenotype: null is hypersensitive to calcofluor white suffer an increased spheroplast lysis rate ORF_Name: YER083C SGDID: S000000885 Locus_Name: GET3 Alias_Name: ARR4 Description: Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity Phenotype: Null: YDL100c gene disruption results in sensitivity to As(III), As(V), Co(II) and Cu(II). ORF_Name: YDL100C SGDID: S000002258 Locus_Name: GET4 Description: Protein of unknown function, highly conserved across species and homologous to human gene C7orf20; interacts with Mdy2p; genetic interactions predict a role in insertion of tail-anchored proteins into the ER membrane ORF_Name: YOR164C SGDID: S000005690 Locus_Name: GFA1 Description: Glutamine-fructose-6-phosphate amidotransferase, catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis Phenotype: Null mutant is viable, glucosamine auxotroph ORF_Name: YKL104C SGDID: S000001587 Locus_Name: GFD1 Description: Coiled-coiled protein of unknown function, identified as a high-copy suppressor of a dbp5 mutation Phenotype: Null mutant is viable; high copy suppressor of rat8-2 ORF_Name: YMR255W SGDID: S000004868 Locus_Name: GFD2 Alias_Name: YCD6 Description: Protein of unknown function, identified as a high-copy suppressor of a dbp5 mutation Phenotype: Null: Identified as high copy suppressor of a ts mutation affecting Dbp5p/Rat8p. ORF_Name: YCL036W SGDID: S000000541 Locus_Name: GGA1 Description: Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi Phenotype: Single and double knockouts are viable at both 30 C and 37 C. Cells lacking GGA1, GGA2 exhibit defects in invertase processing, vacuolar morphology, maturation of alpha-factor, and sorting of CPY, proteinase A to the vacuole, but not endocytosis. ORF_Name: YDR358W SGDID: S000002766 Locus_Name: GGA2 Description: Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi Phenotype: Single and double knockouts are viable at both 30 C and 37 C. Cells lacking GGA1, GGA2 exhibit defects in invertase processing, vacuolar morphology, maturation of alpha-factor, and sorting of CPY, proteinase A to the vacuole, but not endocytosis. ORF_Name: YHR108W SGDID: S000001150 Locus_Name: GGC1 Alias_Name: YHM1 Description: Mitochondrial GTP/GDP transporter, essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family Phenotype: Null mutant is viable; shm1 abf2 double deletion cannot grow on glycerol ORF_Name: YDL198C SGDID: S000002357 Locus_Name: GIC1 Description: Protein of unknown function involved in initiation of budding and cellular polarization, interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain Phenotype: Null mutant is viable; gic1 gic2 double null is temperature sensitive at 33 degrees C ORF_Name: YHR061C SGDID: S000001103 Locus_Name: GIC2 Description: Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region Phenotype: Null mutant is viable and temperature sensitive at 37 degrees C; gic1 gic2 double null is temperature sensitive at 33 degrees C ORF_Name: YDR309C SGDID: S000002717 Locus_Name: GID7 Alias_Name: MOH2 Description: Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions ORF_Name: YCL039W SGDID: S000000544 Locus_Name: GID8 Alias_Name: DCR1 Description: Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START ORF_Name: YMR135C SGDID: S000004742 Locus_Name: GIM3 Alias_Name: PFD4 Description: Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it ORF_Name: YNL153C SGDID: S000005097 Locus_Name: GIM4 Alias_Name: PFD2 Description: Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it Phenotype: Null mutant is viable, sensitive to anti-microtubule drugs benomyl and nocadazole; synthetically lethal with tub4-1 mutations ORF_Name: YEL003W SGDID: S000000729 Locus_Name: GIM5 Alias_Name: PFD5 Description: Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it Phenotype: Null mutant is viable, cold sensitive, benomyl and nocadazole sensitive and fails to grow on YPD+1.2M KCl or YPD+1.8M sorbitol; synthetically lethal with tub4-1 mutations ORF_Name: YML094W SGDID: S000004559 Locus_Name: GIN4 Alias_Name: ERC47 Description: Protein kinase involved in bud growth and assembly of the septin ring, proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Kcc4p and Hsl1p Phenotype: Null mutant is viable, exhibits a mild elongated bud phenotype and some cell clumping ORF_Name: YDR507C SGDID: S000002915 Locus_Name: GIP1 Description: Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p ORF_Name: YBR045C SGDID: S000000249 Locus_Name: GIP2 Description: Putative regulatory subunit of the protein phosphatase Glc7p, involved in glycogen metabolism; contains a conserved motif (GVNK motif) that is also found in Gac1p, Pig1p, and Pig2p ORF_Name: YER054C SGDID: S000000856 Locus_Name: GIP3 Description: Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments ORF_Name: YPL137C SGDID: S000006058 Locus_Name: GIP4 Alias_Name: FUN21 Description: Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate ORF_Name: YAL031C SGDID: S000000029 Locus_Name: GIR2 Description: Highly-acidic cytoplasmic RWD domain-containing protein of unknown function; interacts with Rbg1p and Gcn1p; associates with translating ribosomes; putative intrinsically unstructured protein ORF_Name: YDR152W SGDID: S000002559 Locus_Name: GIS1 Description: JmjC domain-containing histone demethylase; transcription factor involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1 Phenotype: Null mutant is viable and shows enhanced basal level expression of PHR1 ORF_Name: YDR096W SGDID: S000002503 Locus_Name: GIS2 Description: Protein with seven cysteine-rich CCHC zinc-finger motifs, similar to human CNBP, proposed to be involved in the RAS/cAMP signaling pathway ORF_Name: YNL255C SGDID: S000005199 Locus_Name: GIS3 Description: Protein of unknown function ORF_Name: YLR094C SGDID: S000004084 Locus_Name: GIS4 Description: CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway ORF_Name: YML006C SGDID: S000004465 Locus_Name: GIT1 Description: Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability Phenotype: Null mutant is viable, exhibits decreased GroPIns transport ORF_Name: YCR098C SGDID: S000000695 Locus_Name: GLC3 Alias_Name: GHA1 Description: Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Phenotype: Null mutant is viable, glycogen deficient ORF_Name: YEL011W SGDID: S000000737 Locus_Name: GLC7 Alias_Name: CID1|DIS2|DIS2S1|PP1 Description: Type 1 serine/threonine protein phosphatase catalytic subunit, involved in many processes (eg: glycogen metabolism, sporulation, mitosis); accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits ORF_Name: YER133W SGDID: S000000935 Locus_Name: GLC8 Description: Regulatory subunit of protein phosphatase 1 (Glc7p), involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2 ORF_Name: YMR311C SGDID: S000004928 Locus_Name: GLE1 Alias_Name: BRR3|RSS1 Description: Cytoplasmic nucleoporin required for polyadenylated RNA export but not for protein import; component of Nup82p nuclear pore subcomplex; contains a nuclear export signal ORF_Name: YDL207W SGDID: S000002366 Locus_Name: GLE2 Alias_Name: RAE1 Description: Component of the Nup82 subcomplex of the nuclear pore complex; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p ORF_Name: YER107C SGDID: S000000909 Locus_Name: GLG1 Description: Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin Phenotype: Null mutant is viable; disruption of both GLG1 and GLG2 renders cells unable to synthesize glycogen ORF_Name: YKR058W SGDID: S000001766 Locus_Name: GLG2 Description: Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin Phenotype: Null mutant is viable; disruption of both GLG2 and GLG2 renders cells unable to synthesize glycogen ORF_Name: YJL137C SGDID: S000003673 Locus_Name: GLK1 Alias_Name: HOR3 Description: Glucokinase, catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources ORF_Name: YCL040W SGDID: S000000545 Locus_Name: GLN1 Description: Glutamine synthetase (GS), synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation Phenotype: Glutamine synthetase non-derepressible ORF_Name: YPR035W SGDID: S000006239 Locus_Name: GLN3 Description: Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source ORF_Name: YER040W SGDID: S000000842 Locus_Name: GLN4 Description: Glutamine tRNA synthetase, monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu); N-terminal domain proposed to be involved in enzyme-tRNA interactions Gene_Product: glutamyl-tRNA synthetase ORF_Name: YOR168W SGDID: S000005694 Locus_Name: GLO1 Description: Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress ORF_Name: YML004C SGDID: S000004463 Locus_Name: GLO2 Description: Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate ORF_Name: YDR272W SGDID: S000002680 Locus_Name: GLO3 Description: ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p ORF_Name: YER122C SGDID: S000000924 Locus_Name: GLO4 Description: Mitochondrial glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate ORF_Name: YOR040W SGDID: S000005566 Locus_Name: GLR1 Alias_Name: LPG17 Description: Cytosolic and mitochondrial glutathione oxidoreductase, converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia ORF_Name: YPL091W SGDID: S000006012 Locus_Name: GLT1 Description: NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source ORF_Name: YDL171C SGDID: S000002330 Locus_Name: GLU3 Phenotype: glutamate auxotroph; unable to grow on nonfermentable carbon sources SGDID: S000029184 Locus_Name: GLY1 Description: Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis Phenotype: Null mutant is viable, glycine auxotroph, gly1 null mutants are not glycine auxotrophs on ethanol media ORF_Name: YEL046C SGDID: S000000772 Locus_Name: GMH1 Alias_Name: MSG1 Description: Golgi membrane protein of unknown function, interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting ORF_Name: YKR030W SGDID: S000001738 Locus_Name: GNA1 Alias_Name: PAT1 Description: Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA ORF_Name: YFL017C SGDID: S000001877 Locus_Name: GND1 Description: 6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress ORF_Name: YHR183W SGDID: S000001226 Locus_Name: GND2 Description: 6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone ORF_Name: YGR256W SGDID: S000003488 Locus_Name: GNP1 Description: High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids Phenotype: Null mutant is viable but shows reduced glutamine transport and is therefore resistant to the glutamine analog L-glutamic acid gamma-monohydroxamate; overexpression induces sensitivity to heat shock ORF_Name: YDR508C SGDID: S000002916 Locus_Name: GNT1 Description: N-acetylglucosaminyltransferase capable of modification of N-linked glycans in the Golgi apparatus ORF_Name: YOR320C SGDID: S000005847 Locus_Name: GON7 Alias_Name: LDB6|PCC2 Description: Protein proposed to be involved in the modification of N-linked oligosaccharides, osmotic stress response, telomere uncapping and elongation, transcription; component of the EKC/KEOPS protein complex with Kae1p, Cgi121p, Pcc1p, and Bud32p ORF_Name: YJL184W SGDID: S000003720 Locus_Name: GOR1 Description: Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies ORF_Name: YNL274C SGDID: S000005218 Locus_Name: GOS1 Description: v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28 ORF_Name: YHL031C SGDID: S000001023 Locus_Name: GOT1 Description: Evolutionarily conserved non-essential protein present in early Golgi cisternae that may be involved in ER-Golgi transport at a step after vesicle tethering to Golgi membranes, exhibits membrane topology similar to that of Sft2p Phenotype: Null mutant is viable but exhibits ER to Golgi transport defects in vitro. got1 is synthetically lethal with mutations in sft2; the got1 sft2 double mutant exhibits defects in transport to the Golgi complex. ORF_Name: YMR292W SGDID: S000004906 Locus_Name: GPA1 Alias_Name: CDC70|DAC1|SCG1 Description: GTP-binding alpha subunit of the heterotrimeric G protein that couples to pheromone receptors; negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response; activates Vps34p at the endosome Phenotype: The null mutation is inviable in haploids but not diploids. Gpa1 mutants exhibit specific defects in the pheromone responsiveness of both a and alpha cells. ORF_Name: YHR005C SGDID: S000001047 Locus_Name: GPA2 Alias_Name: SSP101 Description: Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery ORF_Name: YER020W SGDID: S000000822 Locus_Name: GPB1 Alias_Name: KRH2 Description: Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb2p ORF_Name: YOR371C SGDID: S000005898 Locus_Name: GPB2 Alias_Name: KRH1 Description: Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb1p Phenotype: Deletion causes a high PKA phenotype. ORF_Name: YAL056W SGDID: S000000052 Locus_Name: GPD1 Alias_Name: DAR1|HOR1|OSG1|OSR5 Description: NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p ORF_Name: YDL022W SGDID: S000002180 Locus_Name: GPD2 Alias_Name: GPD3 Description: NAD-dependent glycerol 3-phosphate dehydrogenase, homolog of Gpd1p, expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria ORF_Name: YOL059W SGDID: S000005420 Locus_Name: GPG1 Description: Proposed gamma subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p; overproduction causes prion curing Phenotype: Null: A modest reduction in pseudohyphal differentiation, invasive growth, and FLO11 expression ORF_Name: YGL121C SGDID: S000003089 Locus_Name: GPH1 Description: Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway Phenotype: Null mutant is viable; haploid cells contain higher levels of intracellular glycogen ORF_Name: YPR160W SGDID: S000006364 Locus_Name: GPI1 Description: Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs Phenotype: Null mutant is viable but is temperature-sensitive for growth, for [3H]inositol incorporation into protein, and for GPI anchor-dependent processing of the Gas1/Ggp1 protein and lacks in vitro N-acetylglucosaminylphosphatidylinositol synthetic activity|Null mutant displays hyperactive Ras Signaling and invasive growth. ORF_Name: YGR216C SGDID: S000003448 Locus_Name: GPI10 Description: Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the GPI core structure; human PIG-Bp is a functional homolog Phenotype: Null mutant is inviable but can be complemented by the homologous cDNA from humans that encodes the PIG-B protein; a mutant with conditional expression of GPI10 is defective in GPI anchor synthesis and GPI-anchored protein transport when GPI10 expression is turned off ORF_Name: YGL142C SGDID: S000003110 Locus_Name: GPI11 Description: ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog ORF_Name: YDR302W SGDID: S000002710 Locus_Name: GPI12 Description: ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp ORF_Name: YMR281W SGDID: S000004894 Locus_Name: GPI13 Alias_Name: MPC1 Description: ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein Phenotype: Null mutant is inviable; Gpi13p-depleted strains accumulate a GPI precursor whose glycan headgroup contains 4 mannoses and a phosphoethanolamine side-branch on the first mannose ORF_Name: YLL031C SGDID: S000003954 Locus_Name: GPI14 Alias_Name: PMH1 Description: Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M ORF_Name: YJR013W SGDID: S000003774 Locus_Name: GPI15 Description: Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein Phenotype: Null mutant is inviable; required for N-acetylglucosaminyl phosphatidylinositol synthesis. ORF_Name: YNL038W SGDID: S000004983 Locus_Name: GPI16 Description: Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog ORF_Name: YHR188C SGDID: S000001231 Locus_Name: GPI17 Description: Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Sp homolog ORF_Name: YDR434W SGDID: S000002842 Locus_Name: GPI18 Alias_Name: FMP44 Description: Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria ORF_Name: YBR004C SGDID: S000000208 Locus_Name: GPI19 Description: Subunit of GPI-GlcNAc transferase involved in synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), which is the first intermediate in glycosylphosphatidylinositol (GPI) anchor synthesis, shares similarity with mammalian PIG-P ORF_Name: YDR437W SGDID: S000002845 Locus_Name: GPI2 Alias_Name: GCR4 Description: Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein ORF_Name: YPL076W SGDID: S000005997 Locus_Name: GPI4 Description: involved in the attachment of glycosylphosphatidylinositol (GPI) anchors to proteins Phenotype: defective in GPI anchor synthesis; sensitive to calcofluor white and hygromycin B SGDID: S000029185 Locus_Name: GPI5 Description: involved in the attachment of glycosylphosphatidylinositol (GPI) anchors to proteins Phenotype: defective in GPI anchor synthesis; sensitive to calcofluor white and hygromycin B SGDID: S000029186 Locus_Name: GPI6 Description: involved in the attachment of glycosylphosphatidylinositol (GPI) anchors to proteins Phenotype: defective in GPI anchor synthesis; sensitive to calcofluor white and hygromycin B SGDID: S000029187 Locus_Name: GPI8 Description: ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog ORF_Name: YDR331W SGDID: S000002739 Locus_Name: GPI9 Description: involved in the attachment of glycosylphosphatidylinositol (GPI) anchors to proteins Phenotype: defective in GPI anchor synthesis; sensitive to calcofluor white and hygromycin B SGDID: S000029188 Locus_Name: GPM1 Description: Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis Phenotype: Required for sporulation ORF_Name: YKL152C SGDID: S000001635 Locus_Name: GPM2 Description: Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event Phenotype: Null mutant is viable, gpm2 gpm3 double deletion mutants exhibit no synthetic phenotypes ORF_Name: YDL021W SGDID: S000002179 Locus_Name: GPM3 Description: Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event Phenotype: Null mutant is viable, gpm3 gpm2 double deletion mutants exhibit no synthetic phenotypes ORF_Name: YOL056W SGDID: S000005417 Locus_Name: GPR1 Description: Plasma membrane G protein coupled receptor (GPCR) that interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis ORF_Name: YDL035C SGDID: S000002193 Locus_Name: GPT2 Alias_Name: GAT1 Description: Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis ORF_Name: YKR067W SGDID: S000001775 Locus_Name: GPX1 Description: Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress ORF_Name: YKL026C SGDID: S000001509 Locus_Name: GPX2 Alias_Name: AMI1 Description: Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress ORF_Name: YBR244W SGDID: S000000448 Locus_Name: GRC3 Description: Protein of unknown function, required for cell growth and possibly involved in rRNA processing; mRNA is cell cycle regulated ORF_Name: YLL035W SGDID: S000003958 Locus_Name: GRD10 Phenotype: mutant is deficient in retention (in the Golgi) of proteins normally residing in the trans-Golgi compartment SGDID: S000029189 Locus_Name: GRD14 Phenotype: mutant is deficient in retention (in the Golgi) of proteins normally residing in the trans-Golgi compartment SGDID: S000029190 Locus_Name: GRD15 Phenotype: mutant is deficient in retention (in the Golgi) of proteins normally residing in the trans-Golgi compartment SGDID: S000029191 Locus_Name: GRD16 Phenotype: mutant is deficient in retention (in the Golgi) of proteins normally residing in the trans-Golgi compartment SGDID: S000029192 Locus_Name: GRD17 Phenotype: mutant is deficient in retention (in the Golgi) of proteins normally residing in the trans-Golgi compartment SGDID: S000029193 Locus_Name: GRD18 Phenotype: mutant is deficient in retention (in the Golgi) of proteins normally residing in the trans-Golgi compartment SGDID: S000029194 Locus_Name: GRD3 Phenotype: mutant is deficient in retention (in the Golgi) of proteins normally residing in the trans-Golgi compartment SGDID: S000029195 Locus_Name: GRD4 Phenotype: mutant is deficient in retention (in the Golgi) of proteins normally residing in the trans-Golgi compartment SGDID: S000029196 Locus_Name: GRD5 Phenotype: mutant is deficient in retention (in the Golgi) of proteins normally residing in the trans-Golgi compartment SGDID: S000029197 Locus_Name: GRE1 Description: Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway Phenotype: Null mutant is viable and shows no phenotype in osmotic, ionic or oxidative stress ORF_Name: YPL223C SGDID: S000006144 Locus_Name: GRE2 Description: 3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway ORF_Name: YOL151W SGDID: S000005511 Locus_Name: GRE3 Description: Aldose reductase involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway ORF_Name: YHR104W SGDID: S000001146 Locus_Name: GRH1 Description: Acetylated, cis-golgi localized protein involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes Phenotype: Null: Null mutation is viable, exhibits defects in spindle checkpoint ORF_Name: YDR517W SGDID: S000002925 Locus_Name: GRR1 Alias_Name: CAT80|COT2|SDC1|SSU2 Description: F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification Phenotype: Null mutant is viable, resistant to high levels of divalent cations, sensitive to sulfite, and defective in high affinity glucose transport and glucose repression; null mutant also exibits an elongated cell morphology ORF_Name: YJR090C SGDID: S000003850 Locus_Name: GRS1 Description: Cytoplasmic and mitochondrial glycyl-tRNA synthase that ligates glycine to the cognate anticodon bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation Gene_Product: glycyl-tRNA synthetase ORF_Name: YBR121C SGDID: S000000325 Locus_Name: GRS2 Description: Protein with sequence similarity to Grs1p, which is a glycyl-tRNA synthetase; cannot substitute for Grs1p; possible pseudogene that is expressed at very low levels ORF_Name: YPR081C SGDID: S000006285 Locus_Name: GRX1 Description: Hydroperoxide and superoxide-radical responsive heat-stable glutathione-dependent disulfide oxidoreductase with active site cysteine pair; protects cells from oxidative damage Phenotype: Null mutant is viable but sensitive to oxidative stress. grx1 grx2 null mutants are viable but lack heat-stable oxidoreductase activity. ORF_Name: YCL035C SGDID: S000000540 Locus_Name: GRX2 Alias_Name: TTR1 Description: Cytoplasmic glutaredoxin, thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress ORF_Name: YDR513W SGDID: S000002921 Locus_Name: GRX3 Description: Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage Phenotype: Null mutant is viable and shows moderate sensitivity to oxidative stress and increased oxidation levels of cell proteins ORF_Name: YDR098C SGDID: S000002505 Locus_Name: GRX4 Description: Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage Phenotype: Null mutant is viable and shows moderate sensitivity to oxidative stress and increased oxidation levels of cell proteins ORF_Name: YER174C SGDID: S000000976 Locus_Name: GRX5 Description: Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; mitochondrial matrix protein involved in the synthesis/assembly of iron-sulfur centers; monothiol glutaredoxin subfamily member along with Grx3p and Grx4p Phenotype: Null mutant is viable and shows high sensitivity to oxidative stress and increased sensitivity to osmotic stress, and increased oxidation levels of cell proteins; grx5 is synthetically lethal with grx2. ORF_Name: YPL059W SGDID: S000005980