15S_RRNA	15S_RRNA_2	Ribosomal RNA of the small mitochondrial ribosomal subunit; MSU1 allele suppresses ochre stop mutations in mitochondrial protein-coding genes	14s rRNA			S000007287
21S_RRNA	21S_rRNA_3|21S_rRNA_4	Mitochondrial 21S rRNA; intron encodes the I-SceI DNA endonuclease				S000007288
21S_RRNA_4		Merged rRNA, does not encodes a discrete transcript; 21S_rRNA_4 was merged into 21S_rRNA_3 to produce a single feature named 21S_rRNA (See GenBank AJ011856)				S000007289
9S_RRNA_1		Deleted rRNA, does not encode a discrete transcript; the annotations for 9S_rRNA_1 and 9S_rRNA_5 have been removed and replaced with a single gene, RPM1, which provides the correct annotation of the 9S RNA component of RNase P				S000007285
9S_RRNA_5		Deleted rRNA, does not encode a discrete transcript; the annotations for 9S_rRNA_1 and 9S_rRNA_5 have been removed and replaced with a single gene, RPM1, which provides the correct annotation of the 9S RNA component of RNase P				S000007286
AAC1		Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator		Null mutant is viable, shows altered colony morphology	YMR056C	S000004660
AAC3	ANC3	Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Pet9p and Aac1p; has roles in maintenance of viability and in respiration		Null mutant is viable; pet9,aac3 double null mutant is inviable under anaerobic conditions	YBR085W	S000000289
AAD10		Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role			YJR155W	S000003916
AAD14		Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role			YNL331C	S000005275
AAD15		Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role			YOL165C	S000005525
AAD16		Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role			YFL057C	S000001837
AAD3		Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role			YCR107W	S000000704
AAD4		Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase, involved in the oxidative stress response; expression induced in cells treated with the mycotoxin patulin		Responds to oxidative stress induced by diamide and di-ethyl maleic acid ester in a YAP1 dependant manner	YDL243C	S000002402
AAD6		Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase, involved in the oxidative stress response; expression induced in cells treated with the mycotoxin patulin		Responds to oxidative stress induced by diamide and di-ethyl maleic acid ester in YAP1 dependant manner	YFL056C	S000001838
AAH1		Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome			YNL141W	S000005085
AAP1	AAP1'	Arginine/alanine aminopeptidase, overproduction stimulates glycogen accumulation		null mutant is viable, decrease in glycogen accumulation	YHR047C	S000001089
AAR2		Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron		growth defect and defect in splicing the pre-mRNA of the MATa1 cistron	YBL074C	S000000170
AAT1		Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis		Null mutant is viable; aat1 leu2 double mutant is inviable.	YKL106W	S000001589
AAT2	ASP5	Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells			YLR027C	S000004017
ABC1	COQ8	Protein required for ubiquinone (coenzyme Q) biosynthesis and for respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis			YGL119W	S000003087
ABD1		Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA			YBR236C	S000000440
ABF1	BAF1|OBF1|REB2|SBF1	DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair			YKL112W	S000001595
ABF2		Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation			YMR072W	S000004676
ABM1		Protein of unknown function, required for normal microtubule organization			YJR108W	S000003869
ABP1		Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization			YCR088W	S000000684
ABP140	YOR240W	Nonessential protein that binds actin filaments and localizes to actin patches and cables, has similarity to S-adenosylmethionine (AdoMet)-dependent methyltransferases			YOR239W	S000005765
ABZ1		Para-aminobenzoate (PABA) synthase, has similarity to Escherichia coli PABA synthase components PabA and PabB		Null mutant is viable and PABA auxotroph	YNR033W	S000005316
ABZ2		Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis		Null: PABA auxotrophy. Defective in 4-amino-4-deoxychorismate lyase activity.	YMR289W	S000004902
ACA1		Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, may regulate transcription of genes involved in utilization of non-optimal carbon sources			YER045C	S000000847
ACB1		Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes		Null mutant is viable, slightly reduced growth rate on ethanol	YGR037C	S000003269
ACC1	ABP2|FAS3|MTR7	Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids		acc1 spores fail to enter vegetative growth	YNR016C	S000005299
ACD1						S000029024
ACE2		Transcription factor that activates expression of early G1-specific genes, localizes to daughter cell nuclei after cytokinesis and delays G1 progression in daughters, localization is regulated by phosphorylation; potential Cdc28p substrate		Null mutant is viable, exhibits decreased CUP1 mRNA expression	YLR131C	S000004121
ACF2	ENG2|PCA1	Intracellular beta-1,3-endoglucanase, expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly		Null mutant shows defect in in vitro actin assembly in the permeabilized cell assay	YLR144C	S000004134
ACF4		Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate			YJR083C	S000003843
ACH1		Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth			YBL015W	S000000111
ACK1		Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria			YDL203C	S000002362
ACM1		Pseudosubstrate inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein			YPL267W	S000006188
ACN9		Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes			YDR511W	S000002919
ACO1	GLU1	Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy			YLR304C	S000004295
ACO2		Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol			YJL200C	S000003736
ACP1		Mitochondrial matrix acyl carrier protein, involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p		The null mutant is viable but respiratory-deficient and contains only 5-10% of the wild-type amount of lipoic acid.	YKL192C	S000001675
ACR1		Involved in sensitivity to aculeacin A		Resistant to aculeacin A, echinocandin B, and papulacandin B		S000029025
ACR2		Involved in sensitivity to aculeacin A		Resistant to aculeacin A, echinocandin B, but not papulacandin B		S000029026
ACR3		Involved in sensitivity to aculeacin A		Resistant to aculeacin A, echinocandin B, and papulacandin B		S000029027
ACR4		Involved in sensitivity to aculeacin A		Resistant to aculeacin A, echinocandin B, and papulacandin B		S000029028
ACS1	FUN44	Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions		Null mutant is viable and grows on ethanol or glucose (but not acetate) as sole carbon source (but with long lag-phase); acs1 acs2 double null mutant is inviable	YAL054C	S000000050
ACS2		Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions		Null mutant is viable, and grows on ethanol or acetate as sole carbon source, but is unable to grow on glucose as sole carbon source; acs1 acs2 double null mutant is inviable	YLR153C	S000004143
ACT1	ABY1|END7	Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions	actin		YFL039C	S000001855
ADA2	SWI8	Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes		Null mutant is viable, grows poorly on minimal media	YDR448W	S000002856
ADD1						S000029029
ADD37		Protein of unknown function involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene			YMR184W	S000004796
ADD66	PBA2|POC2	Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly			YKL206C	S000001689
ADE1		N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine		Null mutant is viable and adenine auxotroph; ade1 mutants produce red pigment when grown in media containing low lvels of adenine.	YAR015W	S000000070
ADE12	BRA9	Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence		Adenine requiring	YNL220W	S000005164
ADE13	BRA1|BRA8	Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency		Unable to grow on complete media with glucose or fructose as a carbon source, but can grow with glycerol or ethanol	YLR359W	S000004351
ADE15				Adenine requiring		S000029030
ADE16		Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade17p; ade16 ade17 mutants require adenine and histidine		Null mutant is viable; ade16 ade17 double mutant requires adenine	YLR028C	S000004018
ADE17		Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade16p; ade16 ade17 mutants require adenine and histidine		Null mutant is viable; ade16 ade17 double mutants require adenine	YMR120C	S000004727
ADE2		Phosphoribosylaminoimidazole carboxylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; red pigment accumulates in mutant cells deprived of adenine		Null mutant is viable and requires adenine. ade2 mutants are blocked at a stage in the adenine biosynthetic pathway that causes an intermediate to accumulate in the vacuole; the intermediate gives the cell a red color.	YOR128C	S000005654
ADE3		Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine		Null mutant is viable, adenine auxotroph, histidine auxotroph	YGR204W	S000003436
ADE4		Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway		Adenine requiring	YMR300C	S000004915
ADE5,7		Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities		Adenine requiring	YGL234W	S000003203
ADE6		Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway		Adenine requiring	YGR061C	S000003293
ADE8		Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway		Adenine requiring	YDR408C	S000002816
ADH1	ADC1	Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway		Null mutant is viable and sensitive to formaldehyde.	YOL086C	S000005446
ADH2	ADR2	Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1			YMR303C	S000004918
ADH3		Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production			YMR083W	S000004688
ADH4	NRC465|ZRG5	Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency			YGL256W	S000003225
ADH5		Alcohol dehydrogenase isoenzyme V; involved in ethanol production			YBR145W	S000000349
ADH6	ADHVI	NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance			YMR318C	S000004937
ADH7	ADHVII	NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance			YCR105W	S000000702
ADI1		Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions			YMR009W	S000004611
ADK1	AKY1|AKY2	Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence			YDR226W	S000002634
ADK2	AKY3|PAK3	Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background			YER170W	S000000972
ADO1		Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle			YJR105W	S000003866
ADP1		Putative ATP-dependent permease of the ABC transporter family of proteins			YCR011C	S000000604
ADR1		Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization		abolished derepression of ADH2	YDR216W	S000002624
ADY2	ATO1	Acetate transporter required for normal sporulation; phosphorylated in mitochondria		Null mutant is viable; forms predominantly asci containing 2 spores (dyads) whensporulated; required for long-term growth on YPD at 37 degrees C; defect in ammonia production in S.cerevisiae colonies	YCR010C	S000000603
ADY3		Protein required for spore wall formation, thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p		Null forms largely asci that contain 2 spores (dyads) when sporulated. Sporulation defect in ady3ady3 cells is due to a failure to synthesize spore wall polymers.	YDL239C	S000002398
ADY4		Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane			YLR227C	S000004217
AEP1	NCA1	Protein required for expression of the mitochondrial OLI1 gene encoding subunit 9 of F1-F0 ATP synthase		permanently respiratory defective; unable to translate OLI1 transcripts	YMR064W	S000004668
AEP2	ATP13	Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader		non-conditional respiratory mutant; unable to express the mitochondrial OLI1 gene; pet mutant	YMR282C	S000004895
AEP3		Peripheral mitochondrial inner membrane protein, located on the matrix face of the membrane; stabilizes the bicistronic AAP1-ATP6 mRNA encoding subunits 6 and 8 of the ATP synthase complex			YPL005W	S000005926
AFG1		Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain			YEL052W	S000000778
AFG2	DRG1	ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; is essential for pre-60S maturation and release of several preribosome maturation factors; may be involved in degradation of aberrant mRNAs			YLR397C	S000004389
AFG3	YTA10	Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes		nuclear petite phenotype; loss of repspiratory competence	YER017C	S000000819
AFI1		Arf3p polarization-specific docking factor, required for the polarized distribution of the ADP-ribosylation factor, Arf3p; participates in polarity development and maintenance of a normal haploid budding pattern; interacts with Cnm7p			YOR129C	S000005655
AFR1		Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; interacts with Cdc12p		defect in alpha-factor-stimulated morphogenesis	YDR085C	S000002492
AFT1	RCS1	Transcription factor involved in iron utilization and homeostasis; binds the consensus site PyPuCACCCPu and activates the expression of target genes in response to changes in iron availability		Null mutant is viable; mutant cells are larger than normal, since critical size for budding is increased; mutant shows incorrect regulation of expression of genes involved in iron uptake; spores from heterozygous diploid have reduced ability to germinate;	YGL071W	S000003039
AFT2		Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; similar to Aft1p		Null: Deletion of AFT2 exacerates iron deficiency of AFT1 disruption.	YPL202C	S000006123
AGA1		Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds	a-agglutinin anchorage subunit	mating defect in liquid medium	YNR044W	S000005327
AGA2		Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds	a-agglutinin adhesion subunit		YGL032C	S000003000
AGC1		Mitochondrial amino acid transporter, acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis		Null: viable. Other phenotypes: not viable on minimal medium supplemented with acetate or oleate	YPR021C	S000006225
AGE1	SAT1	ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif			YDR524C	S000002932
AGE2	SAT2	ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif			YIL044C	S000001306
AGP1	YCC5	Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p)		Null mutant is viable; resistant to the amino acid analog gamma-hydroxyaspartate, decreased growth on asn, gln and some other amino acids in strains in which Gap1 and Gnp1 are also missing.	YCL025C	S000000530
AGP2		High affinity polyamine permease, preferentially uses spermidine over putrescine; expression is down-regulated by osmotic stress; plasma membrane carnitine transporter, also functions as a low-affinity amino acid permease		Null mutant is viable; loss of growth on some amino acids as nitrogen source (leu, thr) in a strain which has no Gap1p or Agp1p function	YBR132C	S000000336
AGP3		Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition		Null mutant is viable; loss of growth on some amino acids as nitrogen source (leu, thr) in a strain which has no Gap1p or Agp1p function	YFL055W	S000001839
AGS1				aminoglycoside antibiotic sensitive		S000029031
AGX1		Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases	alanine:glyoxylate aminotransferase		YFL030W	S000001864
AHA1		Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock			YDR214W	S000002622
AHC1		Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex			YOR023C	S000005549
AHC2		Protein of unknown function, putative transcriptional regulator; proposed to be a Ada Histone acetyltransferase complex component; GFP tagged protein is localized to the cytoplasm and nucleus			YCR082W	S000000678
AHP1		Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p	cTPxIII	hypersensitive to tert-butyl hydroperoxide	YLR109W	S000004099
AHT1		Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; multicopy suppressor of glucose transport defects, likely due to the presence of an HXT4 regulatory element in the region			YHR093W	S000001135
AI1		Reverse transcriptase required for splicing of the COX1 pre-mRNA, encoded by a mobile group II intron within the mitochondrial COX1 gene		unable to excise adjacent aI2 intron; reduced intron mobility	Q0050	S000007261
AI2		Reverse transcriptase required for splicing of the COX1 pre-mRNA, encoded by a mobile group II intron within the mitochondrial COX1 gene		defective in aI1 and aI2 intron mobility	Q0055	S000007262
AI3		Endonuclease I-SceIII, encoded by a mobile group I intron within the mitochondrial COX1 gene	I-SceIII	Mutations that block aI3 splicing cause defects in respiration and accumulate I-SceIII endonuclease.	Q0060	S000007263
AI4		Endonuclease I-SceII, encoded by a mobile group I intron within the mitochondrial COX1 gene; intron is normally spliced by the BI4p maturase but AI4p can mutate to acquire the same maturase activity	I-SceII	Mutations that block aI4 splicing cause defects in respiration; other mutations affect intron mobility or maturase functions.	Q0065	S000007264
AI5_ALPHA		Endonuclease I-SceIV, involved in intron mobility; encoded by a mobile group I intron within the mitochondrial COX1 gene			Q0070	S000007265
AI5_BETA		Protein of unknown function, encoded within an intron of the mitochondrial COX1 gene; translational initiation codon is predicted to be ATA rather than ATG			Q0075	S000007266
AIF1	CPD1	Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase			YNR074C	S000005357
AIM1		Protein involved in mitochondrial function or organization; null mutant displays elevated frequency of mitochondrial genome loss			YAL046C	S000000044
AIM10		Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss			YER087W	S000000889
AIM11	GEP8	Protein of unknown function; null mutant is viable but shows increased loss of mitochondrial genome and synthetic interaction with prohibitin (phb1); contains an intron			YER093C-A	S000002960
AIM13		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria; null mutant displays reduced respiratory growth and reduced frequency of mitochondrial genome loss			YFR011C	S000001907
AIM14		Putative protein of with similarity to iron/copper reductases (FRE1-8), possibly involved in iron homeostasis; may interact with ribosomes; null mutant displays elevated frequency of mitochondrial genome loss			YGL160W	S000003128
AIM17	FMP12	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss			YHL021C	S000001013
AIM18	FMP22	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss			YHR198C	S000001241
AIM19	LRC2	Putative protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth			YIL087C	S000001349
AIM2		Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced frequency of mitochondrial genome loss; potential Hsp82p interactor			YAL049C	S000000047
AIM20		Putative protein of unknown function; overexpression causes a cell cycle delay or arrest; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; null mutant displays elevated frequency of mitochondrial genome loss			YIL158W	S000001420
AIM21		Protein of unknown function involved in mitochondrial migration along actin filament; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton			YIR003W	S000001442
AIM22	LIP3|RRG3	Putative lipoate-protein ligase, required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss			YJL046W	S000003582
AIM23		Putative protein of unknown function; the authentic non-tagged protein is detected in highly purified mitochondria; null mutant is viable, displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss			YJL131C	S000003667
AIM24	FMP26	Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss			YJR080C	S000003841
AIM25		Putative protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to murine NOR1; null mutant is viable and displays elevated frequency of mitochondrial genome loss			YJR100C	S000003861
AIM26		Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT			YKL037W	S000001520
AIM27	EMC3|LRC3	Member of a transmembrane complex required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response			YKL207W	S000001690
AIM29		Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YKR074W is not an essential gene; null mutant displays elevated frequency of mitochondrial genome loss			YKR074W	S000001782
AIM3		Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss			YBR108W	S000000312
AIM31		Putative protein of unknown function; GFP-fusion protein localizes to mitochondria; may interact with respiratory chain complexes III or IV; null mutant is viable and displays reduced frequency of mitochondrial genome loss			YML030W	S000004492
AIM32		Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss			YML050W	S000004514
AIM33		Putative protein of unknown function, highly conserved across species and orthologous to human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss			YML087C	S000004552
AIM34		Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss			YMR003W	S000004605
AIM36	FMP39	Protein of unknown function; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies			YMR157C	S000004766
AIM37		Putative protein of unknown function; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays reduced respiratory growth and reduced frequency of mitochondrial genome los			YNL100W	S000005044
AIM38		Putative protein of unknown function; non-tagged protein is detected in purified mitochondria; may interact with respiratory chain complex IV; null mutant is viable and displays reduced frequency of mitochondrial genome loss			YNR018W	S000005301
AIM39		Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss			YOL053W	S000005414
AIM4	SOY1	Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress			YBR194W	S000000398
AIM41		Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss			YOR215C	S000005741
AIM43	FMP14	Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss			YPL099C	S000006020
AIM44		Protein of unknown function; GFP-fusion protein localizes to the bud neck; transcription is regulated by Swi5p; null mutant displays elevated frequency of mitochondrial genome loss			YPL158C	S000006079
AIM45		Protein with similarity to mammalian electron transfer flavoprotein complex subunit ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss			YPR004C	S000006208
AIM46	FMP34	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss			YHR199C	S000001242
AIM5	FMP51	Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss			YBR262C	S000000466
AIM6	LRC1	Putative protein of unknown function, required for respiratory growth; YDL237W is not an essential gene			YDL237W	S000002396
AIM7		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is viable and displays elevated frequency of mitochondrial genome loss			YDR063W	S000002470
AIM9	FMP29	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss			YER080W	S000000882
AIP1		Actin cortical patch component, interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats			YMR092C	S000004698
AIR1		Zinc knuckle protein, involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; functionally redundant with Air2p			YIL079C	S000001341
AIR2		Zinc knuckle protein, involved in nuclear RNA processing and degredation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; functionally redundant with Air1p			YDL175C	S000002334
AKL1		Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization			YBR059C	S000000263
AKR1		Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats		Null mutant is viable, exhibits slow growth, abnormal morphology, and partial activation of pheromone response; defective for endocytosis of Ste2p and Ste3p	YDR264C	S000002672
AKR2		Ankyrin repeat-containing protein similar to Akr1p; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p			YOR034C	S000005560
ALA1	CDC64	Cytoplasmic and mitochondrial alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog		null mutant is inviable; allele cdc64-1: arrest of proliferation at the regulatory step Start, inhibition of zygote formation and successful conjugation	YOR335C	S000005862
ALB1		Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p			YJL122W	S000003658
ALD2		Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p			YMR170C	S000004780
ALD3		Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose			YMR169C	S000004779
ALD4	ALD7|ALDH2	Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed			YOR374W	S000005901
ALD5		Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed			YER073W	S000000875
ALD6	ALD1	Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress		Null mutant is viable, grows at approximately one-third the rate of wild-type, unable to grow on ethanol as a carbon source	YPL061W	S000005982
ALE1	LCA1|LPT1|SLC4	Broad-specificity lysophospholipid acyltransferase, part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids			YOR175C	S000005701
ALF1		Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance		Null mutant is viable, benomyl super-sensitive, alf1 tub1 mutants are inviable	YNL148C	S000005092
ALG1		Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog			YBR110W	S000000314
ALG11		Alpha-1,2-mannosyltransferase, catalyzes sequential addition of the two terminal alpha 1,2-mannose residues to the Man5GlcNAc2-PP-dolichol intermediate during asparagine-linked glycosylation in the ER		Null mutant displays poor growth and temperature-sensitive lethality	YNL048W	S000004993
ALG12	ECM39	Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation			YNR030W	S000005313
ALG13		Catalytic component of UDP-GlcNAc transferase, required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER membrane via interaction with Alg14p; similar to bacterial and human glycosyltransferases			YGL047W	S000003015
ALG14		Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases			YBR070C	S000000274
ALG2		Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol		Null mutant is inviable, mutants accumulate Man1-2GlcNAc2 and arrest at G1	YGL065C	S000003033
ALG3	RHK1	Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins		Null mutant is viable, resistant to Hansenula killer toxin	YBL082C	S000000178
ALG5		UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum		underglycosylation of carboxypeptidase Y	YPL227C	S000006148
ALG6		Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease		Null mutant is viable and defective in protein glycosylation.	YOR002W	S000005528
ALG7	TUR1	UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin		Asparagine-linked glycosylation deficient; Null mutant is inviable	YBR243C	S000000447
ALG8	YOR29-18	Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p			YOR067C	S000005593
ALG9		Mannosyltransferase, involved in N-linked glycosylation; catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation			YNL219C	S000005163
ALK1		Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; similar to Alk2p and to mammalian haspins			YGL021W	S000002989
ALK2		Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; similar to Alk1p and to mammalian haspins			YBL009W	S000000105
ALO1		D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress		Null mutant is viable, shows increased sensitivity towards oxidative stress	YML086C	S000004551
ALP1	APL1	Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression			YNL270C	S000005214
ALR1	SWC3	Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions		Null mutant is inviable; overexpression increases resistance to aluminum and gallium toxicity	YOL130W	S000005490
ALR2		Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition		Null mutant is viable, overexpression increases resistance to aluminum and gallium toxicity	YFL050C	S000001844
ALT1		Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthetic and catabolic processes; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YLR089C	S000004079
ALT2		Putative alanine transaminase (glutamic pyruvic transaminase)			YDR111C	S000002518
ALY1	ART6	Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm			YKR021W	S000001729
ALY2	ART3	Protein proposed to regulate the endocytosis of plasma membrane proteins; interacts with the cyclin Pcl7p and ubiquitin ligase Rsp5p; phosphorylated by the cyclin-CDK complex, Pcl7p-Pho85p; mRNA is cell cycle regulated, peaking in M phase			YJL084C	S000003620
AMA1	SPO70	Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis		Null mutant is viable; homozygous null mutant does not sporulate but does not exhibit any vegetative phenotype.	YGR225W	S000003457
AMC1	CHL6	controls segregation of artificial minichromosomes during mitosis		affects mitotic transmission of natural chromosomes		S000029032
AMD1	AMD3	AMP deaminase, tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; may be involved in regulation of intracellular adenine nucleotide pools			YML035C	S000004498
AMD2		Putative amidase			YDR242W	S000002650
AME1	ARP100	Essential kinetochore protein associated with microtubules and spindle pole bodies; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance		Null: Null mutant is inviable; localizes to microtubules and SPB region, ame1-1 arrests in G2/M, mutant rescues benomyl sensitivity of TUB4/ tub4 heterozygote, ame1-4 mutant allele and heterozygous mutant confer benomyl resistance, interacts with APC lid protein by two-hybrid	YBR211C	S000000415
AML1		Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae			YGR001C	S000003233
AMN1	CST13|ICS4	Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)			YBR158W	S000000362
AMS1		Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway			YGL156W	S000003124
ANB1	HYP1|TIF51B|eIF-5A	Translation elongation factor eIF-5A, previously thought to function in translation initiation; similar to and functionally redundant with Hyp2p; undergoes an essential hypusination modification; expressed under anaerobic conditions		null mutant is viable; a double mutant containing disruptions of both ANB1 and and the highly homologous HYP2 is inviable	YJR047C	S000003808
ANC4		actin non-complementing mutant				S000029033
ANI1				Anisomycin resistance		S000029034
ANP1	GEM3|MNN8	Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol		Null mutant has altered mannoprotein glycosylation and a defect in N-linked outerchain glycan mannosylation; other mutant phenotypes include aminonitrophenyl propanediol resistance, vanadate resistance, hygromycin B sensitive and a clumpy growth morphology.	YEL036C	S000000762
ANR2		Putative protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm			YKL047W	S000001530
ANS1		Putative protein of unknown function; transcription dependent upon Azf1p			YHR126C	S000001168
ANT1		Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation		Null: growth defect on medium-chain length fatty acids.	YPR128C	S000006332
AOS1	RHC31	Nuclear protein that acts as a heterodimer with Uba2p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability			YPR180W	S000006384
APA1	DTP1	Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase I (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa2p			YCL050C	S000000555
APA2		Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase II (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa1p			YDR530C	S000002938
APC1		Largest subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition			YNL172W	S000005116
APC11		Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition		Null mutant is inviable at 25 C	YDL008W	S000002166
APC2	RSI1|TID2	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; similar to cullin Cdc53p		Null mutant is inviable at 25 deg. C; ts mutants arrest in metaphase due to defect in the degradation of Pds1; extracts from G1-arrested apc2 mutants are defective in the ubiquitination of mitotic cyclins	YLR127C	S000004117
APC4		Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition		Null mutant is inviable at 25 C	YDR118W	S000002525
APC5	RMC1	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition		Null mutant is inviable at 25 C	YOR249C	S000005775
APC9		Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition		Null mutant is viable at 37 C but show delay in entry into anaphase at 37 C	YLR102C	S000004092
APD1		Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus			YBR151W	S000000355
APE2	LAP1|YKL158W	Aminopeptidase yscII; may have a role in obtaining leucine from dipeptide substrates; sequence coordinates have changed since RT-PCR analysis showed that the adjacent ORF YKL158W comprises the 5' exon of APE2/YKL157W			YKL157W	S000001640
APE3	APY1	Vacuolar aminopeptidase Y, processed to mature form by Prb1p		Null mutant is viable but exhibited reduced vacuolar aminopeptidase activities and could not hydrolyze Lys-Ala-MCA to Lys and Ala-MCA.	YBR286W	S000000490
API2		Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology			YDR525W	S000002933
APJ1		Putative chaperone of the HSP40 (DNAJ) family; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YNL077W	S000005021
APL1	YAP80	Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex			YJR005W	S000003765
APL2		Beta-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting			YKL135C	S000001618
APL3		Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport			YBL037W	S000000133
APL4		Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport			YPR029C	S000006233
APL5	YKS4	Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function		Null mutant is viable, rescues yck1,yck2 double mutant	YPL195W	S000006116
APL6	YKS5	Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools		Null mutant is viable, null rescues yck1 yck2 double mutant	YGR261C	S000003493
APM1	YAP54	Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting		Null mutant is viable, enhances the slow growth and late Golgi sorting defects of a chc1-ts mutant	YPL259C	S000006180
APM2		Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport			YHL019C	S000001011
APM3	YKS6	Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway		Null mutant is viable, even combined with apm1 and apm2	YBR288C	S000000492
APM4	AMP1	Mu2-like subunit of the clathrin associated protein complex (AP-2); involved in vesicle transport			YOL062C	S000005423
APN1		Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine		hypersensitive to both oxidative and alkylating agents that damage DNA; higher rate of spontaneous mutation	YKL114C	S000001597
APN2	ETH1	Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII			YBL019W	S000000115
APP1		Protein of unknown function, interacts with Rvs161p and Rvs167p; computational analysis of protein-protein interactions in large-scale studies suggests a possible role in actin filament organization		Null: Viable. Other phenotypes: Unknown	YNL094W	S000005038
APQ12		Protein required for nuclear envelope morphology, nuclear pore complex localization, mRNA export from the nucleus; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism			YIL040W	S000001302
APQ13		Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene NET1; null mutant is sensitive to sorbate			YJL075C	S000003611
APR2						S000029037
APR3						S000029038
APR4						S000029039
APR5						S000029040
APS1	YAP19	Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex		Null mutant is viable; aps1 mutants demonstrate synthetic effects with chc1 alleles	YLR170C	S000004160
APS2	YAP17	Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex		null mutant is viable; slight effect on chc1-ts cell growth	YJR058C	S000003819
APS3	YKS7	Small subunit of the clathrin-associated adaptor complex AP-3, which is involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function		Null mutant is viable, rescues yck1,yck2 double mutant	YJL024C	S000003561
APT1		Adenine phosphoribosyltransferase, catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis			YML022W	S000004484
APT2		Apparent pseudogene, not transcribed or translated under normal conditions; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity			YDR441C	S000002849
AQR1		Plasma membrane multidrug transporter of the major facilitator superfamily, confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids		Null mutant is viable, but exhibits increased susceptibility to low-chain organic acids (C2-C6), azoles, antimalarial quinoline-ring containing drugs, malachite green and crystal violet	YNL065W	S000005009
AQY1		Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance		Null mutant is viable and exhibits improved viability when grown under hypo-osmolar or hyper-osmolar stress.	YPR192W	S000006396
AQY2		Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains			YLL052C	S000003975
ARA1		NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product		Null mutant is viable but cannot produce D-arabinono-1,4-lactone, a precursor of D-erythroascorbic acid	YBR149W	S000000353
ARA2		NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase			YMR041C	S000004644
ARB1		ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p			YER036C	S000000838
ARC1		Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids		Null mutant is viable, leads to slow growth and reduced MetRS activity; arc1- mutants are synthetic lethals and are complemented by the genes for methionyl-tRNA and glutamyl-tRNA synthetase.	YGL105W	S000003073
ARC15		Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches		Null mutant exhibits severe growth defects. Cells with mutations in Arp2 and Arc15 are defective in mitochondrial movement.	YIL062C	S000001324
ARC18		Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches			YLR370C	S000004362
ARC19		Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches		Null mutant is viable, but exhibits severe growth defects	YKL013C	S000001496
ARC35	END9	Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin		Null mutant exhibits severe growth defects; synthetic lethal with vma2.	YNR035C	S000005318
ARC40		Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches			YBR234C	S000000438
ARD1	NAA10	Subunit of N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); acetylates many proteins and thus affects telomeric silencing, cell cycle, heat-shock resistance, mating, and sporulation; human Ard1p levels are elevated in cancer cells			YHR013C	S000001055
ARE1	SAT2	Acyl-CoA:sterol acyltransferase, isozyme of Are2p; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen		Null mutant is viable, slightly reduces in vivo and in vitro ergosterol esterification. Deletion of both ARE1 and ARE2 completely eliminates of in vivo and in vitro ergosterol esterification	YCR048W	S000000644
ARE2	SAT1	Acyl-CoA:sterol acyltransferase, isozyme of Are1p; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen		Null mutant is viable; greatly reduces in vivo and in vitro ergosterol esterification (to 15 - 35 % of wild-type). Deletion of both ARE1 and ARE2 completely eliminates in vivo and in vitro ergosterol esterification	YNR019W	S000005302
ARF1		ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; functionally interchangeable with Arf2p		Null mutant is viable and shows slow growth, cold sensitivity and sensitivity to normally sublethal concentrations of fluoride ion in the medium.	YDL192W	S000002351
ARF2		ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; functionally interchangeable with Arf1p			YDL137W	S000002296
ARF3	ARL2	Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity			YOR094W	S000005620
ARG1	ARG10	Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate		Arginine requiring	YOL058W	S000005419
ARG2	HRB574	Acetylglutamate synthase (glutamate N-acetyltransferase), mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p			YJL071W	S000003607
ARG3	argF	Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine		Arginine requiring	YJL088W	S000003624
ARG4		Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway		Arginine requiring	YHR018C	S000001060
ARG5,6		Protein that is processed in the mitochondrion to yield acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase, which catalyze the 2nd and 3rd steps in arginine biosynthesis; enzymes form a complex with Arg2p		Arginine requiring	YER069W	S000000871
ARG7	ECM40	Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine			YMR062C	S000004666
ARG8		Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine		Arginine requiring	YOL140W	S000005500
ARG80	ARGR1|ARGRI	Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p		Arginine requiring	YMR042W	S000004645
ARG81	ARGR2|ARGRII	Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p			YML099C	S000004565
ARG82	ARGR3|ARGRIII|IPK2	Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes		Null mutant is viable but requires arginine at 23C; growth defect at 30C; inviable at 37C; null is defective in sporulation, mating, amino acid metabolism (fails to grow on medium in which arginine or ornithine is the sole nitrogen source); null mutants accumulate IP3, I(4,5)P2 and have drastically reduced levels of IP4, IP5 and IP6.	YDR173C	S000002580
ARG84				Arginine requiring		S000029041
ARH1		Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability			YDR376W	S000002784
ARI1		NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily			YGL157W	S000003125
ARK1		Serine/threonine protein kinase involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis		Null mutant is viable and shows slight delocalisation of actin cytoskeleton	YNL020C	S000004965
ARL1	DLP2	Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor			YBR164C	S000000368
ARL3		GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor		Null mutant is viable, displays cold-sensitive growth	YPL051W	S000005972
ARN1		Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores			YHL040C	S000001032
ARN2	TAF1	Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C			YHL047C	S000001039
ARO1		Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids		aromatic amino acid requiring; lack of premeiotic DNA synthesis; blocked sporulation in homozygous mutant	YDR127W	S000002534
ARO10		Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway			YDR380W	S000002788
ARO2		Bifunctional chorismate synthase and flavin reductase, catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids		aromatic amino acid requiring; lack of premeiotic DNA synthesis; blocked sporulation in homozygous mutant	YGL148W	S000003116
ARO3		3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan			YDR035W	S000002442
ARO4		3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan			YBR249C	S000000453
ARO7	HGS1|OSM2|TYR7	Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis		Aromatic amino acid requiring; Low osmotic pressure sensitive	YPR060C	S000006264
ARO8		Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis			YGL202W	S000003170
ARO80		Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids			YDR421W	S000002829
ARO9		Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism			YHR137W	S000001179
ARP1	ACT5	Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin		Null mutant is viable, but both null mutations and overexpression lead to defects in spindle orientation and nuclear migration (during mitosis in arp1 mutants the nucleus fails to move into the neck).	YHR129C	S000001171
ARP10		Component of the dynactin complex, localized to the pointed end of the Arp1p filament; may regulate membrane association of the complex			YDR106W	S000002513
ARP2	ACT2	Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity		cells with mutations in Arp2 and Arc15 are defective in mitochondrial movement.	YDL029W	S000002187
ARP3	ACT4	Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity		Mutations in Arp3 lead to defects in actin-patch motility and a rearrangement of the cortical actin cytoskeleton.	YJR065C	S000003826
ARP4	ACT3	Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes			YJL081C	S000003617
ARP5		Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes			YNL059C	S000005004
ARP6		Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A			YLR085C	S000004075
ARP7	RSC11|SWP61	Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation		Null mutant is viable, exhibits typical swi/snf phenotypes, including growth defects on media containing galactose, glycerol, or sucrose as sole carbon sources. ARP7 is required for expression of an HO-lacZ fusion gene and for full transcriptional enhancement by the GAL4 activator	YPR034W	S000006238
ARP8		Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes			YOR141C	S000005667
ARP9	RSC12|SWP59	Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation		Null mutant is viable, exhibits typical swi/snf phenotypes, including growth defects on media containing galactose, glycerol, or sucrose as sole carbon sources. ARP9 is required for expression of an HO-lacZ fusion gene and for full transcriptional enhancement by the GAL4 activator	YMR033W	S000004636
ARR1	ACR1|YAP8	Transcriptional activator of the basic leucine zipper (bZIP) family, required for transcription of genes involved in resistance to arsenic compounds		Null mutant is viable, confers arsenite and arsenate hypersensitivity	YPR199C	S000006403
ARR2	ACR2	Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p		Null mutant is viable but sensitive to arsenate (but not arsenite).	YPR200C	S000006404
ARR3	ACR3	Arsenite transporter of the plasma membrane, required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite		Overexpression confers arsenite but not arsenate resistance	YPR201W	S000006405
ARS1		Early-firing autonomously replicating sequence; highly efficient chromosomal replicator active in nearly every cell cycle				S000029652
ARS101	ARSI-160	ARS containing multiple redundant binding sites for the origin recognition complex				S000077372
ARS110	ARSI-176	Autonomously Replicating Sequence, originally referred to as ADE1 ARS				S000114488
ARS1208	ARSXII-151|CEN12 ARS	Autonomously Replicating Sequence				S000114848
ARS1516	ADE2 ARS|ARSXV-567	Autonomously Replicating Sequence				S000114843
ARS2		Autonomously Replicating Sequence				S000029042
ARS209		Autonomously Replicating Sequence, originally referred to as H4 ARS				S000114517
ARS300		Autonomously Replicating Sequence				S000028476
ARS301	HML-E ARS	Inactive replication origin associated with the silent mating type locus HML, where it functions as a transcriptional silencer				S000028477
ARS302	HML-I ARS	Inactive replication origin associated with the silent mating type locus HML, where it functions as a transcriptional silencer				S000028478
ARS303		Autonomously Replicating Sequence on Chromosome III, inactive as replication origin at native locus near HML				S000028479
ARS304		Autonomously Replicating Sequence on Chromosome III				S000028481
ARS305		Efficient, early-firing chromosomal replication origin on Chromosome III				S000028482
ARS306		Early-firing autonomously replicating sequence on Chromosome III				S000028483
ARS307		Autonomously Replicating Sequence on Chromosome III				S000028484
ARS308		Autonomously Replicating Sequence on Chromosome III				S000028485
ARS309		Autonomously Replicating Sequence on Chromosome III				S000028486
ARS310		Compound autonomously replicating sequence on Chromosome III				S000028487
ARS313	ARSIII-194	Autonomously Replicating Sequence on Chromosome III				S000028488
ARS314	ARSIII-198	Autonomously Replicating Sequence on Chromosome III, active in <10% of cell cycles				S000028489
ARS315	ARSIII-225	Highly-active autonomously replicating sequence, initiates replication in ~90% of cell cycles				S000028490
ARS316	ARSIII-273	Inefficient autonomously replicating sequence, active in ~25% of cell cycles				S000028491
ARS317	HMR-E ARS	Autonomously replicating sequence active in only a small fraction of cell cycles; fires extremely inefficiently and late during S phase compared to other origins in the genome				S000028492
ARS318	HMR-I ARS	Autonomously replicating sequence active in only a small fraction of cell cycles; becomes active if the nearby ARS317/HMR-E silencer is deleted				S000028493
ARS319		Highly-active subtelomeric autonomously replicating sequence, initiates replication in ~90% of cell cycles				S000028494
ARS320		Autonomously Replicating Sequence on Chromosome III, inactive as replication origin at native locus near HML				S000028480
ARS404	HO ARS	Autonomously Replicating Sequence				S000114787
ARS422	ARO1 ARS|ARSIV-703	Autonomously Replicating Sequence				S000114834
ARS600	ARS120	Subtelomeric Autonomously Replicating Sequence; originally published as ARS120				S000029653
ARS601		Autonomously replicating sequence on Chromosome VI, overlaps ARS602, ARS601/ARS602 together appear to be activated during the second half of S phase in ~32% of cell cycles				S000007633
ARS602		Autonomously replicating sequence on Chromosome VI, overlaps ARS601, ARS601/ARS602 together appear to be activated during the second half of S phase in ~32% of cell cycles				S000007634
ARS603		Highly-efficient autonomously replicating sequence on Chromosome VI, activated during the second half of S phase in ~67% of cell cycles				S000007635
ARS603.5		Autonomously replicating sequence on Chromosome VI, activated early in S phase in ~50% of cell cycles				S000007645
ARS604		Extremely inefficient autonomously replicating sequence on Chromosome VI				S000007636
ARS605		Autonomously replicating sequence on Chromosome VI, activated early in S phase in ~27% of cell cycles; inactive during premeiotic S phase				S000007637
ARS606		Highly-efficient autonomously replicating sequence on Chromosome VI, activated early in S phase in ~74% of cell cycles; replication capacity dependent upon Sum1p				S000007638
ARS607		Highly-efficient autonomously replicating sequence on Chromosome VI, activated very early in S phase in >85% of cell cycles				S000007639
ARS608		Extremely inefficient autonomously replicating sequence on Chromosome VI, activated early in S phase in <10% of cell cycles				S000007640
ARS609		Autonomously replicating sequence on Chromosome VI, activated very late in S phase in ~37% of cell cycles				S000007641
ARS610	ARSVI-270	Autonomously Replicating Sequence				S000121260
ARS706	ARO8 ARS	Autonomously Replicating Sequence				S000114845
ARS805	ARSVIII-64|SPO11 ARS	Autonomously Replicating Sequence				S000114849
ARS901	ARS249|ARSIX-215	Autonomously Replicating Sequence				S000007644
ART10		Protein of unknown function that contains 2 PY motifs and is ubiquinated by Rsp5p; green fluorescent protein (GFP)-fusion protein localizes it to the cytoplasm; non-essential gene			YLR392C	S000004384
ART5		Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane			YGR068C	S000003300
ARV1		Protein functioning in transport of glycosylphosphatidylinositol intermediates into the ER lumen; required for normal intracellular sterol distribution and for sphingolipid metabolism; similar to Nup120p and C. elegans R05H5.5 protein		Subcellular membrane accumulation of free sterol; Mutations in yeast ARV1 are complemented by expression of human ARV1|Subcellular membrane accumulation of free sterol; arv1 mutations are complemented by human ARV1 and are synthetically lethal with are1 and are2 null mutations; null mutant is temperature sensitive, anaerobically inviable, polyene antibiotic sensitive, and inviable in the absence of sterol esterification|temperature sensitive, anaerobically inviable, polyene antibiotic sensitive, inviable in the absence of sterol esterification	YLR242C	S000004232
ARX1		Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex			YDR101C	S000002508
ASA1		Putative protein of unknown function; subunit of the ASTRA complex (Rvb1p, Rvb2p, Tra1p, Tti1p, Tti2, Asa1p and Tra1p) which is part of the chromatin remodeling machinery			YPR085C	S000006289
ASC1	CPC2	G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; represses Gcn4p in the absence of amino acid starvation		Null mutant is viable. Null mutation suppresses the absence of growth of a cyp1- strain in anaerobiosis and also causes delayed growth in aerobic or heme sufficient conditions; trp auxotrophs of the asc1 null allele are cold sensitive for growth; other mutants have increased cell size	YMR116C	S000004722
ASC2		CYP1 absence of growth supressor				S000029043
ASE1	YOR29-09	Mitotic spindle midzone localized microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate		Null mutant is viable but temperature sensitive.	YOR058C	S000005584
ASF1	CIA1	Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition			YJL115W	S000003651
ASF2		Anti-silencing protein that causes derepression of silent loci when overexpressed			YDL197C	S000002356
ASG1		Zinc cluster protein proposed to function as a transcriptional regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance		Null: viable. Other phenotypes: suppressor of gcn5 catalytically inactive mutants	YIL130W	S000001392
ASG7		Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell; specific to a-cells and induced by alpha-factor			YJL170C	S000003706
ASH1		Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate		Mutant ash1 daughters can transcribe HO and switch mating type	YKL185W	S000001668
ASI1		Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals			YMR119W	S000004725
ASI2		Integral inner nuclear membrane protein that acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals			YNL159C	S000005103
ASI3		Putative integral membrane E3 ubiquitin ligase; acts with Asi1p and Asi2p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals			YNL008C	S000004953
ASK1		Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases			YKL052C	S000001535
ASK10	RGC2	Component of the RNA polymerase II holoenzyme, phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p, which relieves repression of stress-response genes			YGR097W	S000003329
ASL1						S000029044
ASM4	NUP59	Nuclear pore complex subunit, part of a subcomplex also containing Nup53p, Nup170p, and Pse1p		Null mutant is viable in some strain backgrounds (including CEN.PK2); however, in the FY1679 genetic background, it is inviable.	YDL088C	S000002246
ASN1		Asparagine synthetase, isozyme of Asn2p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway		Null mutant is viable; L-asparagine auxotrophy occurs upon mutation of both ASN1 and ASN2	YPR145W	S000006349
ASN2		Asparagine synthetase, isozyme of Asn1p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway		Null mutant is viable; L-asparagine auxotrophy occurs upon mutation of both ASN1 and ASN2	YGR124W	S000003356
ASP1		Cytosolic L-asparaginase, involved in asparagine catabolism		Aspartic acid requiring	YDR321W	S000002729
ASP3-1	ASP3	Cell-wall L-asparaginase II, involved in asparagine catabolism; expression is induced during nitrogen starvation; four copies of ASP3 are present in the genome reference strain S288C			YLR155C	S000004145
ASP3-2	ASP3	Cell-wall L-asparaginase II, involved in asparagine catabolism; expression is induced during nitrogen starvation; four copies of ASP3 are present in the genome reference strain S288C			YLR157C	S000004147
ASP3-3	ASP3	Cell-wall L-asparaginase II, involved in asparagine catabolism; expression is induced during nitrogen starvation; four copies of ASP3 are present in the genome reference strain S288C			YLR158C	S000004148
ASP3-4	ASP3	Cell-wall L-asparaginase II, involved in asparagine catabolism; expression is induced during nitrogen starvation; four copies of ASP3 are present in the genome reference strain S288C			YLR160C	S000004150
ASR1		Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein			YPR093C	S000006297
AST1		Peripheral membrane protein that interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane, possibly by influencing its incorporation into lipid rafts		multicopy AST1 suppresses pma1 alleles defective for targeting	YBL069W	S000000165
AST2		Protein that may have a role in targeting of plasma membrane [H+]ATPase (Pma1p) to the plasma membrane, as suggested by analysis of genetic interactions		in high copy number, suppresses a pma1 ts mutant that is mis-routed to the vacuole at the restrictive temperature	YER101C	S000000903
ASU9		anti-suppressor that reduces the efficiency of sup45 and sup35		asu9 allele causes sensitivity to paromomycin		S000029045
ATA1		Sporulation-specific gene characterized by ATA sequences				S000029046
ATC1	LIC4	Nuclear protein, possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern			YDR184C	S000002592
ATE1		Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway	arginyl-tRNA-protein transferase	Null mutant is viable, but unable to degrade substrates of the N-end rule pathway that start with residues recognized by the Arg-transferase	YGL017W	S000002985
ATF1		Alcohol acetyltransferase with potential roles in lipid and sterol metabolism; responsible for the major part of volatile acetate ester production during fermentation			YOR377W	S000005904
ATF2		Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important in brewing			YGR177C	S000003409
ATG1	APG1|AUT3|CVT10	Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p		Defective in autophagy; loses viability more rapidly than wild type during nitrogen starvation; defective in vacuolar protein degradation during nitrogen starvation; defective in sporulation	YGL180W	S000003148
ATG10	APG10	Conserved E2-like conjugating enzyme that mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy		Defective autophagy, apg10-1 allele shows reduced viablility under starvation conditions	YLL042C	S000003965
ATG11	CVT9	Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the (PAS)		cvt9 is defective in vacuolar delivery of aminopeptidase I and peroxisome degradation but is not needed for macroautophagy. The null mutant is viable and is relatively starvation-insensitive.|cvt9 is defective in maturation of the vacuolar protein, aminopeptidase I and exhibits minor defects in autophagy	YPR049C	S000006253
ATG12	APG12	Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation		Null mutant is viable, defective in autophagy	YBR217W	S000000421
ATG13	APG13	Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling		Defective in autophagy	YPR185W	S000006389
ATG14	APG14|CVT12	Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I (with Vps34/15/30p); Atg14p targets complex I to the phagophore assembly site (PAS); required for localizing additional ATG proteins to the PAS; homolog of human Barkor		Null mutant is viable but defective in autophagy.	YBR128C	S000000332
ATG15	AUT5|CVT17	Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway		cvt17 is defective in lysis of autophagic vesicles after delivery to the vacuole. Null mutant is starvation-sensitive, accumulates subvacuolar vesicles, defective in maturation of aminopeptidase I and in autophagy.	YCR068W	S000000664
ATG16	APG15|APG16|CVT11|SAP18	Conserved protein that interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which localize to the pre-autophagosomal structure and are required for autophagy		Null mutant is viable, defective in autophagy	YMR159C	S000004769
ATG17	APG17	Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity		Null mutant is viable and has defect in autophagy|required for activation of Apg1 protein kinase	YLR423C	S000004415
ATG18	AUT10|CVT18|NMR1|SVP1	Phosphoinositide binding protein required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein		(NMR1)Null mutant is viable; arrests with 2C DNA content after shift to sporulation medium.	YFR021W	S000001917
ATG19	CVT19	Receptor protein specific for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Lap4p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles		Null: viable, unable to target vacuolar aminopeptidase I and to vacuoles, both under growing and nitrogen starvation conditions.	YOL082W	S000005442
ATG2	APG2|AUT8|SPO72	Peripheral membrane protein required for vesicle formation during autophagy, pexophagy, and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria		The null mutant is viable but blocked in autophagy, pexophagy and import of Ape1 by the cytoplasm to vacuole targeting pathway. Diploids homozygous for the null mutation lack premeitoic DNA synthesis and do not sporulate.	YNL242W	S000005186
ATG20	CVT20|SNX42	Sorting nexin family member required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate		Null: The cvt20 mutant accumulates precursor Ape1 but is normal for autophagy.. Other phenotypes: A mutation of a conserved tyrosine to alanine in the PX domain abolishes binding to PtdIns(3)P.	YDL113C	S000002271
ATG21	HSV1|MAI1	Phosphoinositide binding protein required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein		mai1 null is viable; mai1 aut10 ygr223c triple deletion strain does not grow on a specific acetate medium at 15C	YPL100W	S000006021
ATG22	AUT4	Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation		Null mutant is viable, but exhibits defects in lysis of autophagic vesicles after delivery to the vacuole; vesicles accumulate in the vacuole in the absence of PMSF; maturation of the vacuolar protein, aminopeptidase I is unaffected in aut4	YCL038C	S000000543
ATG23	CVT23	Peripheral membrane protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway and efficient macroautophagy; cycles between the phagophore assembly site (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p			YLR431C	S000004423
ATG26	UGT51	UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy		Null mutant is viable and unable to synthesize sterol glucoside	YLR189C	S000004179
ATG27	ETF1	Type I membrane protein involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; may be involved in membrane delivery to the phagophore assembly site			YJL178C	S000003714
ATG29		Autophagy-specific protein that is required for recruitment of other ATG proteins to the pre-autophagosomal structure (PAS); interacts with Atg17p and localizas to the PAS in a manner interdependent with Atg17p and Cis1p; not conserved			YPL166W	S000006087
ATG3	APG3|AUT1	E2-like enzyme involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt		Null mutant is viable, defective in starvation-induced bulk flow transport of cytoplasmic proteins to the vacuole, exhibits decreased survival rates during starvation, defective in protein degradation in the vacuoles induced by nitrogen starvation, homozygous diploids fail to sporulate	YNR007C	S000005290
ATG32	ECM37	Mitochondrial-anchored transmembrane receptor that interacts with the autophagy adaptor protein, Atg11p, and is essential for mitophagy, the selective vacuolar degradation of mitochondria in response to starvation			YIL146C	S000001408
ATG33		Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at the post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes			YLR356W	S000004348
ATG4	APG4|AUT2	Conserved cysteine protease required for autophagy; cleaves Atg8p to a form required for autophagosome and Cvt vesicle generation		Null mutant is viable but lacks autophagocytosis: i.e. starvation-induced protein transport to the vacuole; homozygous aut2-mutant diploids cannot sporulate	YNL223W	S000005167
ATG5	APG5	Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a complex with Atg16p that is essential for autophagosome formation		reduced viability upon nutrient starvation; defective in autophagy	YPL149W	S000006070
ATG7	APG11|APG7|CVT2	Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation		Null mutant is viable, defective in autophagy	YHR171W	S000001214
ATG8	APG8|AUT7|CVT5	Component of autophagosomes and Cvt vesicles; undergoes conjugation to phosphatidylethanolamine (PE); Atg8p-PE is anchored to membranes, is involved in phagophore expansion, and may mediate membrane fusion during autophagosome formation		Null mutant is viable but lacks autophagocytosis and is unable to sporulate. AUT7 is a suppressor of mutant phenotypes of aut2-1 cells. Uptake of precursor Aminopeptidase I into the vacuole depends on Aut2p and Aut7p.	YBL078C	S000000174
ATG9	APG9|AUT9|CVT7	Transmembrane protein involved in forming Cvt and autophagic vesicles; cycles between the phagophore assembly site (PAS) and other cytosolic punctate structures, not found in autophagosomes; may be involved in membrane delivery to the PAS		Null mutant is viable but blocked in autophagy and aminopeptidase I import into vacuole. Temperature-sensitive mutant accumulates membrane-associated, protease-sensitive API.	YDL149W	S000002308
ATH1		Acid trehalase required for utilization of extracellular trehalose		Null mutant is viable; shows lack of vacuolar acid trehalase activity	YPR026W	S000006230
ATI5		acaciae toxin insensitive		Recessives are insensitive to the toxin produced by Pichia acaciae		S000029047
ATM1		Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol		slow growth on rich medium, inviable on minimal medium; unstable mitochondrial genome; have 'white' mitochondria that completely lack cytochromes	YMR301C	S000004916
ATO2	FUN34	Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p		Null mutant is viable. Other phenotype: defect in ammonia production in S.cerevisiae colonies	YNR002C	S000005285
ATO3		Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters		Null: viable. Other phenotypes: defect in ammonia production in S.cerevisiae colonies	YDR384C	S000002792
ATP1		Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated		null mutant is viable; grows slowly on fermentable carbon sources; exhibits delayed kinetics of protein import for several mitochondrial precursors	YBL099W	S000000195
ATP10		Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6		loss of rutamycin sensitivity in mitochondrial ATPase but no effect on respiratory enzymes	YLR393W	S000004385
ATP11		Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase		greatly reduced ATPase activity; alpha and beta subunits of F1-ATPase accumulate in mitochondria as inactive aggregates	YNL315C	S000005259
ATP12		Conserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency		greatly reduced ATPase activity; alpha and beta subunits of F1-ATPase accumulate in mitochondria as inactive aggregates	YJL180C	S000003716
ATP14		Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis		unable to grow on glycerol medium; no detectable oligomycin-sensitive ATPase activity	YLR295C	S000004286
ATP15	ATPEPSILON	Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated		unable to grow on glycerol medium; no detectable oligomycin-sensitive ATPase activity; oligomycin-sensitive uncoupling of the mitochondrial respiration rate	YPL271W	S000006192
ATP16		Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated		cells are entirely cytoplasmic petite	YDL004W	S000002162
ATP17		Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis		No growth on glycerol	YDR377W	S000002785
ATP18		Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms		Null mutant is viable, deficient in oligomycin-sensitive ATPase activity, and is unable to grow on nonfermentable carbon sources.	YML081C-A	S000007247
ATP19		Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase			YOL077W-A	S000007339
ATP2		Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated		Mutant displays a growth defect on glycerol	YJR121W	S000003882
ATP20		Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex		Null mutant is viable but exhibits a reduced growth rate on respiratory substrates	YPR020W	S000006224
ATP22	TCM10	Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis			YDR350C	S000002758
ATP23		Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex			YNR020C	S000005303
ATP25	LRC4	Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene			YMR098C	S000004704
ATP3		Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis			YBR039W	S000000243
ATP4	LPF7	Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated		Null mutant is viable but is oxidative phosphorylation deficient, is unable to grow on glycerol, shows an F1 loosely bound to mitochondrial membrane, lacks subunit 6 in F0, has a five times lower cytochrome oxidase activity, produces a high percentage of sponteneous rho- mutants, and is oligomycin-insensitive	YPL078C	S000005999
ATP5	OSC1	Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated	oligomycin sensitivity-conferring protein	null mutant is viable, but unable to grow on glycerol; exhibits high level of genetic instability	YDR298C	S000002706
ATP6	OLI2|OLI4|PHO1	Mitochondrially encoded subunit a of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis		oligomycin resistance	Q0085	S000007268
ATP7		Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis		glycerol minus phenotype; mitochondria have no detectable oligomycin-sensitive ATPase activity; F1 loosely bound to the membranous portion	YKL016C	S000001499
ATP8	AAP1	Subunit 8 of the F0 sector of mitochondrial inner membrane F1-F0 ATP synthase, encoded on the mitochondrial genome		Loss of respiratory function	Q0080	S000007267
ATR1	SNQ1	Multidrug efflux pump of the major facilitator superfamily, required for resistance to aminotriazole and 4-nitroquinoline-N-oxide		Null mutant is viable, but is sensitive to very low (5 mM) levels of aminotriazole and to 4-nitroquinoline-N-oxide (4-NQO); multiple copies of ATR1 confer hyper-resistance to 4-NQO; multiple copies of ATR1 in gcn4 background confer resistance to high (80mM) levels of aminotriazole	YML116W	S000004584
ATS1	FUN28|KTI13	Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle		slow growth	YAL020C	S000000018
ATX1		Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake		hypersensitive toward paraquat (a generator of superoxide anion)	YNL259C	S000005203
ATX2	YOR29-30	Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation		Null mutant is viable but has reduced levels of intracellular manganese.	YOR079C	S000005605
AUA1	YFL011W-A	Protein required for the negative regulation by ammonia of Gap1p, which is a general amino acid permease			YFL010W-A	S000001955
AUR1		Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance		Null mutant is inviable; mutant exhibits dominant resistance to aureobasidin A. Wild type (sensitive) is recessive.	YKL004W	S000001487
AUS1		Transporter of the ATP-binding cassette family, involved in uptake of sterols and anaerobic growth		Null mutant is viable but exhibits reduced cholesterol accumulation.	YOR011W	S000005537
AUT6		Defective in autophagocytosis		AUT6 was isolated genetically as a mutant defective in autophagy.		S000029048
AVL9		Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms		Transposon insertion allele is synthetically lethal with pho85-delta	YLR114C	S000004104
AVO1		Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth			YOL078W	S000005438
AVO2		Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth			YMR068W	S000004672
AVT1		Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters			YJR001W	S000003761
AVT2		Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters			YEL064C	S000000790
AVT3		Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters			YKL146W	S000001629
AVT4		Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters			YNL101W	S000005045
AVT5		Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters			YBL089W	S000000185
AVT6		Vacuolar amino acid transporter, exports aspartate and glutamate from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters			YER119C	S000000921
AVT7		Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters			YIL088C	S000001350
AWA1		Putative GPI-anchored protein, localized to the cell wall; involved in foam formation in sake mash by conferring hydrophobicity to the cell surface				S000029703
AXE1		Is very likely an allele of PDR1		Axenomycin resistance		S000029050
AXL1	FUS5|STE22	Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells		Null mutant is viable; exhibits reduced a-factor expresion; haploid mutants show bipolar budding pattern (diploid pattern) rather than the normal axial (spiral) budding pattern	YPR122W	S000006326
AXL2	BUD10|SRO4	Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate			YIL140W	S000001402
AYR1		NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones	1-acyl dihydroxyacetone phosphate reductase	Null mutant is viable. ybr159w/ayr1 double mutant is inviable.	YIL124W	S000001386
AYT1		Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis			YLL063C	S000003986
AZF1		Zinc-finger transcription factor, involved in induction of CLN3 transcription in response to glucose; genetic and physical interactions indicate a possible role in mitochondrial transcription or genome maintenance			YOR113W	S000005639
AZR1		Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole			YGR224W	S000003456
BAG7		Rho GTPase activating protein (RhoGAP), stimulates the intrinsic GTPase activity of Rho1p, which plays a role in actin cytoskeleton organization and control of cell wall synthesis; structurally and functionally related to Sac7p		Null mutant is viable; overexpression suppresses sac7 null mutation	YOR134W	S000005660
BAP2		High-affinity leucine permease, functions as a branched-chain amino acid permease involved in the uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains		reduced uptake of leucine, isoleucine, and valine	YBR068C	S000000272
BAP3	PAP1	Amino acid permease involved in the uptake of cysteine, leucine, isoleucine and valine			YDR046C	S000002453
BAR1	SST1	Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest		MATa bar1 cells are supersensitive to the G1 arrest induced by alpha factor	YIL015W	S000001277
BAS1		Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes			YKR099W	S000001807
BAT1	ECA39|TWT1	Mitochondrial branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during logarithmic phase and repressed during stationary phase		Null mutant is viable; ILV auxotrophy in bat1 bat2 double mutant	YHR208W	S000001251
BAT2	ECA40|TWT2	Cytosolic branched-chain amino acid aminotransferase, homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase			YJR148W	S000003909
BBC1	MTI1|YJL021C	Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches			YJL020C	S000003557
BBP1		Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p		Null mutant is inviable; cells depleted of Bbp1p are defective in nuclear segregation, bud formation, cytokinesis and nuclear spindle formation; overexpression gives ascus that contains asci instead of spores	YPL255W	S000006176
BCD1		Essential protein required for the accumulation of box C/D snoRNA			YHR040W	S000001082
BCH1		Member of the ChAPs family (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; may interact with ribosomes			YMR237W	S000004850
BCH2	FMP50	Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane			YKR027W	S000001735
BCK1	LAS3|SAP3|SLK1|SSP31	Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p		Null mutants are temperature-sensitive and exhibit cell lysis, which can be rescued by 1M sorbitol; null mutants grow very poorly even at the permissive temperature. Some dominant alleles suppress a pkc1 null mutant.	YJL095W	S000003631
BCK2	CTR7	Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations			YER167W	S000000969
BCP1		Essential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport			YDR361C	S000002769
BCS1		Protein of the mitochondrial inner membrane that functions as an ATP-dependent chaperone, required for the incorporation of the Rip1p and Qcr10p subunits into the cytochrome bc(1) complex; member of the CDC48/PAS1/SEC18 ATPase family		Gross reduction in the Rieske iron-sulfur subunit	YDR375C	S000002783
BCY1	SRA1	Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA), a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation		Null mutant is viable; sra1 mutants are associated with reduction of glycogen accumulation, temperature sensitivity, reduced growth rate on maltose and sucrose, inability to grow on galactose and nonfermentable carbon sources and nitrogen starvation intolerance. Cells lacking Sra1p are constitutive for cAPK activity resulting in meiotic arrest prior to premeiotic DNA synthesis	YIL033C	S000001295
BDF1		Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p		Null mutant is viable; defect in sporulation and spore formation, reduced rate of vegetative growth, sensitivity to a DNA-damaging agent, defective in snRNA production	YLR399C	S000004391
BDF2		Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p		Null mutant is viable in FY1679, RAY3A-D, and CEN.PK2 backgrounds, and synthetic lethal with bdf1	YDL070W	S000002228
BDH1	BDH	NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source	(2R,3R)-2,3-butanediol dehydrogenase		YAL060W	S000000056
BDH2		Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3			YAL061W	S000000057
BDP1	TFC5	Essential subunit of RNA polymerase III transcription factor (TFIIIB), which is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs	B"|TFIIIB90	Null mutant is inviable; tfc5 mutant suppresses mutations in the class III transcription system	YNL039W	S000004984
BDS1		Bacterially-derived sulfatase required for use of alkyl- and aryl-sulfates as sulfur sources			YOL164W	S000005524
BEL3				bel3 bel7 mutations cause enhanced transcription of a gene fusion, consisting of the open reading frame of PHO5 connected to the HIS5 promoter (HIS5p) integrated at the ura3 or leu2 locus in a gcn4 null background		S000029051
BEL4				bel4 mutations cause enhanced transcription of a gene fusion, consisting of the open reading frame of PHO5 connected to the HIS5 promoter (HIS5p) integrated at the ura3 or leu2 locus in a gcn4 null background		S000029052
BEL5				bel5 bel6 mutations cause enhanced transcription of a gene fusion, consisting of the open reading frame of PHO5 connected to the HIS5 promoter (HIS5p) integrated at the ura3 or leu2 locus in a gcn4 null background		S000029053
BEL6				bel6 bel5 mutations cause enhanced transcription of a gene fusion, consisting of the open reading frame of PHO5 connected to the HIS5 promoter (HIS5p) integrated at the ura3 or leu2 locus in a gcn4 null background		S000029054
BEL7				bel7 bel3 mutations cause enhanced transcription of a gene fusion, consisting of the open reading frame of PHO5 connected to the HIS5 promoter (HIS5p) integrated at the ura3 or leu2 locus in a gcn4 null background		S000029055
BEM1	SRO1	Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p		Null mutant is viable; exhibits a defect in polarization in vegetative cells, exhibits decreased expression of FUS1	YBR200W	S000000404
BEM2	IPL2|SUP9|TSL1	Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence		randomized bud-site selection at 26 degrees C and defective bud emergence and growth at 37 degrees C	YER155C	S000000957
BEM3		Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly			YPL115C	S000006036
BEM4	ROM7	Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length			YPL161C	S000006082
BER1		Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene			YLR412W	S000004404
BET1	SLY12	Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins			YIL004C	S000001266
BET2		Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p			YPR176C	S000006380
BET3		Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles; component of the TRAPP (transport protein particle) complex			YKR068C	S000001776
BET4		Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p			YJL031C	S000003568
BET5		Component of the TRAPP (transport protein particle) complex, which plays an essential role in the vesicular transport from endoplasmic reticulum to Golgi			YML077W	S000004542
BFA1	IBD1	Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis		Null mutant is viable; mutants are sensitive to microtubule inhibitors, exhibit defects in mitotic checkpoints, and exhibit moderate defects in mating efficiency	YJR053W	S000003814
BFR1		Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity			YOR198C	S000005724
BFR2		Essential protein that is a component of 90S preribosomes; may be involved in rRNA processing; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock		Null mutant is inviable; BFR2 overexpression can suppress the growth defect of mutants blocked at the step of budding or docking of small vessicles en route to the Golgi	YDR299W	S000002707
BGL2		Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance			YGR282C	S000003514
BI2		Mitochondrial mRNA maturase with a role in splicing, encoded by both exon and intron sequences of partially processed COB mRNA			Q0110	S000007271
BI3		Mitochondrial mRNA maturase, forms a complex with Mrs1p to mediate splicing of the bI3 intron of the COB gene; encoded by both exon and intron sequences of partially processed COB mRNA			Q0115	S000007272
BI4		Mitochondrial mRNA maturase, forms a complex with Nam2p to mediate splicing of the bI4 intron of the COB gene; encoded by both exon and intron sequences of partially processed COB mRNA			Q0120	S000007273
BIG1		Integral membrane protein of the endoplasmic reticulum, required for normal content of cell wall beta-1,6-glucan		Null mutant is viable but shows very slow growth on glucose, cells are big and accumulate increased ploidy; overexpression suppresses rot1 rot2 synthetic lethality	YHR101C	S000001143
BIK1	ARM5|PAC14	Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170		Null mutant is viable, bik1 mutants exhibit bilateral defects in karyogamy	YCL029C	S000000534
BIM1	EB1|YEB1	Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally		Null mutant is viable, causes cold sensitivity, benomyl supersensitivity, aberrant microtubule morphology. During mitosis in bim1 mutants, the nucleus fails to move to the mother-bud neck.	YER016W	S000000818
BIO1		Putative pimeloyl-CoA synthetase in S. cerevisiae strains YJM627 and A364a, involved in the biotin biosynthesis pathway				S000125018
BIO2		Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant			YGR286C	S000003518
BIO3		7,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis			YNR058W	S000005341
BIO4		Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels			YNR057C	S000005340
BIO5		Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis			YNR056C	S000005339
BIO6		Putative 7-keto-8-aminopelargonic acid (KAPA) synthetase in sake strains and S. cerevisiae strains YJM627 and A364a, involved in the biotin biosynthesis pathway; homologs present in S. bayanus, S. paradoxus, S. mikatae and S. kudriavzevii				S000029723
BIO7		Putative pimeloyl-CoA synthetase in S. cerevisiae strains YJM627 and A364a, involved in the biotin biosynthesis pathway				S000125022
BIO8		Putative 7-keto-8-aminopelargonic acid (KAPA) synthetase in S. cerevisiae strains YJM627 and A364a, involved in the biotin biosynthesis pathway				S000125021
BIR1		Subunit of chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates chromosome segregation; required for chromosome bi-orientation and for spindle assembly checkpoint activation upon reduced sister kinetochore tension			YJR089W	S000003849
BIT2		Subunit of TORC2, a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; similar to Bit61p			YBR270C	S000000474
BIT61		Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p-Slm1p-Slm2p), a membrane-associated complex that regulates cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity			YJL058C	S000003594
BLM1		Required for resistance to bleomycin, ionizing radiation and oxidative damage by hydrogen peroxide; mutants display slow growth and abnormal morphology; homozygous mutant has reduced spore viability; bleomycin resistance suppressed by MSH4				S000119219
BLM10	YFL006W	Proteasome activator subunit; found in association with core particles, with and without the 19S regulatory particle; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200			YFL007W	S000001887
BLM5		Required for resistance to bleomycin, ionizing radiation and oxidative damage by hydrogen peroxide, required for sporulation		blm5 mutants arrest in meiosis at the mononucleate stage		S000029056
BLS2				Blasticidin-S resistance		S000029057
BMH1	APR6	14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling		Null mutant is viable; bmh1 bmh2 double mutant is inviable; (in strain Sigma-1278b, required for pseudohyphal development but not for viability)	YER177W	S000000979
BMH2	SCD3	14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling		Null mutant is viable; bmh1 bmh2 double mutant is inviable; (in strain Sigma-1278b, required for pseudohyphal development but not for viability)	YDR099W	S000002506
BMK6						S000029058
BMK7						S000029059
BMK8						S000029060
BMS1		GTPase required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, which stimulates its GTPase and U3 snoRNA binding activities; has similarity to Tsr1p		Null mutant is inviable; a temperature-sensitive allele exhibits a synthetic growth defect with bmh1-delta; the temperature-sensitive allele also exhibits diploid specific bud site randomization at the semi-permissive temperature	YPL217C	S000006138
BNA1	HAD1	3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p		Null mutant is viable, nicotinic acid auxotroph. Deletion results in significant rDNA silencing defect only on medium deficient in nicotinic acid, an NAD(+) precursor.	YJR025C	S000003786
BNA2		Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expresssion is upregulated upon telomere uncapping; regulated by Hst1p and Aft2p		Null: Nicotinic acid auxotroph. Other phenotypes: Deletion of the gene is co-lethal with the deletion of NPT1	YJR078W	S000003839
BNA3		Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate		Null: none detected	YJL060W	S000003596
BNA4		Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease		Null: Nicotinic acid auxotroph. Other phenotypes: Deletion of the gene is co-lethal with the deletion of NPT1	YBL098W	S000000194
BNA5		Kynureninase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p		Null: Nicotinic acid auxotroph. Other phenotypes: Deletion of the gene is co-lethal with the deletion of NPT1	YLR231C	S000004221
BNA6	QPT1	Quinolinate phosphoribosyl transferase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p		Null: Nicotinic acid auxotroph. Other phenotypes: Deletion of the gene is co-lethal with the deletion of NPT1	YFR047C	S000001943
BNA7		Formylkynurenine formamidase, involved in the de novo biosynthesis of NAD from tryptophan via kynurenine			YDR428C	S000002836
BNI1	PPF3|SHE5	Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1		Null mutant is viable, bni1 bnr1 double deletion mutants are temperature sensitive and are deficient in bud emergence, exhibit a random distribution of cortical actin patches and often become multinucleate at the restrictive temperature; rho1 bni1 double mutants exhibit synthetic lethality	YNL271C	S000005215
BNI4		Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p		Null mutant is viable, shows delocalized chitin, elongated buds, enlarged bud necks	YNL233W	S000005177
BNI5		Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner		Null: Null mutant is viable, interacts genetically with CDC3, CDC10, CDC11, and CDC12 (septin) genes	YNL166C	S000005110
BNR1		Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1		Null mutant is viable; bni1 bnr1 double mutant exhibits severe temperature sensitive growth	YIL159W	S000001421
BNS1		Protein with some similarity to Spo12p; overexpression bypasses need for Spo12p, but not required for meiosis		Null mutant is viable and exhibits no obvious meiotic defects. When overexpressed, BNS1 can partially suppress the meiotic defect of spo12/spo12 deletion mutants.	YGR230W	S000003462
BOI1	BOB1|GIN7	Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain			YBL085W	S000000181
BOI2	BEB1	Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain		Null boi1 boi2 mutants become large round cells or lysed with buds, display defects in bud formation and in the maintenance of cell polarity	YER114C	S000000916
BOP2		Protein of unknown function		Null: Multicopy suppressor of a pam1 slv3 double deletion mutant	YLR267W	S000004257
BOP3		Protein of unknown function, potential Cdc28p substrate; overproduction confers resistance to methylmercury		Null: Multicopy suppressor of a pam1 slv3 double deletion mutant	YNL042W	S000004987
BOR1		Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1			YNL275W	S000005219
BOS1	SEC32	v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi			YLR078C	S000004068
BPH1		PProtein homologous to human Chediak-Higashi syndrome and murine Beige proteins, which are implicated in disease syndromes due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting		Null mutant is viable, sensitive to low pH	YCR032W	S000000628
BPL1	ACC2	Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation			YDL141W	S000002300
BPT1		ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p		Null mutant is viable but lacks approximately 40% of the trasport activity of unconjugated bilirubin into the vacuolar system of yeast	YLL015W	S000003938
BRE1		E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control		null mutant is sensitive to brefeldin A	YDL074C	S000002232
BRE2	CPS60	Subunit of COMPASS (Set1C) complex, which methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L		Null: null mutant is sensitive to brefeldin A	YLR015W	S000004005
BRE4		Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport			YDL231C	S000002390
BRE5		Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A			YNR051C	S000005334
BRF1	PCF4|TDS4	TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB	TFIIIB70		YGR246C	S000003478
BRL1		Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export			YHR036W	S000001078
BRN1		Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus; may influence multiple aspects of chromosome transmission			YBL097W	S000000193
BRO1	ASI6|LPF2|NPI3|VPS31	Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes			YPL084W	S000006005
BRP1		Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1			YGL007W	S000002975
BRR1		snRNP protein component of spliceosomal snRNPs, required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed			YPR057W	S000006261
BRR2	PRP44|RSS1|SLT22|SNU246	RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD		Null mutant is inviable; stabilized splicing intermediates which contain a mutant hammerhead cis-targeted ribozyme, decreased steady-state levels of endogneous mRNAs, increased ratio of pre-mRNA to mRNA of specific message(s); synthetic lethal with U2 mutants	YER172C	S000000974
BRR4				brr4 mutations inhibit splicing before the first step of the reaction		S000029061
BRR6		Essential nuclear envelope integral membrane protein required for nuclear envelope morphology, nuclear pore complex localization, nuclear export; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism			YGL247W	S000003216
BRX1		Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif			YOL077C	S000005437
BSC1		Protein of unconfirmed function, similar to cell surface flocculin Muc1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression			YDL037C	S000002195
BSC2		Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression			YDR275W	S000002683
BSC3		Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 100% of YLR465C overlaps the uncharacterized ORF YLR464W and 86% of YLR465C overlaps the verified gene YRF1-4			YLR465C	S000004457
BSC4		Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p			YNL269W	S000005213
BSC5		Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression			YNR069C	S000005352
BSC6		Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression			YOL137W	S000005497
BSD2		Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification			YBR290W	S000000494
BSP1		Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton			YPR171W	S000006375
BST1	PER17	GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules			YFL025C	S000001869
BST3		Negatively regulated COPII vesicle formation		Suppress mutations in SEC13; mutation slows secretion of some secretory proteins and causes resident ER proteins Kar2p and Pdi1p to leak more rapidly from the ER		S000029062
BTN2		v-SNARE binding protein that facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase			YGR142W	S000003374
BTS1		Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic			YPL069C	S000005990
BTT1		Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3			YDR252W	S000002660
BUB1		Protein kinase that forms a complex with Mad1p and Bub3p that is crucial in the checkpoint mechanism required to prevent cell cycle progression into anaphase in the presence of spindle damage, associates with centromere DNA via Skp1p		Mutants are unable to recover from transient loss of spindle function. Overexpression of BUB1 rescues the cold sensitivity of tub1-729.	YGR188C	S000003420
BUB2	PAC7	Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage		Reduces the cell cycle delay which accompanies activation of a conditionally dicentric chromosome	YMR055C	S000004659
BUB3		Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p			YOR026W	S000005552
BUD11		bud site selection		Recessive mutants have a bud site selection phenotype in a and alpha cells and are sensitive to hydroxyurea.		S000029063
BUD12		bud site selection		Semi-dominant mutants have a bud site selection phenotype in a and alpha cells.		S000029064
BUD13	CWC26	Subunit of the RES complex, which is required for nuclear pre-mRNA retention and splicing; involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern		Null mutant is viable; diploid null mutants exhibit unipolar budding and elongate phenotype.	YGL174W	S000003142
BUD14		Protein involved in bud-site selection, Bud14p-Glc7p complex is a cortical regulator of dynein; inhibitor of the actin assembly factor Bnr1p (formin); diploid mutants display a random budding pattern instead of the wild-type bipolar pattern			YAR014C	S000000069
BUD16		Putative pyridoxal kinase, a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; similarity to yeast BUD17 and human pyridoxal kinase (PDXK)			YEL029C	S000000755
BUD17		Putative pyridoxal kinase, a key enzyme in vitamin B6 metabolism; involved in bud-site selection; diploid mutants display a random rather than a bipolar budding pattern; similarity to yeast BUD16 and human pyridoxal kinase (PDXK)			YNR027W	S000005310
BUD19		Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay			YJL188C	S000003724
BUD2	CLA2|ERC25	GTPase activating factor for Rsr1p/Bud1p required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types		Null mutant is viable, with random bud site selection in all cell types	YKL092C	S000001575
BUD20		Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern			YLR074C	S000004064
BUD21	UTP16|YOR29-29	Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern		Null mutant is viable; random budding in diploid null mutants; null has both reduced growth and reduced protein synthesis rates	YOR078W	S000005604
BUD22		Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern			YMR014W	S000004616
BUD23		Methyltransferase, methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; diploid mutant displays random budding pattern			YCR047C	S000000643
BUD25		Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern			YER014C-A	S000007590
BUD26		Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay			YDR241W	S000002649
BUD27	URI1	Protein involved in bud-site selection, nutrient signaling, and gene expression controlled by TOR kinase; diploid mutants show a random budding pattern rather than the wild-type bipolar pattern; plays a role in regulating Ty1 transposition			YFL023W	S000001871
BUD28		Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay		Diploid null mutants exhibit random budding	YLR062C	S000004052
BUD3	YCL012W	Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding		Null mutant is viable; bipolar budding pattern in all cell types	YCL014W	S000000520
BUD30		Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay			YDL151C	S000002310
BUD31	CWC14	Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern		Diploid mutants exhibit random budding	YCR063W	S000000659
BUD32	LDB14	Protein kinase proposed to be involved in bud-site selection, telomere uncapping and elongation, and transcription; component of the EKC/KEOPS protein complex with Kae1p, Cgi121p, Pcc1p, and Gon7p		Diploid mutants exhibit random budding	YGR262C	S000003494
BUD4		Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding; potential Cdc28p substrate		Null mutant is viable, haploids have dipolar budding, normally they have axial budding, no effects on diploids	YJR092W	S000003852
BUD5		GTP/GDP exchange factor for Rsr1p (Bud1p) required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types		bud5 mutants select bud sites randomly	YCR038C	S000000634
BUD6	AIP3	Actin- and formin-interacting protein, involved in actin cable nucleation and polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate		Null mutant is viable; mutants exhibit severe disruption of the actin cytoskeleton; deletion strains have a depolarized cytoskeleton, mitotic delay, and probable cytokinesis defects	YLR319C	S000004311
BUD7		Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane		Diploid-specific heterogenous bud site selection	YOR299W	S000005825
BUD8		Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole		A bud8 bud9 double mutant buds almost exclusively from the proximal pole	YLR353W	S000004345
BUD9		Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole		In null mutants bipolar-budding cells bud preferentially at distal pole	YGR041W	S000003273
BUG1		Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes			YDL099W	S000002257
BUL1	DAG1|RDS1|SMM2	Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex, functional homolog of Bul2p, disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases			YMR275C	S000004888
BUL2		Component of the Rsp5p E3-ubiquitin ligase complex, involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions, functional homolog of BUL1			YML111W	S000004579
BUR2	CST4	Cyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II		Uncharacterized mutant allele causes increased transcription of SUC2 in the absence of its UAS; Overexpression induces chromosome loss	YLR226W	S000004216
BUR6	NCB1	Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha		Null mutant is viable, but grows very poorly	YER159C	S000000961
BYE1		Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit		Null: viable, 6-AU resistant	YKL005C	S000001488
BZZ1	LSB7	SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins			YHR114W	S000001156
CAB1		Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA)			YDR531W	S000002939
CAB2		Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity)			YIL083C	S000001345
CAB3		Subunit of a phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaBC			YKL088W	S000001571
CAB4		Probable pantetheine-phosphate adenylyltransferase (PPAT), which catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; null mutant lethality is complemented by E. coli coaD (encoding PPAT); widely conserved			YGR277C	S000003509
CAB5		Probable dephospho-CoA kinase (DPCK) that catalyzes the last step in coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaE (encoding DPCK); detected in purified mitochondria in high-throughput studies			YDR196C	S000002604
CAC2		Component of the chromatin assembly complex (with Rlf2p and Msi1p) that assembles newly synthesized histones onto recently replicated DNA, required for building functional kinetochores, conserved from yeast to humans			YML102W	S000004570
CAD1	YAP2	AP-1-like basic leucine zipper (bZIP) transcriptional activator involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA			YDR423C	S000002831
CAF120		Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation			YNL278W	S000005222
CAF130		Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation			YGR134W	S000003366
CAF16		Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator			YFL028C	S000001866
CAF20	CAF2|CAP20	Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E	p20		YOR276W	S000005802
CAF4		WD40 repeat-containing protein associated with the CCR4-NOT complex, interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission			YKR036C	S000001744
CAF40		Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p			YNL288W	S000005232
CAG1		alpha-specific gene involved in the regulation of sex agglutinin synthesis		Constitutively agglutinable at 36 degrees C		S000029065
CAJ1		Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly			YER048C	S000000850
CAK1	CIV1	Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases		Null mutant is inviable; temperature-sensitive mutant confers a G2 delay accompanied by low Cdc28p protein kinase activity	YFL029C	S000001865
CAM1	TEF3	Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma	CPBP		YPL048W	S000005969
CAN1		Plasma membrane arginine permease, requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance		Canavanine resistance	YEL063C	S000000789
CAP1		Alpha subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches		Null mutant is viable; severe deficit of actin cables and increased number of actin spots in the mother; round, relatively large cells	YKL007W	S000001490
CAP2		Beta subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches		Null mutant is viable, exhibits abnormal actin distribution (including loss of actin cables); round, large cells with heterogeneous size distribution; slower growing; chitin found over entire mother cell surface rather than restricted to the mother-bud junction	YIL034C	S000001296
CAR1	LPH15|cargA	Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance		Null mutant is viable but defective in arginine catabolism	YPL111W	S000006032
CAR2	cargB	L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive		Catabolism of arginine defective	YLR438W	S000004430
CAT2	YCAT	Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes		Null mutant is viable; cat2 cit2 double mutants cannot grow on oleate.	YML042W	S000004506
CAT5	COQ7	Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation		Null mutant is viable, results in complete loss of glucose derepression affecting gluconeogenic key enzymes. Respiration, but not mitochondrial cytochrome c oxidase activity, are also affected; fails to synthesize ubiquinone	YOR125C	S000005651
CAT8	DIL1|MSP8	Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements		Null mutant is viable but unable to grow on non-fermentable carbon sources due to failure to derepress all major gluconeogenic enzymes; overexpression of Cat8p suppress inability of snf1 and snf4 mutants to grow on ethanol	YMR280C	S000004893
CAX4	CWH8	Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation		Null mutant is viable with severely affected growth rate, hypo-N-glycosylation of secretory proteins, and severely reduced levels of dolichol-linked oligosaccharides in the endoplasmic reticulum. Exhibits defective actin organization and calcofluor white hypersensitivity. Synthetically lethal with a temperature sensitve allele of CMD1	YGR036C	S000003268
CBC2	CBP20|MUD13|SAE1	Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif		mutants exhibit promiscuous 3'-end formation; sae-1 mutation causes temporary cell cycle arrest in meiotic prophase	YPL178W	S000006099
CBF1	CEP1|CPF1	Helix-loop-helix protein that binds the motif CACRTG, which is present at several sites including MET gene promoters and centromere DNA element I (CDEI); required for nucleosome positioning at this motif; targets Isw1p to DNA		Null mutant is viable, but grows slowly and causes partial loss of centromere function (increased chromosome loss), benomyl and thiabendazole sensitivity, methionine auxotrophy, and changes in chromatin structure at CENs and some promoters. Null mutation causes precocious sister segregation at MI, and reduced spore viability.	YJR060W	S000003821
CBF2	CBF3A|CEP2|CSL5|CTF14|NDC10	Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo			YGR140W	S000003372
CBF5		Pseudouridine synthase catalytic subunit of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), acts on both large and small rRNAs and on snRNA U2; mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita			YLR175W	S000004165
CBK1		Serine/threonine protein kinase that regulates cell morphogenesis pathways; involved in cell wall biosynthesis, apical growth, proper mating projection morphology, bipolar bud site selection in diploid cells, and cell separation		Null mutation is viable; shows alpha factor resistance; in liquid culture large aggregates of cells are formed	YNL161W	S000005105
CBP1		Mitochondrial protein that interacts with the 5'-untranslated region of the COB mRNA and has a role in its stability and translation; found in a complex at the inner membrane along with Pet309p		Null mutant is viable, unable to respire due to degradation of mitochondrially encoded cytochrome b (cob) RNA	YJL209W	S000003745
CBP2		Mitochondrial protein required for splicing of the group I intron aI5 of the COB pre-mRNA, binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene			YHL038C	S000001030
CBP3		Mitochondrial protein required for assembly of ubiquinol cytochrome-c reductase complex (cytochrome bc1 complex); interacts with Cbp4p and function is partially redundant with that of Cbp4p		reduced levels of a subset of subunit polypeptides of the coenzyme QH2-cytochrome c reductase complex	YPL215W	S000006136
CBP4		Mitochondrial protein required for assembly of ubiquinol cytochrome-c reductase complex (cytochrome bc1 complex); interacts with Cbp3p and function is partially redundant with that of Cbp3p		Inability to respire, pleiotropic reduction in steady state levels of four subunits of ubiquinol-cytochrome c reductase	YGR174C	S000003406
CBP6		Mitochondrial translational activator of the COB mRNA; phosphorylated		Null mutant is viable, repiratory deficiency with concomitant loss of cytochrome b	YBR120C	S000000324
CBR1	CBR5	Microsomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia			YIL043C	S000001305
CBS1		Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader			YDL069C	S000002227
CBS2	CBP7	Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader		Null mutant is viable, exhibits a mitochondrial apocytochrome b mRNA translational defect	YDR197W	S000002605
CBT1	SOC1	Protein involved in 5' end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p			YKL208W	S000001691
CCA1	TNT1	ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites			YER168C	S000000970
CCB1		cross-complementation of budding defect				S000029066
CCC1		Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation		Wild-type complements csg1 (calcium sensitive-group) mutants when overexpressed. Deletion of CCC1 results in decreased vacuolar iron content and decreased iron stores, which affect cytosolic iron levels and cell growth.	YLR220W	S000004210
CCC2		Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases		Null mutant is viable, exhibits defects in respiration and iron uptake	YDR270W	S000002678
CCE1	MGT1	Mitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA		Null mutant is viable, exhibits a higher than normal frequency of appearance of petite cells	YKL011C	S000001494
CCH1		Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together		Null mutant is viable; exhibits reduced growth rate, viability and calcium uptake; exhibits a defect in pheromone-induced Ca2+ uptake; suppressor of cdc1 temperature-sensitive mutant	YGR217W	S000003449
CCL1		Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters			YPR025C	S000006229
CCM1	RRG2	Protein required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport			YGR150C	S000003382
CCP1		Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress			YKR066C	S000001774
CCR4	FUN27|NUT21	Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening		reduced levels of ADH2 expression under both glucose and ethanol growth conditions; temperature sensitive growth on nonfermentative medium	YAL021C	S000000019
CCS1	CCS|LYS7	Copper chaperone for superoxide dismutase Sod1p, involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation		Null mutant is viable, methionine and lysine auxotroph, pH and temperature sensitive; sensitive to superoxide generating drugs and light irradiation, exhibits diminution of calcineurin activity	YMR038C	S000004641
CCT2	BIN3|TCP2	Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo			YIL142W	S000001404
CCT3	BIN2|TCP3	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo		Defects in microtubule and actin assembly in vivo, aberrant chromosome segregation, supersensitivity to benomyl	YJL014W	S000003551
CCT4	ANC2|TCP4	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo			YDL143W	S000002302
CCT5	TCP5	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo			YJR064W	S000003825
CCT6	HTR3|TCP20|TCP6	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif			YDR188W	S000002596
CCT7	TCP7	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo			YJL111W	S000003647
CCT8		Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo			YJL008C	S000003545
CCW1						S000029067
CCW10						S000029068
CCW12		Cell wall mannoprotein, mutants are defective in mating and agglutination, expression is downregulated by alpha-factor		Null mutant is viable and shows decrease in mating efficiency and defect in agglutination	YLR110C	S000004100
CCW14	SSR1|YLR391W|YLR391W-A	Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall		Null mutant is viable but causes increased sensitivities to calcofluor white, Congo red, and zymolyase digestion. Overexpression also causes calcofluor white and Congo red sensitivity. (see Moukadiri et al (1997) J. Bacteriol. 179:2154-62).	YLR390W-A	S000006429
CCW2						S000029069
CCW3						S000029070
CCW4						S000029071
CCW9						S000029073
CCZ1	CVT16	Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway		Null mutant is viable, but is sensitive to caffeine, calcium and zinc; no sporulation in homozygous null diploids	YBR131W	S000000335
CDA1		Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall		Null mutant is viable, mutants spores disrupted for both cda1 and cda2 fail to emit natural fluorescence and are sensitive to hydrolyrtic enzymes, ether, and heat shock	YLR307W	S000004298
CDA2		Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall		Null mutant is viable, mutant spores disrupted for both cda1 and cda2 fail to emit natural fluorescence and are sensitive to hydrolyrtic enzymes, ether, and heat shock	YLR308W	S000004299
CDC1	DSC1|DSR1|ESP2	Putative lipid phosphatase of the endoplasmic reticulum; shows Mn2+ dependence and may affect Ca2+ signaling; mutants display actin and general growth defects and pleiotropic defects in cell cycle progression and organelle distribution			YDR182W	S000002590
CDC10		Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM		abnormal cell-wall deposition and bud growth, inability to complete cytokinesis, failure to form the ring of 10nm filaments in the neck region of budding cells	YCR002C	S000000595
CDC11	PSL9	Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM		abnormal cell-wall deposition and bud growth, inability to complete cytokinesis, failure to form the ring of 10nm filaments in the neck region of budding cells	YJR076C	S000003837
CDC12	CLA10|PSL7	Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM		abnormal cell-wall deposition and bud growth, inability to complete cytokinesis, failure to form the ring of 10nm filaments in the neck region of budding cells	YHR107C	S000001149
CDC123		Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein			YLR215C	S000004205
CDC13	EST4	Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping			YDL220C	S000002379
CDC14	OAF3	Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit		Null mutant is inviable; ts mutant arrests at late anaphase with phenotypes similar to cdc5 mutants	YFR028C	S000001924
CDC15	LYT1	Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II		Null mutant inviable, arrests in G2; buds at distal instead of axial position, undergoes autolysis when buds reach the size of mother cells; the mitotic, but not meiotic, phenotype is suppressible by overexpressing SPO12.	YAR019C	S000000072
CDC16		Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation		Null mutant is inviable; sensitive to caffeine; cdc16 mutants are unable to progress through the G(sub)2/M transition, cell division cycle blocked at 36 degrees C	YKL022C	S000001505
CDC19	PYK1	Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration		Null mutant is inviable. cdc19 mutants are pyruvate kinase deficient and show cell division cycle blocked at 36 degrees C	YAL038W	S000000036
CDC20	PAC5	Cell-cycle regulated activator of anaphase-promoting complex/cyclosome (APC/C), which is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; potential Cdc28p substrate		Null mutant is inviable; conditional alleles show cell cycle arrest in G2	YGL116W	S000003084
CDC21	CRT9|TMP1|YOR29-25	Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S		defective in continued replication during S phase of the cell cycle; temperature-sensitive thymidylate auxotroph	YOR074C	S000005600
CDC22	DNA1					S000029074
CDC23		Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition		unable to complete G(sub)2/M transition	YHR166C	S000001209
CDC24	CLS4	Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing		temperature sensitive mutation affecting bud formation and localized cell surface growth at a restrictive temperature	YAL041W	S000000039
CDC25	CDC25'|CTN1	Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1		Null mutant is inviable; arrests at G(sub)1; low levels cAMP and decreased levels of Mg2+-dependent cyclase activity	YLR310C	S000004301
CDC26	HIT3|SCD26	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition		thermosensitive cell growth (lethal at high temperature)	YFR036W	S000001932
CDC27	APC3|SNB1	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition		Null mutant is inviable. Some conditional alleles overreplicate their DNA.	YBL084C	S000000180
CDC28	CDK1|HSL5|SRM5	Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates		arrests at G1/S transition <br> arrests at G2/M transition	YBR160W	S000000364
CDC29		Cell division cycle blocked at 36 degree C				S000029075
CDC3		Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM		Null mutant is inviable; other mutants show abnormal cell-wall deposition and bud growth, inability to complete cytokinesis, and failure to form the ring of 10nm filaments in the neck region of budding cells.	YLR314C	S000004306
CDC31	DSK1	Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation		Null mutant is inviable. cdc31 mutants form reductional dyads with unduplicated spindle pole bodies	YOR257W	S000005783
CDC33	TIF45	Cytoplasmic mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p)	eIF4E	Null mutant is inviable. cdc33 mutants arrest at G(sub)1. cdc33 has normal cAMP pools and is not suppressed by cAPK mutants, suggesting sporulation is independent of the cAMP pathway	YOL139C	S000005499
CDC34	DNA6|UBC3	Ubiquitin-conjugating enzyme (E2) and catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation		overexpression confers resistance to xenobiotics (methylmercury, mercuric chloride, and p-chloromercuribenzoate).	YDR054C	S000002461
CDC36	DNA19|NOT2	Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor		Null mutant is viable, cdc36 mutant arrests in G(sub)1; forms shmoo morphology at restrictive temperature, arrests at pachytene at the mononucleate stage with duplicated spindle pole bodies and no spindles	YDL165W	S000002324
CDC37	SMO1	Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding		Null mutant is inviable; temperature-sensitive mutants arrest in G1 and form shmoo morphology at the restrictive temperature	YDR168W	S000002575
CDC39	NOT1|ROS1|SMD6	Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor		Null mutant is inviable; arrests in G(sub)1 at pachytene at the mononucleate stage with duplicated, unseparated spindle pole bodies and no spindles; temperature sensitive mutation which causes increased basal transcription of many genes	YCR093W	S000000689
CDC4		F-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p		Null mutant is inviable. cdc4 mutants arrest in meiosis at the mononucleate stage with duplicated spindle pole bodies.	YFL009W	S000001885
CDC40	PRP17|SLT15|SLU4	Pre-mRNA splicing factor, important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression; required for DNA synthesis during mitosis and meiosis; has WD repeats		Null mutant is viable, temperature sensitive at 36 degrees celsius, arrests at the mononucleate stage; synthetically lethal with U2 snRNA LSR1; blocks pre-mRNA splicing in vivo and in vitro	YDR364C	S000002772
CDC42		Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins		Null mutant is inviable; temperature sensitive mutations unable to form buds and display delocalized cell-surface deposition at the restrictive temperature	YLR229C	S000004219
CDC43	CAL1	Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis		temperature sensitive mutants unable to form buds and display delocalized cell-surface deposition	YGL155W	S000003123
CDC45	SLD4	DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes		required for minichromosome maintenance and chromosomal DNA replication	YLR103C	S000004093
CDC48		ATPase in ER, nuclear membrane and cytosol with homology to mammalian p97; in a complex with Npl4p and Ufd1p participates in retrotranslocation of ubiquitinated proteins from the ER into the cytosol for degradation by the proteasome			YDL126C	S000002284
CDC5	MSD2|PKX2	Polo-like kinase with similarity to Xenopus Plx1 and S. pombe Plo1p; found at bud neck, nucleus and SPBs; has multiple functions in mitosis and cytokinesis through phosphorylation of substrates; may be a Cdc28p substrate			YMR001C	S000004603
CDC50		Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Ynr048wp and Lem3p		Null mutant is cold-sensitive and sensitive to MMS and HU	YCR094W	S000000690
CDC53		Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation		Cells arrest in G1 with active Cln kinases but no Clb-associated Cdc28p kinase activity	YDL132W	S000002290
CDC55		Non-essential regulatory subunit B of protein phosphatase 2A (PP2A), which has multiple roles in mitosis and protein biosynthesis; involved in regulation of mitotic exit; found in the nucleus of most cells, also at bud neck and bud tip		abnormally elongated buds, delay or partial block of septation and/or cell separation; deletion mutant is cold-sensitive	YGL190C	S000003158
CDC6		Essential ATP-binding protein required for DNA replication, component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p		arrest at initiation of S phase	YJL194W	S000003730
CDC60		Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA	LeuRS|leucyl-tRNA synthetase	arrest at START point of cell cycle upon shift to restrictive temperature	YPL160W	S000006081
CDC61						S000029076
CDC62		Cell division cycle blocked at 36 degree C				S000029077
CDC65	DNA33|SUP60|SUP70	tRNA-Gln; glutamine tRNA with anticodon CUG		A temperature-sensitive allele inhibits zygote formation and conjugation.		S000006690
CDC67		Regulator of the cell cycle at Start		Arrest of proliferation at the regulatory step Start, inhibition of zygote formation and successful conjugation		S000029078
CDC7	LSD6|SAS1	DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in mitosis through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression		Null mutant is inviable. cdc7 mutant arrests at G(sub)1/S phase with duplicated spindle pole bodies and no spindles; the spindle pole bodies eventually enlarge, invaginate from the nuclear envelope into the center of the nucleus, sometimes fragmenting into three or four smaller spindle pole bodies. In heterozygotes, cdc7 spores fail to germinate.	YDL017W	S000002175
CDC73		Component of the Paf1p complex that binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance		Mutations affect cell growth and the abundance of transcripts from a subset of genes	YLR418C	S000004410
CDC77	NDC2	Cell division cycle blocked at 36 degree C				S000029079
CDC8		Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p		Null mutant is inviable. cdc8 mutants are defective in continued replication during S phase of the cell cycle. cdc8 arrests at the mononucleate stage with duplicated spindle pole bodies and no spindles.	YJR057W	S000003818
CDC9	MMS8	DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination		cell division cycle blocked at 36 degrees, increased sensitivity to ultraviolet radiation and bleomycin; temperature sensitive	YDL164C	S000002323
CDD1		Cytidine deaminase; catalyzes the modification of cytidine to uridine in vitro but native RNA substrates have not been identified, localizes to both the nucleus and cytoplasm			YLR245C	S000004235
CDH1	HCT1	Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p		Null mutant is viable but defective in Clb2p and Ase1p degradation; deletion of cdh1 causes pheromone resistance and is synthetically lethal with sic1 deletion; overexpression causes ectopic degradation of Clb2p and Ase1p	YGL003C	S000002971
CDL1				some alleles cause lethality in combination with chc1 null mutants		S000029080
CDS1	CDG1	Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids			YBR029C	S000000233
CEF1	NTC85	Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p		Null mutant is inviable, arrests in G2/M, exhibits abnormal nuclear morphologies. Essential for mRNA splicing.	YMR213W	S000004826
CEG1		Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphophatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide			YGL130W	S000003098
CEM1		Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration		Null mutant is viable; exhibits respiratory-deficient growth	YER061C	S000000863
CEM11						S000029081
CEN1		Chromosome I centromere				S000006463
CEN10		Chromosome X centromere				S000006471
CEN11		Chromosome XI centromere				S000006472
CEN12		Chromosome XII centromere				S000006473
CEN13		Chromosome XIII centromere				S000006474
CEN14		Chromosome XIV centromere				S000006475
CEN15		Chromosome XV centromere				S000006476
CEN16		Chromosome XVI centromere				S000006477
CEN2		Chromosome II centromere				S000006464
CEN3		Chromosome III centromere				S000006465
CEN4		Chromosome IV centromere				S000006466
CEN5		Chromosome V centromere				S000006467
CEN6		Chromosome VI centromere				S000001896
CEN7		Chromosome VII centromere				S000006468
CEN8		Chromosome VIII centromere				S000006469
CEN9		Chromosome IX centromere				S000006470
CEP3	CBF3|CBF3B|CSL1	Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain		Null mutant is inviable; mutations within the zinc finger domain result in cells that exhibit a G2-M cell cycle delay and increased chromosome loss in each mitotic cell division; at nonpermissive temperature the cep3 cells arrest with an undivided nucleus and a short mitotic spindle; at permissive temperature cep3 cells are unable to support segregation of minichromosomes with mutations in the central part of element III of yeast centromere DNA	YMR168C	S000004778
CET1	CES5	Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide			YPL228W	S000006149
CEX1		Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p			YOR112W	S000005638
CFD1	DRE3	Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol			YIL003W	S000001265
CFT1	YHH1	RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF			YDR301W	S000002709
CFT13						S000029082
CFT2	YDH1	Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein.			YLR115W	S000004105
CGI121		Protein involved in telomere uncapping and elongation as component of the KEOPS protein complex with Bud32p, Kae1p, Pcc1p, and Gon7p; also shown to be a component of the EKC protein complex; homolog of human CGI-121			YML036W	S000004500
CGR1		Protein involved in nucleolar integrity and processing of the pre-rRNA for the 60S ribosome subunit; transcript is induced in response to cytotoxic stress but not genotoxic stress		Null mutant is inviable; CGR1 expression is down-regulated in the postdiauxic growth phase	YGL029W	S000002997
CHA1		Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine		Null mutant is viable and cannot grow on media with L-serine or L-threonine as sole nitrogen source	YCL064C	S000000569
CHA4	SIL2|SIL3	DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain		Unable to grow with serine or threonine as the sole nitrogen source, suppresses ilv1 mutant by causing inducer-independent, constitutive expression of CHA1	YLR098C	S000004088
CHC1	SWA5	Clathrin heavy chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; two heavy chains form the clathrin triskelion structural component; the light chain (CLC1) is thought to regulate function		Null mutant is viable, but is slow-growing and shows defects in mating, sporulation and vesicle ultrastructure (however it shows little or no defect in secretion); null mutants easily become inviable due to second site mutations in a number of unlinked genes such as SCD1 and CDL1. Null mutants also exhibit an endocytosis defect, late Golgi protein mislocalization. chc1-5 exhibits delayed vacuolar protein transport.	YGL206C	S000003174
CHD1		Nucleosome remodeling factor that functions in regulation of transcription elongation; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes		Null mutant is viable, resistant to 6-azauracil	YER164W	S000000966
CHK1		Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase		Mutants are defective in the DNA damage checkpoint operating at metaphase	YBR274W	S000000478
CHL1	CTF1|LPA9|MCM12	Conserved nuclear protein required to establish sister-chromatid pairing during S-phase, probable DNA helicase with similarity to human BACH1, which associates with tumor suppressor BRCA1; associates with acetyltransferase Ctf7p		Null mutant is viable, ts mutants mis-segregate chromosomes at permissive temperature leading to increased rate of mitotic chromosome loss, at non-permissive temperature ts mutants transiently arrest as large-budded cells with G(sub)2 DNA content and short spindle	YPL008W	S000005929
CHL2		Involved in controlling mitotic transmission of yeast chromosomes		increase in the rate of mitotic chromosome loss		S000029083
CHL4	CTF17|MCM17	Outer kinetochore protein required for chromosome stability, interacts with kinetochore proteins Ctf19p, Ctf3p, and Iml3p; exhibits a two-hybrid interaction with Mif2p; association with CEN DNA requires Ctf19p		Null mutant is viable. Some authors report a temperature-senstive deletion allele, while others fine no temperature sensitivity in another deletion allele. Fidelity of chromosome transmission and minichromosome nondisjunction in mitosis is decreased at all temperatures.	YDR254W	S000002662
CHL5		Involved in controlling mitotic transmission of yeast chromosomes		increase in the rate of mitotic chromosome loss		S000029084
CHL8	AMC3|CTF12	Identified as a chromosome transmission fidelity mutant that has a high rate of chromosome loss		Increase in the rate of mitotic chromosome loss and temperature sensitivity		S000029085
CHL9	AMC4	Involved in controlling the segregation of natural chromosomes in yeast		Impaired segregation of artificial minichromosomes, affects on the mitotic transmission of natural chromosomes		S000029086
CHO1	PSS1	Phosphatidylserine synthase, functions in phospholipid biosynthesis; catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine, transcriptionally repressed by myo-inositol and choline		The null mutant is viable but grows slowly on minimal medium. The growth rate of the null mutant on minimal medium can be increased by supplementing the medium with choline or other phospholipid precursors.	YER026C	S000000828
CHO2	PEM1	Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis		Null mutant is viable and accumulates phosphatidylethanolamine and has reduced levels of phosphatidylcholine	YGR157W	S000003389
CHS1	USA4	Chitin synthase I, requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for repairing the chitin septum during cytokinesis; transcription activated by mating factor			YNL192W	S000005136
CHS2		Chitin synthase II; catalyzes transfer of N-acetylglucosamine (GlcNAc) to chitin upon activation of zymogenic form; required for chitin synthesis in the primary septum during cytokinesis; localization regulated by Cdk1p during mitosis			YBR038W	S000000242
CHS3	CAL1|CSD2|DIT101|KTI2	Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan			YBR023C	S000000227
CHS5	CAL3	Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane			YLR330W	S000004322
CHS6	CSD3	Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane			YJL099W	S000003635
CHS7		Protein of unknown function, involved in chitin biosynthesis by regulating Chs3p export from the ER			YHR142W	S000001184
CHZ1		Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif			YER030W	S000000832
CIA1		WD40 repeat protein involved in assembly of cytosolic and nuclear iron-sulfur proteins; similar to the human Ciao1 protein; YDR267C is an essential gene			YDR267C	S000002675
CIC1	NSA3	Essential protein that interacts with proteasome components and has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles		Null: lethal. Other phenotypes: cic1-2 ts mutant stabilizes F-box proteins.	YHR052W	S000001094
CIK1		Kinesin-associated protein required for both karyogamy and mitotic spindle organization, interacts stably and specifically with Kar3p and may function to target this kinesin to a specific cellular role; has similarity to Vik1p		Null mutant is viable but is defective in both karyogamy and chromosome maintenance and does not show proper localization of Kar3p to microtubule-associated structures	YMR198W	S000004811
CIN1		Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl		Null mutant is viable, exhibits cold sensitivity for viability; defect in nuclear migration and nuclear fusion, supersensitivity to benomyl and nocodozole	YOR349W	S000005876
CIN2		GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2		Null mutant is viable but shows supersensitivity to benomyl and nocodazole, cold sensitivity, defects in karyogamy, and increased rates of chromosome loss; shows genetic interaction with tubulin mutations	YPL241C	S000006162
CIN4	GTP1|UGX1	GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog		Null mutant is viable; supersensitivity to benomyl and nocodozole	YMR138W	S000004746
CIN5	HAL6|YAP4	Basic leucine zipper (bZIP) transcription factor of the yAP-1 family, mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions		Null mutant is viable and suppresses the cold sensitivity of yap1 mutants	YOR028C	S000005554
CIN8	KSL2|SDS15	Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation		Null mutant is viable; cin8 dyn1 and cin8 kip1 double deletion mutants are inviable	YEL061C	S000000787
CIR1		Protein that interacts with frataxin (Yfh1p); putative homolog of mammalian electron transfer flavoprotein complex subunit ETF-beta; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YGR207C	S000003439
CIR2		Mitochondrial protein with similarity to flavoprotein-type oxidoreductases; found in a large supramolecular complex with other mitochondrial dehydrogenases			YOR356W	S000005883
CIS1	ATG31	Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion			YDR022C	S000002429
CIS3	CCW11|CCW5|PIR4	Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family		Null mutant is viable; CIS3 is a high copy suppressor of cik1 deletion mutants	YJL158C	S000003694
CIT1	CS1|LYS6	Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein		Null mutant is viable; disruption of both CIT1 and CIT2 result in glutamate auxotrophy and poor growth on rich medium containing lactate	YNR001C	S000005284
CIT2		Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors			YCR005C	S000000598
CIT3		Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate		Null mutant shows severely reduced growth on the respiratory substrate glycerol in a delta cit1 background	YPR001W	S000006205
CKA1		Alpha catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA2, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases		Null mutant is viable; however, strains lacking both cka1 and cka2 (the alpha and alpha' subunits of protein kinase CK2, respectively) are inviable.	YIL035C	S000001297
CKA2	YOR29-12	Alpha' catalytic subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKB1 and CKB2, the many substrates include transcription factors and all RNA polymerases		Null mutant is viable, cka1 cka2 double deletion mutants are inviable; Cells in which protein kinase CK2 activity is depleted increase substantially in size prior to growth arrest, and a significant fraction of the arrested cells exhibit a pseudomycelial morphology. Disruption of the activity also results in flocculation. Yeast strains lacking both endogenous catalytic subunit genes can be rescued by expression of the alpha and beta subunits of Drosophila protein kinase CK2 or by expression of the Drosophila alpha subunit alone	YOR061W	S000005587
CKB1		Beta regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB2, the many substrates include transcription factors and all RNA polymerases		Null mutant is viable, exhibits salt sensitivity specific to NaCl and LiCl	YGL019W	S000002987
CKB2		Beta' regulatory subunit of casein kinase 2, a Ser/Thr protein kinase with roles in cell growth and proliferation; the holoenzyme also contains CKA1, CKA2 and CKB1, the many substrates include transcription factors and all RNA polymerases			YOR039W	S000005565
CKI1		Choline kinase, catalyzing the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway			YLR133W	S000004123
CKS1		Cyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters		Null mutant is viable in W303 and BF246-15DU backgrounds|Null mutant is inviable and arrests in G1.	YBR135W	S000000339
CLA4	ERC10	Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, which also includes Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, and cytokinesis; phosphorylates septins Cdc3p and Cdc10p		Null mutant is viable, possesses a cytokinesis defect; cla4 cln1 cln2 strains are inviable; cla4 ste20 double deletion mutants cannot maintain septin rings at the bud neck and and cannot undergo cytokinesis	YNL298W	S000005242
CLB1	SCB1	B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome			YGR108W	S000003340
CLB2		B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome			YPR119W	S000006323
CLB3		B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation			YDL155W	S000002314
CLB4		B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation			YLR210W	S000004200
CLB5		B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase		Null mutant is viable, but has an extended S phase	YPR120C	S000006324
CLB6		B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1			YGR109C	S000003341
CLC1	SCD4	Clathrin light chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component		Null mutant is viable but slow-growing and shows defects in receptor-mediated endocytosis, maturation of alpha factor and levels of clathrin heavy chain (Chc1p); high copy suppresses the inviable double mutant chc1-delete, scd1-i-allele; elevated CHC1 expression suppresses some clc1-delete phenotypes	YGR167W	S000003399
CLD1		Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58			YGR110W	S000003342
CLF1	NTC77|SYF3	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins		Null mutant is inviable; clf1 alleles show synthetic lethality with cdc40/prp17 and are defective in 5' splice site cleavage	YLR117C	S000004107
CLG1		Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2			YGL215W	S000003183
CLN1		G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)		Null mutant is viable, exhibits G1 arrest	YMR199W	S000004812
CLN2		G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)		Null mutant is viable, exhibits G1 arrest; dominant mutation advances the G(sub)1- to S- phase transition and impairs ability of cells to arrest in G(sub)1 phase in response to external signals	YPL256C	S000006177
CLN3	DAF1|FUN10|WHI1	G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis		Null mutant is viable; dominant mutation causes alpha-factor resistance and small cell size; chromosomal deletion increases cell volume	YAL040C	S000000038
CLP1		Subunit of cleavage factor I (CFI), involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation			YOR250C	S000005776
CLS1				Calcium-sensitive		S000029088
CLU1	TIF31	eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant		Null mutant is viable, growth is normal, mitochondrial network is collapsed to one side of the cell	YMR012W	S000004614
CLY2				Cell lysis at 36 degree C		S000029089
CLY3				Cell lysis at 36 degree C		S000029090
CLY7				Null phenotype unknown; cly7 mutants lyse at high temperature		S000029091
CLY8				Cell lysis at 36 degree C		S000029092
CLY9						S000029093
CMC1		Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif			YKL137W	S000001620
CMC2		Protein of the mitochondrial intermembrane space with a role in respiratory chain complex assembly or maintenance; contains twin Cx9C motifs that can form coiled coil-helix-coiled-coil helix fold			YBL059C-A	S000007488
CMC4		Protein that is necessary for respiratory growth and that localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; contains twin cysteine-x(9)-cysteine motifs			YMR194C-B	S000028514
CMD1	CaM	Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin			YBR109C	S000000313
CMK1		Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk2p and mammalian Cam Kinase II			YFR014C	S000001910
CMK2		Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk1p and mammalian Cam Kinase II		Null mutant is viable, exhibits slow rate of spore germination	YOL016C	S000005376
CMP2	CNA2	Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1			YML057W	S000004521
CMR1		Putative protein of unknown function; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus			YDL156W	S000002315
CMR2		Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents			YOR093C	S000005619
CMR3		Putative zinc finger protein; YPR013C is not an essential gene			YPR013C	S000006217
CMS1		Subunit of U3-containing 90S preribosome processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; overexpression rescues supressor mutant of mcm10; null mutant is viable			YLR003C	S000003993
CNA1	CMP1	Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1			YLR433C	S000004425
CNB1	CRV1|YCN2	Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1		Null mutant is viable, Li+ and Na+ sensitive, cnb1 fks1 and cnb1 vma3 double mutants are inviable	YKL190W	S000001673
CNE1	FUN48	Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast		Null mutant is viable, increase of cell-surface expression of ste2-3p, increase in secretion of heterologously expressed mammalian alpha 1-antitrypsin. ~30% decrease in beta-1,6-glucan upon disruption of CNE1.	YAL058W	S000000054
CNM67		Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration		Null mutant is viable but shows slow growth and a nuclear migration defect	YNL225C	S000005169
CNN1		Kinetochore protein of unknown function; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by both Clb5-Cdk1 and, to a lesser extent, Clb2-Cdk1.			YFR046C	S000001942
CNS1		TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion		Null mutant is inviable; overexpression of CNS1 restores normal growth and Hsp90 activity in a cpr7 mutant strain.	YBR155W	S000000359
COA1	FMP35	Mitochondrial inner membrane protein required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assembly			YIL157C	S000001419
COA2		Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p			YPL189C-A	S000028527
COA4	CMC3	Protein that localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; mutants exhibit glycogen storage defects and growth defects on a non-fermentable carbon source; contains twin cysteine-x9-cysteine motifs			YLR218C	S000004208
COB	COB1|CYTB	Cytochrome b, mitochondrially encoded subunit of the ubiquinol-cytochrome c reductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p			Q0105	S000007270
COF1		Cofilin, promotes actin filament depolarization in a pH-dependent manner; binds both actin monomers and filaments and severs filaments; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes	cofilin		YLL050C	S000003973
COG1	COD3|LDB11|SEC36	Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments			YGL223C	S000003191
COG2	SEC35	Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments		Null mutant shows severe growth defect at 30 degrees and is inviable at 21 degrees; sec35-1 allele is temperature-sensitive for growth	YGR120C	S000003352
COG3	GRD20|SEC34	Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments		Strains carrying the null allele are extremely slow growing; they display a severe growth defect at 25 or 30 degrees, and fail to grow at 14 or 37 degrees. In addition to defects in protein localization and sorting, sec34 mutants exhibit defects in polarization of filamentous actin.	YER157W	S000000959
COG4	COD1|SEC38|SGF1	Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments			YPR105C	S000006309
COG5	API4|COD4	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments			YNL051W	S000004996
COG6	COD2|SEC37	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments			YNL041C	S000004986
COG7	COD5	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments			YGL005C	S000002973
COG8	DOR1	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments			YML071C	S000004536
COM2		Protein of unknown function			YER130C	S000000932
COP1	RET1|SEC33|SOO1	Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway		Null mutant is inviable; other cop1 alleles show secretion and protein sorting defects	YDL145C	S000002304
COQ1		Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis			YBR003W	S000000207
COQ10		Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q<sub>6</sub> to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes			YOL008W	S000005368
COQ2		Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis		Null mutant is viable but is respiratory defective and lacks PHB:polyprenyltransferase activity	YNR041C	S000005324
COQ3		O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein		Null mutant is viable, fails to grow on H2O2; fails to grow on glycerol	YOL096C	S000005456
COQ4		Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex		Unable to produce ubiquinone, hypersensitivity to polyunsaturated fatty acid treatment	YDR204W	S000002612
COQ5	DBI56	2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes	2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase	Null mutant is viable, respiratory deficient, petite.	YML110C	S000004578
COQ6		Putative flavin-dependent monooxygenase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes		Unable to produce ubiquinone, hypersensitivity to polyunsaturated fatty acid treatment	YGR255C	S000003487
COQ9	FMP53	Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes			YLR201C	S000004191
COR1	QCR1	Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain		deficiency in cytochrome b; slow growth on glycerol	YBL045C	S000000141
COS1		Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins			YNL336W	S000005280
COS10		Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins			YNR075W	S000005358
COS111		Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YBR203W	S000000407
COS12		Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins			YGL263W	S000003232
COS2		Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins			YBR302C	S000000506
COS3		Protein involved in salt resistance; interacts with sodium:hydrogen antiporter Nha1p; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins			YML132W	S000004601
COS4		Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins			YFL062W	S000001832
COS5		Protein of unknown function, member the DUP380 subfamily of conserved, often subtelomerically-encoded proteins			YJR161C	S000003922
COS6		Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins			YGR295C	S000003527
COS7		Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YDL248W	S000002407
COS8		Nuclear membrane protein, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; regulation suggests a potential role in the unfolded protein response			YHL048W	S000001040
COS9		Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins			YKL219W	S000001702
COT1		Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium		Null mutant is viable, yet increased sensitivity to cobalt	YOR316C	S000005843
COX1	OXI3	Subunit I of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits			Q0045	S000007260
COX10		Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders		mutant lacks cytochrome oxidase activity and cytochromes a and a3 and is respiratory-defective	YPL172C	S000006093
COX11	LPI13|PSO7	Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p		deficient in cytochrome oxidase; sensitive to photoactivated 3-carbethoxypsoralen, UV light, radiomimetic mutagens, and oxidative stress	YPL132W	S000006053
COX12		Subunit VIb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated		Null mutant is viable, grows poorly at room temperature, fails to grow on glycerol/ethanol media at 37 degrees	YLR038C	S000004028
COX13		Subunit VIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP		Null mutant is viable, shows slightly reduced growth rate on nonfermentable carbon sources	YGL191W	S000003159
COX14		Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes		Nuclear respiration deficient, lack cytochromes a and a3 and detectable cytochrome oxidase activity	YML129C	S000004598
COX15		Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase		fail to synthesize cytochrome oxidase	YER141W	S000000943
COX16		Mitochondrial inner membrane protein, required for assembly of cytochrome c oxidase		Null: viable, respiration deficient	YJL003W	S000003540
COX17		Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs		Null mutant is viable, respiratory defective, rescued by addition of copper to growth media and/or high copy expression of SCO1 and SCO2 genes	YLL009C	S000003932
COX18	OXA2	Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC		Null mutant is viable, respiratory deficient due to inactivity of cytochrome oxidase	YGR062C	S000003294
COX19		Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs			YLL018C-A	S000007245
COX2	OXI1|OXII	Subunit II of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits			Q0250	S000007281
COX20		Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase		Null mutant is respiratory-deficient and has no cytochrome oxidase activity or accumulation of precursor of CoxII	YDR231C	S000002639
COX23		Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs			YHR116W	S000001158
COX3	OXI2	Subunit III of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits			Q0275	S000007283
COX4		Subunit IV of cytochrome c oxidase, the terminal member of the mitochondrial inner membrane electron transport chain; precursor N-terminal 25 residues are cleaved during mitochondrial import; phosphorylated; spermidine enhances translation			YGL187C	S000003155
COX5A		Subunit Va of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth		Null mutant is viable, respires at 10-15% of the wild-type rate due to the presence of COX5B; cox5a cox5b double deletion mutants are completely non-respiratory	YNL052W	S000004997
COX5B		Subunit Vb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth			YIL111W	S000001373
COX6		Subunit VI of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels		Null mutant is viable, sensitive to H2O2	YHR051W	S000001093
COX7		Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain		Null mutant is viable, lacks cytochrome c oxidase activity and haem a/a3 spectra; respiratory deficient	YMR256C	S000004869
COX8		Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain		Null mutant is viable, deficient in cellular respiration and cytochrome C oxidase activity	YLR395C	S000004387
COX9		Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain		Lacks functional cytochrome c oxidase holoenzyme	YDL067C	S000002225
COY1		Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function			YKL179C	S000001662
CPA1		Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader			YOR303W	S000005829
CPA2		Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor			YJR109C	S000003870
CPD1		Cyclic nucleotide phosphodiesterase, hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression		null: viable, no detected growth defects, defective in hydrolysis of ADP-ribose 1'',2''-cyclic phosphate (Appr>p)	YGR247W	S000003479
CPR1	CPH1|CYP1	Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A			YDR155C	S000002562
CPR2	CYP2	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway		Null mutant is viable; sensitive to heat	YHR057C	S000001099
CPR3	CYP3	Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria		Null mutant is viable, unable to grow on L-lactate at 37 degrees C	YML078W	S000004543
CPR4	CYP4|SCC3|YCR070W	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway		suppressor of cdc65	YCR069W	S000000665
CPR5	CYP5	Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER			YDR304C	S000002712
CPR6	CYP40	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity		Null mutant is viable, has normal growth rate	YLR216C	S000004206
CPR7		Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity			YJR032W	S000003793
CPR8		Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway			YNR028W	S000005311
CPS1		Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions		Null mutant is viable; leucine auxotroph	YJL172W	S000003708
CPT1		Cholinephosphotransferase, required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription		Null mutant is viable, cpt1 ept1 double deletion mutants are viable	YNL130C	S000005074
CRC1		Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation			YOR100C	S000005626
CRD1	CLS1	Cardiolipin synthase; produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function; also required for normal vacuolar ion homeostasis		Null mutant is viable, exhibits growth defects in galactose and glycerol/ethanol media	YDL142C	S000002301
CRF1		Transcriptional corepressor involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain			YDR223W	S000002631
CRG1		Putative S-adenosylmethionine-dependent methyltransferase; mediates cantharidin resistance			YHR209W	S000001252
CRH1		Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress		Null mutant is viable and hypersensitive to Congo Red and Calcofluor White	YGR189C	S000003421
CRL1				Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole.		S000029095
CRL10		may be involved in the fidelity of protein translation		Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole.		S000029096
CRL11				Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole.		S000029097
CRL12		may be involved in the fidelity of protein translation		arrest late in the cell cycle after several divisions at the nonpermissive temperature		S000029098
CRL15				Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole.		S000029099
CRL16				Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole.		S000029100
CRL17				Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole.		S000029101
CRL18				Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole.		S000029102
CRL2				Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole.		S000029103
CRL22				Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole.		S000029104
CRL4				Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole.		S000029105
CRL7				Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole.		S000029106
CRL9				Null is inviable. ts mutants are unable to grow at 37 C, arresting late in cell cycle after several divisions; they also fail to arrest at G1 when starved for a single amino acid (but do arrest at G1 when deprived of all nitrogen), are resistant to cyclohexamide, and are hypersensitive to amino acid analogs, hygromycin B and 3-aminotriazole.		S000029107
CRM1	KAP124|XPO1	Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin		Null mutant is inviable; a temperature sensitive crm1 allele shows defects in nuclear protein export	YGR218W	S000003450
CRN1		Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly		Overexpression of CRN1 causes growth arrest and redistribution of Arp2p and Crn1p into aberrant actin loops.	YLR429W	S000004421
CRP1		Protein that binds to cruciform DNA structures		Null: Null mutant is viable and shows no growth defects	YHR146W	S000001189
CRR1		Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation			YLR213C	S000004203
CRS5		Copper-binding metallothionein, required for wild-type copper resistance		Null mutant is viable, exhibits increased sensitivity to copper toxicity	YOR031W	S000005557
CRT10	HUS1	Protein involved in transcriptional regulation of RNR2 and RNR3; expression of the gene is induced by DNA damage and null mutations confer increased resistance to hydroxyurea; N-terminal region has a leucine repeat and a WD40 repeat			YOL063C	S000005424
CRT2				crt2 mutants show a defect in basal level expression of RNR1-lacZ reporter constructs		S000029108
CRZ1	HAL8|TCN1	Transcription factor that activates transcription of genes involved in stress response; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation			YNL027W	S000004972
CSE1	KAP109	Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation			YGL238W	S000003207
CSE2	MED9	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; component of the Med9/10 module; required for regulation of RNA polymerase II activity		Null mutant is viable, accumulates large-budded cells, results in significant increase in chromosome missegregation, slower growth, and defective meiosis	YNR010W	S000005293
CSE4	CSL2	Centromere protein that resembles histone H3, required for proper kinetochore function; homolog of human CENP-A		Null mutant is inviable; cse4-1 mutant causes increased non-disjunction of chromosome with mutated CEN and t.s. arrest at G2/M boundary with 2N DNA content	YKL049C	S000001532
CSF1		Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YLR087C	S000004077
CSG2	CLS2	Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations		Null mutant is viable but Ca2+-sensitive; a presumed point mutant is sensitive to Ca2+ levels greater than 10 mM (but remains insensitive to 50 mM Sr2+)	YBR036C	S000000240
CSH1		Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p		Null mutant is viable, does not exhibit calcium sensitivity or alter the calcium sensitive phenotype of a sur1 null strain	YBR161W	S000000365
CSI1		Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling			YMR025W	S000004627
CSI2		Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene		Null mutant is viable but shows delocalized chitin deposition	YOL007C	S000005367
CSL4	SKI4	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1)		Null mutant is inviable, csl4-1 exhibits double mutant inviability in combination with cbf1(cep1) deletion mutants	YNL232W	S000005176
CSM1		Nucleolar protein that forms a complex with Lrs4p and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation			YCR086W	S000000682
CSM2		Protein involved in a Rad51p-, Rad54p-dependent pathway for homologous recombination repair, required for accurate chromosome segregation during meiosis		Null: missegregates chromosomes in meiosis	YIL132C	S000001394
CSM3		Protein required for accurate chromosome segregation during meiosis		Null: missegregates chromosomes in meiosis	YMR048W	S000004651
CSM4		Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements		Null: missegregates chromosomes in meiosis	YPL200W	S000006121
CSN12		Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in mRNA splicing and adaptation to pheromone signaling			YJR084W	S000003844
CSN9		Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling			YDR179C	S000002586
CSR1	SFH2	Phosphatidylinositol transfer protein with a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance			YLR380W	S000004372
CSR2	ART8|MRG19	Nuclear protein proposed to regulate utilization of nonfermentable carbon sources and endocytosis of plasma membrane proteins; overproduction suppresses chs5 spa2 lethality at high temp; ubiquitinated by Rsp5p, deubiquitinated by Ubp2p			YPR030W	S000006234
CST14		Chromosome STability		Overexpression of CSTs induces chromosome loss		S000029121
CST18		Chromosome STability		Overexpression of CSTs induces chromosome loss		S000029122
CST21		Chromosome STability		Overexpression of CSTs induces chromosome loss		S000029123
CST26	PSI1	Protein required for incorporation of stearic acid into phosphatidylinositol; affects chromosome stability when overexpressed			YBR042C	S000000246
CST3		Chromosome STability		Overexpression of CSTs induces chromosome loss		S000029124
CST6	ACA2|SHF1	Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, activates transcription of genes involved in utilization of non-optimal carbon sources; involved in telomere maintenance		Overexpression of CSTs induces chromosome loss	YIL036W	S000001298
CST9	ZIP3	SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; potential Cdc28p substrate		Null mutant is viable, but exhibits delayed sporulation and reduced viability; overexpression of CSTs induces chromosome loss	YLR394W	S000004386
CTA1		Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation		Null mutant is viable and heat sensitive	YDR256C	S000002664
CTF13	CBF3C	Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis			YMR094W	S000004700
CTF18	CHL12	Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint		Null mutant is viable, exhibits increased level of spontaneous mitotic recombination, slow growth, and cold sensitivity	YMR078C	S000004683
CTF19	MCM18	Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly			YPL018W	S000005939
CTF3	CHL3	Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules			YLR381W	S000004373
CTF4	CHL15|POB1	Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion		Null mutant is viable but shows increase in the rate of mitotic chromosome loss, increased mitotic recombination, shift toward cells with G2 DNA content, and large budded cells with the nucleus in the bud neck; shows synthetic interactions with rad52, pol1, rad9, and esr1	YPR135W	S000006339
CTF8		Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion			YHR191C	S000001234
CTH1		Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis		Null mutant is viable, displays a threefold increase in CTH2 mRNA accumulation. CTH1 overexpression causes delayed entry of cell cultures into exponential growth, and a decrease in final cell density. Removal of the zinc finger domain of Cth1p by truncation or deletion completely reverses the overexpression slow growth phenotype	YDR151C	S000002558
CTI6	RXT1	Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain			YPL181W	S000006102
CTK1		Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity		Null mutations in each of the CTK1, CTK2, and CTK3 genes cause slow growth, cold-sensitivity, flocculence, and enlarged cell size.	YKL139W	S000001622
CTK2		Beta subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity		Null mutations in each of the CTK1, CTK2, and CTK3 genes cause slow growth, cold-sensitivity, flocculence, and enlarged cell size.	YJL006C	S000003543
CTK3		Gamma subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity		Null mutations in each of the CTK1, CTK2, and CTK3 genes cause slow growth, cold-sensitivity, flocculence, and enlarged cell size.	YML112W	S000004580
CTL1	CTH1	RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm		Null mutant is viable at 15/30/37C, on media lacking inositol, and on media containing 15nM caffeine. CTL1 shows no genetic interaction with ceg1-250, cet1-4, nor CTD truncation mutants and does not suppress (in high copy) any of these mutants.	YMR180C	S000004792
CTM1		Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth		lack of trimethylation of cytochrome C Lys72	YHR109W	S000001151
CTP1		Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family			YBR291C	S000000495
CTR1		High-affinity copper transporter of the plasma membrane, mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels		Null mutant is viable, deficient in ferrous iron uptake	YPR124W	S000006328
CTR2		Putative low-affinity copper transporter of the vacuolar membrane; mutation confers resistance to toxic copper concentrations, while overexpression confers resistance to copper starvation		ctr2 mutants display a high level of resistance to toxic copper concentrations. CTR2 overexpression provides increased resistance to copper starvation and is also associated with an increased sensitivity to copper toxicity.	YHR175W	S000001218
CTR3		High-affinity copper transporter of the plasma membrane, acts as a trimer; gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae		Null mutant is viable, grows slower than w.t. under conditons of copper limitation on non-fermentable carbon source; strains with a deletion of both CTR1 and CTR3 are unable to grow on nonfermentable carbon sources	YLR411W	S000004403
CTR86		Essential protein of unknown function; upstream region contains a Gcn4p responsive site suggesting a possible role in amino acid biosynthesis			YCR054C	S000000650
CTR9	CDP1	Component of the Paf1p complex that binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; contains TPR repeats		Null mutant is viable, loses chromosomes and shows temperature sensitivity	YOL145C	S000005505
CTS1		Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p			YLR286C	S000004276
CTS2		Protein similar to Ashbya gossypii sporulation-specific chitinase		Null mutant fails to form mature asci, synthesis of spore wall surface layers is affected.	YDR371W	S000002779
CTT1	SPS101	Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide		Null mutant is viable and heat sensitive	YGR088W	S000003320
CUE1	KIS4	Endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination		Null mutant is viable and shows stabilization of ER degradation substrates	YMR264W	S000004877
CUE2		Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination			YKL090W	S000001573
CUE3		Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination			YGL110C	S000003078
CUE4		Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination			YML101C	S000004568
CUE5		Protein containing a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern			YOR042W	S000005568
CUL3	CULB	Ubiquitin-protein ligase, member of the cullin family with similarity to Cdc53p and human CUL3; required for ubiquitin-dependent degredation of the RNA Polymerase II subunit RPO21	CULLIN B		YGR003W	S000003235
CUP1-1	CUP1	Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C		Copper resistance	YHR053C	S000001095
CUP1-2	CUP1	Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C		Copper resistance	YHR055C	S000001097
CUP14		copper homeostasis		Copper resistance		S000029125
CUP2	ACE1	Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations		Null mutant is sensitive to Cu2+	YGL166W	S000003134
CUP3				Copper resistance		S000029126
CUP5	CLS7|GEF2|VMA3	Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis		Null mutant is viable, petite, copper sensitive	YEL027W	S000000753
CUP9		Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription		Null mutant is viable, associated with loss of copper resistance	YPL177C	S000006098
CUR1		Protein of unknown function involved in destabilization of [URE3] prions; similar in sequence to Btn2p			YPR158W	S000006362
CUS1		Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p		suppresses cold sensitivity of a U2 G53A cs mutant	YMR240C	S000004853
CUS2		Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs)		Null mutant is viable, enhances U2 mutations; mutations in this gene suppress the cold sensitive phenotype of U2 RNA mutation G53A	YNL286W	S000005230
CVT14				cvt14 is defective in maturation of the vacuolar protein, aminopeptidase I		S000029127
CVT15				cvt15 is defective in maturation of the vacuolar protein, aminopeptidase I		S000029128
CVT16				cvt16 is defective in maturation of the vacuolar protein, aminopeptidase I		S000029129
CVT3				cvt3 is defective in maturation of the vacuolar protein, aminopeptidase I and exhibits minor defects in autophagy		S000029130
CVT6				cvt6 is defective in maturation of the vacuolar protein, aminopeptidase I and exhibits minor defects in autophagy		S000029131
CWC15		Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p			YDR163W	S000002570
CWC2	NTC40	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2		Null: required for pre-mRNA splicing	YDL209C	S000002368
CWC21		Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; may bind RNA; has similarity to S. pombe Cwf21p			YDR482C	S000002890
CWC22		Essential protein, component of a complex containing Cef1p, has similarity to S. pombe Cwf22p; putative spliceosomal component, based on computational analysis of large-scale protein-protein interaction data			YGR278W	S000003510
CWC23		Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p			YGL128C	S000003096
CWC24		Essential protein, component of a complex containing Cef1p; has similarity to S. pombe Cwf24p			YLR323C	S000004315
CWC25		Heat-stable protein required for the first step of pre-mRNA splicing; component of a complex containing Cef1p; has similarity to S. pombe Cwf25p			YNL245C	S000005189
CWC27		Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p			YPL064C	S000005985
CWH41	DER7|GLS1	Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress		Null mutant is viable, associated with K1 killer toxin-resistant phenotype and a 50% reduction in the cell wall beta 1,6-glucan level	YGL027C	S000002995
CWH43		Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion			YCR017C	S000000610
CWP1	YJU1	Cell wall mannoprotein that localizes specifically to birth scars of daughter cells, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance		Null mutant is viable, has increased sensitivities to calcoflour white and congo red	YKL096W	S000001579
CWP2	LPR1|YKL097W-A	Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored		Null mutant is viable, displays increased sensitivity to Congo red, calcofluor white, and Zymolyase	YKL096W-A	S000001956
CYB2		Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions		Null mutant is viable but is deficient in cytochrome b2 and L-lactate dehydrogenase activity and is unable to use L-lactate as a sole carbon source	YML054C	S000004518
CYB5		Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation		Null mutant is viable, cyb5 mutations suppress ketoconazole hypersensitivity of a P450 reductase deficient strain	YNL111C	S000005055
CYC1		Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration	iso-1-cytochrome c	Cytochrome c deficiency	YJR048W	S000003809
CYC2		Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)		Null mutant is viable. Deletion of CYC2 leads to accumulation of apocytochrome c in the cytoplasm; strains with deletions of CYC2 still import low levels of cytochrome c into mitochondria	YOR037W	S000005563
CYC3		Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)		Cytochrome c deficiency	YAL039C	S000000037
CYC7		Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration	iso-2-cytochrome c		YEL039C	S000000765
CYC8	CRT8|SSN6	General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters; can form the prion [OCT+]		Null mutant is viable; high level constitutivity for invertase, clumpiness, temperature-sensitive growth, alpha-specific mating defects and failure of homozygous diploids to sporulate	YBR112C	S000000316
CYH1				Cycloheximide resistance		S000029132
CYH10				Cycloheximide resistance		S000029133
CYH101						S000029134
CYH35						S000029135
CYH4				Cycloheximide resistance		S000029136
CYH5				Cycloheximide resistance		S000029137
CYH82						S000029138
CYH98						S000029139
CYK3		SH3-domain protein located in the mother-bud neck and the cytokinetic actin ring; mutant phenotype and genetic interactions suggest a role in cytokinesis		Null mutant is viable, exhibits slow growth, mild cytokinesis defects, and aberrant mother-bud neck morphology. cyk3/hof1 and cyk3/myo1 double mutants are inviable	YDL117W	S000002275
CYM1	MOP112	Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology			YDR430C	S000002838
CYR1	CDC35|FIL1|HSR1|SRA4|TSM0185	Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation		Null mutant is inviable. cyr1 transiently arrests in G1 and sporulates precociously. N-terminal domain is dispensable for mitotic G1 arrest after nitrogen starvation, but required for sporulation. When altered, cAMP levels remain high and cells continue to bud with abnormal spindles	YJL005W	S000003542
CYS1				Mutant is a cysteine auxotroph and lacks serine acetyltransferase activity		S000029140
CYS2				cys2 and cys4 mutations are linked together and co-operatively confer cysteine dependence		S000029141
CYS3	CYI1|FUN35|STR1	Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine		Null mutant is viable, cysteine auxotroph	YAL012W	S000000010
CYS4	NHS5|STR4|VMA41	Cystathionine beta-synthase, catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; mutations in human ortholog cause homocystinuria		Null exhibits vacuolar acidification defects; cys2 and cys4 mutations are linked together and cooperatively confer cysteine dependence.	YGR155W	S000003387
CYT1	CTC1|YOR29-16	Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex			YOR065W	S000005591
CYT2		Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1	CC1HL|cytochrome c1 heme lyase		YKL087C	S000001570
DAD1		Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis		Null mutant is inviable; temperature-sensitive mutant arrests with large buds and a short mitotic spindle	YDR016C	S000002423
DAD2	HSK1	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis			YKR083C	S000001791
DAD3		Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis			YBR233W-A	S000007595
DAD4	HSK2	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis			YDR320C-A	S000007604
DAK1		Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation		Null mutant is viable and shows no growth defect in normal medium; mutant lacking both dak1 and dak2 is sensitive to dihydroxyacetone during saline growth	YML070W	S000004535
DAK2		Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation		Null mutant is viable and show no growth defect in normal medium; mutant lacking both dak1 and dak2 is sensitive to dihydroxyacetone during saline growth	YFL053W	S000001841
DAL1		Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression		Allantoin degradation deficient	YIR027C	S000001466
DAL2	ALC1	Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation		Allantoin degradation deficient	YIR029W	S000001468
DAL3		Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression			YIR032C	S000001471
DAL4		Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation		Null mutant is viable, lacks allantoin transport capability	YIR028W	S000001467
DAL5	UREP1	Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression		Null mutant is viable, unable to transport allontoate or ureidosuccinate	YJR152W	S000003913
DAL7	MLS2|MSL2	Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation			YIR031C	S000001470
DAL80	UGA43	Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Deh1p		Null mutant is viable, deficient in allantoin degradation	YKR034W	S000001742
DAL81	UGA35	Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism		Null mutant is viable, unable to degrade allantoin	YIR023W	S000001462
DAL82		Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain		loss of induction for allantoin degradation pathways	YNL314W	S000005258
DAM1		Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments			YGR113W	S000003345
DAN1	CCW13	Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth			YJR150C	S000003911
DAN4		Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth			YJR151C	S000003912
DAP1		Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis		Null mutant exhibits sensitivity to MMS, elongated telomeres, elevated petite formation, partial arrest in sterol synthesis	YPL170W	S000006091
DAP2	DPP2	Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p		Null mutant is viable and lacks dipeptidyl aminopeptidase yscV activity	YHR028C	S000001070
DAS1		Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C			YJL149W	S000003685
DAS2	RRT3	Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases			YDR020C	S000002427
DAT1		DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability		Null mutant is viable, but phenotypically distinguishable	YML113W	S000004581
DBF1		Protein required for DNA replication; expression is constant across the cell cycle		Dumbell formation		S000029142
DBF2		Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis		Null mutant is viable, dbf1 dbf20 null mutants are inviable; mutants show dumb-bell phenotype	YGR092W	S000003324
DBF20		Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis		Dumbell formation	YPR111W	S000006315
DBF4	DNA52|LSD7	Regulatory subunit of Cdc7p-Dbf4p kinase complex, required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated		Null mutant is inviable; conditional alleles cause cell cycle arrest at the G1/S transition; dumbbell shape	YDR052C	S000002459
DBL1				Alcian blue dye binding deficient		S000029143
DBP1	LPH8	Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs			YPL119C	S000006040
DBP10		Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis			YDL031W	S000002189
DBP2		Essential ATP-dependent RNA helicase of the DEAD-box protein family, involved in nonsense-mediated mRNA decay and rRNA processing			YNL112W	S000005056
DBP3		Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis			YGL078C	S000003046
DBP5	RAT8	Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family involved in mRNA export from the nucleus; involved in translation termination		dbp5(ts) strains exhibit rapid, synchronous accumulation of poly(A)+ RNA in nuclei when shifted to the non-permissive temperature	YOR046C	S000005572
DBP6		Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family		Null mutant is inviable; Dbp6p depletion leads to decreased production of the 27S and 7S precursors, resulting in a depletion of the mature 25S and 5.8S rRNAs	YNR038W	S000005321
DBP7		Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis; essential for growth under anaerobic conditions			YKR024C	S000001732
DBP8		ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esp2p			YHR169W	S000001212
DBP9		ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 60S ribosomal subunit			YLR276C	S000004266
DBR1	PRP26	RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition		Null mutant is viable; reduces Ty1 transposition frequency; defective in the process of intron turnover	YKL149C	S000001632
DCC1		Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance		benomyl sensitive and defective in sister chromatid cohesion	YCL016C	S000000521
DCD1		Deoxycytidine monophosphate (dCMP) deaminase required for dCTP and dTTP synthesis; expression is NOT cell cycle regulated		Null mutant is viable, resistant to 5-fluoro-2'-deoxycytidylate	YHR144C	S000001187
DCG1		Protein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain			YIR030C	S000001469
DCI1	ECI2	Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed			YOR180C	S000005706
DCN1		Scaffold-type E3 ligase required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation			YLR128W	S000004118
DCP1		Subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p		Null mutant is inviable in the FY1679 background, but viable, though grows slowly, in the CEN.PK141 background.	YOL149W	S000005509
DCP2	PSU1	Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; member of the Nudix hydrolase family			YNL118C	S000005062
DCR2		Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START			YLR361C	S000004353
DCS1	DcpS	Non-essential hydrolase involved in mRNA decapping, may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; interacts with neutral trehalase Nth1p			YLR270W	S000004260
DCS2		Non-essential, stress induced regulatory protein containing a HIT (histidine triad) motif; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway, similar to Dcs1p.			YOR173W	S000005699
DCW1		Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p			YKL046C	S000001529
DDC1		DNA damage checkpoint protein, part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate		Null mutant is viable, sensitive to DNA damage and defective in delaying G1-S and G2-M transistion and in decreasing rate of DNA synthesis when DNA is damaged during G1, G2 or S phase, respectively	YPL194W	S000006115
DDI1	VSM1	DNA damage-inducible v-SNARE binding protein, contains a ubiquitin-associated (UBA) domain, may act as a negative regulator of constitutive exocytosis, may play a role in S-phase checkpoint control			YER143W	S000000945
DDI2		Protein of unknown function; expression is induced over 100-fold by DNA damage; induction decreased in rad6 and rad18 mutants			YFL061W	S000001833
DDI3		Protein of unknown function; expression is induced over 100-fold by DNA damage; induction decreased in rad6 and rad18 mutants			YNL335W	S000005279
DDP1		Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; has high specificity for diadenosine hexa- and pentaphosphates; member of the MutT family of nucleotide hydrolases			YOR163W	S000005689
DDR2	DDRA2|YOL053C-A	Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses		Null mutant is viable, shows no defect in heat shock recovery or thermotolerance and appear normal for DNA damage sensitivity and mutagenesis	YOL052C-A	S000005413
DDR48	FSP	DNA damage-responsive protein, expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS		Null mutant is viable, displays reduced spontaneous mutation rate	YMR173W	S000004784
DDS2		Depressed DNA synthesis		Null phenotype unknown; temperature sensitive mutant ceases DNA synthesis at restrictive temperature		S000029144
DED1	SPP81	ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility			YOR204W	S000005730
DED81		Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA	asparaginyl-tRNA synthetase		YHR019C	S000001061
DEF1	VID31	RNAPII degradation factor, forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; mutant is deficient in Zip1p loading onto chromosomes during meiosis		Null: slow growth. Other phenotypes: unable to degrade RNAPII in response to UV-damage. def1delta and def1delta rad26delta cells are not UV-sensitive, but def1delta rad16delta and def1delta rad14delta cells are much more sensitive than the rad16delta and rad14delta single mutants. def1delta and to a much larger degree def1delta dst1delta are sensitive to the elongation inhibitor 6-azauracil.	YKL054C	S000001537
DEG1	HRM3|PUS3	tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability		Null mutant is viable, but demonstrates depressed growth rate	YFL001W	S000001895
DEM1	EXO5	Mitochondrial 5'-3' exonuclease and sliding exonuclease, required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2			YBR163W	S000000367
DEP1	FUN54	Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation			YAL013W	S000000011
DER1		Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p		Null mutant is viable, but blocks ER-degradation of target proteins	YBR201W	S000000405
DET1		Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel			YDR051C	S000002458
DFG10		Protein of unknown function, involved in filamentous growth		Null mutant is viable and defective in filamentous growth	YIL049W	S000001311
DFG16	ECM41|ZRG12	Probable multiple transmembrane protein, involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; required for accumulation of processed Rim101p		Null mutant is viable, a Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white.	YOR030W	S000005556
DFG5		Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p		Null mutant is viable and defective in filamentous growth	YMR238W	S000004851
DFM1		ER localized derlin-like family member involved in ER stress and homeostasis; not involved in ERAD or substrate retrotranslocation; interacts with CDC48; contains four transmembrane domains and two SHP boxes			YDR411C	S000002819
DFR1		Dihydrofolate reductase, part of the dTTP biosynthetic pathway, involved in folate metabolism, possibly required for mitochondrial function			YOR236W	S000005762
DGA1		Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles			YOR245C	S000005771
DGK1	HSD1	Diacylglycerol kinase, localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain			YOR311C	S000005838
DGR1		Protein of unknown function; dgr1 null mutant is resistant to 2-deoxy-D-glucose			YNL130C-A	S000028579
DGR2		Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds			YKL121W	S000001604
DHH1		Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping, coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation		Null mutant is viable, but grows poorly	YDL160C	S000002319
DHR2		Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis		Null: essential	YKL078W	S000001561
DIA1		Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern		Null mutant is viable and causes invasive growth in haploids and pseudohyphal growth in diploids	YMR316W	S000004935
DIA2	YOR29-31	Origin-binding F-box protein that forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication, involved in invasive and pseudohyphal growth		Enhanced invasive growth in haploids; haploid budding pattern becomes polar.	YOR080W	S000005606
DIA3		Protein of unknown function, involved in invasive and pseudohyphal growth		Null mutant is viable and causes invasive growth in haploids and pseudohyphal growth in diploids	YDL024C	S000002182
DIA4		Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth		Null mutant is viable and causes agar invasion in haploids, pseudohyphal growth in diploids; unable to grow on glycerol	YHR011W	S000001053
DIB1	SNU16	17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein			YPR082C	S000006286
DIC1		Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix			YLR348C	S000004340
DID2	CHM1|FTI1|VPL30|VPS46	Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors		Overexpression causes growth inhibition and G2 arrest in rad52 and cdc9 mutants; null mutants are canavanine-hypersensitive, temperature sensitive, and suppress defects associated with loss of DOA4	YKR035W-A	S000006435
DID4	CHM2|GRD7|REN1|VPL2|VPS14|VPS2|VPT14	Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis			YKL002W	S000001485
DIE2	ALG10	Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase of the ER, functions in the pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1			YGR227W	S000003459
DIE3		De-repression of ITR1 Expression				S000029145
DIF1		Protein that regulates the nuclear localization of ribonucleotide reductase Rnr2p and Rnr4p subunits; phosphorylated by Dun1p in response to DNA damage and degraded; N-terminal half has similarity to S. pombe Spd1 protein			YLR437C	S000004429
DIG1	RST1	Regulatory protein of unknown function, constitutively-expressed, involved in the regulation of mating-specific genes and the invasive growth pathway, required for MAP-kinase imposed repression, inhibits pheromone-responsive transcription		Null mutant is viable, shows abnormal bud morphology; dig1 dig2 double mutants show constitutive mating defect and invasive growth; overexpression causes pheromone resistance	YPL049C	S000005970
DIG2	RST2	Regulatory protein of unknown function, pheromone-inducible, involved in the regulation of mating-specific genes and the invasive growth pathway, required for MAP-kinase imposed repression, inhibits pheromone-responsive transcription		Null mutant is viable; dig1 dig2 double mutants show constitutive mating pheromone specific gene expression and invasive growth	YDR480W	S000002888
DIM1	CDH1	Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing			YPL266W	S000006187
DIN7	DIN3	Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination			YDR263C	S000002671
DIP2	UTP12	Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex			YLR129W	S000004119
DIP5		Dicarboxylic amino acid permease, mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly		Null mutant is viable, exhibits loss of L-aspartate and L-glutamate uptake	YPL265W	S000006186
DIS1		Required for mitotic segregation, meiosis I segregation, and spore viability		mutants cause mitotic and meiotic nondisjunction		S000029146
DIS3	RRP44	Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3			YOL021C	S000005381
DIT1		Sporulation-specific enzyme required for spore wall maturation, involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure		lack outermost layer of spore wall	YDR403W	S000002811
DIT2	CYP56	N-formyltyrosine oxidase, sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s		lack outermost layer of spore wall	YDR402C	S000002810
DJP1	ICS1|PAS22	Cytosolic J-domain-containing protein, required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ		Null mutant is viable but shows partial mislocalisation of peroxisomal matrix proteins to the cytosol	YIR004W	S000001443
DLD1		D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane		Null mutant is viable and cannot grow on media containing lactate as the sole carbon source	YDL174C	S000002333
DLD2	AIP2	D-lactate dehydrogenase, located in the mitochondrial matrix			YDL178W	S000002337
DLD3		D-lactate dehydrogenase, part of the retrograde regulon which consists of genes whose expression is stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source, located in the cytoplasm			YEL071W	S000000797
DLP1		Delayed loss of proliferation activity				S000029147
DLS1		Subunit of ISW2/yCHRAC chromatin accessibility complex along with Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing			YJL065C	S000003601
DLT1		Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)		Null: Poor growth at 15 degrees; phenotype is less apparent in prototrophic strains. Other phenotypes: Sensitive to heat shock and hydrogen peroxide	YMR126C	S000004733
DMA1	CHF1	Protein involved in ubiquitin ligation; plays a role in regulating spindle position and orientation; functionally redundant with Dma2p; orthologous to human RNF8 protein, also has sequence similarity to human Chfr.			YHR115C	S000001157
DMA2	CHF2	Protein involved in ubiquitination; plays a role in regulating spindle position and orientation; functionally redundant with Dma1p; orthologous to human RNF8 protein, also has sequence similarity to human Chfr			YNL116W	S000005060
DMC1	ISC2	Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein			YER179W	S000000981
DML1		Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family		Null: inviable. Other phenotypes: Meiotic progeny DML1 cells of the DML1/dml1Delta heterozygote are completely devoid of mtDNA ([rho0]). In addition, meiotic transmission of centromeric plasmids also appears to be impaired.	YMR211W	S000004824
DNA1	MAK1-3			Deficient in the initiation step of DNA synthesis		S000029148
DNA2	WEB2	Tripartite DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization			YHR164C	S000001207
DNF1		Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase		viable. drs2 dnf1 mutant grows slowly, massively accumulates intracellular membranes, and exhibits a substantial defect in the transport of alkaline phosphatase to the vacuole.	YER166W	S000000968
DNF2		Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase			YDR093W	S000002500
DNF3		Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; localizes to the trans-Golgi network; likely involved in protein transport; type 4 P-type ATPase			YMR162C	S000004772
DNL4	LIG4	DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth		Null mutant is viable, deficient in non-homologous double-strand end joining	YOR005C	S000005531
DNM1		Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance		Null mutant is viable, shows mating defects consistent with a delay in receptor-mediated endocytosis	YLL001W	S000003924
DOA1	UFD3|ZZZ4	WD repeat protein required for ubiquitin-mediated protein degradation, forms complex with Cdc48p, plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase		Null mutant is viable and defective in degradation of ubiquitinated proteins; homozygous null diploid shows sporulation defect	YKL213C	S000001696
DOA4	DOS1|MUT4|NPI2|SSV7|UBP4	Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole		Null mutant is viable, but exhibits uncoordinated DNA replication|A nonsense mutation in the doa4-10 mutant eliminates the catalytic residues of the deubiquitinating enzyme while keeping the rhodanase domain intact. At 36 degrees C, this doa4-10 mutant exhibits increased sensitivity to camptothecin (CPT), osmotic stress, and hydroxyurea, and a reversible petite phenotype.	YDR069C	S000002476
DOC1	APC10	Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis			YGL240W	S000003209
DOG1		2-deoxyglucose-6-phosphate phosphatase, similar to Dog2p, member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified	2-deoxyglucose-6-phosphate phosphatase		YHR044C	S000001086
DOG2		2-deoxyglucose-6-phosphate phosphatase, member of a family of low molecular weight phosphatases, similar to Dog1p, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed	2-deoxyglucose-6-phosphate phosphatase		YHR043C	S000001085
DOM34		Endoribonuclease; functions in no-go mRNA decay, protein translation to promote G1 progression and differentiation, required for meiotic cell division; similar to the eukaryotic Pelota			YNL001W	S000004946
DON1		Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II			YDR273W	S000002681
DOP1		Protein of unknown function, essential for viability, involved in establishing cellular polarity and morphogenesis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies		essential gene	YDR141C	S000002548
DOS2		Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm			YDR068W	S000002475
DOT1	PCH1	Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response	KMT4	Null mutant is viable, bypasses meiotic arrest of zip1 mutant, and shows decreased silencing at telomeres, HML, and HMR. Overexpression causes loss of silencing at telomeres, HML, HMR, and slightly at rDNA	YDR440W	S000002848
DOT5		Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth			YIL010W	S000001272
DOT6	PBF2	Protein involved in rRNA and ribosome biogenesis; binds polymerase A and C motif; subunit of the RPD3L histone deacetylase complex; similar to Tod6p; has chromatin specific SANT domain; involved in telomeric gene silencing and filamentation			YER088C	S000000890
DPB11		Replication initiation protein that loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; ortholog of human TopBP1		Null mutant is inviable; conditional allele demonstrates defective S-phase progression	YJL090C	S000003626
DPB2		Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for normal yeast chromosomal replication; expression peaks at the G1/S phase boundary; potential Cdc28p substrate		Null mutant is inviable; conditional mutant shows defects in DNA replication	YPR175W	S000006379
DPB3		Third-largest subunit of DNA polymerase II (DNA polymerase epsilon), required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; mRNA abundance peaks at the G1/S boundary of the cell cycle		Null mutant is viable, shows increased spontaneous mutation rate	YBR278W	S000000482
DPB4		Shared subunit of DNA polymerase (II) epsilon and of ISW2/yCHRAC chromatin accessibility complex; involved in both chromosomal DNA replication and in inheritance of telomeric silencing			YDR121W	S000002528
DPD1						S000029150
DPH1	KIF48	Protein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11p			YIL103W	S000001365
DPH2		Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p			YKL191W	S000001674
DPH5		Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm			YLR172C	S000004162
DPL1	BST1	Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate			YDR294C	S000002702
DPM1	SED3	Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation			YPR183W	S000006387
DPP1	ZRG1	Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism			YDR284C	S000002692
DPS1		Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation	AspRS|aspartyl-tRNA synthetase		YLL018C	S000003941
DRE2		Protein that may prevent apoptosis by forming a complex with Tah18p in the absence of stress; required for iron-sulfur cluster assembly and sister chromatid cohesion; homolog of human anti-apoptotic protein Ciapin1			YKR071C	S000001779
DRN1		Putative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus			YGR093W	S000003325
DRS1		Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles			YLL008W	S000003931
DRS2	FUN38|SWA3	Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease		Null mutant is viable, cold sensitive with perturbed late Golgi function; drs2 arf1 double mutants are inviable. drs2 dnf1 mutants grow slowly, accumulate intracellular membranes, exhibit substantial defect in transport of alkaline phosphatase to vacuole.	YAL026C	S000000024
DRS3				defective in assembly of ribosomes		S000029151
DSD1		D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate			YGL196W	S000003164
DSE1		Daughter cell-specific protein, may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall			YER124C	S000000926
DSE2		Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP			YHR143W	S000001186
DSE3		Daughter cell-specific protein, may help establish daughter fate			YOR264W	S000005790
DSE4	ENG1	Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother			YNR067C	S000005350
DSF1		Deletion suppressor of mpt5 mutation			YEL070W	S000000796
DSF2		Deletion suppressor of mpt5 mutation			YBR007C	S000000211
DSK2		Nuclear-enriched ubiquitin-like polyubiquitin-binding protein, required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle, involved in proteolysis, interacts with the proteasome			YMR276W	S000004889
DSL1	RNS1	Peripheral membrane protein needed for Golgi-to-ER retrograde traffic; forms a complex with Sec39p and Tip20p that interacts with ER SNAREs Sec20p and Use1p; component of the ER target site that interacts with coatomer; interacts with Cin5p			YNL258C	S000005202
DSM1				Premeiotic DNA synthesis deficient. Semi-dominant ts allele partially suppresses spo8-1 ts. Restores premeioticDNA synthesis, intragenic recombination, but not reciprocal recombination or ascus formation to spo8-1 at a restrictive temperature. DSM1 alone is dispensable for sporulation.		S000029152
DSN1		Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation			YIR010W	S000001449
DSS1	MSU1	3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs			YMR287C	S000004900
DSS4		Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol			YPR017C	S000006221
DST1	PPR2	General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites	P37|S-II|SII|TFIIS	Null mutant is viable; reduced induction of DNA strand transfer; sensitivity to 6-azauracil	YGL043W	S000003011
DTD1		D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes	D-tyrosyl-tRNA(Tyr) deacylase		YDL219W	S000002378
DTR1		Putative dityrosine transporter, required for spore wall synthesis; expressed during sporulation; member of the major facilitator superfamily (DHA1 family) of multidrug resistance transporters		Null: Null mutant is viable; bisformyl dityrosine accumulates in cytoplasm of spores; spore wall dityrosine is significantly reduced	YBR180W	S000000384
DUF1		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid			YOL087C	S000005447
DUG1		Cys-Gly metallo-di-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)			YFR044C	S000001940
DUG2		Probable di- and tri-peptidase; forms a complex with Dug1p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)			YBR281C	S000000485
DUG3		Probable glutamine amidotransferase, forms a complex with Dug1p and Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)			YNL191W	S000005135
DUN1		Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair		Null mutant is viable, defective in DNA damage repair and DNA damage-resposive induction of RNR genes, and sensitive to DNA damaging agents. dun1pan2 and dun1pan3 double mutants are hypersensitive to replicational stress.	YDL101C	S000002259
DUO1		Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis		Null mutant is inviable; overexpression arrests cells at large budded stage	YGL061C	S000003029
DUR1,2	DUR80	Urea amidolyase, contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation		Null mutant is viable; urea degradation deficient	YBR208C	S000000412
DUR3		Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway		Null mutant is viable; urea degradation deficient	YHL016C	S000001008
DUR4				Urea degradation deficient		S000029153
DUS1		Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17			YML080W	S000004545
DUS3		Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region			YLR401C	S000004393
DUS4		Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p			YLR405W	S000004397
DUT1		dUTPase, catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability			YBR252W	S000000456
DYN1	DHC1|PAC6	Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p		Null mutant is viable, demonstrates misalignment of the spindle relative to the bud neck during cell division and abnormal distribution of the dividing nuclei between the mother cell and the bud	YKR054C	S000001762
DYN2	SLC1	Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex			YDR424C	S000002832
DYN3		Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration			YMR299C	S000004914
DYS1		Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric			YHR068W	S000001110
EAF1	VID21	Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1			YDR359C	S000002767
EAF3		Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition			YPR023C	S000006227
EAF5		Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex			YEL018W	S000000744
EAF6		Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3			YJR082C	S000003842
EAF7		Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A			YNL136W	S000005080
EAM1		endogenous ethanolamine biosynthesis		Null phenotype unknown; a recessive allele suppresses ethanolamine requirement in cho1 mutants		S000029154
EAM2		endogenous ethanolamine biosynthesis		Null phenotype unknown; a recessive allele suppresses ethanolamine requirement in cho1 mutants		S000029155
EAM6						S000029156
EAP1		eIF4E-associated protein, competes with eIF4G for binding to eIF4E; inhibits cap-dependent translation; functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade		Mutant is temperature sensitive and partially resistant to rapamycin	YKL204W	S000001687
EAR1		Specificity factor required for Rsp5p-dependent ubiquitination and sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p			YMR171C	S000004781
EBP2		Essential protein required for the maturation of 25S rRNA and 60S ribosomal subunit assembly, localizes to the nucleolus; constituent of 66S pre-ribosomal particles			YKL172W	S000001655
EBS1		Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors			YDR206W	S000002614
ECI1		Peroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced		Null mutant is viable but fails to metabolize unsaturated fatty acids	YLR284C	S000004274
ECL1		Protein of unknown function, affects chronological lifespan; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation			YGR146C	S000003378
ECM1		Protein of unknown function, localized in the nucleoplasm and the nucleolus, genetically interacts with MTR2 in 60S ribosomal protein subunit export			YAL059W	S000000055
ECM10	SSC3	Heat shock protein of the Hsp70 family, localized in mitochondrial nucleoids, plays a role in protein translocation, interacts with Mge1p in an ATP-dependent manner; overexpression induces extensive mitochondrial DNA aggregations		A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white.	YEL030W	S000000756
ECM11		Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure		A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white.	YDR446W	S000002854
ECM12		Non-essential protein of unknown function		A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white.	YHR021W-A	S000003531
ECM13		Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation		A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white.	YBL043W	S000000139
ECM14		Putative metalloprotease with similarity to the zinc carboxypeptidase family, required for normal cell wall assembly		A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white.	YHR132C	S000001174
ECM15		Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis		A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white.	YBL001C	S000000097
ECM16	DHR1	Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesis		A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white.	YMR128W	S000004735
ECM18		Protein of unknown function, similar to Rlp24p		A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white.	YDR125C	S000002532
ECM19		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies		A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white.	YLR390W	S000004382
ECM2	SLT11	Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p		Synthetic lethal with U2 snRNA (LSR1); temperature-sensitive; blocks pre-mRNA splicing in vivo and in vitro; a Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white.	YBR065C	S000000269
ECM21	ART2	Protein involved in regulating the endocytosis of plasma membrane proteins; identified as a substrate for ubiquitination by Rsp5p and deubiquitination by Ubp2p; promoter contains several Gcn4p binding elements		A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white.	YBL101C	S000000197
ECM22		Sterol regulatory element binding protein, regulates transcription of sterol biosynthetic genes; contains Zn[2]-Cys[6] binuclear cluster; homologous to Upc2p; relocates from intracellular membranes to perinuclear foci on sterol depletion			YLR228C	S000004218
ECM23	SRD2	Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p			YPL021W	S000005942
ECM25		Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p			YJL201W	S000003737
ECM27		Non-essential protein of unknown function		A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white.	YJR106W	S000003867
ECM29		Major component of the proteasome; tethers the proteasome core particle to the regulatory particle, and enhances the stability of the proteasome			YHL030W	S000001022
ECM3	YOR3165W	Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation		A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white.	YOR092W	S000005618
ECM30		Non-essential protein of unknown function			YLR436C	S000004428
ECM31		Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate			YBR176W	S000000380
ECM32	HEL1|MTT1	DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes			YER176W	S000000978
ECM33		GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p			YBR078W	S000000282
ECM34		Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins			YHL043W	S000001035
ECM38	CIS2	Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation			YLR299W	S000004290
ECM4	GTO2	Omega class glutathione transferase; not essential; similar to Ygr154cp; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm		A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white.	YKR076W	S000001784
ECM5		Non-essential protein of unknown function, contains ATP/GTP-binding site motif A; null mutant exhibits cellular volume up to four times greater than wild-type, also large drooping buds with elongated necks			YMR176W	S000004788
ECM7	ZRG15	Non-essential putative integral membrane protein; mutant has cell wall defects; transcription is induced under conditions of zinc deficiency			YLR443W	S000004435
ECM8		Non-essential protein of unknown function			YBR076W	S000000280
ECM9	YKR004C-A	Non-essential protein of unknown function			YKR004C	S000001712
ECO1	CTF7	Acetytransferase required for sister chromatid cohesion; modifies Smc3p at DNA replication forks during S-phase; modifies Mcd1p in response to double-strand DNA breaks during G2/M; acetylation of cohesin subunits antagonizes Rad61p			YFR027W	S000001923
EDC1		RNA-binding protein, activates mRNA decapping directly by binding to the mRNA substrate and enhancing the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress			YGL222C	S000003190
EDC2		RNA-binding protein, activates mRNA decapping directly by binding to the mRNA substrate and enhancing the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress			YER035W	S000000837
EDC3	DCP3|LSM16	Non-essential conserved protein of unknown function, plays a role in mRNA decapping by specifically affecting the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies			YEL015W	S000000741
EDE1	BUD15	Key endocytic protein involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins			YBL047C	S000000143
EDS1		Putative zinc cluster protein; YBR033W is not an essential gene		Null: calcofluor resistant.. Other phenotypes: Deletion suppresses lysis defect of a swi4 deletion.	YBR033W	S000000237
EEB1		Acyl-coenzymeA:ethanol O-acyltransferase responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification			YPL095C	S000006016
EFB1	TEF5	Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site			YAL003W	S000000003
EFG1	YGR272C	Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus			YGR271C-A	S000007608
EFR3		Non-essential protein of unknown function; exhibits synthetic lethal genetic interactions with PHO85; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies and is phosphorylated			YMR212C	S000004825
EFT1		Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin			YOR133W	S000005659
EFT2		Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin			YDR385W	S000002793
EGD1		Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b			YPL037C	S000005958
EGD2		Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes			YHR193C	S000001236
EGT2		Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner			YNL327W	S000005271
EHD3	MRP5	3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis			YDR036C	S000002443
EHT1		Acyl-coenzymeA:ethanol O-acyltransferase that plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane		Null mutant is viable, temperature sensitive, and contains higher amounts of phosphatidylinositol, phosphatidic acid, and ergosteryl esters	YBR177C	S000000381
EIP1						S000029157
EKI1		Ethanolamine kinase, primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway			YDR147W	S000002554
ELA1		Elongin A, F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degredation of the RNA Polymerase II subunit RPO21; subunit of the Elongin-Cullin-Socs (ECS) ligase complex			YNL230C	S000005174
ELC1		Elongin C, involved in transcription elongation as a heterodimer with Ela1p; required for ubiquitin-dependent degradation of Rpo21p; plays a role in global genomic nucleotide excision repair; expression highly upregulated during sporulation		The deletion mutant is not sensitive to UV damage, however the elc1 rad23 double mutant is more UV sensitive than the rad23 mutant alone.	YPL046C	S000005967
ELF1		Transcription elongation factor that contains a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression			YKL160W	S000001643
ELG1	RTT110	Protein required for S phase progression and telomere homeostasis, forms an alternative replication factor C complex important for DNA replication and genome integrity; involved in homologous recombination-mediated DNA repair			YOR144C	S000005670
ELM1	LDB9	Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases; forms part of the bud neck ring			YKL048C	S000001531
ELO1		Elongase I, medium-chain acyl elongase, catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids		Null mutant is viable, but shows no growth on media supplemented with less than 16-C saturated fatty acid in a fatty acid synthase minus background	YJL196C	S000003732
ELP2	KTI3|TOT2	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin			YGR200C	S000003432
ELP3	HPA1|KTI8|TOT3	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin	KAT9		YPL086C	S000006007
ELP4	HAP1|KTI9|TOT7	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity			YPL101W	S000006022
ELP6	HAP3|KTI4|TOT6	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity			YMR312W	S000004929
EMC1		Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p			YCL045C	S000000550
EMC2		Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response			YJR088C	S000003848
EMC4		Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; human ortholog TMEM85 may function in apoptosis			YGL231C	S000003200
EMC6		Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response			YLL014W	S000003937
EMG1	NEP1	Member of the alpha/beta knot fold methyltransferase superfamily; required for maturation of 18S rRNA and for 40S ribosome production; interacts with RNA and with S-adenosylmethionine; associates with spindle/microtubules; forms homodimers			YLR186W	S000004176
EMI1		Non-essential protein required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs			YDR512C	S000002920
EMI2		Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression is regulated by glucose-repression transcription factors Mig1/2p			YDR516C	S000002924
EMI5	SDH5	Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)			YOL071W	S000005432
EMP24	BST2	Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport			YGL200C	S000003168
EMP46		Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport			YLR080W	S000004070
EMP47		Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport			YFL048C	S000001846
EMP70	TMN1|p24a	Protein with a role in cellular adhesion and filamentous growth; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments; 24kDa cleavage product found in endosome-enriched membrane fractions			YLR083C	S000004073
EMT1		tRNA-Met; tRNA that accepts methionine, functions in translational elongation but not translational initiation		Anticodon mutation (CAT->CAG) confers defects in pre-mRNA processing.		S000006659
EMT2		tRNA-Met; tRNA that accepts methionine, functions in translational elongation but not translational initiation				S000006666
EMT3		tRNA-Met; tRNA that accepts methionine, functions in translational elongation but not translational initiation				S000006662
EMT4		tRNA-Met; tRNA that accepts methionine, functions in translational elongation but not translational initiation				S000006664
EMT5		tRNA-Met; tRNA that accepts methionine, functions in translational elongation but not translational initiation				S000006661
ENA1	HOR6|PMR2	P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance		Null mutant is sensitive to Na+	YDR040C	S000002447
ENA2		P-type ATPase sodium pump, involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux		Null mutant is viable and sensitive to Na+, Li+, and alkaline pH	YDR039C	S000002446
ENA5		Protein with similarity to P-type ATPase sodium pumps, member of the Na+ efflux ATPase family			YDR038C	S000002445
ENA6		Plasma membrane sodium-pumping ATPase; the ENA6 gene is found in the PMR2 locus in the CEN.PK113-7D strain of S. cerevisiae, where other common lab strains have a varying number of the ENA genes (ENA1-ENA5) at the same locus				S000130715
ENB1	ARN4	Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment			YOL158C	S000005518
END10				end10 mutants are synthetically lethal with vat2/vma2 mutants		S000029158
END3		EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p		Null mutant is viable and defective in endocytosis	YNL084C	S000005028
ENO1	HSP48	Enolase I, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose	enolase		YGR254W	S000003486
ENO2		Enolase II, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is induced in response to glucose	enolase		YHR174W	S000001217
ENP1	MEG1	Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus			YBR247C	S000000451
ENP2		Essential nucleolar protein of unknown function; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p			YGR145W	S000003377
ENS2	Endo.SceI|RF3	Mitochondrially-encoded 50 kD subunit of Endo.SceI, a dimeric multi-site-specific endonuclease that introduces double-stranded breaks at a number of well-defined sites on the mitochondrial DNA, inducing homologous recombination				S000029698
ENT1		Epsin-like protein involved in endocytosis and actin patch assembly and functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus		Null mutant is viable, synthetically lethal with ent2 (YLR206w). ent1/2 double mutants have endocytosis and actin cytoskeleton defects.	YDL161W	S000002320
ENT2		Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus		Null mutant is viable; synthetically lethal with ent1 (YDL161w). ent2/1 double mutants have endocytosis and actin cytoskeleton defects.	YLR206W	S000004196
ENT3		Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p			YJR125C	S000003886
ENT4		Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome			YLL038C	S000003961
ENT5		Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin			YDR153C	S000002560
ENV7					YPL236C	S000006157
EOS1		Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene			YNL080C	S000005024
EPL1		Component of NuA4, which is an essential histone H4/H2A acetyltransferase complex; homologous to Drosophila Enhancer of Polycomb			YFL024C	S000001870
EPS1		ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family			YIL005W	S000001267
EPT1		sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability			YHR123W	S000001165
ERB1		Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1			YMR049C	S000004652
ERD1	LDB2	Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p)		disruption of the retention system for ER proteins; defects in the Golgi-dependent modification of glycoproteins|exhibits defects in N-glycosylation of proteins	YDR414C	S000002822
ERD2		HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins			YBL040C	S000000136
ERF2		Subunit of a palmitoyltransferase, composed of Erf2p and Shr5p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole		Null mutant is viable, but has a synthetic growth defect in the absence of RAS2; Deletion of ERF2 results in the reduction of steady-state levels of Ras2p palmitoylation.	YLR246W	S000004236
ERG1		Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine		Null mutant is inviable when cells are grown under aerobic conditions; erg1 null mutants are viable under anaerobic conditions during which ergosterol is taken up by the cells	YGR175C	S000003407
ERG10	LPB3|TSM0115	Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis		Nul mutant is inviable; other mutants are ergosterol biosynthesis defective or nystatin resistant	YPL028W	S000005949
ERG11	CYP51	Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family		Null mutant is inviable, erg11 null inviability is suppressed by deletion of ERG3; erg11 mutants are ergosterol biosynthesis defective; many are also nystatin resistant	YHR007C	S000001049
ERG12	RAR1	Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate		Null mutant is inviable and unable to grow vegetatively or germinate spores; mutants exhibit increased mitotic stability of plasmids with weak ARS elements.	YMR208W	S000004821
ERG13	HMGS	3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis			YML126C	S000004595
ERG2	END11	C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis		synthetic lethal with vma2.	YMR202W	S000004815
ERG20	BOT3|FDS1|FPP1	Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis			YJL167W	S000003703
ERG201						S000029159
ERG24		C-14 sterol reductase, acts in ergosterol biosynthesis; mutants accumulate the abnormal sterol ignosterol (ergosta-8,14 dienol), and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions		Null mutant appears to be inviable in some genetic backgrounds and conditionally lethal in others; erg24 mutations are suppessed by fen1 and fen2 mutations	YNL280C	S000005224
ERG25		C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol			YGR060W	S000003292
ERG26		C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis			YGL001C	S000002969
ERG27		3-keto sterol reductase, catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs			YLR100W	S000004090
ERG28	BUD18	Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p		Null mutant is viable; random budding in diploid null mutants; null cells have an unusual sterol content.	YER044C	S000000846
ERG29		Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes			YMR134W	S000004741
ERG3	PSO6|SYR1	C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources		Null mutant is inviable; suppresses syringomycin resistant mutant; sensitive to photoactivated 3-carbethoxypsoralen, UV light, radiomimetic mutagens, and oxidative stress	YLR056W	S000004046
ERG4		C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol			YGL012W	S000002980
ERG5	CYP61	C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs			YMR015C	S000004617
ERG6	ISE1|LIS1|SED6|VID1	Delta(24)-sterol C-methyltransferase, converts zymosterol to fecosterol in the ergosterol biosynthetic pathway by methylating position C-24; localized to both lipid particles and mitochondrial outer membrane		The null mutant is viable, cannot methylate ergosterol precursors at C-24, and lacks ergosterol. The null mutant shows defective conjugation, diminished capacity for transformation, and defective tryptophan uptake. The null mutant is hypersensitive to cycloheximide, Li+, and Na+, sensitive to anthracyclines, dactinomycin, and bretfeldin A, and resistant to nystatin.	YML008C	S000004467
ERG7		Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis			YHR072W	S000001114
ERG8		Phosphomevalonate kinase, an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate			YMR220W	S000004833
ERG9		Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway			YHR190W	S000001233
ERI1	RIN1	Endoplasmic reticulum membrane protein that binds to and inhibits GTP-bound Ras2p at the ER; component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein			YPL096C-A	S000028423
ERJ5		Type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response			YFR041C	S000001937
ERM6		Vacuolar protein of unknown function; potential Cdc28p substrate			YJR054W	S000003815
ERO1		Thiol oxidase required for oxidative protein folding in the endoplasmic reticulum		Null mutant is inviable; in ero1-1(ts) mutants newly synthesized carboxypeptidase Y is retained in the ER and lacks disulfide bonds; ero1 mutants are hypersensitive to to the reductant DTT, whereas overexpression of ERO1 confers resistance to DTT, the oxidant diamide can restore growth and secretion in ero1 mutants	YML130C	S000004599
ERP1		Protein that forms a heterotrimeric complex with Erp2p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles		null mutant is viable; delayed transport of Gas1p and invertase	YAR002C-A	S000002129
ERP2		Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles		null mutant is viable; delayed transport of Gas1p	YAL007C	S000000005
ERP3		Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport			YDL018C	S000002176
ERP4		Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport			YOR016C	S000005542
ERP5		Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport			YHR110W	S000001152
ERP6		Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YGL002W	S000002970
ERR1		Protein of unknown function, has similarity to enolases			YOR393W	S000005920
ERR2		Protein of unknown function, has similarity to enolases			YPL281C	S000006202
ERR3		Protein of unknown function, has similarity to enolases			YMR323W	S000004942
ERS1		Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains			YCR075C	S000000671
ERT1		Transcriptional regulator of nonfermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition			YBR239C	S000000443
ERV1		Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as part of a disulfide relay system that promotes IMS retention of imported proteins; ortholog of human hepatopoietin (ALR)		Null mutant is inviable; mutants demonstrate defects in mitochondrial biogenesis	YGR029W	S000003261
ERV14		Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon		Null mutant is viable but exhibits defects in sporulation (diploids) and bud site selection (haploids). Null mutants also retain the bud site selection marker, Axl2p, in the ER and exhibit slow recovery from selective to rich media.	YGL054C	S000003022
ERV15		Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p			YBR210W	S000000414
ERV2		Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER		Deletion of ERV2 or depletion of Erv2p by regulated gene expression is not associated with any detectable growth defects.	YPR037C	S000006241
ERV25		Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport		Null mutant is viable, displays a selective defect in transport of secretory proteins from the ER to Golgi complex.	YML012W	S000004473
ERV29		Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo			YGR284C	S000003516
ERV41		Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein			YML067C	S000004532
ERV46	FUN9	Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport			YAL042W	S000000040
ESA1	TAS1	Catalytic subunit of the histone acetyltransferase complex (NuA4) that acetylates four conserved internal lysines of histone H4 N-terminal tail; required for cell cycle progression and transcriptional silencing at the rDNA locus	KAT5		YOR244W	S000005770
ESBP6	MCH3	Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane			YNL125C	S000005069
ESC1		Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p			YMR219W	S000004832
ESC2		Protein involved in silencing; may recruit or stabilize Sir proteins; role in Rad51-dependent homologous recombination repair and intra S-phase DNA damage checkpoint; member of the RENi (Rad60-Esc2-Nip45) family of SUMO-like domain proteins			YDR363W	S000002771
ESC3		escape of sugars control				S000029160
ESC8		Protein involved in telomeric and mating-type locus silencing, interacts with Sir2p and also interacts with the Gal11p, which is a component of the RNA pol II mediator complex		Null: Viable, HMR silencing defect	YOL017W	S000005377
ESF1		Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels			YDR365C	S000002773
ESF2	ABT1	Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome			YNR054C	S000005337
ESL1		Putative protein of unknown function, predicted to contain a PINc domain			YIL151C	S000001413
ESL2		Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; predicted to contain a PINc domain			YKR096W	S000001804
ESP1		Separase, a caspase-like cysteine protease that promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p		Null mutant is inviable, produces extra spindle pole bodies, shows disrupted cell cycle control	YGR098C	S000003330
ESS1	PIN1|PTF1	Peptidylprolyl-cis/trans-isomerase (PPIase) specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNA polymerase II large subunit (Rpo21p) C-terminal domain		Null mutant is inviable; arrest phenotype of mitotic arrest and nuclear fragmentation	YJR017C	S000003778
EST1		TLC1 RNA-associated factor involved in telomere length regulation as the recruitment subunit of the telomerase holoenzyme, has a possible role in activating Est2p-TLC1-RNA bound to the telomere			YLR233C	S000004223
EST2	TERT	Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia		Null mutant is viable, exhibits progressively shorter telomeres, cellular senescence and a telomerase-minus defect; est2 rad52 mutants are inviable	YLR318W	S000004310
EST3		Component of the telomerase holoenzyme, involved in telomere replication		Null mutant shows progressively shorter telomeres and cellular senescence; telomerase activity is still present in est3-* extracts	YIL009C-A	S000006432
ETC1		Locus of unknown function that is associated with the TFIIIC component Tfc4p, located between the two divergently transcribed genes ADE8 and SIZ1				S000077072
ETC2		Locus of unknown function that is associated with the TFIIIC component Tfc4p, located upstream of ARG8				S000077073
ETC3		Locus of unknown function that is associated with the TFIIIC component Tfc4p, located upstream of BCK1				S000077074
ETC4		Locus of unknown function that is associated with the TFIIIC component Tfc4p, located upstream of RAD2				S000077075
ETC5		Locus of unknown function that is associated with the TFIIIC component Tfc4p, located upstream of RAD14				S000077076
ETC6		Locus of unknown function that is associated with the TFIIIC component Tfc4p, located between the two divergently transcribed genes TFC6 and ESC2				S000077077
ETC7		Locus of unknown function that is associated with the TFIIIC component Tfc4p, located between the two divergently transcribed genes WTM2 and YOR228C				S000077078
ETC8		Locus of unknown function that is associated with the TFIIIC component Tfc4p, located between the two divergently transcribed genes RPB5 and CNS1				S000077079
ETH3		affects methionine biosynthesis		Ethionine resistant		S000029161
ETP1	BRP2	Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences			YHL010C	S000001002
ETR1	MRF1|MRF1'	2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis	2-enoyl thioester reductase, E.C. 1.3.1.-		YBR026C	S000000230
ETS1-1	5' ETS	Non-coding region located immediately upstream of RDN18, that is transcribed as part of the 35S rRNA precursor transcript; contains an essential U3 snoRNA binding site required for maturation of 18S rRNA				S000029717
ETS1-2	5' ETS	Non-coding region located immediately upstream of RDN18, transcribed as part of the 35S rRNA precursor transcript; contains an essential U3 snoRNA binding site required for maturation of 18S rRNA				S000029707
ETS2-1	3' ETS	Non-coding region located adjacent to and downstream of RDN25, transcribed as part of the 35S rRNA precursor transcript; contains the primary rRNA transcription termination site at +93 and a secondary termination site between +211 and +250				S000029718
ETS2-2	3' ETS	Non-coding region located adjacent to RDN25, transcribed as part of the 35S rRNA precursor transcript; contains the primary rRNA transcription termination site at +93 and a secondary termination site between +211 and +250				S000029713
EUG1		Protein disulfide isomerase of the endoplasmic reticulum lumen, function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER			YDR518W	S000002926
EXA2		extragenic suppressor of hsp70 subfamily A		affect regulation of the stress response		S000029162
EXG1	BGL1	Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes		Null mutant is viable, displays modest increase in killer toxin sensitivity and beta 1,6-glucan levels	YLR300W	S000004291
EXG2		Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor			YDR261C	S000002669
EXO1	DHS1	5'-3' exonuclease and flap-endonuclease involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains		Mutants demonstrate sensitivity to cycloheximide, bleomycin, actinomycin D, 5-fluorouracil, and several other antibiotics, as well as irregular shapes and sensitivity to zymolase digestion	YOR033C	S000005559
EXO70		Subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which directs secretory vesicles to active sites of exocytosis; acts with Sec3p in membrane targeting of the exocyst via PI(4,5)P2 binding			YJL085W	S000003621
EXO84	USA3	Essential protein with dual roles in spliceosome assembly and exocytosis; the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p) mediates polarized targeting of secretory vesicles to active sites of exocytosis		Null mutant is inviable, defective in secretion	YBR102C	S000000306
FAA1		Long chain fatty acyl-CoA synthetase with a preference for C12:0-C16:0 fatty acids; involved in the activation of imported fatty acids; localized to both lipid particles and mitochondrial outer membrane; essential for stationary phase		Null mutant is viable as long as fatty acid synthase (fas) complex is active	YOR317W	S000005844
FAA2	FAM1	Long chain fatty acyl-CoA synthetase; accepts a wider range of acyl chain lengths than Faa1p, preferring C9:0-C13:0; involved in the activation of endogenous pools of fatty acids		Not essential for vegetative growth when fatty acid synthase (fas) is active	YER015W	S000000817
FAA3		Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery		Not essential for vegetative growth when fatty acid synthase (fas) is active	YIL009W	S000001271
FAA4		Long chain fatty acyl-CoA synthetase, regulates protein modification during growth in the presence of ethanol, functions to incorporate palmitic acid into phospholipids and neutral lipids		Not essential for vegetative growth when fatty acid synthase (fas) is active	YMR246W	S000004860
FAB1	SVL7	1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis		Null mutant is temperature-sensitive. Mutation causes pleiotropic effects on nuclear migration and orientation, and separation of mitotic chromosomes (forms aploid and binucleate cells); has defects in vacuolar function and morphology.	YFR019W	S000001915
FAD1		Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin			YDL045C	S000002203
FAF1		Protein required for pre-rRNA processing and 40S ribosomal subunit assembly			YIL019W	S000001281
FAL1		Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases		Null mutant is inviable; when Fal1p is depleted, either in a temperature-sensitive fal1-1 mutant or in glucose medium when Fal1p is under a gal promoter, there is a decrease in 40S ribosomal subunits, and those strains are sensitive to paromomycin and neomycin	YDR021W	S000002428
FAP1		Protein that binds to Fpr1p, conferring rapamycin resistance by competing with rapamycin for Fpr1p binding; accumulates in the nucleus upon treatment of cells with rapamycin; has similarity to D. melanogaster shuttle craft and human NFX1		Null mutant is viable and shows no phenotype; overexpression confers rapamycin resistance	YNL023C	S000004968
FAP7		Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D			YDL166C	S000002325
FAR1		Cyclin-dependent kinase inhibitor that mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate			YJL157C	S000003693
FAR10		Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate		Null: Defective for pheromone-induced G1 arrest	YLR238W	S000004228
FAR11		Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far10p; has similarity to the N- and C-termini of N. crassa HAM-2		Null: Defective for pheromone-induced G1 arrest	YNL127W	S000005071
FAR3		Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum		Null mutant does not arrest in G1 in response to pheromone but does have an intact signal transduction pathway leading to FAR1 transcriptional induction	YMR052W	S000004656
FAR7		Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p		Null: Defective for pheromone-induced G1 arrest	YFR008W	S000001904
FAR8		Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p		Null: Defective for pheromone-induced G1 arrest	YMR029C	S000004631
FAS1		Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities			YKL182W	S000001665
FAS2		Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains beta-ketoacyl reductase and beta-ketoacyl synthase activities; phosphorylated		Fatty acid synthetase deficient	YPL231W	S000006152
FAT1		Fatty acid transporter and very long-chain fatty acyl-CoA synthetase, may form a complex with Faa1p or Faa4p that imports and activates exogenous fatty acids		Null mutant is viable, but is Ole- in presence of cerulenin (i.e., unable to grow on YPD supplemented with oleic acid and cerulenin)	YBR041W	S000000245
FAU1		5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis		Null mutant is viable, but is unable to utilize folinic acid in place of folic acid.	YER183C	S000000985
FBA1	LOT1	Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress		Null mutant is viable, lacks aldolase enzymatic activity and fails to grow in media containing as a carbon source metabolites of only one side of the aldolase reaction	YKL060C	S000001543
FBP1	ACN8	Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; interacts with Vid30p		unable to grow with ethanol	YLR377C	S000004369
FBP26		Fructose-2,6-bisphosphatase, required for glucose metabolism		Null mutant lacks fructose-2,6-biphosphatase activity but can grow on glucose, fructose, galactose, pyruvate, glycerol and lactate	YJL155C	S000003691
FCF1	UTP24	Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p			YDR339C	S000002747
FCF2		Essential nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon			YLR051C	S000004041
FCJ1	AIM28|FMP13	Mitochondrial inner membrane protein involved in formation and molecular structure of crista junctions; impairs oligomerization of F1F0-ATP synthase; null shows altered mitochondrial morphology and abnormal mitochondrial genome maintenance			YKR016W	S000001724
FCP1		Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p)			YMR277W	S000004890
FCY1	yCD	Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU)			YPR062W	S000006266
FCY2	BRA7	Purine-cytosine permease, mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation			YER056C	S000000858
FCY21		Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function			YER060W	S000000862
FCY22		Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function			YER060W-A	S000002958
FDH1		NAD(+)-dependent formate dehydrogenase, may protect cells from exogenous formate			YOR388C	S000005915
FDH2		NAD(+)-dependent formate dehydrogenase, may protect cells from exogenous formate; YPL275W and YPL276W comprise a continuous open reading frame in some S. cerevisiae strains but not in the genomic reference strain S288C				S000006196
FEN1	ELO2|GNS1|VBM2	Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway		Null mutant is viable; slow growth; fenpropimorph resistant; resistant to a pneumocandin B0 analog (L-733,560); mating and sporulation defects; synthetic lethality with ELO3	YCR034W	S000000630
FEN2		Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph			YCR028C	S000000623
FES1		Hsp70 (Ssa1p) nucleotide exchange factor, cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum		Null mutant is thermosensitive. Other phenotypes: cycloheximide sensitive.	YBR101C	S000000305
FET1						S000029163
FET3		Ferro-O2-oxidoreductase required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases		The null mutant is viable but defective for high affinity Fe(II) uptake. The null mutant is inviable when environmental iron is limiting.	YMR058W	S000004662
FET4		Low-affinity Fe(II) transporter of the plasma membrane		Mutant lacks low affinity Fe(II) transport but has more active high affinity Fe(II) transport activity	YMR319C	S000004938
FET5		Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport		overexpression of FET5 suppresses a fet3 null mutant.	YFL041W	S000001853
FHL1	SPP42	Transcriptional activator with similarity to DNA-binding domain of Drosophila forkhead but unable to bind DNA in vitro; required for rRNA processing; isolated as a suppressor of splicing factor prp4		Null mutant shows reduced growth rate and lower rRNA content	YPR104C	S000006308
FIG1		Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating		Null mutant is viable, deficient in mating	YBR040W	S000000244
FIG2		Cell wall adhesin, expressed specifically during mating; may be involved in maintenance of cell wall integrity during mating		Null mutant is viable, deficient in mating under non-optimal conditions	YCR089W	S000000685
FIG4		Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain		Null mutant is viable, mating defective	YNL325C	S000005269
FIM1						S000029164
FIN1		Spindle pole body-related intermediate filament protein, forms cell cycle-specific filaments between spindle pole bodies in mother and daughter cells, able to self-assemble, expression induced during S/G2, localization cell-cycle dependent			YDR130C	S000002537
FIP1		Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity		Null mutant is inviable. At restrictive temperature, a temperature-sensitive mutant shows shortening of poly(A) tails	YJR093C	S000003853
FIR1	PIP1	Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate		Null mutant is viable, shows slow growth in all media	YER032W	S000000834
FIS1	MDV2	Protein involved in mitochondrial membrane fission and peroxisome abundance; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation		Null mutant is viable, mitochondrial fission blocked, mitochondrial membranes form nets	YIL065C	S000001327
FIT1		Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall		Impaired siderophore-iron uptake, activation of the major iron-dependent transcription factor AFT1.	YDR534C	S000002942
FIT2		Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall			YOR382W	S000005909
FIT3		Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall			YOR383C	S000005910
FKH1		Forkhead family transcription factor with a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; regulates donor preference during switching			YIL131C	S000001393
FKH2		Forkhead family transcription factor with a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase			YNL068C	S000005012
FKR1		FK506 resistant		resistant to FK506		S000029165
FKR2		FK506 resistant		resistant to FK506		S000029166
FKR3		FK506 resistant		resistant to FK506		S000029167
FKS1	CND1|CWH53|ETG1|GSC1|PBR1	Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling		Null mutant is viable, demonstrates slow growth, hypersensitivity to FK506 and cyclosporin A, sensitivity to echinocandin and a reduction in 1,3-beta-D-glucan synthase activity in vitro; sensitivity to papulacandin B	YLR342W	S000004334
FKS3		Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YMR306W	S000004923
FLC1	BOP1|HUF1	Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance			YPL221W	S000006142
FLC2	HUF2	Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance			YAL053W	S000000049
FLC3	HUF3	Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER			YGL139W	S000003107
FLD1	SEI1	Seipin protein involved in lipid droplet morphology, number, and size; proposed to be involved in lipid metabolism; related to the human BSCL2 which is associated with lipodystrophy	seipin		YLR404W	S000004396
FLO1	FLO2|FLO4	Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p		Flocculation	YAR050W	S000000084
FLO10		Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation			YKR102W	S000001810
FLO5		Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p		Mutations in FLO5 appear to have no effect on filamentous growth.	YHR211W	S000001254
FLO8	PHD5|YER108C	Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene		Null mutant is viable; wild-type gene is required for flocculation and for pseudo-hyphal growth	YER109C	S000000911
FLO9		Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation			YAL063C	S000000059
FLP1		Site-specific recombinase encoded on the 2-micron plasmid, required for 2-micron plasmid propagation as part of a plasmid amplification system that compensates for any copy number decreases caused by missegregation events			R0010W	S000029654
FLR1		Plasma membrane multidrug transporter of the major facilitator superfamily, involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin		Null mutant is viable; overexpression confers resistance to fluconazole, cycloheximide, 4-nitroquinoline N-oxide	YBR008C	S000000212
FLS1				fails to grow in the presence of 30 mg of fluphenazine per ml		S000029168
FLX1		Protein required for transport of flavin adenine dinucleotide (FAD), a synthesis product of riboflavin, across the mitochondrial membrane			YIL134W	S000001396
FMC1		Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p		Null mutant is viable and shows growth deficiency on non-fermentable carbon sources at 37 degrees C	YIL098C	S000001360
FMN1		Riboflavin kinase, phosphorylates riboflavin to form riboflavin monophosphate (FMN), which is a necessary cofactor for many enzymes; localizes to microsomes and to the mitochondrial inner membrane			YDR236C	S000002644
FMO1		Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins			YHR176W	S000001219
FMP10		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YER182W	S000000984
FMP16		Putative protein of unknown function; proposed to be involved in responding to conditions of stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YDR070C	S000002477
FMP21		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YBR269C	S000000473
FMP23		Putative protein of unknown function; proposed to be involved in iron or copper homeostatis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YBR047W	S000000251
FMP25		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YLR077W	S000004067
FMP27		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YLR454W	S000004446
FMP30		Protein of unknown function proposed to be involved in N-acylethanolamine metabolism; related to human NAPE-selective phospholipase D enzyme; native protein is detected in highly purified mitochondria in high-throughput studies			YPL103C	S000006024
FMP32		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YFL046W	S000001848
FMP33		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YJL161W	S000003697
FMP37		Putative protein of unknown function; highly conserved across species and orthologous to human gene BRP44L; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YGL080W	S000003048
FMP40		Putative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YPL222W	S000006143
FMP41		Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YNL168C	S000005112
FMP42		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy			YMR221C	S000004834
FMP43		Putative protein of unknown function; expression regulated by osmotic and alkaline stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YGR243W	S000003475
FMP45		Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C			YDL222C	S000002381
FMP46		Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YKR049C	S000001757
FMP48		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation			YGR052W	S000003284
FMP49		Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria			YER038W-A	S000028746
FMP52		Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation			YER004W	S000000806
FMS1		Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis			YMR020W	S000004622
FMT1		Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate	methionyl-tRNA transformylase	Null mutant is viable and lacks mitochondrial formyl-Met-tRNA	YBL013W	S000000109
FOB1	HRM1	Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases		Loss of replication fork blocking and recombinational hotspot activities.	YDR110W	S000002517
FOL1		Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities		essential, induces pseudohyphal growth	YNL256W	S000005200
FOL2		GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway		Folinic acid requiring	YGR267C	S000003499
FOL3		Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis		Null mutant is viable; requires folinic acid for growth	YMR113W	S000004719
FOX2	POX2	Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities		mutant lacks 2-enoyl-CoA hydratase and D-3-hydroxyacyl-CoA dehydrogenase activities	YKR009C	S000001717
FPK1		Ser/Thr protein kinase that regulates the putative phospholipid translocases Lem3p-Dnf1p/Dnf2p; phosphorylates and inhibits upstream inhibitory kinase, Ypk1p; localizes to the cytoplasm, early endosome/TGN compartments, and plasma membrane			YNR047W	S000005330
FPR1	FKB1|RBP1	Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function			YNL135C	S000005079
FPR2	FKB2	Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking			YDR519W	S000002927
FPR3	NPI46	Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p		Null mutant is viable; overexpression gives no phenotype except is growth inhibitory in fpr1 mutant; both null mutant and over-expressor show wild-type sensitivity to FK506 and rapamycin; npi46 fpr1 fpr2 triple mutant is viable	YML074C	S000004539
FPR4		Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones			YLR449W	S000004441
FPS1		Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress			YLL043W	S000003966
FRA1	RUP2	Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation			YLL029W	S000003952
FRA2	AIM15	Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel			YGL220W	S000003188
FRE1		Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels		Null mutant is viable, fre1-1 mutants are deficient in the uptake of ferric iron and are extremely sensitive to iron deprivation	YLR214W	S000004204
FRE2		Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels			YKL220C	S000001703
FRE3		Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels			YOR381W	S000005908
FRE4		Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels			YNR060W	S000005343
FRE5		Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YOR384W	S000005911
FRE6		Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels			YLL051C	S000003974
FRE7		Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels			YOL152W	S000005512
FRE8		Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p			YLR047C	S000004037
FRM2	YCLX08C	Protein of unknown function, involved in the integration of lipid signaling pathways with cellular homeostasis; expression induced in cells treated with the mycotoxin patulin; has similarity to bacterial nitroreductases		Null mutant is viable and sensitive to arachidonic acid	YCL026C-A	S000000589
FRO1				Frothing		S000029169
FRO2				Frothing		S000029170
FRQ1		N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily			YDR373W	S000002781
FRS1		Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control	cytoplasmic phenylalanyl-tRNA synthetase beta subunit		YLR060W	S000004050
FRS2		Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar	cytoplasmic phenylalanyl-tRNA synthetase alpha subunit		YFL022C	S000001872
FRT1	HPH1	Tail-anchored, endoplasmic reticulum membrane protein that is a substrate of the phosphatase calcineurin, interacts with homolog Frt2p, promotes cell growth in conditions of high Na+, alkaline pH, and cell wall stress			YOR324C	S000005851
FRT2	HPH2	Tail-anchored endoplasmic reticulum membrane protein, interacts with homolog Frt1p but is not a substrate of calcineurin (unlike Frt1p), promotes growth in conditions of high Na+, alkaline pH, or cell wall stress; potential Cdc28p substrate			YAL028W	S000000026
FSF1		Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis			YOR271C	S000005797
FSH1		Putative serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to S. cerevisiae Fsh2p and Fsh3p and the human candidate tumor suppressor OVCA2			YHR049W	S000001091
FSH2		Putative serine hydrolase that localizes to the cytoplasm; sequence is similar to S. cerevisiae Fsh1p and Fsh3p and the human candidate tumor suppressor OVCA2			YMR222C	S000004835
FSH3		Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; sequence is similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2			YOR280C	S000005806
FSP2		Protein of unknown function, expression is induced during nitrogen limitation			YJL221C	S000003757
FSR1				growth arrested at 35 degrees after nuclear division		S000029171
FSR2				Fluphenazine-resistant; arrests in G2 at 35 degrees in Ca2+-poor medium		S000029172
FTH1		Putative high affinity iron transporter involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis			YBR207W	S000000411
FTR1		High affinity iron permease involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron		Lacks high affinity iron uptake	YER145C	S000000947
FUI1		High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport			YBL042C	S000000138
FUM1		Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria			YPL262W	S000006183
FUN12	yIF2	GTPase, required for general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; homolog of bacterial IF2	eIF5B		YAL035W	S000000033
FUN14		Mitochondrial protein of unknown function			YAL008W	S000000006
FUN19		Non-essential protein of unknown function; expression induced in response to heat stress			YAL034C	S000002134
FUN26		Nucleoside transporter with broad nucleoside selectivity; localized to intracellular membranes			YAL022C	S000000020
FUN30		Protein whose overexpression affects chromosome stability, potential Cdc28p substrate; homolog of Snf2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YAL019W	S000000017
FUR1		Uracil phosphoribosyltransferase, synthesizes UMP from uracil; involved in the pyrimidine salvage pathway			YHR128W	S000001170
FUR4		Uracil permease, localized to the plasma membrane; expression is tightly regulated by uracil levels and environmental cues			YBR021W	S000000225
FUS1		Membrane protein localized to the shmoo tip, required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrate		Null mutant is viable; in fus1 x fus1 matings there is an interruption of the mating process just before cytoplasmic fusion	YCL027W	S000000532
FUS2		Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before nuclear fusion during mating		Null mutant is viable, fus2 mutants have strong defects in karyogamy and fail to orient microtubules between parental nuclei in zygotes	YMR232W	S000004845
FUS3	DAC2	Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its degradation		sterile; divide continuously in the presence of pheromones; form prezygotes with wild-type cells of opposite mating type but cannot undergo cell fusion	YBL016W	S000000112
FYV1		Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin		Null phenotype is K1 killer toxin hypersensitive	YDR024W	S000002431
FYV10	GID9	Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in proteasome-dependent catabolite inactivation of FBPase; contains CTLH domain; plays role in anti-apoptosis		Null mutant is viable but exhibits K1 killer toxin hypersensitivity.	YIL097W	S000001359
FYV12		Protein of unknown function, required for survival upon exposure to K1 killer toxin		Null mutant is viable but exhibits K1 killer toxin hypersensitivity.	YOR183W	S000005709
FYV4		Protein of unknown function, required for survival upon exposure to K1 killer toxin		Null phenotype is K1 killer toxin hypersensitive	YHR059W	S000001101
FYV5		Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in ion homeostasis		Null mutant is viable but exhibits K1 killer toxin hypersensitivity.	YCL058C	S000000563
FYV6		Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining		Null mutant is K1 killer toxin hypersensitive	YNL133C	S000005077
FYV7		Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin			YLR068W	S000004058
FYV8		Protein of unknown function, required for survival upon exposure to K1 killer toxin		Null phenotype is K1 killer toxin hypersensitive	YGR196C	S000003428
FZF1	NRC299|RSU1|SUL1	Transcription factor involved in sulfite metabolism, sole identified regulatory target is SSU1, overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers			YGL254W	S000003223
FZO1		Mitofusin, mitochondrial integral membrane protein involved in mitochondrial fusion and mitochondrial genome maintenance; contains N-terminal GTPase domain; targeted for destruction by cytosolic components of the ubiquitin-proteasome system		Null mutant is viable, exhibits a petite phenotype and fragmented mitochondrial morphology	YBR179C	S000000383
GAA1	END2	Subunit of the GPI (glycosylphosphatidylinositol):protein transamidase complex, removes the GPI-anchoring signal and attaches GPI to proteins in the ER			YLR088W	S000004078
GAB1	CDC91	GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI			YLR459W	S000004451
GAC1		Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock			YOR178C	S000005704
GAD1		Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress			YMR250W	S000004862
GAL1		Galactokinase, phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p		Null mutant is viable and cannot utilize galactose.	YBR020W	S000000224
GAL10		UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers		Null mutant is viable and cannot utilize galactose.	YBR019C	S000000223
GAL11	ABE1|MED15|RAR3|SDS4|SPT13	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors		Null mutant is viable, exhibits reduced expression of Gal4 regulated genes	YOL051W	S000005411
GAL2		Galactose permease, required for utilization of galactose; also able to transport glucose		Galactose non-utilizer	YLR081W	S000004071
GAL3		Transcriptional regulator involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity		Galactose non-utilizer	YDR009W	S000002416
GAL4	GAL81	DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p		Null mutant is viable, cannot utilize galactose as sole carbon source	YPL248C	S000006169
GAL7		Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism		Null mutant is viable and cannot utilize galactose.	YBR018C	S000000222
GAL80		Transcriptional regulator involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding		Null mutant is viable but has constitutive expression of the GAL genes.	YML051W	S000004515
GAL83	SPM1	One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain			YER027C	S000000829
GAP1		General amino acid permease; localization to the plasma membrane is regulated by nitrogen source		abolished activity of the general amino acid transport system	YKR039W	S000001747
GAR1		Protein component of the H/ACA snoRNP pseudouridylase complex, involved in the modification and cleavage of the 18S pre-rRNA			YHR089C	S000001131
GAS1	CWH52|GGP1	Beta-1,3-glucanosyltransferase, required for cell wall assembly and also has a role in transcriptional silencing; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor; also found at the nuclear periphery			YMR307W	S000004924
GAS2		1,3-beta-glucanosyltransferase, involved with Gas4p in spore wall assembly; has similarity to Gas1p			YLR343W	S000004335
GAS3		Putative 1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall			YMR215W	S000004828
GAS4		1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall			YOL132W	S000005492
GAS5		1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall			YOL030W	S000005390
GAT1	MEP80|NIL1	Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p			YFL021W	S000001873
GAT2		Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine			YMR136W	S000004744
GAT3		Protein containing GATA family zinc finger motifs			YLR013W	S000004003
GAT4		Protein containing GATA family zinc finger motifs		being investigated	YIR013C	S000001452
GBP2	RLF6	Poly(A+) RNA-binding protein, involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Hrb1p and Npl3p; also binds single-stranded telomeric repeat sequence in vitro		Mutation alters the distribution of Rap1p, a telomere-associated protein, but has no effect on telomere length or telomere position	YCL011C	S000000517
GCD1	TRA3	Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression		affect growth rate under nonstarvation conditions	YOR260W	S000005786
GCD10	TRM6	Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression	1-methyladenosine tRNA methyltransferase subunit	Null mutant is inviable. There are mutants available that show constitutive HIS4 transcription and slow growth	YNL062C	S000005006
GCD11	SUI4	Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met		Null mutant is inviable, gcd11 mutants have slower growth rate under nonstarvation conditions	YER025W	S000000827
GCD13		Negative regulator of GCN4 expression		Slow growth; constitutive expression of GCN4		S000029173
GCD14	TRM61	Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression	1-methyladenosine tRNA methyltransferase subunit	3-Aminotriazole resistance; unconditional slow growth	YJL125C	S000003661
GCD2	GCD12	Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression		Null mutant is inviable; resistance to 5-methyltryptophan, 5-fluorotryptophan and canavanine; override requirement for GCN2 and GCN3 gene products for derepression of GCN4 constitutive derepression and slow growth; temperature sensitive for growth	YGR083C	S000003315
GCD3		Negative regulator gene in general amino acid biosynthetic pathway, possibly upstream of GCN4		Resistant to 5-methyltrytophan, 5-fluorotryptophan and canavanine; slow growth; elevated mRNA levels of genes in amino acid biosynthesis		S000029174
GCD4		Negative regulatory gene in general amino acid biosynthetic pathway; upstream of GCN4		Resistant to 5-methyltrytophan, 5-fluorotryptophan and canavanine; slow growth; elevated mRNA levels of genes in amino acid biosynthesis		S000029175
GCD6		Catalytic epsilon subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression		Null mutant is inviable; non-null mutations increase GCN4 translation	YDR211W	S000002619
GCD7		Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression		Null mutant is inviable; non-null mutants exhibit an increase in GCN4 translation	YLR291C	S000004282
GCDX						S000029176
GCE1		cAMP-binding protein; localized to plasma membrane via glycosyl-phosphatidylinositol (GPI)-anchor				S000123791
GCN1		Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn20p; proposed to stimulate Gcn2p activation by an uncharged tRNA		Null mutant is viable and sensitive to 3-aminotriazole	YGL195W	S000003163
GCN2	AAS1	Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control		Null mutant is viable, unable to grow on medium containing 3-aminotriazole (3-AT), a competitive inhibitor of histidine biosynthesis, because it cannot derepress GCN4 and its target genes in the histidine biosynthetic pathway	YDR283C	S000002691
GCN20		Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA		Null mutant is viable and shows impaired derepression of GCN4 translation and reduced levels of eIF-2 alpha phosphorylation	YFR009W	S000001905
GCN3	AAS2	Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression		null mutants fail to derepress amino acid-regulated genes under conditions of amino acid starvation	YKR026C	S000001734
GCN4	AAS3|ARG9	Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels		The null mutant is viable but requires arginine on minimal medium and issensitive to 3-amino-1,2,4-triazole. General control of amino acid synthesis non-derepressible in the null mutant.	YEL009C	S000000735
GCN5	ADA4|SWI9	Histone acetyltransferase, acetylates N-terminal lysines on histones H2B and H3; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; founding member of the Gcn5p-related N-acetyltransferase superfamily	KAT2	Null mutant is viable, sensitive to intra-S-phase DNA damage, and grows poorly on minimal media.	YGR252W	S000003484
GCN6		Positive regulator of GCN4 transcription		Sensitivity to amino acid analogs; decreased mRNA levels of genes under general control of amino acid biosynthesis		S000029177
GCN7		Positive regulator of GCN4 transcription		Sensitivity to amino acid analogs; decreased mRNA levels of genes under general control of amino acid biosynthesis		S000029178
GCN8				Sensitivity to amino acid analogs; decreased mRNA levels of genes under general control of amino acid biosynthesis		S000029179
GCN9				Sensitivity to amino acid analogs; decreased mRNA levels of genes under general control of amino acid biosynthesis		S000029180
GCR1	LPF10	Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p		Null mutant has a severe growth defect when grown in the presence of glucose, but grows quite well on medium with non-fermentable carbon sources; on permissive medium, the null mutant principally affects the expression of glycolytic enzyme genes and transcripts encoded by Ty elements. Mutant exhibits reduction in the intracellular concentration of enolase and glyceraldehyde-3-phosphate dehydrogenase polypeptides	YPL075W	S000005996
GCR2		Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p		Null mutant is viable and has partial growth defect on glucose-containing media	YNL199C	S000005143
GCS1		ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p			YDL226C	S000002385
GCV1	GSD1	T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm		Null mutant is viable but cannot use glycine as sole nitrogen source	YDR019C	S000002426
GCV2	GSD2	P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm		Inability to convert glycine to serine (ser1 background); Inability to utilize glycine as a nitogen source.	YMR189W	S000004801
GCV3		H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF		Null mutant is viable but does not grow if glycine is the sole nitrogen source	YAL044C	S000000042
GCY1	GCY	Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; member of the aldo-keto reductase (AKR) family			YOR120W	S000005646
GDA1		Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate			YEL042W	S000000768
GDB1		Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria		Null mutant is viable but unable to degrade glycogen.	YPR184W	S000006388
GDE1		Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes			YPL110C	S000006031
GDH1	DHE4|GDH-A|GDHA|URE1	NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources			YOR375C	S000005902
GDH2	GDH-B|GDHB	NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels		Null mutant is viable, grows very poorly on glutamate as a nitrogen source	YDL215C	S000002374
GDH3	FUN51	NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources			YAL062W	S000000058
GDI1	SEC19	GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins			YER136W	S000000938
GDR1				Mutation alters nutritional control of germination		S000029181
GDR2				Mutation alters nutritional control of germination		S000029182
GDS1		Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies		Null mutant is viable, shows partial impairment of growth on medium containing glycerol as the carbon source. Overexpxression suppresses NAM9-1 glycerol deficient phenotype	YOR355W	S000005882
GDT1		Putative protein of unknown function; expression is reduced in a gcr1 null mutant; GFP-fusion protein localizes to the vacuole; expression pattern and physical interactions suggest a possible role in ribosome biogenesis			YBR187W	S000000391
GEA1		Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs), involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; similar to but not functionally redundant with Gea2p			YJR031C	S000003792
GEA2		Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs), involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; similar to but not functionally redundant with Gea1p		Null mutant is viable, synthetically lethal with gea1 null mutant	YEL022W	S000000748
GEF1	CLC	Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels			YJR040W	S000003801
GEM1	GON1	Evolutionarily-conserved tail-anchored outer mitochondrial membrane GTPase which regulates mitochondrial morphology; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; not required for pheromone-induced cell death		Null mutant is viable but exhibits slightly reduced secretion of over-produced PrA. Null mutants also grow slowly in the presence of high concentrations of calcium. Overexpression enhances secretion of overexpressed PrA.	YAL048C	S000000046
GEP3	AIM40|FMP38|LRC5	Protein of unknown function; null mutant is defective in respiration and interacts synthetically with prohibitin (phb1); the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies			YOR205C	S000005731
GEP4		Protein of unknown function required for respiratory growth; detected in highly purified mitochondria in high-throughput studies; null mutation confers sensitivity to tunicamycin and DTT and decreased levels of phosphatidylethanol			YHR100C	S000001142
GEP5	RRG5	Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine			YLR091W	S000004081
GEP7		Protein of unknown function; null mutant exhibits a respiratory growth defect and synthetic interactions with prohibitin (phb1) and gem1; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YGL057C	S000003025
GET1	MDM39	Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance		Null: Required for spore wall formation, but not IME1 induction or nuclear division	YGL020C	S000002988
GET2	HUR2|RMD7	Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division		null is hypersensitive to calcofluor white suffer an increased spheroplast lysis rate	YER083C	S000000885
GET3	ARR4	Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity		Null: YDL100c gene disruption results in sensitivity to As(III), As(V), Co(II) and Cu(II).	YDL100C	S000002258
GET4		Protein of unknown function, highly conserved across species and homologous to human gene C7orf20; interacts with Mdy2p; genetic interactions predict a role in insertion of tail-anchored proteins into the ER membrane			YOR164C	S000005690
GFA1		Glutamine-fructose-6-phosphate amidotransferase, catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis		Null mutant is viable, glucosamine auxotroph	YKL104C	S000001587
GFD1		Coiled-coiled protein of unknown function, identified as a high-copy suppressor of a dbp5 mutation		Null mutant is viable; high copy suppressor of rat8-2	YMR255W	S000004868
GFD2	YCD6	Protein of unknown function, identified as a high-copy suppressor of a dbp5 mutation		Null: Identified as high copy suppressor of a ts mutation affecting Dbp5p/Rat8p.	YCL036W	S000000541
GGA1		Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi		Single and double knockouts are viable at both 30 C and 37 C. Cells lacking GGA1, GGA2 exhibit defects in invertase processing, vacuolar morphology, maturation of alpha-factor, and sorting of CPY, proteinase A to the vacuole, but not endocytosis.	YDR358W	S000002766
GGA2		Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi		Single and double knockouts are viable at both 30 C and 37 C. Cells lacking GGA1, GGA2 exhibit defects in invertase processing, vacuolar morphology, maturation of alpha-factor, and sorting of CPY, proteinase A to the vacuole, but not endocytosis.	YHR108W	S000001150
GGC1	YHM1	Mitochondrial GTP/GDP transporter, essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family		Null mutant is viable; shm1 abf2 double deletion cannot grow on glycerol	YDL198C	S000002357
GIC1		Protein of unknown function involved in initiation of budding and cellular polarization, interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain		Null mutant is viable; gic1 gic2 double null is temperature sensitive at 33 degrees C	YHR061C	S000001103
GIC2		Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region		Null mutant is viable and temperature sensitive at 37 degrees C; gic1 gic2 double null is temperature sensitive at 33 degrees C	YDR309C	S000002717
GID7	MOH2	Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions			YCL039W	S000000544
GID8	DCR1	Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START			YMR135C	S000004742
GIM3	PFD4	Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it			YNL153C	S000005097
GIM4	PFD2	Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it		Null mutant is viable, sensitive to anti-microtubule drugs benomyl and nocadazole; synthetically lethal with tub4-1 mutations	YEL003W	S000000729
GIM5	PFD5	Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it		Null mutant is viable, cold sensitive, benomyl and nocadazole sensitive and fails to grow on YPD+1.2M KCl or YPD+1.8M sorbitol; synthetically lethal with tub4-1 mutations	YML094W	S000004559
GIN4	ERC47	Protein kinase involved in bud growth and assembly of the septin ring, proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Kcc4p and Hsl1p		Null mutant is viable, exhibits a mild elongated bud phenotype and some cell clumping	YDR507C	S000002915
GIP1		Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p			YBR045C	S000000249
GIP2		Putative regulatory subunit of the protein phosphatase Glc7p, involved in glycogen metabolism; contains a conserved motif (GVNK motif) that is also found in Gac1p, Pig1p, and Pig2p			YER054C	S000000856
GIP3		Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments			YPL137C	S000006058
GIP4	FUN21	Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate			YAL031C	S000000029
GIR2		Highly-acidic cytoplasmic RWD domain-containing protein of unknown function; interacts with Rbg1p and Gcn1p; associates with translating ribosomes; putative intrinsically unstructured protein			YDR152W	S000002559
GIS1		JmjC domain-containing histone demethylase; transcription factor involved in the expression of genes during nutrient limitation; also involved in the negative regulation of DPP1 and PHR1		Null mutant is viable and shows enhanced basal level expression of PHR1	YDR096W	S000002503
GIS2		Protein with seven cysteine-rich CCHC zinc-finger motifs, similar to human CNBP, proposed to be involved in the RAS/cAMP signaling pathway			YNL255C	S000005199
GIS3		Protein of unknown function			YLR094C	S000004084
GIS4		CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway			YML006C	S000004465
GIT1		Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability		Null mutant is viable, exhibits decreased GroPIns transport	YCR098C	S000000695
GLC3	GHA1	Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern		Null mutant is viable, glycogen deficient	YEL011W	S000000737
GLC7	CID1|DIS2|DIS2S1|PP1	Type 1 serine/threonine protein phosphatase catalytic subunit, involved in many processes (eg: glycogen metabolism, sporulation, mitosis); accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits			YER133W	S000000935
GLC8		Regulatory subunit of protein phosphatase 1 (Glc7p), involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2			YMR311C	S000004928
GLE1	BRR3|RSS1	Cytoplasmic nucleoporin required for polyadenylated RNA export but not for protein import; component of Nup82p nuclear pore subcomplex; contains a nuclear export signal			YDL207W	S000002366
GLE2	RAE1	Component of the Nup82 subcomplex of the nuclear pore complex; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p			YER107C	S000000909
GLG1		Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin		Null mutant is viable; disruption of both GLG1 and GLG2 renders cells unable to synthesize glycogen	YKR058W	S000001766
GLG2		Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin		Null mutant is viable; disruption of both GLG2 and GLG2 renders cells unable to synthesize glycogen	YJL137C	S000003673
GLK1	HOR3	Glucokinase, catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources			YCL040W	S000000545
GLN1		Glutamine synthetase (GS), synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation		Glutamine synthetase non-derepressible	YPR035W	S000006239
GLN3		Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source			YER040W	S000000842
GLN4		Glutamine tRNA synthetase, monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu); N-terminal domain proposed to be involved in enzyme-tRNA interactions	glutamyl-tRNA synthetase		YOR168W	S000005694
GLO1		Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress			YML004C	S000004463
GLO2		Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate			YDR272W	S000002680
GLO3		ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p			YER122C	S000000924
GLO4		Mitochondrial glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate			YOR040W	S000005566
GLR1	LPG17	Cytosolic and mitochondrial glutathione oxidoreductase, converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia			YPL091W	S000006012
GLT1		NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source			YDL171C	S000002330
GLU3				glutamate auxotroph; unable to grow on nonfermentable carbon sources		S000029184
GLY1		Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis		Null mutant is viable, glycine auxotroph, gly1 null mutants are not glycine auxotrophs on ethanol media	YEL046C	S000000772
GMH1	MSG1	Golgi membrane protein of unknown function, interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting			YKR030W	S000001738
GNA1	PAT1	Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA			YFL017C	S000001877
GND1		6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress			YHR183W	S000001226
GND2		6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone			YGR256W	S000003488
GNP1		High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids		Null mutant is viable but shows reduced glutamine transport and is therefore resistant to the glutamine analog L-glutamic acid gamma-monohydroxamate; overexpression induces sensitivity to heat shock	YDR508C	S000002916
GNT1		N-acetylglucosaminyltransferase capable of modification of N-linked glycans in the Golgi apparatus			YOR320C	S000005847
GON7	LDB6|PCC2	Protein proposed to be involved in the modification of N-linked oligosaccharides, osmotic stress response, telomere uncapping and elongation, transcription; component of the EKC/KEOPS protein complex with Kae1p, Cgi121p, Pcc1p, and Bud32p			YJL184W	S000003720
GOR1		Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YNL274C	S000005218
GOS1		v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28			YHL031C	S000001023
GOT1		Evolutionarily conserved non-essential protein present in early Golgi cisternae that may be involved in ER-Golgi transport at a step after vesicle tethering to Golgi membranes, exhibits membrane topology similar to that of Sft2p		Null mutant is viable but exhibits ER to Golgi transport defects in vitro. got1 is synthetically lethal with mutations in sft2; the got1 sft2 double mutant exhibits defects in transport to the Golgi complex.	YMR292W	S000004906
GPA1	CDC70|DAC1|SCG1	GTP-binding alpha subunit of the heterotrimeric G protein that couples to pheromone receptors; negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response; activates Vps34p at the endosome		The null mutation is inviable in haploids but not diploids. Gpa1 mutants exhibit specific defects in the pheromone responsiveness of both a and alpha cells.	YHR005C	S000001047
GPA2	SSP101	Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery			YER020W	S000000822
GPB1	KRH2	Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb2p			YOR371C	S000005898
GPB2	KRH1	Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb1p		Deletion causes a high PKA phenotype.	YAL056W	S000000052
GPD1	DAR1|HOR1|OSG1|OSR5	NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p			YDL022W	S000002180
GPD2	GPD3	NAD-dependent glycerol 3-phosphate dehydrogenase, homolog of Gpd1p, expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria			YOL059W	S000005420
GPG1		Proposed gamma subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p; overproduction causes prion curing		Null: A modest reduction in pseudohyphal differentiation, invasive growth, and FLO11 expression	YGL121C	S000003089
GPH1		Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway		Null mutant is viable; haploid cells contain higher levels of intracellular glycogen	YPR160W	S000006364
GPI1		Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs		Null mutant is viable but is temperature-sensitive for growth, for [3H]inositol incorporation into protein, and for GPI anchor-dependent processing of the Gas1/Ggp1 protein and lacks in vitro N-acetylglucosaminylphosphatidylinositol synthetic activity|Null mutant displays hyperactive Ras Signaling and invasive growth.	YGR216C	S000003448
GPI10		Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the GPI core structure; human PIG-Bp is a functional homolog		Null mutant is inviable but can be complemented by the homologous cDNA from humans that encodes the PIG-B protein; a mutant with conditional expression of GPI10 is defective in GPI anchor synthesis and GPI-anchored protein transport when GPI10 expression is turned off	YGL142C	S000003110
GPI11		ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog			YDR302W	S000002710
GPI12		ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp			YMR281W	S000004894
GPI13	MPC1	ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein		Null mutant is inviable; Gpi13p-depleted strains accumulate a GPI precursor whose glycan headgroup contains 4 mannoses and a phosphoethanolamine side-branch on the first mannose	YLL031C	S000003954
GPI14	PMH1	Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M			YJR013W	S000003774
GPI15		Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein		Null mutant is inviable; required for N-acetylglucosaminyl phosphatidylinositol synthesis.	YNL038W	S000004983
GPI16		Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog			YHR188C	S000001231
GPI17		Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Sp homolog			YDR434W	S000002842
GPI18	FMP44	Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria			YBR004C	S000000208
GPI19		Subunit of GPI-GlcNAc transferase involved in synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), which is the first intermediate in glycosylphosphatidylinositol (GPI) anchor synthesis, shares similarity with mammalian PIG-P			YDR437W	S000002845
GPI2	GCR4	Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein			YPL076W	S000005997
GPI4		involved in the attachment of glycosylphosphatidylinositol (GPI) anchors to proteins		defective in GPI anchor synthesis; sensitive to calcofluor white and hygromycin B		S000029185
GPI5		involved in the attachment of glycosylphosphatidylinositol (GPI) anchors to proteins		defective in GPI anchor synthesis; sensitive to calcofluor white and hygromycin B		S000029186
GPI6		involved in the attachment of glycosylphosphatidylinositol (GPI) anchors to proteins		defective in GPI anchor synthesis; sensitive to calcofluor white and hygromycin B		S000029187
GPI8		ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog			YDR331W	S000002739
GPI9		involved in the attachment of glycosylphosphatidylinositol (GPI) anchors to proteins		defective in GPI anchor synthesis; sensitive to calcofluor white and hygromycin B		S000029188
GPM1		Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis		Required for sporulation	YKL152C	S000001635
GPM2		Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event		Null mutant is viable, gpm2 gpm3 double deletion mutants exhibit no synthetic phenotypes	YDL021W	S000002179
GPM3		Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event		Null mutant is viable, gpm3 gpm2 double deletion mutants exhibit no synthetic phenotypes	YOL056W	S000005417
GPR1		Plasma membrane G protein coupled receptor (GPCR) that interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis			YDL035C	S000002193
GPT2	GAT1	Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis			YKR067W	S000001775
GPX1		Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress			YKL026C	S000001509
GPX2	AMI1	Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress			YBR244W	S000000448
GRC3		Protein of unknown function, required for cell growth and possibly involved in rRNA processing; mRNA is cell cycle regulated			YLL035W	S000003958
GRD10				mutant is deficient in retention (in the Golgi) of proteins normally residing in the trans-Golgi compartment		S000029189
GRD14				mutant is deficient in retention (in the Golgi) of proteins normally residing in the trans-Golgi compartment		S000029190
GRD15				mutant is deficient in retention (in the Golgi) of proteins normally residing in the trans-Golgi compartment		S000029191
GRD16				mutant is deficient in retention (in the Golgi) of proteins normally residing in the trans-Golgi compartment		S000029192
GRD17				mutant is deficient in retention (in the Golgi) of proteins normally residing in the trans-Golgi compartment		S000029193
GRD18				mutant is deficient in retention (in the Golgi) of proteins normally residing in the trans-Golgi compartment		S000029194
GRD3				mutant is deficient in retention (in the Golgi) of proteins normally residing in the trans-Golgi compartment		S000029195
GRD4				mutant is deficient in retention (in the Golgi) of proteins normally residing in the trans-Golgi compartment		S000029196
GRD5				mutant is deficient in retention (in the Golgi) of proteins normally residing in the trans-Golgi compartment		S000029197
GRE1		Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway		Null mutant is viable and shows no phenotype in osmotic, ionic or oxidative stress	YPL223C	S000006144
GRE2		3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway			YOL151W	S000005511
GRE3		Aldose reductase involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway			YHR104W	S000001146
GRH1		Acetylated, cis-golgi localized protein involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes		Null: Null mutation is viable, exhibits defects in spindle checkpoint	YDR517W	S000002925
GRR1	CAT80|COT2|SDC1|SSU2	F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification		Null mutant is viable, resistant to high levels of divalent cations, sensitive to sulfite, and defective in high affinity glucose transport and glucose repression; null mutant also exibits an elongated cell morphology	YJR090C	S000003850
GRS1		Cytoplasmic and mitochondrial glycyl-tRNA synthase that ligates glycine to the cognate anticodon bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation	glycyl-tRNA synthetase		YBR121C	S000000325
GRS2		Protein with sequence similarity to Grs1p, which is a glycyl-tRNA synthetase; cannot substitute for Grs1p; possible pseudogene that is expressed at very low levels			YPR081C	S000006285
GRX1		Hydroperoxide and superoxide-radical responsive heat-stable glutathione-dependent disulfide oxidoreductase with active site cysteine pair; protects cells from oxidative damage		Null mutant is viable but sensitive to oxidative stress. grx1 grx2 null mutants are viable but lack heat-stable oxidoreductase activity.	YCL035C	S000000540
GRX2	TTR1	Cytoplasmic glutaredoxin, thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress			YDR513W	S000002921
GRX3		Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage		Null mutant is viable and shows moderate sensitivity to oxidative stress and increased oxidation levels of cell proteins	YDR098C	S000002505
GRX4		Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage		Null mutant is viable and shows moderate sensitivity to oxidative stress and increased oxidation levels of cell proteins	YER174C	S000000976
GRX5		Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; mitochondrial matrix protein involved in the synthesis/assembly of iron-sulfur centers; monothiol glutaredoxin subfamily member along with Grx3p and Grx4p		Null mutant is viable and shows high sensitivity to oxidative stress and increased sensitivity to osmotic stress, and increased oxidation levels of cell proteins; grx5 is synthetically lethal with grx2.	YPL059W	S000005980
GRX6		Cis-golgi localized monothiol glutaredoxin that binds an iron-sulfur cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; functional overlap with GRX7			YDL010W	S000002168
GRX7		Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; functional overlap with GRX6			YBR014C	S000000218
GRX8		Glutaredoxin that employs a dithiol mechanism of catalysis; monomeric; activity is low and null mutation does not affect sensitivity to oxidative stress; GFP-fusion protein localizes to the cytoplasm; expression strongly induced by arsenic			YLR364W	S000004356
GSC2	FKS2	Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)		Null mutant is viable and shows partially reduced 1,3-beta-glucan synthase activity	YGR032W	S000003264
GSD3				exhibits defects in conversion of glycine to serine; unable to grow on glycine as a sole nitrogen source		S000029198
GSD4				exhibits defects in conversion of glycine to serine		S000029199
GSD5				exhibits defects in conversion of glycine to serine		S000029200
GSD6				exhibits defects in conversion of glycine to serine		S000029201
GSF1		Glucose Signaling Factor		defective in glucose repression		S000029202
GSF2	ECM6	ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression		A Tn3 insertion into this gene causes hypersensitivity to the cell surface polymer perturbing agent calcofluor white; Defective in glucose repression; mutants decrease transcriptional repression by MIG1; alter glucose-regulated subunit interactions within the Snf1 protein kinase complex; the effects of eff1 and eff2 on SUC2 repression are strongly synergistic.	YML048W	S000004511
GSF3				defective in glucose repression.		S000029203
GSG1	MUM1|TRS85	Subunit of TRAPP (transport protein particle), a multi-subunit complex involved in targeting and/or fusion of ER-to-Golgi transport vesicles with their acceptor compartment; protein has late meiotic role, following DNA replication			YDR108W	S000002515
GSH1		Gamma glutamylcysteine synthetase catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury		Null mutant is viable, exhibits alteration of glutathione content and reduction in growth rate	YJL101C	S000003637
GSH2		Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock		Null mutant is viable, growth was poor under aerobic conditions in minimum medium	YOL049W	S000005409
GSM1		Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis			YJL103C	S000003639
GSP1	CNR1|CST17	Ran GTPase, GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; regulated by Srm1p, Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p and Kap95p; yeast Gsp2p homolog			YLR293C	S000004284
GSP2	CNR2	GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability			YOR185C	S000005711
GSY1		Glycogen synthase with similarity to Gsy2p, the more highly expressed yeast homolog; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase		Null mutant is viable. Mutant lacking both GSY1 and GSY2 is viable but lacks glycogen synthase activity and glycogen deposition	YFR015C	S000001911
GSY2		Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase		Null mutant is viable. Mutant lacking both GSY1 and GSY2 is viable but lacks glycogen synthase activity and glycogen deposition	YLR258W	S000004248
GTB1		Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p, involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER			YDR221W	S000002629
GTO1		Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization			YGR154C	S000003386
GTO3		Omega class glutathione transferase; putative cytosolic localization			YMR251W	S000004863
GTR1		Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB		Null mutant is viable but grows slowly, is cold-sensitive, and has defects in phosphate uptake	YML121W	S000004590
GTR2		Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD			YGR163W	S000003395
GTS1	FHT1|LSR1	Arf3p GTPase Activating Protein (GAP) that localizes to endocytic patches; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms; localizes to nucleus and induces flocculation when overexpressed		Null mutant is viable; shows reduced lag phase	YGL181W	S000003149
GTT1		ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p		heat shock sensitive at stationary phase	YIR038C	S000001477
GTT2		Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p			YLL060C	S000003983
GTT3		Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery			YEL017W	S000000743
GUA1		GMP synthase, an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation		Null mutant is viable but is a guanine auxotroph	YMR217W	S000004830
GUD1		Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures			YDL238C	S000002397
GUF1		Mitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor			YLR289W	S000004280
GUK1	PUR5	Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins			YDR454C	S000002862
GUP1		Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport			YGL084C	S000003052
GUP2		Probable membrane protein with a possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases; Gup1p homolog			YPL189W	S000006110
GUS1	GSN1	Glutamyl-tRNA synthetase (GluRS), forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm	GluRS		YGL245W	S000003214
GUT1		Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p		Null mutant is viable but is unable to grow on glycerol	YHL032C	S000001024
GUT2		Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner		Null mutant is viable, unable to utilize glycerol as a carbon source	YIL155C	S000001417
GVP36		BAR domain-containing protein that localizes to both early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis		Null: no notable phenotype	YIL041W	S000001303
GWT1		Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors		overexpression confers 1-[4-butylbenzyl]isoquinoline (BIQ)-resistant growth in S. cerevisiae.	YJL091C	S000003627
GYL1	APP2	Putative GTPase activating protein (GAP) that may have a role in polarized exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p			YMR192W	S000004804
GYP1	YOR29-21	Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion		Null mutant is viable and shows no phenotype	YOR070C	S000005596
GYP5		GTPase-activating protein (GAP) for yeast Rab family members, involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p			YPL249C	S000006170
GYP6		GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated protein transport			YJL044C	S000003580
GYP7		GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking			YDL234C	S000002393
GYP8		GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport			YFL027C	S000001867
GZF3	DEH1|NIL2	GATA zinc finger protein and Dal80p homolog that negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p		Null mutant is partially NCR-insensitive	YJL110C	S000003646
HAA1		Transcriptional activator involved in the transcription of TPO2, YRO2, and other genes putatively encoding membrane stress proteins; involved in adaptation to weak acid stress			YPR008W	S000006212
HAC1	ERN4|IRE15	Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog) that regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis		Null mutant is viable but is sensitive to caffeine (suppressed by high-copy SRA5) and stresses that produce unfolded proteins. High-copy HAC1 suppresses S. pombe cdc10-129	YFL031W	S000001863
HAH1		Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YGR021W	S000003253
HAL1		Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p		Null mutant is viable, shows decreased salt tolerance	YPR005C	S000006209
HAL5		Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters			YJL165C	S000003701
HAL9		Putative transcription factor containing a zinc finger; overexpression increases salt tolerance through increased expression of the ENA1 (Na+/Li+ extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression		Null mutant is viable, exhibits decreased salt tolerance and ENA1 expression; HAL9 overexpression increases sodium and lithium tolerance	YOL089C	S000005449
HAM1		Conserved protein with deoxyribonucleoside triphosphate pyrophosphohydrolase activity, mediates exclusion of noncanonical purines from deoxyribonucleoside triphosphate pools; mutant is sensitive to the base analog 6-N-hydroxylaminopurine		Null mutant is viable but is sensitive to 6-N-hydroxylaminopurine (HAP), a mutagen; however, mutant does not show higher spontaneous mutation rate	YJR069C	S000003830
HAP1	CYP1	Zinc finger transcription factor involved in the complex regulation of gene expression in response to levels of heme and oxygen; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus		Essential for anaerobic or heme deficient growth; Null mutant is viable, deficient in expression of CYC1 and CYC7	YLR256W	S000004246
HAP2		Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding			YGL237C	S000003206
HAP3		Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding			YBL021C	S000000117
HAP4		Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex		hap4 point mutants or disruptions are unable to grow on non-fermentable carbon sources	YKL109W	S000001592
HAP5		Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex			YOR358W	S000005885
HAS1		ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles			YMR290C	S000004903
HAT1		Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair	KAT1		YPL001W	S000005922
HAT2		Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing			YEL056W	S000000782
HBN1	YCL027C-A	Putative protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein becomes insoluble upon intracellular iron depletion			YCL026C-B	S000007548
HBO10						S000029206
HBS1		GTP binding protein with sequence similarity to the elongation factor class of G proteins, EF-1alpha and Sup35p; associates with Dom34p, and shares a similar genetic relationship with genes that encode ribosomal protein components			YKR084C	S000001792
HBT1		Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis			YDL223C	S000002382
HCA4	DBP4|ECM24	Putative nucleolar DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis			YJL033W	S000003570
HCH1		Heat shock protein regulator that binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; GFP-fusion protein localizes to the cytoplasm and nucleus		Null mutant is viable; when overexpressed, HCH1 is an allele-specific suppressor of hsp82 ts mutants	YNL281W	S000005225
HCM1		Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role		Null mutant is viable; exacerbates temperature-sensitivity of a cmd1-1 (calmodulin) mutant	YCR065W	S000000661
HCR1		Dual function protein involved in translation initiation as a substoichiometric component (eIF3j) of translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA			YLR192C	S000004182
HCS1	DIP1	Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities			YKL017C	S000001500
HDA1		Putative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylation			YNL021W	S000004966
HDA2	PLO2	Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance			YDR295C	S000002703
HDA3	PLO1	Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex that contains an Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; has similarity to Hda2p			YPR179C	S000006383
HED1		Meiosis-specific protein that down-regulates Rad51p-mediated mitotic recombination when the meiotic recombination machinery is impaired; early meiotic gene, transcribed specifically during meiotic prophase			YDR014W-A	S000113613
HEF3	ZRG7	Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells			YNL014W	S000004959
HEH2		Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle			YDR458C	S000002866
HEK2	KHD1	RNA binding protein involved in the asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K		Null: ASH1 mRNA is partially delocalized	YBL032W	S000000128
HEM1	CYD1|OLE3	5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p		Null mutant is viable; auxotroph for heme and methionine	YDR232W	S000002640
HEM10				Heme synthesis deficient		S000029207
HEM11		Involved in heme biosynthesis		Null mutant is viable; auxotroph for heme and methionine		S000029208
HEM12	HEM6	Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda			YDR047W	S000002454
HEM13		Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)			YDR044W	S000002451
HEM14		Protoporphyrinogen oxidase, a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX; inhibited by diphenyl ether-type herbicides		Null mutant is viable but is protoporphyrinogen oxidase deficient (heme deficiency and accumlation of heme precursors)	YER014W	S000000816
HEM15		Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway		Null mutant is inviable in certain genetic backgrounds	YOR176W	S000005702
HEM2	OLE4|SLU1	Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus		Null mutant is viable; auxotroph for heme and methionine	YGL040C	S000003008
HEM3	OLE2	Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme		auxotroph for heme and methionine	YDL205C	S000002364
HEM4	SLU2	Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria		respiratory deficiency, accumulation of porphyrins, and heme auxotrophy	YOR278W	S000005804
HEM5				hem5 mutants accumulate protoporphyrin IX		S000029209
HER1		Protein of unknown function required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments			YOR227W	S000005753
HER2	GEP6|LRC6|RRG6	Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase		null is unable to grow on glycerol	YMR293C	S000004907
HES1	OSH5	Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP)		pleiotropic sterol-related phenotypes	YOR237W	S000005763
HFA1		Mitochondrial acetyl-coenzyme A carboxylase, catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis			YMR207C	S000004820
HFD1		Putative fatty aldehyde dehydrogenase, located in the mitochondrial outer membrane and also in lipid particles; has similarity to human fatty aldehyde dehydrogenase (FALDH) which is implicated in Sjogren-Larsson syndrome			YMR110C	S000004716
HFI1	ADA1|GAN1|SRM12|SUP110	Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions		Null mutant phenotypes similar to spt20/ada5 and spt7 mutants. Null mutant is viable, elongated cells, hyperpolarized actin cytoskeleton, heat sensitive, non-respiratory, inositol auxotroph, exhibits suppression of Ty insertion mutations; hfi1 hta1 double mutant is inviable.	YPL254W	S000006175
HFM1	MER3	Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity			YGL251C	S000003220
HGH1		Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16)			YGR187C	S000003419
HHF1		Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity			YBR009C	S000000213
HHF2		Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF1); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity			YNL030W	S000004975
HHO1		Histone H1, a linker histone required for nucleosome packaging at restricted sites; suppresses DNA repair involving homologous recombination; not required for telomeric silencing, basal transcriptional repression, or efficient sporulation		Null mutant is viable; other phenotype: Increased basal expression of a CYC1-lacz reporter gene; nuclear localization of a Hho1-GFP fusion protein	YPL127C	S000006048
HHT1	BUR5|SIN2	Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation			YBR010W	S000000214
HHT2		Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation			YNL031C	S000004976
HHY1	ENV6	Dubious open reading frame unlikely to encode a functional protein; mutant is hypersensitive to hygromycin B indicative of defects in vacuolar trafficking			YEL059W	S000000785
HIF1		Non-essential component of the HAT-B histone acetyltransferase complex (Hat1p-Hat2p-Hif1p), localized to the nucleus; has a role in telomeric silencing		Null mutant is viable and does not show any obvious phenotypes	YLL022C	S000003945
HIM1		Protein of unknown function involved in DNA repair			YDR317W	S000002725
HIP1		High-affinity histidine permease, also involved in the transport of manganese ions		requires supplementation with large amounts of histidine for growth	YGR191W	S000003423
HIR1		Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores		Null mutant is viable, but HTA1-HTB1 transcription is derepressed and is no longer cell-cycle regulated; other mutations in this gene give 'spt' gene-class phenotype	YBL008W	S000000104
HIR2	SPT1	Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p		Null mutant is viable, but HTA1-HTB1 transcription is derepressed and is no longer cell-cycle regulated; other mutations in this gene give 'spt' gene-class phenotype	YOR038C	S000005564
HIR3	HPC1	Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly		HTA1-HTB1 transcription is derepressed and is no longer cell-cycle regulated	YJR140C	S000003901
HIR4		Involved in cell-cycle regulation of histone transcription		Dominant mutant is available that lacks proper cell cycle-dependent regulation of HTA1-HTB1 transcription		S000029211
HIS1		ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control		Null mutant is viable and requires histidine	YER055C	S000000857
HIS2		Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control		Null mutant is viable and requires histidine	YFR025C	S000001921
HIS3	HIS10|HIS8	Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p		Null mutant is viable and requires histidine	YOR202W	S000005728
HIS4		Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis		Null mutant is viable and requires histidine	YCL030C	S000000535
HIS5		Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts		Null mutant is viable and requires histidine	YIL116W	S000001378
HIS6		Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts		Null mutant is viable and requires histidine	YIL020C	S000001282
HIS7		Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase), catalyzes the fifth and sixth steps of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor		Null mutant is viable and requires histidine	YBR248C	S000000452
HIT1		Protein of unknown function, required for growth at high temperature		no growth at high temperature; confers pet phenotype	YJR055W	S000003816
HIT4				Mutant available that is temperature-sensitive		S000029213
HKR1		Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection		Null mutant is inviable; overexpression confers resistance to Hanenula mrakii killer toxin	YDR420W	S000002828
HLJ1		Co-chaperone for Hsp40p, anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ			YMR161W	S000004771
HLR1		Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A			YDR528W	S000002936
HMF1	HIG1	Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro		Null mutant grows faster than wild-type cells and has higher survival rate at 42.5c; overexpression inhibits cell growth	YER057C	S000000859
HMG1		One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae		Null mutant is viable, sensitive to compactin, a competitive inhibitor of HMG-CoA reductase; hmg1 hmg2 double deletion mutants are inviable	YML075C	S000004540
HMG2		One of two isozymes of HMG-CoA reductase that convert HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks		Null mutant is viable, sensitive to compactin, a competitive inhibitor of HMG-CoA reductase; hmg1 hmg2 double deletion mutants are inviable	YLR450W	S000004442
HMI1		Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD			YOL095C	S000005455
HML		Mating type cassette - left				S000029214
HMLALPHA1	ALPHA1	Silenced copy of ALPHA1 at HML, encoding a transcriptional coactivator involved in the regulation of mating-type alpha-specific gene expression			YCL066W	S000000571
HMLALPHA2	ALPHA2	Silenced copy of ALPHA2 at HML; homeobox-domain protein that associates with Mcm1p in haploid cells to repress a-specific gene expression and interacts with a1p in diploid cells to repress haploid-specific gene expression			YCL067C	S000000572
HMO1	HSM2	Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase		Null mutant is viable, but grows slowly and shows higher than normal plasmid loss rate	YDR174W	S000002581
HMR		Mating type cassette - right				S000029655
HMRA1	YCR097WB	Silenced copy of a1 at HMR; homeobox corepressor that interacts with Alpha2p to repress haploid-specific gene transcription in diploid cells		Null mutant is viable; deletion of the expressed copy of A1 causes mating defect; diploids in which the expressed copy of a1 is mutated cannot undergo meiosis and sporulation	YCR097W	S000000694
HMRA2	A2	Silenced copy of a2 at HMR; similarity to Alpha2p; required along with a1p for inhibiting expression of the HO endonuclease in a/alpha HO/HO diploid cells with an active mating-type interconversion system			YCR096C	S000000692
HMS1		Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant		Null mutant is viable; multicopy expression suppresses the pseudohyphal defect of mep2/mep2 strains	YOR032C	S000005558
HMS2		Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant		Null mutant is viable; multicopy expression suppresses the pseudohyphal defect of mep2/mep2 strains	YJR147W	S000003908
HMT1	HCP1|ODP1|RMT1	Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; also methylates ribosomal protein Rps2p		Null mutant is viable, hmt1 npl3-1 mutants are inviable	YBR034C	S000000238
HMX1		ER localized, heme-binding peroxidase involved in the degradation of heme; does not exhibit heme oxygenase activity despite similarity to heme oxygenases; expression regulated by AFT1			YLR205C	S000004195
HNM1	CTR1	Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol		Null mutant is viable, but hyper-resistant to nitrogen mustard; ctr1,cho1 double null is inviable	YGL077C	S000003045
HNT1		Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint			YDL125C	S000002283
HNT2	APH1	Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins			YDR305C	S000002713
HNT3		Member of the third branch of the histidine triad (HIT) superfamily of nucleotide-binding proteins; similar to Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia			YOR258W	S000005784
HO		Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p		Null mutant is viable and cannot undergo mating type switching	YDL227C	S000002386
HOC1		Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele		Null mutant is viable but is hypersensitive to calcofluor white and hygromycin B and has lowered restrictive temperature in a pkc1-371 background; high copy suppressor of pkc1-371	YJR075W	S000003836
HOF1	CYK2	Bud neck-localized, SH3 domain-containing protein required for cytokinesis; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p		Null mutant is defective in cytokinesis	YMR032W	S000004635
HOG1	SSK3	Mitogen-activated protein kinase involved in osmoregulation via three independent osmosensors; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p		Null mutant is viable and unable to grow in high osmolarity media	YLR113W	S000004103
HOL1		Putative transporter in the major facilitator superfamily (DHA1 family) of multidrug resistance transporters; mutations in membrane-spanning domains permit cation and histidinol uptake		Null mutant is viable, unable to uptake histidinol or Na+. Gain-of-function mutations confer non-selective cation transport and abolish translational repression by a small upstream open reading frame	YNR055C	S000005338
HOM2		Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis		Homoserine requiring	YDR158W	S000002565
HOM3	BOR1|SIL4	Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis		Homoserine requiring; Borrelidin resistance	YER052C	S000000854
HOM6		Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions		Homoserine requiring	YJR139C	S000003900
HOP1		Meiosis-specific DNA binding protein that displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for homologous chromosome synapsis and chiasma formation		decreased levels of meiotic crossing over and intragenic recombination between markers on homologous chromosomes	YIL072W	S000001334
HOP2		Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair		Null mutant is viable; homozygous hop2 null diploids arrest in meiotic prophase prior to the first meiotic division	YGL033W	S000003001
HOR2	GPP2	One of two redundant DL-glycerol-3-phosphatases (RHR2/GPP1 encodes the other) involved in glycerol biosynthesis; induced in response to hyperosmotic stress and oxidative stress, and during the diauxic transition		Mutants lacking both RHR2 and HOR2 are devoid of glycerol 3-phosphatase activity and produce only a small amount of glycerol. Overproduction of both genes does not significantly enhance glycerol production.	YER062C	S000000864
HOR7		Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor			YMR251W-A	S000004864
HOS1		Putative class I histone deacetylase (HDAC) with sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; deletion results in increased histone acetylation at rDNA repeats; interacts with the Tup1p-Ssn6p corepressor complex			YPR068C	S000006272
HOS2	RTL1	Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity			YGL194C	S000003162
HOS3		Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats			YPL116W	S000006037
HOS4		Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate			YIL112W	S000001374
HOT1		Transcription factor required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p		osmostress hypersensitivity	YMR172W	S000004783
HOT13		Mitochondrial intermembrane space protein, first component of a pathway mediating assembly of small TIM (Translocase of the Inner Membrane) complexes which escort hydrophobic inner membrane proteins en route to the TIM22 complex			YKL084W	S000001567
HPA2		Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity	KAT10	Null mutant is viable and does not show any detectable phenotype	YPR193C	S000006397
HPA3		D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro		Null mutant is viable and does not show any detectable phenotype	YEL066W	S000000792
HPC2		Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes		altered cell cycle regulation of histone gene transcription; suppresses delta insertion mutations in the HIS4 and LYS2 loci	YBR215W	S000000419
HPC3				altered cell cycle regulation of histone gene transcription		S000029215
HPC4				altered cell cycle regulation of histone gene transcription		S000029216
HPC5				altered cell cycle regulation of histone gene transcription; derepression occurs only in the presence of hydroxyurea but not alpha-factor		S000029217
HPF1		Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines			YOL155C	S000005515
HPR1	TRF1	Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p		Increased intrachromosomal recombination	YDR138W	S000002545
HPR2		Involved in mitotic intrachromosomal recombination		hpr2 mutations increase intrachromosomal gene conversion between repeated sequences and increase loss of a marker between duplicated genes		S000029218
HPR4		Involved in mitotic intrachromosomal recombination		hpr4 mutations increase intrachromosomal gene conversion between repeated sequences		S000029219
HPR7		Involved in mitotic intrachromosomal recombination		hpr7 mutations increase intrachromosomal gene conversion between repeated sequences and increase loss of a marker between duplicated genes		S000029220
HPR8		Involved in mitotic intrachromosomal recombination		hpr8 mutations increase intrachromosomal gene conversion between repeated sequences		S000029221
HPT1	BRA6|HPRT	Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine monophosphate and guanosine monophosphate; mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome	HGPRTase		YDR399W	S000002807
HRA1		Non-protein-coding RNA, substrate of RNase P, possibly involved in rRNA processing, specifically maturation of 20S precursor into the mature 18S rRNA				S000119380
HRB1	TOM34	Poly(A+) RNA-binding protein, involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Gbp2p and Npl3p			YNL004W	S000004949
HRD1	DER3	Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger		Null mutant is viable, slows degradation of Hmg2p	YOL013C	S000005373
HRD3		Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD), forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events		Null mutant is viable, slows degradation of Hmg2p	YLR207W	S000004197
HRK1		Protein kinase implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis			YOR267C	S000005793
HRP1	NAB4|NAB5	Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences		Null mutant is inviable; mutants can suppress temperature-sensitive alleles of npl3 (but not npl3 null mutants)	YOL123W	S000005483
HRQ1		Putative RecQ helicase; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS)			YDR291W	S000002699
HRR25	KTI14	Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta)		Null mutant is viable but shows slow growth; hrr25-1 mutation results in sensitivity to continuous expression of HO endonuclease, to methylmethanesulfonate, and to x-irradiation; homozygous hrr25-1 mutants are unable to sporulate	YPL204W	S000006125
HRS3				Suppresses hyper-deletion phenotype of hpr1 null mutant		S000029222
HRS4				Suppresses hyper-deletion phenotype of hpr1 null mutant; also has hyper-mutator phenotype		S000029223
HRS5				Suppresses hyper-deletion phenotype of hpr1 null mutant		S000029224
HRT1	HRT2|RBX1|ROC1	RING finger containing subunit of Skp1-Cullin-F-box ubiquitin protein ligases (SCF); required for Gic2p, Far1p, Sic1p and Cln2p degradation; may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF			YOL133W	S000005493
HRT3		Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies			YLR097C	S000004087
HSC82	HSP90	Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock		Null mutant is viable at 25 degrees C; ability to grow at higher temperatures varies with gene copy number	YMR186W	S000004798
HSE1		Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes		Null: accumulates enlarged prevacuolar/endosomal compartment. Fails to sort proteins into the vacuolar lumen.. Other phenotypes: secretes CPY	YHL002W	S000000994
HSF1	EXA3|MAS3	Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated			YGL073W	S000003041
HSH155		U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155			YMR288W	S000004901
HSH49		U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM)			YOR319W	S000005846
HSK3		Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis			YKL138C-A	S000028421
HSL1	ELM2|NIK1	Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p		Null mutant is viable; synthetically lethal with histone H3 mutations; G2 delay	YKL101W	S000001584
HSL7		Protein arginine N-methyltransferase that exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p		Null mutant is viable; synthetically lethal with histone H3 mutations; G2 delay	YBR133C	S000000337
HSM3		Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; related to human 19S subunit S5b		Null mutant is viable, hsm3 null mutants exhibit enhanced rates of spontaneous mutation to canavanine resistance and reversions of lys1-1 and his1-7, increased rate of intragenic mitotic recombination at the ADE2 gene, and reduced ability to correct DNA heteroduplexes	YBR272C	S000000476
HSP10	CPN10	Mitochondrial matrix co-chaperonin that inhibits the ATPase activity of Hsp60p, a mitochondrial chaperonin; involved in protein folding and sorting in the mitochondria; 10 kD heat shock protein with similarity to E. coli groES		Null mutant is inviable; temperature-sensitive mutants are available	YOR020C	S000005546
HSP104		Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation		Null mutant is viable and defective in induced thermotolerance	YLL026W	S000003949
HSP12	GLP1|HOR5	Plasma membrane localized protein that protects membranes from desiccation; induced by heat shock, oxidative stress, osmostress, stationary phase entry, glucose depletion, oleate and alcohol; regulated by the HOG and Ras-Pka pathways		Null mutant is viable, but shows induction of heat shock response under conditions normally associated with low-level HSP12 expression	YFL014W	S000001880
HSP150	CCW7|ORE1|PIR2	O-mannosylated heat shock protein that is secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation			YJL159W	S000003695
HSP26		Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires a heat-induced conformational change; not expressed in unstressed cells		Null mutant is viable; hsp26 hsp42 double deletion mutants are viable	YBR072W	S000000276
HSP30	YRO1	Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase			YCR021C	S000000615
HSP31		Possible chaperone and cysteine protease with similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site			YDR533C	S000002941
HSP32		Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp33p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease			YPL280W	S000006201
HSP33		Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease			YOR391C	S000005918
HSP42		Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock		Null mutant is viable; hsp42 hsp26 double deletion mutants are viable; hsp42 null mutants subjected to moderate thermal stress reorganize the actin cytoskeleton more slowly than wild-type	YDR171W	S000002578
HSP60	CPN60|MIF4|MNA2	Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated			YLR259C	S000004249
HSP78		Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates		Null mutant is viable but in ssc1 mutant background gives rho- phenotype	YDR258C	S000002666
HSP82	HSP90	Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p		Null mutant is viable at 25 degrees C; ability to grow at higher temperatures varies with gene copy number	YPL240C	S000006161
HST1		NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and mitotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance		Overexpression restores transcriptional silencing in a sir2 mutant	YOL068C	S000005429
HST2		Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro			YPL015C	S000005936
HST3		Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism			YOR025W	S000005551
HST4		Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism			YDR191W	S000002599
HSV2		Phosphatidylinositol 3,5-bisphosphate-binding protein, plays a role in micronucleophagy; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization			YGR223C	S000003455
HSX1		tRNA-Arg of low abundance; required for growth on nonfermentable carbon sources at high temperatures, for synthesis of heat shock protein Ssc1p, and for Ty1 retrotransposition through the regulation of translational frameshifting		Null mutant is viable, HSX1 is required for growth at 37 degrees on a nonfermentable carbon source, synthesis of the Ssc1 heat shock protein, and normal Ty1 retrotransposition		S000006707
HTA1	H2A1|SPT11	Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p			YDR225W	S000002633
HTA2	H2A2	Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p		Null mutant is viable. Deletion of the HTA2-HTB2 (TRT2) locus has no reported observable phenotypes, presumably because HTA1-HTB1 (TRT1) expression is upregulated and can compensate in the absence of TRT2. Overexpression of TRT2 can suppress Ty insertion mutations	YBL003C	S000000099
HTB1	SPT12	Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB2; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation			YDR224C	S000002632
HTB2		Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation		Null mutant is viable. Deletion of the HTA2-HTB2 (TRT2) locus has no reported observable phenotypes, presumably because HTA1-HTB1 (TRT1) expression is upregulated and can compensate in the absence of TRT2	YBL002W	S000000098
HTD2	RMD12	Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology			YHR067W	S000001109
HTL1		Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance		Null mutant is viable but shows temperature-sensitive lethality	YCR020W-B	S000006439
HTS1	TSM4572	Cytoplasmic and mitochondrial histidine tRNA synthetase; encoded by a single nuclear gene that specifies two messages; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence	histidyl-tRNA synthetase	Certain mutations can be made to disrupt either cytoplasmic or mitochondrial form of Hts1p; loss of mitochondrial synthetase gives Pet- phenotype; loss of cytoplasmic synthetase can result in lethality or respiratory deficiency	YPR033C	S000006237
HTZ1	HTA3	Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin	H2A.F/Z|H2AZ	Null mutant is viable at 28C; high copy suppressor of histone H4 point mutant affecting nucleosome structure	YOL012C	S000005372
HUA1		Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly			YGR268C	S000003500
HUA2		Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly			YOR284W	S000005810
HUB1		Ubiquitin-like protein modifier, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear			YNR032C-A	S000007251
HUG1		Protein involved in the Mec1p-mediated checkpoint pathway that responds to DNA damage or replication arrest, transcription is induced by DNA damage		Null mutant is viable and shows suppression of dun1 delta HU sensitivity.	YML058W-A	S000007472
HUL4		Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability			YJR036C	S000003797
HUL5		Ubiquitin-conjugating enzyme (E4), elongates polyubiquitin chains on substrate proteins; works in opposition to Ubp6p polyubiquitin-shortening activity; required for retrograde transport of misfolded proteins into cytoplasm during ERAD			YGL141W	S000003109
HUR1		Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene		Null mutant is viable but sensitive to HU	YGL168W	S000003136
HUT1		Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1			YPL244C	S000006165
HVG1	YEM9	Protein of unknown function, has homology to Vrg4p			YER039C	S000000841
HXK1		Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p		Null mutant is viable, is able to ferment fructose, and has little or no effect on glucose repression; hxk1, hxk2 double null mutant cannot ferment fructose and fails to show glucose repression at SUC2, CYC1, GAL10	YFR053C	S000001949
HXK2	HEX1|HKB|SCI2	Hexokinase isoenzyme 2 that catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene		Null mutant is viable and can ferment fructose, but fails to show glucose repression at SUC2, CYC1, GAL10. hxk1, hxk2 double null mutant cannot ferment fructose	YGL253W	S000003222
HXT1	HOR4	Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting			YHR094C	S000001136
HXT10		Putative hexose transporter, expressed at low levels and expression is repressed by glucose			YFL011W	S000001883
HXT11	LGT3	Putative hexose transporter that is nearly identical to Hxt9p, has similarity to major facilitator superfamily (MFS) transporters and is involved in pleiotropic drug resistance		Other phenotypes: Shortens the G1 phase of the cell cycle when present in high-copy|Null mutant is viable, cycloheximide, sulfomethuron methyl, and 4-NQO (4-nitroquinoline-N-oxide) resistant	YOL156W	S000005516
HXT12		Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family				S000001432
HXT13		Hexose transporter, induced in the presence of non-fermentable carbon sources, induced by low levels of glucose, repressed by high levels of glucose			YEL069C	S000000795
HXT14		Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YNL318C	S000005262
HXT15		Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose			YDL245C	S000002404
HXT16		Protein of unknown function with similarity to hexose transporter family members, expression is repressed by high levels of glucose			YJR158W	S000003919
HXT17		Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose			YNR072W	S000005355
HXT2		High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose			YMR011W	S000004613
HXT3		Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions		Null mutant is viable but grows slowly on galactose; some mutant alleles confer sodium hypersensitivity.	YDR345C	S000002753
HXT4	LGT1|RAG1	High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose			YHR092C	S000001134
HXT5		Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs			YHR096C	S000001138
HXT6		High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3		Null mutant is viable; snf3 hxt1 hxt2 hxt3 hxt4 hxt6 hxt7 mutant cannot grow on media containing glucose as sole carbon source	YDR343C	S000002751
HXT7		High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels		Null mutant is viable; snf3 hxt1 hxt2 hxt3 hxt4 HXT7 hxt7 mutant cannot grow on media containing glucose as sole carbon source	YDR342C	S000002750
HXT8		Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose			YJL214W	S000003750
HXT9		Putative hexose transporter that is nearly identical to Hxt11p, has similarity to major facilitator superfamily (MFS) transporters, expression of HXT9 is regulated by transcription factors Pdr1p and Pdr3p		Null mutant is viable, cycloheximide, sulfomethuron methyl, and 4-NQO (4-nitroquinoline-N-oxide) resistant	YJL219W	S000003755
HYG4				Hygromycin resitance		S000029225
HYM1		Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response			YKL189W	S000001672
HYP2	TIF51A|eIF-5A|eIF5A	Translation elongation factor eIF-5A, previously thought to function in translation initiation; similar to and functionally redundant with Anb1p; structural homolog of bacterial EF-P; undergoes an essential hypusination modification		Null mutant is viable; a double mutant containing disruptions of both HYP2 and and the highly homologous ANB1 is inviable	YEL034W	S000000760
HYR1	GPX3|ORP1	Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor		Null mutant is hypersensitive to oxidative stress	YIR037W	S000001476
IAH1		Isoamyl acetate-hydrolyzing esterase, required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing		The null mutant is viable but cannot hydrolyze isoamyl acetate.	YOR126C	S000005652
IAR1		Involved in regulating invertase (SUC5) activity and may be in part responsible for low levels of invertase activity observed in diploids		Mutants allow higher levels of invertase expression		S000029226
IBA57	CAF17	Mitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system		Null mutant is viable, shows petite phenotype	YJR122W	S000003883
IBD2		Component of the BUB2-dependent spindle checkpoint pathway, interacts with Bfa1p and functions upstream of Bub2p and Bfa1p		Null: viable, sensitive to benomyl	YNL164C	S000005108
IBI1		Putative protein of unknown function; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; YGR273C is not an essential gene			YGR273C	S000003505
IBI2		Protein of unknown function that associates with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud; YMR295C is not an essential gene			YMR295C	S000004910
ICE2		Integral ER membrane protein with type-III transmembrane domains; mutations cause defects in cortical ER morphology in both the mother and daughter cells			YIL090W	S000001352
ICK1		found as an extragenic suppressor of ctf13-30				S000029227
ICL1		Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose		Null mutant is viable, fails to grow on ethanol as a carbon source	YER065C	S000000867
ICL2		2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol			YPR006C	S000006210
ICP55		Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of the aminopeptidase P family			YER078C	S000000880
ICR1		Long intergenic ncRNA, has a key role in regulating transcription of the nearby protein-coding ORF MUC1; initiated far upstream from MUC1 and transcribed across much of the large promoter of MUC1, repressing MUC1 transcription in cis				S000132612
ICS2		Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization			YBR157C	S000000361
ICS3		Protein of unknown function			YJL077C	S000003613
ICT1		Lysophosphatidic acid acyltransferase, responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress			YLR099C	S000004089
ICY1		Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation			YMR195W	S000004808
ICY2		Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate			YPL250C	S000006171
IDH1		Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle		Null mutant is viable, grows at a reduced rate on glycerol, lactate, and acetate	YNL037C	S000004982
IDH2		Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated			YOR136W	S000005662
IDI1	BOT2|LPH10	Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase), catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability			YPL117C	S000006038
IDP1		Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes			YDL066W	S000002224
IDP2		Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose			YLR174W	S000004164
IDP3		Peroxisomal NADP-dependent isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids		Null mutant is viable but is unable to grow on polyunsaturated fatty acids as sole carbon source	YNL009W	S000004954
IDS2		Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation		Null mutations reduce or abolish the ability of IME2p to activate expression of early, middle, and late meiotic genes. Recessive and null ids2 mutants prevent toxicity of Ime2p expression in rad52 haploids, but do not affect Ime2p polypeptide accumulation.	YJL146W	S000003682
IES1		Subunit of the INO80 chromatin remodeling complex			YFL013C	S000001881
IES2		Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; essential for growth under anaerobic conditions			YNL215W	S000005159
IES3		Subunit of the INO80 chromatin remodeling complex			YLR052W	S000004042
IES4		Component of the INO80 chromatiin remodeling complex and target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses		Null: non essential.	YOR189W	S000005715
IES5		Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions		Null: non essential.	YER092W	S000000894
IES6		Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes		Null: non essential.	YEL044W	S000000770
IFA38		Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides			YBR159W	S000000363
IFH1		Essential protein with a highly acidic N-terminal domain; IFH1 exhibits genetic interactions with FHL1, overexpression interferes with silencing at telomeres and HM loci; potential Cdc28p substrate		Null mutant is inviable, ifh1 fhl1 double deletion mutant is viable	YLR223C	S000004213
IFM1		Mitochondrial translation initiation factor 2		Null mutant is viable but is respiratory-deficient and has defects in mitochondrial protein synthesis	YOL023W	S000005383
IGO1		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus			YNL157W	S000005101
IGO2		Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance is decreased upon intracellular iron depletion			YHR132W-A	S000007496
IKI1	ELP5|HAP2|TOT5	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin		Null mutant is viable but is insensitive to pGLK killer toxin; zymotoxin resistant; slow growth; thermo-sensitive above 38 0C; caffeine, Calcofluor White and 6-azauracil sensitive; G1 cell cycle delay	YHR187W	S000001230
IKI2				insensitive to killer toxin		S000029228
IKI3	ELP1|KTI7|TOT1	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)		Null mutant is viable; insensitive to pGKL killer toxin; zymotoxin resistant; slow growth; thermo-sensitive above 38 0C; caffeine, Calcofluor White and 6-azauracil sensitive; G1 cell cycle delay	YLR384C	S000004376
IKI4				insensitive to killer toxin		S000029229
IKI5				insensitive to killer toxin		S000029230
IKS1		Putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p		Null mutant is heat shock sensitive	YJL057C	S000003593
ILM1		Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth			YJR118C	S000003879
ILP1						S000029231
ILS1		Cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin A	isoleucyl-tRNA synthetase	Arrests in early G1 at nonpermissive temperature of 36 degrees C	YBL076C	S000000172
ILV1	ISO1	Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation			YER086W	S000000888
ILV2	SMR1|THI1	Acetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control		Isoleucine-plus-valine requiring; Sulfometuron methyl resistance	YMR108W	S000004714
ILV3		Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids		Null mutant is viable and requires isoleucine and valine	YJR016C	S000003777
ILV5		Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosynthesis, also required for maintenance of wild-type mitochondrial DNA and found in mitochondrial nucleoids		Isoleucine-plus-valine requiring	YLR355C	S000004347
ILV6		Regulatory subunit of acetolactate synthase, which catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria			YCL009C	S000000515
IMD1		Nonfunctional protein with homology to IMP dehydrogenase; probable pseudogene, located close to the telomere; is not expressed at detectable levels; YAR073W and YAR075W comprise a continuous reading frame in some strains of S. cerevisiae			YAR073W	S000000095
IMD2	PUR5	Inosine monophosphate dehydrogenase, catalyzes the rate-limiting step in GTP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitatio			YHR216W	S000001259
IMD3		Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed			YLR432W	S000004424
IMD4		Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed			YML056C	S000004520
IME1		Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p		The null mutant is viable. Diploids homozygous for the null mutation lack premeiotic DNA synthesis and do not sporulate; these phenotypes are recessive.	YJR094C	S000003854
IME2	SME1	Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p		Null mutant is viable, homozygous null mutants are sporulation defective. High copy IME2 stimulates meiotic recombination without starvation and permits meiosis in an ime1 null background	YJL106W	S000003642
IME4	SPO8	Probable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid cells; haploids repress IME4 transcription via production of antisense IME4 transcripts; antisense transcription is repressed in diploids		Homozygous mutant diploid cannot accumulate IME1 mRNA during early stages of meiosis and cannot sporulate	YGL192W	S000003160
IMG1		Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome		Null mutant is viable; respiration deficient	YCR046C	S000000642
IMG2		Mitochondrial ribosomal protein of the large subunit		Null mutant is viable but shows respiratory deficiency and loss of wild-type mtDNA: conversion to rho- and rho zero petites	YCR071C	S000000667
IMH1	SYS3	Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi		Null mutant is viable; imh1 ypt6 double disruption causes growth inhibition	YLR309C	S000004300
IML1		Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane			YJR138W	S000003899
IML2		Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies			YJL082W	S000003618
IML3	MCM19	Protein with a role in kinetochore function, localizes to the outer kinetochore in a Ctf19p-dependent manner, interacts with Chl4p and Ctf19p		Null mutant is viable, but exhibits chromosome loss and abnormal chromosomal segregation	YBR107C	S000000311
IMP1	PET-TS2858	Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p		petite; unable to grow on non-fermentable carbon sources	YMR150C	S000004758
IMP2		Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p			YMR035W	S000004638
IMP2'	IMP2	Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat		Null mutant is viable, Inability to grow on maltose, galactose and raffinose in respiratory-deficient conditions or in the presence of ethidium bromide and erythromycin; leaky phenotype on oxidizable carbon sources: sensitivity to heat shock and sporulation deficiency	YIL154C	S000001416
IMP3		Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA		Null mutant is inviable. Depletion of Imp3p prevents the synthesis of mature 18S rRNA.	YHR148W	S000001191
IMP4		Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs			YNL075W	S000005019
IMT1		tRNA-IMet; one of four initiator methionine tRNAs in yeast that are functional for translation				S000006665
IMT2		tRNA-IMet; one of four initiator methionine tRNAs in yeast that are functional for translation				S000006667
IMT3		tRNA-IMet; one of four initiator methionine tRNAs in yeast that are functional for translation				S000006663
IMT4		tRNA-IMet; one of four initiator methionine tRNAs in yeast that are functional for translation				S000006660
INH1		Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase; inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has similarity to Stf1p; has a calmodulin-binding motif and binds calmodulin in vitro		Null mutant is viable; exhibits marked ATP hydrolysis in response to the uncoupler carbonylcyanide-m-chlorophenylhydrazone	YDL181W	S000002340
INM1		Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate			YHR046C	S000001088
INM2		Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy			YDR287W	S000002695
INN1		Essential protein that associates with the contractile actomyosin ring, required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function			YNL152W	S000005096
INO1	APR1	Inositol 1-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element		Null mutant is viable, inositol auxotroph	YJL153C	S000003689
INO2	DIE1|SCS1	Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion		The null mutant is viable but auxotrophic for inositol and choline. The null mutant can also display aberant cell shape and defects in nuclear segregation. Homozygous mutant ino2 delta-1 diploids fail to sporulate. Other mutant alleles show pleiotropic defects in phospholipid metabolism.	YDR123C	S000002530
INO4		Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain		The null mutant is viable but auxotrophic for inositol and choline. The null mutant expresses repressed levels of inositol-1-phosphate synthase (INO1) mRNA and exhibits reduced phosphatidylcholine biosynthesis.	YOL108C	S000005468
INO80		ATPase, subunit of a complex containing actin and several actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; has a role in modulating stress gene transcription			YGL150C	S000003118
INP1		Peripheral membrane protein of peroxisomes involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane			YMR204C	S000004817
INP2		Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene			YMR163C	S000004773
INP51	SJL1	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth		Null mutant is viable, has abnormal vacuoles	YIL002C	S000001264
INP52	SJL2	Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain		Null mutant is viable, has abnormal vacuoles	YNL106C	S000005050
INP53	SJL3|SOP2	Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains		Null mutant is viable but has abnormal vacuoles	YOR109W	S000005635
INP54		Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins			YOL065C	S000005426
IOC2		Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif			YLR095C	S000004085
IOC3		Member of a complex (Isw1a) with Isw1p that has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; has homology to Esc8p, which is involved in silencing			YFR013W	S000001909
IOC4		Member of a complex (Isw1b) with Isw1p and Ioc2p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PWWP motif			YMR044W	S000004647
IPA1				ipa1 mutant has no phenotype, but ipa1 udt1 double mutant accumulates more porphyrin than udt1 mutant		S000029232
IPA2				ipa2 mutant has no phenotype, but ipa2 udt1 double mutant accumulates more porphyrin than udt1 mutant		S000029233
IPA3				ipa3 mutant has no phenotype, but ipa3 udt1 double mutant accumulates more porphyrin than udt1 mutant		S000029234
IPI1		Essential component of the Rix1 complex (with Rix1p and Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles			YHR085W	S000001127
IPI3		Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; highly conserved and contains WD40 motifs; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles			YNL182C	S000005126
IPK1	GSL1	Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable		Null mutant is viable but is severely compromised in ability to produce IP6 (100x decrease); null has 100x greater amounts of IP5 and PP-IP4; null also has increased IP3 and IP4; synthetic lethal with gle1-4 (GSL); null has mRNA export defects, fails to grow at 37C after 10 generations	YDR315C	S000002723
IPL1	PAC15	Aurora kinase subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase		temperature-sensitive mutant lacks proper chromosome segregation at non-permissive temperature	YPL209C	S000006130
IPP1	PPA1	Cytoplasmic inorganic pyrophosphatase (PPase), homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase			YBR011C	S000000215
IPT1	KTI6|SYR4	Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid;, can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin		Null mutant is viable but cannot synthesize M(IP)2C, instead accumulates the precursor, mannose-inositol-P-ceramide, and is slightly resistant to calcium	YDR072C	S000002479
IQG1	CYK1	Essential protein required for determination of budding pattern, promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family		Null mutant is inviable (spores germinate, divide several times and lyse); cells are multinucleate and have defects in cytokinesis, morphology, actin, and tubulin	YPL242C	S000006163
IRA1	GLC1|PPD1	GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase		Null mutant is viable, exhibits constitutive activation of the Ras/cyclic AMP (cAMP) pathway, heat shock sensitivity, nitrogen starvation sensitivity, sporulation deficiency, suppresses lethality of cdc25, but not cyr1, ras1, or ras2 mutants	YBR140C	S000000344
IRA2	CCS1|GLC4	GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin		Null mutant is viable, exhibits increased sensitivity to heat shock and nitrogen starvation, sporulation defects, and suppression of the lethality of a cdc25 mutants	YOL081W	S000005441
IRC10		Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci			YOL015W	S000005375
IRC11		Dubious opening reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YOR012C; null mutant displays increased levels of spontaneous Rad52 foci			YOR013W	S000005539
IRC13		Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci			YOR235W	S000005761
IRC14		Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YOR136W; null mutant displays increased levels of spontaneous Rad52 foci			YOR135C	S000005661
IRC15		Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci			YPL017C	S000005938
IRC16		Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YPR037C; null mutant displays increased levels of spontaneous Rad52p foci			YPR038W	S000006242
IRC18		Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci			YJL037W	S000003574
IRC19	GON2|RRG4	Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci			YLL033W	S000003956
IRC2		Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci			YDR112W	S000002519
IRC20		Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci			YLR247C	S000004237
IRC21		Putative protein of unknown function; proposed to be involved in resistance to carboplatin and cisplatin; shares similarity to a human cytochrome oxidoreductase; null mutant displays increased levels of spontaneous Rad52p foci			YMR073C	S000004677
IRC22		Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci			YEL001C	S000000727
IRC23		Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; null mutant displays increased levels of spontaneous Rad52p foci			YOR044W	S000005570
IRC24		Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci			YIR036C	S000001475
IRC25	DMP2|PBA3|POC3	Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions			YLR021W	S000004011
IRC3		Putative RNA helicase of the DEAH/D-box family; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion			YDR332W	S000002740
IRC4		Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus			YDR540C	S000002948
IRC5		Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci			YFR038W	S000001934
IRC6		Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci			YFR043C	S000001939
IRC7		Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner			YFR055W	S000001952
IRC8		Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc			YJL051W	S000003587
IRC9		Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YJL141C; null mutant displays increased levels of spontaneous Rad52p foci			YJL142C	S000003678
IRE1	ERN1	Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress		Null mutant is viable, myo-inositol auxotroph; IRE1 is essential for viability under stress conditions that cause unfolded proteins to accumulate in the ER	YHR079C	S000001121
IRR1	SCC3	Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability		Null mutant is inviable; decreased transcription of mutant causes irregularity of zygotes, colonies, decreased adhesion to solid supports	YIL026C	S000001288
IRS4		EH domain-containing protein involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS		Null mutant is viable and shows increased rDNA silencing	YKR019C	S000001727
ISA1		Mitochondrial matrix protein involved in biogenesis of the iron-sulfur (Fe/S) cluster of Fe/S proteins, isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon sources			YLL027W	S000003950
ISA2		Protein required for maturation of mitochondrial and cytosolic Fe/S proteins, localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations		null mutant is viable; exhibits dependency on lysine and glutamate for growth, an increase in mitochondrial iron concentration, and a respiratory deficiency due to accumulation of mutations in mitochondrial DNA	YPR067W	S000006271
ISC1		Mitochondrial membrane localized inositol phosphosphingolipid phosp